{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:52:07Z","timestamp":1793339527667,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG058679"],"award-info":[{"award-number":["R01AG058679"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG072972"],"award-info":[{"award-number":["P30AG072972"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG073627"],"award-info":[{"award-number":["R01AG073627"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH2AG083289"],"award-info":[{"award-number":["UH2AG083289"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32AG050061"],"award-info":[{"award-number":["T32AG050061"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.tjpad.2024.100046","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T04:12:29Z","timestamp":1737691949000},"page":"100046","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Social isolation, loneliness, and their joint effects on cognitive decline and incident Alzheimer's disease: Findings from the Chicago health and aging project"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7348-0410","authenticated-orcid":false,"given":"Ted K.S.","family":"Ng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8781-2105","authenticated-orcid":false,"given":"Todd","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle R.","family":"Dennis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0904-5905","authenticated-orcid":false,"given":"Pankaja","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Krueger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klodian","family":"Dhana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis A.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar B.","family":"Rajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.tjpad.2024.100046_bib0001","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1001\/archpsyc.64.2.234","article-title":"Loneliness and risk of Alzheimer disease","volume":"64","author":"Wilson","year":"2007","journal-title":"Arch Gen Psychiatry"},{"issue":"11","key":"10.1016\/j.tjpad.2024.100046_bib0002","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/gps.5174","article-title":"Are loneliness and social isolation associated with cognitive decline?","volume":"34","author":"Lara","year":"2019","journal-title":"Int J Geriatr Psychiatry"},{"key":"10.1016\/j.tjpad.2024.100046_bib0003","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.arr.2019.03.002","article-title":"Does loneliness contribute to mild cognitive impairment and dementia? A systematic review and meta-analysis of longitudinal studies","volume":"52","author":"Lara","year":"2019","journal-title":"Ageing Res Rev"},{"issue":"7","key":"10.1016\/j.tjpad.2024.100046_bib0004","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1093\/geronb\/gby112","article-title":"Loneliness and risk of dementia","volume":"75","author":"Sutin","year":"2020","journal-title":"J Gerontol Ser B"},{"issue":"4","key":"10.1016\/j.tjpad.2024.100046_bib0005","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.3233\/JAD-220832","article-title":"Loneliness and cognitive function in older adults without dementia: a systematic review and meta-analysis","volume":"91","author":"Harrington","year":"2023","journal-title":"J Alzheimers Dis"},{"issue":"10452","key":"10.1016\/j.tjpad.2024.100046_bib0006","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.tjpad.2024.100046_bib0007","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1353\/pbm.2003.0049","article-title":"Social isolation and health, with an emphasis on underlying mechanisms","volume":"46","author":"Cacioppo","year":"2003","journal-title":"Perspect Biol Med"},{"issue":"6","key":"10.1016\/j.tjpad.2024.100046_bib0008","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.jrp.2005.11.007","article-title":"Loneliness within a nomological net: an evolutionary perspective","volume":"40","author":"Cacioppo","year":"2006","journal-title":"J Res Personal"},{"issue":"15","key":"10.1016\/j.tjpad.2024.100046_bib0009","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1073\/pnas.1219686110","article-title":"Social isolation, loneliness, and all-cause mortality in older men and women","volume":"110","author":"Steptoe","year":"2013","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.tjpad.2024.100046_bib0010","series-title":"Handbook of individual differences in social behavior","author":"Leary","year":"2009"},{"key":"10.1016\/j.tjpad.2024.100046_bib0011","series-title":"Advances in experimental social psychology","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/bs.aesp.2018.03.003","article-title":"Loneliness in the modern age: an evolutionary theory of loneliness (ETL)","author":"Cacioppo","year":"2018"},{"key":"10.1016\/j.tjpad.2024.100046_bib0012","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-clinpsy-032816-045159","article-title":"Social safety theory: a biologically based evolutionary perspective on life stress, health, and behavior","volume":"16","author":"Slavich","year":"2020","journal-title":"Annu Rev Clin Psychol"},{"key":"10.1016\/j.tjpad.2024.100046_bib0013","unstructured":"New APA Poll: One in three Americans feels lonely every week [Internet]. [cited 2024 May 13]. Available from: https:\/\/www.psychiatry.org:443\/news-room\/news-releases\/new-apa-poll-one-in-three-americans-feels-lonely-e"},{"key":"10.1016\/j.tjpad.2024.100046_bib0014","unstructured":"General US. Our epidemic of loneliness and isolation. The U.S. Surgeon General's Advisory on the Healing Effects of Social Connection and Community 2023. 2023;"},{"key":"10.1016\/j.tjpad.2024.100046_bib0015","series-title":"Social isolation and loneliness in older adults: opportunities for the health care system","year":"2020"},{"issue":"2","key":"10.1016\/j.tjpad.2024.100046_bib0016","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jamda.2020.11.018","article-title":"Differential effects of loneliness and depression on mortality","volume":"22","author":"Ng","year":"2021","journal-title":"J Am Med Dir Assoc"},{"issue":"6","key":"10.1016\/j.tjpad.2024.100046_bib0017","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1037\/amp0000103","article-title":"Advancing social connection as a public health priority in the United States","volume":"72","author":"Holt-Lunstad","year":"2017","journal-title":"Am Psychol"},{"issue":"4","key":"10.1016\/j.tjpad.2024.100046_bib0018","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.3233\/JAD-180439","article-title":"The association between social engagement, loneliness, and risk of dementia: a systematic review and meta-analysis","volume":"66","author":"Penninkilampi","year":"2018","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"10.1016\/j.tjpad.2024.100046_bib0019","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/geronb\/gbx087","article-title":"Loneliness, social integration, and incident dementia over 6 years: prospective findings from the English longitudinal study of ageing","volume":"75","author":"Rafnsson","year":"2020","journal-title":"J Gerontol Ser B"},{"issue":"14","key":"10.1016\/j.tjpad.2024.100046_bib0020","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1017\/S0033291720001014","article-title":"Social isolation, rather than loneliness, is associated with cognitive decline in older adults: the China health and retirement longitudinal study","volume":"51","author":"Yu","year":"2021","journal-title":"Psychol Med"},{"issue":"2","key":"10.1016\/j.tjpad.2024.100046_bib0021","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/PSY.0b013e31827f09cd","article-title":"Social isolation and loneliness: relationships with cognitive function during 4 years of follow-up in the English longitudinal study of ageing","volume":"75","author":"Shankar","year":"2013","journal-title":"Psychosom Med"},{"issue":"5","key":"10.1016\/j.tjpad.2024.100046_bib0022","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3233\/JAD-2003-5501","article-title":"Design of the Chicago health and aging project (CHAP)","volume":"5","author":"Bienias","year":"2003","journal-title":"J Alzheimers Dis"},{"issue":"6","key":"10.1016\/j.tjpad.2024.100046_bib0023","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/ana.25874","article-title":"Remote blood biomarkers of longitudinal cognitive outcomes in a population study","volume":"88","author":"Rajan","year":"2020","journal-title":"Ann Neurol"},{"issue":"3","key":"10.1016\/j.tjpad.2024.100046_bib0024","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D scale: a self-report depression scale for research in the general population","volume":"1","author":"Radloff","year":"1977","journal-title":"Appl Psychol Meas"},{"issue":"2","key":"10.1016\/j.tjpad.2024.100046_bib0025","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/089826439300500202","article-title":"Two shorter forms of the CES-D depression symptoms index","volume":"5","author":"Kohout","year":"1993","journal-title":"J Aging Health"},{"issue":"6","key":"10.1016\/j.tjpad.2024.100046_bib0026","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1212\/01.WNL.0000083989.44027.05","article-title":"Cognitive activity and cognitive decline in a biracial community population","volume":"61","author":"Wilson","year":"2003","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.tjpad.2024.100046_bib0027","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1212\/WNL.0000000000001774","article-title":"Cognitive impairment 18 years before clinical diagnosis of Alzheimer disease dementia","volume":"85","author":"Rajan","year":"2015","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.tjpad.2024.100046_bib0028","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1001\/archneur.60.2.185","article-title":"Incidence of Alzheimer disease in a biracial urban community: relation to apolipoprotein E allele status","volume":"60","author":"Evans","year":"2003","journal-title":"Arch Neurol"},{"issue":"7","key":"10.1016\/j.tjpad.2024.100046_bib0029","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.tjpad.2024.100046_bib0030","doi-asserted-by":"crossref","DOI":"10.1002\/gps.5644","article-title":"Social isolation, social support, and loneliness and their relationship with cognitive health and dementia","volume":"37","author":"Joyce","year":"2022","journal-title":"Int J Geriatr Psychiatry"},{"issue":"2","key":"10.1016\/j.tjpad.2024.100046_bib0031","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1212\/WNL.0000000000200583","article-title":"Associations of social isolation and loneliness with later dementia","volume":"99","author":"Shen","year":"2022","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.tjpad.2024.100046_bib0032","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1093\/geronb\/gby086","article-title":"Longitudinal associations between loneliness and cognitive ability in the Lothian Birth Cohort 1936","volume":"74","author":"Okely","year":"2019","journal-title":"J Gerontol Ser B"},{"issue":"2","key":"10.1016\/j.tjpad.2024.100046_bib0033","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3233\/JAD-160862","article-title":"Psychosocial risk and protective factors and incident mild cognitive impairment and dementia in community dwelling elderly: findings from the Singapore longitudinal ageing study","volume":"57","author":"Rawtaer","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2024.100046_bib0034","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2020.612771","article-title":"Is loneliness a cause or consequence of dementia? A public health analysis of the literature","volume":"11","author":"Victor","year":"2021","journal-title":"Front Psychol"},{"issue":"13","key":"10.1016\/j.tjpad.2024.100046_bib0035","doi-asserted-by":"crossref","first-page":"e1337","DOI":"10.1212\/WNL.0000000000200039","article-title":"Association of loneliness with 10-year dementia risk and early markers of vulnerability for neurocognitive decline","volume":"98","author":"Salinas","year":"2022","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.tjpad.2024.100046_bib0036","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/gps.5304","article-title":"Loneliness is associated with risk of cognitive impairment in the survey of health, ageing and retirement in Europe","volume":"35","author":"Luchetti","year":"2020","journal-title":"Int J Geriatr Psychiatry"},{"issue":"s1","key":"10.1016\/j.tjpad.2024.100046_bib0037","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.3233\/JAD-180501","article-title":"Social isolation and cognitive function in later life: a systematic review and meta-analysis","volume":"70","author":"Evans","year":"2019","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"10.1016\/j.tjpad.2024.100046_bib0038","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3233\/ADR-230011","article-title":"The impact of loneliness and social isolation on cognitive aging: a narrative review","volume":"7","author":"Guarnera","year":"2023","journal-title":"J Alzheimers Dis Rep"},{"key":"10.1016\/j.tjpad.2024.100046_bib0039","series-title":"Advances in experimental social psychology","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/bs.aesp.2018.03.003","article-title":"Loneliness in the modern age: an evolutionary theory of loneliness (ETL)","author":"Cacioppo","year":"2018"},{"issue":"1","key":"10.1016\/j.tjpad.2024.100046_bib0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/02699931.2013.837379","article-title":"Evolutionary mechanisms for loneliness","volume":"28","author":"Cacioppo","year":"2014","journal-title":"Cogn Emot"},{"key":"10.1016\/j.tjpad.2024.100046_bib0041","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s10519-005-6040-8","article-title":"Genetic and environmental contributions to loneliness in adults: the Netherlands twin register study","volume":"35","author":"Boomsma","year":"2005","journal-title":"Behav Genet"},{"issue":"2","key":"10.1016\/j.tjpad.2024.100046_bib0042","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/0265407594112006","article-title":"Loneliness and the evaluation of relational events","volume":"11","author":"Duck","year":"1994","journal-title":"J Soc Pers Relatsh"},{"issue":"1","key":"10.1016\/j.tjpad.2024.100046_bib0043","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0962-1849(99)80008-0","article-title":"Lonely hearts: psychological perspectives on loneliness","volume":"8","author":"Ernst","year":"1999","journal-title":"Appl Prev Psychol"},{"key":"10.1016\/j.tjpad.2024.100046_bib0044","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00127-007-0279-8","article-title":"Perceived social isolation in a community sample: its prevalence and correlates with aspects of peoples\u2019 lives","volume":"43","author":"Hawthorne","year":"2008","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"issue":"10","key":"10.1016\/j.tjpad.2024.100046_bib0045","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.tics.2009.06.005","article-title":"Perceived social isolation and cognition","volume":"13","author":"Cacioppo","year":"2009","journal-title":"Trends Cogn Sci"},{"issue":"1","key":"10.1016\/j.tjpad.2024.100046_bib0046","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1521\/ijct.2012.5.1.50","article-title":"Cognitive vulnerability, stress generation, and anxiety: symptom clusters and gender differences","volume":"5","author":"Auerbach","year":"2012","journal-title":"Int J Cogn Ther"},{"issue":"1","key":"10.1016\/j.tjpad.2024.100046_bib0047","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10802-009-9344-y","article-title":"Cognitive vulnerability to depression in Canadian and Chinese adolescents","volume":"38","author":"Auerbach","year":"2010","journal-title":"J Abnorm Child Psychol"},{"key":"10.1016\/j.tjpad.2024.100046_bib0048","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bbi.2019.08.189","article-title":"Social engagement and loneliness are differentially associated with neuro-immune markers in older age: time-varying associations from the English longitudinal study of ageing","volume":"82","author":"Walker","year":"2019","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.tjpad.2024.100046_bib0049","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.neubiorev.2020.02.002","article-title":"The association between loneliness, social isolation and inflammation: a systematic review and meta-analysis","volume":"112","author":"Smith","year":"2020","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.tjpad.2024.100046_bib0050","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.socscimed.2018.04.007","article-title":"Loneliness in middle age and biomarkers of systemic inflammation: findings from midlife in the United States","volume":"209","author":"Nersesian","year":"2018","journal-title":"Soc Sci Med"},{"key":"10.1016\/j.tjpad.2024.100046_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2023.106023","article-title":"Sex differences in the mediating role of chronic inflammation on the association between social isolation and cognitive functioning among older adults in the United States","volume":"149","author":"Qi","year":"2023","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.tjpad.2024.100046_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.socscimed.2021.114191","article-title":"Social connectedness as a mediator for horticultural therapy's biological effect on community-dwelling older adults: secondary analyses of a randomized controlled trial","volume":"284","author":"Ng","year":"2021","journal-title":"Soc Sci Med"},{"issue":"6","key":"10.1016\/j.tjpad.2024.100046_bib0053","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1177\/0164027504268574","article-title":"A short scale for measuring loneliness in large surveys: results from two population-based studies","volume":"26","author":"Hughes","year":"2004","journal-title":"Res Aging"},{"issue":"3","key":"10.1016\/j.tjpad.2024.100046_bib0054","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/014662168500900307","article-title":"The development of a Rasch-type loneliness scale","volume":"9","author":"De Jong-Gierveld","year":"1985","journal-title":"Appl Psychol Meas"},{"issue":"5","key":"10.1016\/j.tjpad.2024.100046_bib0055","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1177\/0164027506289723","article-title":"A 6-item scale for overall, emotional, and social loneliness: confirmatory tests on survey data","volume":"28","author":"Gierveld","year":"2006","journal-title":"Res Aging"},{"key":"10.1016\/j.tjpad.2024.100046_bib0056","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00127-017-1392-y","article-title":"A life less lonely: the state of the art in interventions to reduce loneliness in people with mental health problems","volume":"52","author":"Mann","year":"2017","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"issue":"4","key":"10.1016\/j.tjpad.2024.100046_bib0057","doi-asserted-by":"crossref","first-page":"gnad147","DOI":"10.1093\/geront\/gnad147","article-title":"Internet-based conversational engagement randomized controlled clinical trial (I-CONECT) among socially isolated adults 75+ years old with normal cognition or mild cognitive impairment: topline results","volume":"64","author":"Dodge","year":"2024","journal-title":"Gerontologist"},{"issue":"3","key":"10.1016\/j.tjpad.2024.100046_bib0058","first-page":"203","article-title":"Models of care for socially isolated older rural carers: barriers and implications","volume":"11","author":"Winterton","year":"2011","journal-title":"Rural Remote Health"},{"issue":"4","key":"10.1016\/j.tjpad.2024.100046_bib0059","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/jrh.12344","article-title":"Differences in social isolation and its relationship to health by rurality","volume":"35","author":"Henning-Smith","year":"2019","journal-title":"J Rural Health"},{"key":"10.1016\/j.tjpad.2024.100046_bib0060","series-title":"National academies of sciences E and medicine. social isolation and engagement","author":"Casola","year":"2024"},{"issue":"8","key":"10.1016\/j.tjpad.2024.100046_bib0061","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/gerona\/glac213","article-title":"Investigating biological pathways underpinning the longitudinal association between loneliness and cognitive impairment","volume":"78","author":"Yu","year":"2023","journal-title":"J Gerontol Ser A"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580724006381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580724006381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:52:12Z","timestamp":1785977532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580724006381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2274580724006381"],"URL":"https:\/\/doi.org\/10.1016\/j.tjpad.2024.100046","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Social isolation, loneliness, and their joint effects on cognitive decline and incident Alzheimer's disease: Findings from the Chicago health and aging project","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjpad.2024.100046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Masson SAS on behalf of SERDI Publisher.","name":"copyright","label":"Copyright"}],"article-number":"100046"}}