{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T15:27:09Z","timestamp":1793287629733,"version":"4.5.0"},"reference-count":14,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T00:00:00Z","timestamp":1643932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004861","name":"Mackay Memorial Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MMH-E-110-04"],"award-info":[{"award-number":["MMH-E-110-04"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.tjog.2022.02.028","type":"journal-article","created":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T16:33:01Z","timestamp":1648485181000},"page":"356-358","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Detection of paternal origin of fetal de novo rea(21q;21q) down syndrome in a pregnancy of a young woman associated with an abnormal first-trimester maternal serum screening result"],"prefix":"10.1016","volume":"61","author":[{"given":"Chih-Ping","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-Bin","family":"Jou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schu-Rern","family":"Chern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Tzu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayseen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjog.2022.02.028_bib1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S1028-4559(09)60331-4","article-title":"Prenatal diagnosis of Down syndrome and its recurrence due to unbalanced homologous acrocentric rearrangements by amniocentesis","volume":"48","author":"Chen","year":"2009","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2022.02.028_bib2","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.tjog.2012.09.031","article-title":"Detection of mosaic balanced homologous acrocentric rearrangement rea(21q21q) in a woman with repeated pregnancy losses","volume":"51","author":"Chen","year":"2012","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2022.02.028_bib3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/ajmg.a.10113","article-title":"Mosaicism in a patient with Down syndrome reveals post-fertilization formation of a Robertsonian translocation and isochromosome","volume":"116A","author":"Bandyopadhyay","year":"2003","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2022.02.028_bib4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF00210673","article-title":"Isochromosome not translocation in trisomy 21q21q","volume":"84","author":"Grasso","year":"1989","journal-title":"Hum Genet"},{"key":"10.1016\/j.tjog.2022.02.028_bib5","first-page":"968","article-title":"Analysis of DNA polymorphisms suggests that most de novo dup(21q) chromosomes in patients with Down syndrome are isochromosomes and not translocations","volume":"47","author":"Antonarakis","year":"1990","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.tjog.2022.02.028_bib6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/BF00201838","article-title":"A\u00a0molecular genetic approach to the identification of isochromosomes of chromosome 21","volume":"86","author":"Shaffer","year":"1991","journal-title":"Hum Genet"},{"key":"10.1016\/j.tjog.2022.02.028_bib7","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/ajmg.1320470818","article-title":"Further characterization of 19 cases of rea(21q21q) and delineation as isochromosomes or Robertsonian translocations in Down syndrome","volume":"47","author":"Shaffer","year":"1993","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2022.02.028_bib8","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/ajmg.a.20156","article-title":"Under-ascertainment of mosaic carriers of balanced homologous acrocentric translocations and isochromosomes","volume":"121A","author":"Kovaleva","year":"2003","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.tjog.2022.02.028_bib9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1136\/jmg.14.3.221","article-title":"Reproduction in a woman with low percentage t(21q21q) mosaicism","volume":"14","author":"Mark","year":"1977","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.tjog.2022.02.028_bib10","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000130850","article-title":"Structural chromosome abnormalities in Down syndrome: a study of two families","volume":"20","author":"Jacobs","year":"1978","journal-title":"Cytogenet Cell Genet"},{"key":"10.1016\/j.tjog.2022.02.028_bib11","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1136\/jmg.15.5.406","article-title":"Reproduction in a woman with mosaicism","volume":"15","author":"Wilroy","year":"1978","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.tjog.2022.02.028_bib12","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1136\/jmg.28.7.502","article-title":"Parental mosaicism in de novo translocation (21q21q) Down's syndrome","volume":"28","author":"Croci","year":"1991","journal-title":"J\u00a0Med Genet"},{"issue":"Suppl","key":"10.1016\/j.tjog.2022.02.028_bib13","first-page":"A156","article-title":"Gonadal mosaicism for a Robertsonian translocation: a search for the best reproductive options for a couple with five spontaneous abortions","volume":"63","author":"Yu","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.tjog.2022.02.028_bib14","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/ajmg.1320220228","article-title":"Recurrence risk in de novo 21q21q translocation Down syndrome","volume":"22","author":"Hall","year":"1985","journal-title":"Am J Med Genet"}],"container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455922000286?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455922000286?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:21:24Z","timestamp":1760898084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1028455922000286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S1028455922000286"],"URL":"https:\/\/doi.org\/10.1016\/j.tjog.2022.02.028","relation":{},"ISSN":["1028-4559"],"issn-type":[{"value":"1028-4559","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Detection of paternal origin of fetal de novo rea(21q;21q) down syndrome in a pregnancy of a young woman associated with an abnormal first-trimester maternal serum screening result","name":"articletitle","label":"Article Title"},{"value":"Taiwanese Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjog.2022.02.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}