{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:35:58Z","timestamp":1793723758933,"version":"4.6.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024370","name":"Ministero dell&apos;Istruzione dell&apos;Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.tjpad.2024.100027","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T06:39:14Z","timestamp":1737614354000},"page":"100027","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Core blood biomarkers of Alzheimer's disease: A single-center real-world performance study"],"prefix":"10.1016","volume":"12","author":[{"given":"Federico Emanuele","family":"Pozzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Conti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Remoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccol\u00f2","family":"dell'Orto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Andreoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"Da Re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gessica","family":"Sala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cuffaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Ferrarese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildebrando","family":"Appollonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara Paola","family":"Zoia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Tremolizzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.tjpad.2024.100027_bib0001","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci14010055","article-title":"Brain health and cognition in older adults: roadmap and milestones towards the implementation of preventive strategies","volume":"14","author":"Pozzi","year":"2024","journal-title":"Brain Sci"},{"key":"10.1016\/j.tjpad.2024.100027_bib0002","first-page":"1","article-title":"Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup","author":"Jack","year":"2024","journal-title":"Alzheimers Dement"},{"issue":"6","key":"10.1016\/j.tjpad.2024.100027_bib0003","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1515\/cclm-2023-1434","article-title":"Blood-based biomarkers in Alzheimer's disease \u2013 moving towards a new era of diagnostics","volume":"62","author":"Arslan","year":"2024","journal-title":"Clin Chem Lab Med"},{"issue":"4","key":"10.1016\/j.tjpad.2024.100027_bib0004","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1007\/s00415-023-12148-5","article-title":"Head-to-head study of diagnostic accuracy of plasma and cerebrospinal fluid p-tau217 versus p-tau181 and p-tau231 in a memory clinic cohort","volume":"271","author":"Mendes","year":"2024","journal-title":"J Neurol"},{"issue":"4","key":"10.1016\/j.tjpad.2024.100027_bib0005","first-page":"1","article-title":"Plasma p-tau217, p-tau181, and NfL as early indicators of dementia risk in a community cohort: the Shanghai Aging Study. Alzheimer's Dement Diagnosis","volume":"15","author":"Xiao","year":"2023","journal-title":"Assess Dis Monit"},{"key":"10.1016\/j.tjpad.2024.100027_bib0006","article-title":"Plasma p-tau217 predicts cognitive impairments up to ten years before onset in normal older adults","author":"Yakoub","year":"2024","journal-title":"medRxiv [Preprint]"},{"issue":"4","key":"10.1016\/j.tjpad.2024.100027_bib0007","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12040786","article-title":"Evaluating p-tau217 and p-tau231 as Biomarkers for Early Diagnosis and Differentiation of Alzheimer's Disease: a Narrative Review","volume":"12","author":"Jarek","year":"2024","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.tjpad.2024.100027_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-024-01469-w","article-title":"Combining plasma A\u03b2 and p-tau217 improves detection of brain amyloid in non-demented elderly","volume":"16","author":"Niimi","year":"2024","journal-title":"Alzheimer's Res Ther"},{"issue":"7","key":"10.1016\/j.tjpad.2024.100027_bib0009","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/JGP.0b013e318172b406","article-title":"Interpreting the clinical significance of capacity scores for informed consent in alzheimer disease clinical trials","volume":"16","author":"Karlawish","year":"2008","journal-title":"Am J Geriatr Psychiatry"},{"issue":"3","key":"10.1016\/j.tjpad.2024.100027_bib0010","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Albert","year":"2011","journal-title":"Alzheimer's Dement"},{"key":"10.1016\/j.tjpad.2024.100027_bib0011","doi-asserted-by":"crossref","DOI":"10.1038\/s41582-024-00977-5","article-title":"Acceptable performance of blood biomarker tests of amyloid pathology \u2014 recommendations from the Global CEO Initiative on Alzheimer's Disease","author":"Schindler","year":"2024","journal-title":"Nat Rev Neurol"},{"issue":"3","key":"10.1016\/j.tjpad.2024.100027_bib0012","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3233\/JAD-230473","article-title":"Can Traditional Board Games Prevent or Slow Down Cognitive Impairment? A Systematic Review and Meta-Analysis","volume":"95","author":"Pozzi","year":"2023","journal-title":"J Alzheimer's Dis"},{"key":"10.1016\/j.tjpad.2024.100027_bib0013","doi-asserted-by":"crossref","unstructured":"Arranz J., Zhu N., Rubio-Guerra S., Rodr\u00edguez-Baz \u00cd., Carmona-Iragui M., Barroeta I., et al. Diagnostic performance of plasma A\u03b21-42, A\u03b21-40 and pTau181 in the LUMIPULSE automated platform for the detection of Alzheimer disease. medRxiv. 2023;2023.04.20.23288852.","DOI":"10.21203\/rs.3.rs-3725688\/v1"},{"key":"10.1016\/j.tjpad.2024.100027_bib0014","doi-asserted-by":"crossref","unstructured":"Pilotto A., Quaresima V., trasciatti chiara, tolassi chiara, bertoli diego, mordenti cristina, et al. Plasma p-tau217 in Alzheimer disease: Lumipulse and ALZpath SIMOA head-to-head comparison. medRxiv. 2024;12:2024.05.02.24306780.","DOI":"10.1101\/2024.05.02.24306780"},{"key":"10.1016\/j.tjpad.2024.100027_bib0015","doi-asserted-by":"crossref","DOI":"10.1007\/s00415-024-12631-7","article-title":"Diagnostic accuracy of automated Lumipulse plasma pTau-217 in Alzheimer's disease","author":"Cecchetti","year":"2024","journal-title":"J Neurol"},{"key":"10.1016\/j.tjpad.2024.100027_bib0016","doi-asserted-by":"crossref","first-page":"6506","DOI":"10.1002\/alz.14140","article-title":"Optimizing cutpoints for clinical interpretation of brain amyloid status using plasma p-tau217 immunoassays","author":"Figdore","year":"2024","journal-title":"Alzheimer's Dement"},{"issue":"1","key":"10.1016\/j.tjpad.2024.100027_bib0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-022-01116-2","article-title":"Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer's disease","volume":"14","author":"Wilson","year":"2022","journal-title":"Alzheimer's Res Ther"},{"issue":"1","key":"10.1016\/j.tjpad.2024.100027_bib0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-024-01397-9","article-title":"Exploring the potential of fully automated LUMIPULSE G plasma assays for detecting Alzheimer's disease pathology","volume":"16","author":"Silva-Sp\u00ednola","year":"2024","journal-title":"Alzheimer's Res Ther"},{"issue":"4","key":"10.1016\/j.tjpad.2024.100027_bib0019","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1002\/alz.13687","article-title":"Fully automated measurement of plasma A\u03b242\/40 and p-tau181: analytical robustness and concordance with cerebrospinal fluid profile along the Alzheimer's disease continuum in two independent cohorts","volume":"20","author":"Bellomo","year":"2024","journal-title":"Alzheimer's Dement"},{"issue":"4","key":"10.1016\/j.tjpad.2024.100027_bib0020","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1093\/brain\/awac333","article-title":"Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer's disease","volume":"146","author":"Janelidze","year":"2023","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.tjpad.2024.100027_bib0021","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25094594","article-title":"Assessment of the Correlation and Diagnostic Accuracy between Cerebrospinal Fluid and Plasma Alzheimer's Disease Biomarkers: a Comparison of the Lumipulse and Simoa Platforms","volume":"25","author":"Dakterzada","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.tjpad.2024.100027_bib0022","first-page":"1","article-title":"Performance of the Lumipulse plasma A\u03b242\/40 and pTau181 immunoassays in the detection of amyloid pathology. Alzheimer's Dement Diagnosis","volume":"16","author":"Figdore","year":"2024","journal-title":"Assess Dis Monit"},{"issue":"1","key":"10.1016\/j.tjpad.2024.100027_bib0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-023-01319-1","article-title":"Accuracy of plasma A\u03b240, A\u03b242, and p-tau181 to detect CSF Alzheimer's pathological changes in cognitively unimpaired subjects using the Lumipulse automated platform","volume":"15","author":"Mart\u00ednez-Dubarbie","year":"2023","journal-title":"Alzheimer's Res Ther"},{"issue":"10","key":"10.1016\/j.tjpad.2024.100027_bib0024","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1002\/alz.13157","article-title":"Longitudinal changes in Alzheimer's-related plasma biomarkers and brain amyloid","volume":"19","author":"Bilgel","year":"2023","journal-title":"Alzheimer's Dement"},{"issue":"4","key":"10.1016\/j.tjpad.2024.100027_bib0025","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/alz.12724","article-title":"Plasma A\u03b242\/40 ratio, p-tau181, GFAP, and NfL across the Alzheimer's disease continuum: a cross-sectional and longitudinal study in the AIBL cohort","volume":"19","author":"Chatterjee","year":"2023","journal-title":"Alzheimer's Dement"},{"issue":"9","key":"10.1016\/j.tjpad.2024.100027_bib0026","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1007\/s10072-023-06882-x","article-title":"Influence of kidney function and CSF\/serum albumin ratio on plasma A\u03b242 and A\u03b240 levels measured on a fully automated platform in patients with Alzheimer's disease","volume":"44","author":"Verde","year":"2023","journal-title":"Neurol Sci"},{"issue":"4","key":"10.1016\/j.tjpad.2024.100027_bib0027","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1002\/alz.12787","article-title":"Confounding factors of Alzheimer's disease plasma biomarkers and their impact on clinical performance","volume":"19","author":"Pichet Binette","year":"2023","journal-title":"Alzheimer's Dement"},{"issue":"1","key":"10.1016\/j.tjpad.2024.100027_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-024-01391-1","article-title":"Effects of certain pre-analytical factors on the performance of plasma phospho-tau217","volume":"16","author":"Bali","year":"2024","journal-title":"Alzheimer's Res Ther"},{"issue":"1","key":"10.1016\/j.tjpad.2024.100027_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-021-00805-8","article-title":"Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer's disease pathology and clinical disease progression","volume":"13","author":"Clark","year":"2021","journal-title":"Alzheimer's Res Ther"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580724006198?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580724006198?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:35:02Z","timestamp":1784180102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580724006198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S2274580724006198"],"URL":"https:\/\/doi.org\/10.1016\/j.tjpad.2024.100027","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Core blood biomarkers of Alzheimer's disease: A single-center real-world performance study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjpad.2024.100027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Masson SAS on behalf of SERDI Publisher.","name":"copyright","label":"Copyright"}],"article-number":"100027"}}