{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:47:54Z","timestamp":1791488874500,"version":"4.3.4"},"reference-count":22,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["109-D07"],"award-info":[{"award-number":["109-D07"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["109\u2013105"],"award-info":[{"award-number":["109\u2013105"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["109\u2013106"],"award-info":[{"award-number":["109\u2013106"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["110-D06"],"award-info":[{"award-number":["110-D06"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["110\u2013088"],"award-info":[{"award-number":["110\u2013088"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["110\u2013090"],"award-info":[{"award-number":["110\u2013090"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["110\u2013143"],"award-info":[{"award-number":["110\u2013143"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["VGHKS109-103"],"award-info":[{"award-number":["VGHKS109-103"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 110-2314-B-075B-006"],"award-info":[{"award-number":["MOST 110-2314-B-075B-006"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST-109-2314-B-075B-014-MY2"],"award-info":[{"award-number":["MOST-109-2314-B-075B-014-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.tjog.2022.02.008","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T20:32:55Z","timestamp":1648499575000},"page":"223-229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["DHEA restores mitochondrial dynamics of cumulus cells by regulating PGAM5 expression in poor ovarian responders"],"prefix":"10.1016","volume":"61","author":[{"given":"Yung-Ling","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Jung","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Te","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"San-Nung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Hong","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Hao","family":"Tsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.tjog.2022.02.008_bib1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.14336\/AD.2020.1113","article-title":"The molecular regulation in the pathophysiology in ovarian aging","volume":"12","author":"Li","year":"2021","journal-title":"Aging Dis"},{"issue":"3","key":"10.1016\/j.tjog.2022.02.008_bib2","doi-asserted-by":"crossref","first-page":"R139","DOI":"10.1530\/JME-16-0013","article-title":"Novel mechanisms for DHEA action","volume":"56","author":"Prough","year":"2016","journal-title":"J\u00a0Mol Endocrinol"},{"issue":"2","key":"10.1016\/j.tjog.2022.02.008_bib3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4103\/0974-1208.183515","article-title":"Effective treatment protocol for poor ovarian response: a systematic review and meta-analysis","volume":"9","author":"Jeve","year":"2016","journal-title":"J\u00a0Hum Reprod Sci"},{"issue":"4","key":"10.1016\/j.tjog.2022.02.008_bib4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/00912709922007903","article-title":"DHEA and DHEA-S: a review","volume":"39","author":"Kroboth","year":"1999","journal-title":"J\u00a0Clin Pharmacol"},{"issue":"2","key":"10.1016\/j.tjog.2022.02.008_bib5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0039-128X(99)00090-2","article-title":"Influence of oral dehydroepiandrosterone (DHEA) on urinary steroid metabolites in males and females","volume":"65","author":"Callies","year":"2000","journal-title":"Steroids"},{"issue":"4","key":"10.1016\/j.tjog.2022.02.008_bib6","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/humupd\/dms013","article-title":"Testosterone concentrations, using different assays, in different types of ovarian insufficiency: a systematic review and meta-analysis","volume":"18","author":"Janse","year":"2012","journal-title":"Hum Reprod Update"},{"issue":"21","key":"10.1016\/j.tjog.2022.02.008_bib7","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798899","article-title":"Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy","volume":"37","author":"Sugo","year":"2018","journal-title":"EMBO J"},{"issue":"10","key":"10.1016\/j.tjog.2022.02.008_bib8","first-page":"756","article-title":"[Angiogenesis related gene expression profiles of human endometrial endothelial cells isolated from tissue of endometrial cancer]","volume":"47","author":"Du","year":"2012","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"issue":"30","key":"10.1016\/j.tjog.2022.02.008_bib9","doi-asserted-by":"crossref","first-page":"30017","DOI":"10.18632\/oncotarget.5013","article-title":"Bax-PGAM5L-Drp1 complex is required for intrinsic apoptosis execution","volume":"6","author":"Xu","year":"2015","journal-title":"Oncotarget"},{"issue":"10","key":"10.1016\/j.tjog.2022.02.008_bib10","article-title":"Dehydroepiandrosterone ameliorates abnormal mitochondrial dynamics and mitophagy of cumulus cells in poor ovarian responders","volume":"7","author":"Li","year":"2018","journal-title":"J\u00a0Clin Med"},{"issue":"11","key":"10.1016\/j.tjog.2022.02.008_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines8110451","article-title":"A\u00a0novel biomarker driving poor-prognosis liver cancer: overexpression of the mitochondrial calcium gatekeepers","volume":"8","author":"Li","year":"2020","journal-title":"Biomedicines"},{"issue":"12","key":"10.1016\/j.tjog.2022.02.008_bib12","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1111\/jog.13456","article-title":"Dehydroepiandrosterone as a potential agent to slow down ovarian aging","volume":"43","author":"Lin","year":"2017","journal-title":"J\u00a0Obstet Gynaecol Res"},{"issue":"4","key":"10.1016\/j.tjog.2022.02.008_bib13","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.rbmo.2009.06.006","article-title":"Dehydroepiandrosterone supplementation improves ovarian response and cycle outcome in poor responders","volume":"19","author":"S\u00f6nmezer","year":"2009","journal-title":"Reprod Biomed Online"},{"issue":"7","key":"10.1016\/j.tjog.2022.02.008_bib14","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1210\/me.2010-0006","article-title":"Granulosa cell-specific androgen receptors are critical regulators of ovarian development and function","volume":"24","author":"Sen","year":"2010","journal-title":"Mol Endocrinol"},{"issue":"2","key":"10.1016\/j.tjog.2022.02.008_bib15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1385\/ENDO:17:2:129","article-title":"Dehydroepiandrosterone regulates insulin-like growth factor-1 system in adult rat hypothalamus","volume":"17","author":"Ribeiro","year":"2002","journal-title":"Endocrine"},{"key":"10.1016\/j.tjog.2022.02.008_bib16","doi-asserted-by":"crossref","first-page":"110949","DOI":"10.1016\/j.exger.2020.110949","article-title":"Impact of dehydroepianrosterone (DHEA) supplementation on serum levels of insulin-like growth factor 1 (IGF-1): a dose-response meta-analysis of randomized controlled trials","volume":"136","author":"Xie","year":"2020","journal-title":"Exp Gerontol"},{"issue":"1","key":"10.1016\/j.tjog.2022.02.008_bib17","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/molehr\/gaq073","article-title":"In human granulosa cells from small antral follicles, androgen receptor mRNA and androgen levels in follicular fluid correlate with FSH receptor mRNA","volume":"17","author":"Nielsen","year":"2011","journal-title":"Mol Hum Reprod"},{"issue":"2","key":"10.1016\/j.tjog.2022.02.008_bib18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1530\/REP-17-0016","article-title":"DHEA protects mitochondria against dual modes of apoptosis and necroptosis in human granulosa HO23 cells","volume":"154","author":"Tsui","year":"2017","journal-title":"Reproduction"},{"issue":"2","key":"10.1016\/j.tjog.2022.02.008_bib19","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/09513590.2016.1214262","article-title":"Protection of cumulus cells following dehydroepiandrosterone supplementation","volume":"33","author":"Lin","year":"2017","journal-title":"Gynecol Endocrinol"},{"issue":"6","key":"10.1016\/j.tjog.2022.02.008_bib20","doi-asserted-by":"crossref","first-page":"585","DOI":"10.7150\/ijms.18706","article-title":"The application of dehydroepiandrosterone on improving mitochondrial function and reducing apoptosis of cumulus cells in poor ovarian responders","volume":"14","author":"Lin","year":"2017","journal-title":"Int J Med Sci"},{"issue":"7","key":"10.1016\/j.tjog.2022.02.008_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/nu13072449","article-title":"Dehydroepiandrosterone shifts energy metabolism to increase mitochondrial biogenesis in female fertility with advancing age","volume":"13","author":"Li","year":"2021","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.tjog.2022.02.008_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics10050295","article-title":"Combining bioinformatics and experiments to identify CREB1 as a key regulator in senescent granulosa cells","volume":"10","author":"Lin","year":"2020","journal-title":"Diagnostics"}],"updated-by":[{"DOI":"10.1016\/j.tjog.2022.07.004","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000}}],"container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455922000080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455922000080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T04:21:12Z","timestamp":1689999672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1028455922000080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S1028455922000080"],"URL":"https:\/\/doi.org\/10.1016\/j.tjog.2022.02.008","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.tjog.2022.07.004","asserted-by":"object"}]},"ISSN":["1028-4559"],"issn-type":[{"value":"1028-4559","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DHEA restores mitochondrial dynamics of cumulus cells by regulating PGAM5 expression in poor ovarian responders","name":"articletitle","label":"Article Title"},{"value":"Taiwanese Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjog.2022.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}