{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T06:40:14Z","timestamp":1792305614576,"version":"4.4.0"},"reference-count":12,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.tjog.2023.08.003","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T21:02:16Z","timestamp":1700859736000},"page":"852-857","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Risk factors of heavy uterine bleeding in patients with endometriosis and adenomyosis treated with dienogest"],"prefix":"10.1016","volume":"62","author":[{"given":"Hiroaki","family":"Takagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Takakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Sasagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjog.2023.08.003_bib1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.steroids.2007.10.003","article-title":"Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile","volume":"73","author":"Sasagawa","year":"2008","journal-title":"Steroids"},{"key":"10.1016\/j.tjog.2023.08.003_bib2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2147\/IJWH.S5633","article-title":"Dienogest in long-term treatment of endometriosis","volume":"3","author":"Schindler","year":"2011","journal-title":"Int J Wom Health"},{"key":"10.1016\/j.tjog.2023.08.003_bib3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2147\/IJWH.S77202","article-title":"Safety and tolerability of dienogest in endometriosis: pooled analysis from the European clinical study program","volume":"7","author":"Strowitzki","year":"2015","journal-title":"Int J Wom Health"},{"key":"10.1016\/j.tjog.2023.08.003_bib4","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1447-0756.2009.01076.x","article-title":"Long-term use of dienogest for the treatment of endometriosis","volume":"35","author":"Momoeda","year":"2009","journal-title":"J\u00a0Obstet Gynaecol Res"},{"key":"10.1016\/j.tjog.2023.08.003_bib5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00404-011-1941-7","article-title":"Reduced pelvic pain in women with endometriosis: efficacy of long-term dienogest treatment","volume":"285","author":"Petraglia","year":"2012","journal-title":"Arch Gynecol Obstet"},{"key":"10.1016\/j.tjog.2023.08.003_bib6","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/jog.14209","article-title":"Long-term use of dienogest for the treatment of primary and secondary dysmenorrhea","volume":"46","author":"Osuga","year":"2020","journal-title":"J\u00a0Obstet Gynaecol Res"},{"key":"10.1016\/j.tjog.2023.08.003_bib7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1447-0578.2007.00189.x","article-title":"Hormonal and histological study on irregular genital bleeding in patients with endometriosis during treatment with dienogest, a novel progestational therapeutic agent","volume":"6","author":"Irahara","year":"2007","journal-title":"Reprod Med Biol"},{"key":"10.1016\/j.tjog.2023.08.003_bib8","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1111\/jog.13406","article-title":"Long-term use of dienogest in the treatment of painful symptoms in adenomyosis","volume":"43","author":"Osuga","year":"2017","journal-title":"J\u00a0Obstet Gynaecol Res"},{"key":"10.1016\/j.tjog.2023.08.003_bib9","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ejogrb.2011.03.012","article-title":"Maintenance therapy with dienogest following gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain","volume":"157","author":"Kitawaki","year":"2011","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.tjog.2023.08.003_bib10","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1111\/jog.13674","article-title":"Long-term dienogest administration in patients with symptomatic adenomyosis","volume":"44","author":"Neriishi","year":"2018","journal-title":"J\u00a0Obstet Gynaecol Res"},{"key":"10.1016\/j.tjog.2023.08.003_bib11","doi-asserted-by":"crossref","first-page":"17654","DOI":"10.1038\/s41598-019-54096-z","article-title":"Subtype I (intrinsic) adenomyosis is an independent risk factor for dienogest-related serious unpredictable bleeding in patients with symptomatic adenomyosis","volume":"9","author":"Matsubara","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.tjog.2023.08.003_bib12","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1447-0756.2011.01778.x","article-title":"Risk factors of treatment discontinuation due to uterine bleeding in adenomyosis patients treated with dienogest","volume":"38","author":"Nagata","year":"2012","journal-title":"J\u00a0Obstet Gynaecol Res"}],"container-title":["Taiwanese Journal of Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455923002425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1028455923002425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:22:12Z","timestamp":1760898132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1028455923002425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S1028455923002425"],"URL":"https:\/\/doi.org\/10.1016\/j.tjog.2023.08.003","relation":{},"ISSN":["1028-4559"],"issn-type":[{"value":"1028-4559","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk factors of heavy uterine bleeding in patients with endometriosis and adenomyosis treated with dienogest","name":"articletitle","label":"Article Title"},{"value":"Taiwanese Journal of Obstetrics and Gynecology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjog.2023.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}