{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:41:08Z","timestamp":1790671268684,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.tjog.2022.10.006","type":"journal-article","created":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T14:24:34Z","timestamp":1675002274000},"page":"101-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Maternal serum ischemia-modified albumin (IMA), total-sulphydryl concentrations, and some subclinic inflammatory markers in hyperemesis gravidarum (HG)"],"prefix":"10.1016","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5576-6789","authenticated-orcid":false,"given":"Kaz\u0131m","family":"U\u00e7kan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halit","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canan","family":"Demir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjog.2022.10.006_bib1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/jcla.20298","article-title":"Serum lipid profile, oxidative status, and paraoxonase 1 activity in hyperemesis gravidarum","volume":"23","author":"Aksoy","year":"2009","journal-title":"J\u00a0Clin Lab Anal"},{"key":"10.1016\/j.tjog.2022.10.006_bib2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1067\/mob.2002.122594","article-title":"Nausea and vomiting in pregnancy: the problem of perception \u2013 is it really a disease?","volume":"186","author":"Miller","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2022.10.006_bib3","first-page":"94","article-title":"Hospitalizations during pregnancy among managed care enrollees","volume":"100","author":"Gazmararian","year":"2002","journal-title":"Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.tjog.2022.10.006_bib4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/humupd\/dmi021","article-title":"Hyperemesis gravidarum, a literature review","volume":"1","author":"Verberg","year":"2005","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.tjog.2022.10.006_bib5","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/humrep\/den029","article-title":"Defective endovascular trophoblast invasion in the first trimester is associated with increased maternal serum ischemia-modified albumin","volume":"23","author":"Papageorghiou","year":"2008","journal-title":"Hum Reprod"},{"key":"10.1016\/j.tjog.2022.10.006_bib6","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1093\/humrep\/dem095","article-title":"First trimester maternal serum ischaemia-modified albumin: a marker of hypoxia \u2013 ischaemiadriven early trophoblast development","volume":"22","author":"Prefumo","year":"2007","journal-title":"Hum Reprod (Eynsham)"},{"key":"10.1016\/j.tjog.2022.10.006_bib7","series-title":"Free radicals in biology and medicine","first-page":"542","author":"Halliwell","year":"1993"},{"issue":"2","key":"10.1016\/j.tjog.2022.10.006_bib8","first-page":"83","article-title":"Protein oksidasyonunun ana mekanizmalar\u0131","volume":"35","author":"Kayal\u0131","year":"2004","journal-title":"Cerrahpasa J Med"},{"issue":"5","key":"10.1016\/j.tjog.2022.10.006_bib9","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.clinre.2012.06.004","article-title":"Assessment of neutrophil-lymphocyte ratio in ulcerative colitis: a promising marker in predicting disease severity","volume":"36","author":"Torun","year":"2012","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.tjog.2022.10.006_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13052-016-0211-5","article-title":"Diagnostic role of inflammatory markers in pediatric Brucella arthritis","volume":"42","author":"Aktar","year":"2016","journal-title":"Ital J Pediatr"},{"issue":"6","key":"10.1016\/j.tjog.2022.10.006_bib11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.5603\/GP.a2017.0059","article-title":"Evaluation of the hematologic system as a marker of subclinical inflammation in hyperemesis gravidarum: a case control study","volume":"88","author":"Beyazit","year":"2017","journal-title":"Ginekol Pol"},{"key":"10.1016\/j.tjog.2022.10.006_bib12","first-page":"149","article-title":"Subclinical inflammation markers in hyperemesis gravidarum and ketonuria: a case-control study","volume":"11","author":"\u00c7intesun","year":"2019","journal-title":"J\u00a0Lab Physicians"},{"issue":"3","key":"10.1016\/j.tjog.2022.10.006_bib13","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/01.AOG.0000278571.93861.26","article-title":"Hyperemesis gravidarum and Helicobacter Pylori infection: a systematic review","volume":"110","author":"Golberg","year":"2007","journal-title":"Obstet Gynecol"},{"issue":"9","key":"10.1016\/j.tjog.2022.10.006_bib14","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S1701-2163(16)34298-0","article-title":"Nausea and vomiting of pregnancy: using the 24-hour pregnancy-unique quantification of emesis (PUQE-24) scale","volume":"31","author":"Ebrahimi","year":"2009","journal-title":"J\u00a0Obstet Gynaecol Can"},{"issue":"1","key":"10.1016\/j.tjog.2022.10.006_bib15","doi-asserted-by":"crossref","first-page":"71.e1","DOI":"10.1016\/j.ajog.2007.05.051","article-title":"Validity of a modified pregnancy unique quantification of emesis and nausea (PUQE) scoring index to assess severity of nausea and vomiting of pregnancy","volume":"198","author":"Lacasse","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.tjog.2022.10.006_bib16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0736-4679(00)00255-9","article-title":"A\u00a0novel assay for cobalt alb\u00fcmin binding and its potential as a marker for myocardial ischemia-a preliminary report","volume":"19","author":"BarOD","year":"2000","journal-title":"J\u00a0Emerg Med"},{"key":"10.1016\/j.tjog.2022.10.006_bib17","first-page":"724","article-title":"Effect of hematoporphyrin derivates and light on sulfhydryl groups in brain tumour cells","volume":"33","author":"Joshi","year":"1995","journal-title":"Indian J Exp Biol"},{"key":"10.1016\/j.tjog.2022.10.006_bib18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1136\/hrt.2004.049643","article-title":"Role of reactive oxygen species on the formation of the novel diagnostic marker ischaemia modified albumin","volume":"92","author":"Roy","year":"2006","journal-title":"Heart"},{"key":"10.1016\/j.tjog.2022.10.006_bib19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cca.2005.11.020","article-title":"Prognostic significance of ischemia modified albumin after percutaneous coronary intervention","volume":"367","author":"Dusek","year":"2006","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.tjog.2022.10.006_bib20","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1373\/49.4.581","article-title":"Evaluation of human serum albumin cobalt binding assay for the assessment of myocardial ischemia and myocardial infarction","volume":"49","author":"Bhagavan","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.tjog.2022.10.006_bib21","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3109\/10641955.2014.931418","article-title":"IMA and IMAR in serum and saliva of preeclampsia \u2013 a preliminary study","volume":"33","author":"D\u2019souza","year":"2014","journal-title":"Hypertens Pregnancy"},{"issue":"6","key":"10.1016\/j.tjog.2022.10.006_bib22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1155\/2008\/784313","article-title":"Ischemia-modified albumin level in type 2 diabetes mellitus\u2013preliminary report","volume":"24","author":"Piwowar","year":"2008","journal-title":"Dis Markers"},{"key":"10.1016\/j.tjog.2022.10.006_bib23","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1373\/clinchem.2004.031690","article-title":"Ischemia-modified albumin concentrations in patients with peripheral vascular disease and exercise-induced skeletal muscle ischemia","volume":"50","author":"Roy","year":"2004","journal-title":"Clin Chem"},{"issue":"12","key":"10.1016\/j.tjog.2022.10.006_bib24","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1080\/14767058.2017.1422718","article-title":"Evaluation of maternal serum ischemia modified albumin and total antioxidant status in ectopic pregnancy","volume":"32","author":"BozkayaG","year":"2019","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"key":"10.1016\/j.tjog.2022.10.006_bib25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.placenta.2021.09.013","article-title":"Oxidative stress biomarkers in fetal growth restriction with and without preeclampsia","volume":"115","author":"Hoorn","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.tjog.2022.10.006_bib26","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ejogrb.2016.12.022","article-title":"Ischemia modified albumin in perinatology","volume":"210","author":"Yarc\u0131","year":"2017","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.tjog.2022.10.006_bib27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1055\/s-2002-23554","article-title":"Hyperemesis gravidarum is associated with oxidative stress","volume":"19","author":"Fait","year":"2002","journal-title":"Am J Perinatol"},{"issue":"4","key":"10.1016\/j.tjog.2022.10.006_bib28","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1515\/jpm-2015-0421","article-title":"Hyperemesis gravidarum is associated with increased maternal serum ischemia-modified albumin","volume":"24","author":"S\u00e2ri","year":"2017","journal-title":"J\u00a0Perinat Med"},{"issue":"3","key":"10.1016\/j.tjog.2022.10.006_bib29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1179\/1351000214Y.0000000110","article-title":"The oxidative stress index increases among patients with hyperemesis gravidarum but not in normal pregnancies","volume":"20","author":"Yilmaz","year":"2015","journal-title":"Redox Rep"},{"issue":"8","key":"10.1016\/j.tjog.2022.10.006_bib30","doi-asserted-by":"crossref","first-page":"825","DOI":"10.3109\/14767058.2013.842549","article-title":"Relationship between oxidant and antioxidant activity in hyperemesis gravidarum","volume":"27","author":"Onaran","year":"2014","journal-title":"J\u00a0Matern Fetal Neonatal Med"},{"issue":"2","key":"10.1016\/j.tjog.2022.10.006_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5455\/medarh.2019.73.97-100","article-title":"Comparison of serum Ykl-40 and ischemia modified albulmin levels between pregnant women with hyperemesis gravidarum and normal pregnant women","volume":"73","author":"Bulan\u0131k","year":"2019","journal-title":"Med Arch"},{"key":"10.1016\/j.tjog.2022.10.006_bib32","first-page":"38","article-title":"Measurement of protein thiolgroups and glutathione \u0130n plasma","volume":"233","author":"Hu","year":"1994","journal-title":"Me\u00eehodEnzymol"},{"issue":"5","key":"10.1016\/j.tjog.2022.10.006_bib33","first-page":"668","article-title":"Elevated circulating nitric oxide levels correlates with enhanced oxidative stress in patients with hyperemesis","volume":"38","author":"Beyazit","year":"2018","journal-title":"Gravidarum"},{"key":"10.1016\/j.tjog.2022.10.006_bib34","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/jp.2015.81","article-title":"Dynamic thiol-disulfide homeostasis in hyperemesis gravidarum","volume":"35","author":"Ergin","year":"2015","journal-title":"J\u00a0Perinatol"},{"key":"10.1016\/j.tjog.2022.10.006_bib35","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000371762","article-title":"Preoperative neutrophil-to-lymphocyte ratio has a better predictive capacity in diagnosing tubo-ovarian abscess","volume":"80","author":"Yildirim","year":"2015","journal-title":"Gynecol Obstet Invest"},{"issue":"4","key":"10.1016\/j.tjog.2022.10.006_bib36","doi-asserted-by":"crossref","first-page":"297","DOI":"10.4274\/imj.galenos.2020.54037","article-title":"Serum ischaemia-modified albumin concentration in hyperemesis gravidarum","volume":"21","author":"Yaman","year":"2020","journal-title":"Istanbul Med J"},{"key":"10.1016\/j.tjog.2022.10.006_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13052-016-0211-5","article-title":"Diagnostic role of inflammatory markers in pediatric Brucella arthritis","volume":"11","author":"Aktar","year":"2016","journal-title":"Ital J Pediatr"},{"key":"10.1016\/j.tjog.2022.10.006_bib38","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.ajem.2019.05.007","article-title":"Evaluation of relationship between inflammatory markers and hyperemesis gravidarum in patients admitted to emergency department","volume":"38","author":"Kan","year":"2020","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.tjog.2022.10.006_bib39","first-page":"176","article-title":"Relation of red cell distribution width and mean platelet vol\u00fcme with the severity of preeclampsia","volume":"55","author":"Viana-Rojas","year":"2017","journal-title":"Rev Med Inst Mex Seguro Soc"},{"key":"10.1016\/j.tjog.2022.10.006_bib40","doi-asserted-by":"crossref","first-page":"507","DOI":"10.3233\/CBM-160591","article-title":"The significance of RDW in patients with hepatocellular carcinoma after radical resection","volume":"16","author":"Zhao","year":"2016","journal-title":"Cancer Biomarkers"},{"issue":"3","key":"10.1016\/j.tjog.2022.10.006_bib41","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/jog.13228","article-title":"Association between platelet to lymphocyte ratio, platelet crit and the presence and severity of hyperemesis gravidarum","volume":"43","author":"Tayfur","year":"2017","journal-title":"J\u00a0Obstet Gynaecol Res"},{"issue":"9","key":"10.1016\/j.tjog.2022.10.006_bib42","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1111\/jog.14857","article-title":"The relationship between inflammation markers and ketonuria in hyperemesis gravidarum","volume":"47","author":"Cenk","year":"2021","journal-title":"J\u00a0Obstet Gynaecol Res"},{"key":"10.1016\/j.tjog.2022.10.006_bib43","doi-asserted-by":"crossref","first-page":"165","DOI":"10.5152\/eajem.2017.51523","article-title":"Prognostic value of the neutrophil\u2013lymphocyte and platelet\u2013lymphocyte ratios in predicting one-year mortality in patients with hip fractures and aged over 60 years","volume":"16","author":"Emektar","year":"2017","journal-title":"Eur J Emerg Med"},{"issue":"2","key":"10.1016\/j.tjog.2022.10.006_bib44","first-page":"155","article-title":"Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio predict mucosal disease severity in ulcerative colitis","volume":"37","author":"Akpinar","year":"2018","journal-title":"J\u00a0Med Biochem"},{"key":"10.1016\/j.tjog.2022.10.006_bib45","first-page":"138","article-title":"Vaspin and C-reactive protein levels in hyperemesis gravidarum","volume":"17","author":"Engin-Ustun","year":"2013","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.tjog.2022.10.006_bib46","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/jog.12949","article-title":"Serum levels of neopterin, inflammatory markers and oxidative stress indicators in hyperemesis gravidarum","volume":"6","author":"Tunc","year":"2016","journal-title":"J\u00a0Obstet Gynaecol Res"}],"container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455922003497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455922003497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:21:24Z","timestamp":1760898084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1028455922003497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S1028455922003497"],"URL":"https:\/\/doi.org\/10.1016\/j.tjog.2022.10.006","relation":{},"ISSN":["1028-4559"],"issn-type":[{"value":"1028-4559","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal serum ischemia-modified albumin (IMA), total-sulphydryl concentrations, and some subclinic inflammatory markers in hyperemesis gravidarum (HG)","name":"articletitle","label":"Article Title"},{"value":"Taiwanese Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjog.2022.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}