{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:59:34Z","timestamp":1787612374515,"version":"build-2736575974"},"reference-count":22,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T00:00:00Z","timestamp":1688860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.tjog.2023.07.012","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T22:18:20Z","timestamp":1694125100000},"page":"709-712","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Molecular analysis and clinical significance of hemoglobin Quong Sze in Huizhou city, Southern China"],"prefix":"10.1016","volume":"62","author":[{"given":"Zeyan","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyang","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxing","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunxiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"S1","key":"10.1016\/j.tjog.2023.07.012_bib1","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.5045\/br.2021.2020332","article-title":"Molecular basis and diagnosis of thalassemia","volume":"56","author":"Lee","year":"2021","journal-title":"Blood Res"},{"issue":"D1","key":"10.1016\/j.tjog.2023.07.012_bib2","doi-asserted-by":"crossref","first-page":"D1192","DOI":"10.1093\/nar\/gkaa959","article-title":"Clinically relevant updates of the HbVar database of human hemoglobin variants and thalassemia mutations","volume":"49","author":"Giardine","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.tjog.2023.07.012_bib3","doi-asserted-by":"crossref","DOI":"10.1177\/10760296221119807","article-title":"Molecular epidemiology and hematologic characterization of thalassemia in Guangdong province, southern China","volume":"28","author":"Xian","year":"2022","journal-title":"Clin Appl Thromb Hemost"},{"issue":"5","key":"10.1016\/j.tjog.2023.07.012_bib4","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1136\/jcp.2003.014456","article-title":"The prevalence and spectrum of alpha and beta thalassaemia in Guangdong Province: implications for the future health burden and population screening","volume":"57","author":"Xu","year":"2004","journal-title":"J\u00a0Clin Pathol"},{"issue":"5","key":"10.1016\/j.tjog.2023.07.012_bib5","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/cge.13923","article-title":"Early genetic screening uncovered a high prevalence of thalassemia among 18 309 neonates in Guizhou, China","volume":"99","author":"Tan","year":"2021","journal-title":"Clin Genet"},{"issue":"2","key":"10.1016\/j.tjog.2023.07.012_bib6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1515\/cclm-2018-0647","article-title":"Thalassemia in the laboratory: pearls, pitfalls, and promises","volume":"57","author":"Aliyeva","year":"2018","journal-title":"Clin Chem Lab Med"},{"issue":"4","key":"10.1016\/j.tjog.2023.07.012_bib7","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.tjog.2021.05.031","article-title":"Genetic counseling and prenatal decision for hemoglobin H disease caused by the rare alpha 2 codon 30 (-GAG) (HBA2: c.91_93delGAG) mutation and the SEA deletion: case series study","volume":"60","author":"Guan","year":"2021","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"2","key":"10.1016\/j.tjog.2023.07.012_bib8","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1093\/labmed\/lmy043","article-title":"Clinical features and genotypes of patients with hemoglobin H disease in Taiwan","volume":"50","author":"Lin","year":"2019","journal-title":"Lab Med"},{"issue":"2","key":"10.1016\/j.tjog.2023.07.012_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089855","article-title":"The prevalence and molecular spectrum of alpha- and beta-globin gene mutations in 14,332 families of Guangdong Province, China","volume":"9","author":"Yin","year":"2014","journal-title":"PLoS One"},{"issue":"20","key":"10.1016\/j.tjog.2023.07.012_bib10","doi-asserted-by":"crossref","first-page":"7354","DOI":"10.3390\/ijerph17207354","article-title":"Prevalence of alpha(alpha)-thalassemia in Southeast Asia (2010-2020): a meta-analysis involving 83,674 subjects","volume":"17","author":"Goh","year":"2020","journal-title":"Int J Environ Res Publ Health"},{"key":"10.1016\/j.tjog.2023.07.012_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bcmd.2017.09.004","article-title":"Molecular basis of alpha-thalassemia","volume":"70","author":"Farashi","year":"2018","journal-title":"Blood Cells Mol Dis"},{"issue":"3","key":"10.1016\/j.tjog.2023.07.012_bib12","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3109\/03630269.2014.910669","article-title":"Screening and diagnosis of Hb Quong Sze [HBA2: c.377T > C (or HBA1)] in a prenatal control program for thalassemia","volume":"38","author":"Yang","year":"2014","journal-title":"Hemoglobin"},{"issue":"11","key":"10.1016\/j.tjog.2023.07.012_bib13","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00277-009-0716-8","article-title":"Diversity in clinical presentation of hemoglobin H disease induced by the SEA deletion and the hemoglobin Quong Sze","volume":"88","author":"Liao","year":"2009","journal-title":"Ann Hematol"},{"key":"10.1016\/j.tjog.2023.07.012_bib14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1182\/asheducation-2009.1.26","article-title":"Hb H disease: clinical course and disease modifiers","volume":"1","author":"Fucharoen","year":"2009","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"3","key":"10.1016\/j.tjog.2023.07.012_bib15","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1600-0609.2005.00493.x","article-title":"Hemoglobin H hydrops fetalis syndrome resulting from the association of the - -SEA deletion and the alphaQuong Szealpha mutation in a Chinese woman","volume":"75","author":"Li","year":"2005","journal-title":"Eur J Haematol"},{"issue":"9","key":"10.1016\/j.tjog.2023.07.012_bib16","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/pd.2058","article-title":"Fetal anemia and hydrops associated with homozygosity for hemoglobin Quong Sze","volume":"28","author":"Liao","year":"2008","journal-title":"Prenat Diagn"},{"issue":"2","key":"10.1016\/j.tjog.2023.07.012_bib17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.hoc.2017.11.003","article-title":"Molecular basis and genetic modifiers of thalassemia","volume":"32","author":"Mettananda","year":"2018","journal-title":"Hematol Oncol Clin N Am"},{"issue":"24","key":"10.1016\/j.tjog.2023.07.012_bib18","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1182\/blood.2020005301","article-title":"The HRI-regulated transcription factor ATF4 activates BCL11A transcription to silence fetal hemoglobin expression","volume":"135","author":"Huang","year":"2020","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.tjog.2023.07.012_bib19","first-page":"112","article-title":"Thalassemia and erythroid transcription factor KLF1 mutations associated with borderline hemoglobin A2 in the Thai population","volume":"18","author":"Srivorakun","year":"2022","journal-title":"Arch Med Sci"},{"issue":"11","key":"10.1016\/j.tjog.2023.07.012_bib20","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1002\/ajh.26316","article-title":"2021 update on clinical trials in beta-thalassemia","volume":"96","author":"Musallam","year":"2021","journal-title":"Am J Hematol"},{"issue":"9","key":"10.1016\/j.tjog.2023.07.012_bib21","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1080\/17474086.2020.1803736","article-title":"Analysis of Hb levels and degree of anemia in relation to genotype in 615 patients with hemoglobin H disease","volume":"13","author":"Luo","year":"2020","journal-title":"Expert Rev Hematol"},{"issue":"5","key":"10.1016\/j.tjog.2023.07.012_bib22","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/03630269.2020.1807355","article-title":"Pedigree analysis of nonhomologous sequence recombination of HBA1 and HBA2 genes","volume":"44","author":"Luo","year":"2020","journal-title":"Hemoglobin"}],"container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455923001857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455923001857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:21:42Z","timestamp":1760898102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1028455923001857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S1028455923001857"],"URL":"https:\/\/doi.org\/10.1016\/j.tjog.2023.07.012","relation":{},"ISSN":["1028-4559"],"issn-type":[{"value":"1028-4559","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular analysis and clinical significance of hemoglobin Quong Sze in Huizhou city, Southern China","name":"articletitle","label":"Article Title"},{"value":"Taiwanese Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjog.2023.07.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}