{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T19:44:54Z","timestamp":1786563894721,"version":"build-2736575974"},"reference-count":55,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012317","name":"UCLH Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Korea Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HU21C0066"],"award-info":[{"award-number":["HU21C0066"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017506","name":"Alzheimer\u2019s Society","doi-asserted-by":"publisher","award":["AS-PG-15\\u2013025"],"award-info":[{"award-number":["AS-PG-15\\u2013025"]}],"id":[{"id":"10.13039\/501100017506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017478","name":"FLENI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["20\/00448"],"award-info":[{"award-number":["20\/00448"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000320","name":"Alzheimer's Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016145","name":"Ministerio de Sanidad, Consumo y Bienestar Social","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016145","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020206","name":"Korea Dementia Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["SG-20\\u2013690363-DIAN"],"award-info":[{"award-number":["SG-20\\u2013690363-DIAN"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P014372\/1"],"award-info":[{"award-number":["MR\/P014372\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005224","name":"German Centre for Neurodegenerative Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19AG032438"],"award-info":[{"award-number":["U19AG032438"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.tjpad.2025.100133","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T01:22:51Z","timestamp":1742520171000},"page":"100133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7833-616X","authenticated-orcid":false,"given":"David M","family":"Cash","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy E","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette","family":"O'Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D","family":"Veale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7512-7856","authenticated-orcid":false,"given":"Ian B","family":"Malone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Poole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammie LS","family":"Benzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ibanez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1340-6694","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge J.","family":"Llibre-Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"McDade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7792-1698","authenticated-orcid":false,"given":"Jasmeer P","family":"Chhatwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5133-5538","authenticated-orcid":false,"given":"Gregory S","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Huey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Jucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-8167","authenticated-orcid":false,"given":"Yoshiki","family":"Niimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0648-6702","authenticated-orcid":false,"given":"James M","family":"Noble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3243-0529","authenticated-orcid":false,"given":"Jee Hoon","family":"Roh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7750-896X","authenticated-orcid":false,"given":"Racquel","family":"S\u00e1nchez-Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2967-9662","authenticated-orcid":false,"given":"Peter R","family":"Schofield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall J","family":"Bateman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0098-9915","authenticated-orcid":false,"given":"Chris","family":"Frost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6660-657X","authenticated-orcid":false,"given":"Nick C","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjpad.2025.100133_bib0001","first-page":"1","article-title":"Lecanemab in early Alzheimer's Disease","author":"van Dyck","year":"2022","journal-title":"N Engl J. Med."},{"key":"10.1016\/j.tjpad.2025.100133_bib0002","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/jama.2023.13239","article-title":"Donanemab in early symptomatic Alzheimer disease","volume":"330","author":"Sims","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.tjpad.2025.100133_bib0003","doi-asserted-by":"crossref","first-page":"197","DOI":"10.14283\/jpad.2022.30","article-title":"Two randomized phase 3 studies of Aducanumab in early Alzheimer's disease","volume":"9","author":"Budd Haeberlein","year":"2022","journal-title":"J Prev Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2025.100133_bib0004","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid \u03b2 deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.tjpad.2025.100133_bib0005","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer's disease","volume":"367","author":"Bateman","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tjpad.2025.100133_bib0006","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/S1474-4422(16)30193-4","article-title":"Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series","volume":"15","author":"Ryan","year":"2016","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.tjpad.2025.100133_bib0007","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1212\/WNL.0000000000000596","article-title":"Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis","volume":"83","author":"Ryman","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2025.100133_bib0008","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.neuron.2014.10.038","article-title":"The evolution of preclinical Alzheimer's disease: implications for prevention trials","volume":"84","author":"Sperling","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.tjpad.2025.100133_bib0009","doi-asserted-by":"crossref","first-page":"E322","DOI":"10.1212\/WNL.0000000000007831","article-title":"Determining clinically meaningful decline in preclinical Alzheimer disease","volume":"93","author":"Insel","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2025.100133_bib0010","unstructured":"US Food and Drug Administration. Early Alzheimer's disease: developing drugs for treatment; draft guidance for industry. 2018."},{"key":"10.1016\/j.tjpad.2025.100133_bib0011","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/alz.12748","article-title":"The AHEAD 3-45 study: design of a prevention trial for Alzheimer's disease","volume":"19","author":"Rafii","year":"2023","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.tjpad.2025.100133_bib0012","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/s41591-021-01369-8","article-title":"A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease","volume":"27","author":"Salloway","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.tjpad.2025.100133_bib0013","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/alzrt213","article-title":"Dominantly Inherited Alzheimer Network: facilitating research and clinical trials","volume":"5","author":"Moulder","year":"2013","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.tjpad.2025.100133_bib0014","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.trci.2019.07.007","article-title":"Two-period linear mixed effects models to analyze clinical trials with run-in data when the primary outcome is continuous: applications to Alzheimer's disease","volume":"5","author":"Wang","year":"2019","journal-title":"Alzheimer's Dement.: Transl. Res. Clin. Interv."},{"key":"10.1016\/j.tjpad.2025.100133_bib0015","doi-asserted-by":"crossref","first-page":"975","DOI":"10.4155\/cli.12.93","article-title":"Developing an international network for Alzheimer research: the dominantly inherited Alzheimer Network","volume":"2","author":"Morris","year":"2012","journal-title":"Clin Investig (L.)"},{"key":"10.1016\/j.tjpad.2025.100133_bib0016","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2025.100133_bib0017","doi-asserted-by":"crossref","first-page":"E4502","DOI":"10.1073\/pnas.1317918110","article-title":"Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease","volume":"110","author":"Benzinger","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.tjpad.2025.100133_bib0018","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1109\/TMI.2015.2418298","article-title":"Geodesic information flows: spatially-variant graphs and their application to segmentation and fusion","volume":"34","author":"Cardoso","year":"2015","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.tjpad.2025.100133_bib0019","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.neuroimage.2014.09.034","article-title":"Accurate automatic estimation of total intracranial volume: a nuisance variable with less nuisance","volume":"104","author":"Malone","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.tjpad.2025.100133_bib0020","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.neuroimage.2009.12.059","article-title":"Robust atrophy rate measurement in Alzheimer's disease using multi-site serial MRI: tissue-specific intensity normalization and parameter selection","volume":"50","author":"Leung","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.tjpad.2025.100133_bib0021","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/j.neurobiolaging.2014.04.035","article-title":"Measuring brain atrophy with a generalized formulation of the boundary shift integral","volume":"36","author":"Prados","year":"2015","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.tjpad.2025.100133_bib0022","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1109\/42.640753","article-title":"The boundary shift integral: an accurate and robust measure of cerebral volume changes from registered repeat MRI","volume":"16","author":"Freeborough","year":"1997","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.tjpad.2025.100133_bib0023","doi-asserted-by":"crossref","unstructured":"Su Y., Angelo G.M.D., Vlassenko A.G., Zhou G., Snyder A.Z., Marcus D.S., et al. Quantitative analysis of PiB-PET with FreeSurfer ROIs 2013;8. https:\/\/doi.org\/10.1371\/journal.pone.0073377.","DOI":"10.1371\/journal.pone.0073377"},{"key":"10.1016\/j.tjpad.2025.100133_bib0024","first-page":"1257","article-title":"Predominant deposition of amyloid-\u03b242(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene","volume":"148","author":"Mann","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tjpad.2025.100133_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2021.102749","article-title":"PET evidence of preclinical cerebellar amyloid plaque deposition in autosomal dominant Alzheimer's disease-causing Presenilin-1 E280A mutation carriers","volume":"31","author":"Ghisays","year":"2021","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.tjpad.2025.100133_bib0026","first-page":"904","article-title":"Correction for partial volume effects in PET: principle and validation","volume":"39","author":"Rousset","year":"1998","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.tjpad.2025.100133_bib0027","doi-asserted-by":"crossref","unstructured":"Su Y., Blazey T.M., Snyder A.Z., Raichle M.E., Marcus D.S., Ances B.M., et al. NeuroImage partial volume correction in quantitative amyloid imaging 2015;c:55\u201364. https:\/\/doi.org\/10.1016\/j.neuroimage.2014.11.058.","DOI":"10.1016\/j.neuroimage.2014.11.058"},{"key":"10.1016\/j.tjpad.2025.100133_bib0028","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3007901","article-title":"Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease","volume":"6","author":"Fagan","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.tjpad.2025.100133_bib0029","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nrd3505","article-title":"The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics","volume":"10","author":"Karran","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.tjpad.2025.100133_bib0030","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa2100708","article-title":"Donanemab in early Alzheimer's disease","volume":"384","author":"Mintun","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tjpad.2025.100133_bib0031","doi-asserted-by":"crossref","DOI":"10.1186\/alzrt244","article-title":"Interpreting Alzheimer's disease clinical trials in light of the effects on amyloid-\u03b2","volume":"6","author":"Toyn","year":"2014","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.tjpad.2025.100133_bib0032","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/s41591-021-01369-8","article-title":"A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease","volume":"27","author":"Salloway","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.tjpad.2025.100133_bib0033","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1002\/sim.3280","article-title":"Optimizing the design of clinical trials where the outcome is a rate . Can estimating a baseline rate in a run-in period increase efficiency?","volume":"27","author":"Frost","year":"2008","journal-title":"Stat Med"},{"key":"10.1016\/j.tjpad.2025.100133_bib0034","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1002\/mds.27122","article-title":"Design optimization for clinical trials in early-stage manifest Huntington's disease","volume":"32","author":"Frost","year":"2017","journal-title":"Mov. Disord."},{"key":"10.1016\/j.tjpad.2025.100133_bib0035","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1212\/WNL.0b013e3182a841c6","article-title":"The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study","volume":"81","author":"Cash","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2025.100133_bib0036","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jalz.2017.06.2268","article-title":"Presymptomatic atrophy in autosomal dominant Alzheimer's disease: a serial magnetic resonance imaging study","volume":"14","author":"Kinnunen","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.tjpad.2025.100133_bib0037","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1474-4422(18)30028-0","article-title":"Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study","volume":"17","author":"Gordon","year":"2018","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.tjpad.2025.100133_bib0038","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1002\/sim.7811","article-title":"A novel cognitive disease progression model for clinical trials in autosomal-dominant Alzheimer's disease","volume":"37","author":"Wang","year":"2018","journal-title":"Stat Med"},{"key":"10.1016\/j.tjpad.2025.100133_bib0039","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000006277","article-title":"Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease","author":"McDade","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2025.100133_bib0040","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jalz.2016.07.005","article-title":"The DIAN-TU Next Generation Alzheimer's prevention trial: adaptive design and disease progression model","volume":"13","author":"Bateman","year":"2017","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.tjpad.2025.100133_bib0041","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1056\/NEJMoa2305032","article-title":"Trial of Solanezumab in preclinical Alzheimer's disease","volume":"12","author":"Sperling","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tjpad.2025.100133_bib0042","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1177\/1536867X211045512","article-title":"Power and sample-size calculations for trials that compare slopes over time: introducing the slopepower command","volume":"21","author":"Nash","year":"2021","journal-title":"Stata J"},{"key":"10.1016\/j.tjpad.2025.100133_bib0043","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jalz.2017.06.2268","article-title":"Presymptomatic atrophy in autosomal dominant Alzheimer's disease: a serial magnetic resonance imaging study","volume":"14","author":"Kinnunen","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.tjpad.2025.100133_bib0044","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13195-014-0087-9","article-title":"Imaging endpoints for clinical trials in Alzheimer's disease","volume":"6","author":"Cash","year":"2014","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.tjpad.2025.100133_bib0045","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1007\/s13311-021-01027-4","article-title":"The use, standardization, and interpretation of brain imaging data in clinical trials of neurodegenerative disorders","volume":"18","author":"Schwarz","year":"2021","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.tjpad.2025.100133_bib0046","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S1474-4422(24)00335-1","article-title":"Brain volume change following anti-amyloid\u03b2 immunotherapy for Alzheimer's disease: amyloid-removal-related pseudo-atrophy","volume":"23","author":"Belder","year":"2024","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.tjpad.2025.100133_bib0047","doi-asserted-by":"crossref","unstructured":"Bateman R.J., Li Y., McDade E., Llibre Guerra J.J., Clifford D., Atri A., et al. Amyloid reduction and dementia progression in dominantly inherited Alzheimer's diseaseafter long-term Gantenerumab treatment: results from the Dian-Tu trial n.d. https:\/\/doi.org\/10.2139\/SSRN.4906344.","DOI":"10.2139\/ssrn.4906344"},{"key":"10.1016\/j.tjpad.2025.100133_bib0048","first-page":"1","article-title":"Tau accumulation in autosomal dominant Alzheimer's disease: a longitudinal [18F]flortaucipir study","volume":"15","author":"O'Connor","year":"2023","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.tjpad.2025.100133_bib0049","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1093\/brain\/awz019","article-title":"Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers","volume":"142","author":"Gordon","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.tjpad.2025.100133_bib0050","doi-asserted-by":"crossref","DOI":"10.3233\/JAD-121255","article-title":"Genetic influences on atrophy patterns in familial {A}lzheimer's Disease: a comparison of {APP} and {PSEN1} mutations","author":"Scahill","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2025.100133_bib0051","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S1474-4422(21)00375-6","article-title":"Variant-dependent heterogeneity in amyloid\u03b2 burden in autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analyses of an observational study","volume":"21","author":"Chhatwal","year":"2022","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.tjpad.2025.100133_bib0052","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12874-023-02093-2","article-title":"How important is the linearity assumption in a sample size calculation for a randomised controlled trial where treatment is anticipated to affect a rate of change?","volume":"23","author":"Morgan","year":"2023","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.tjpad.2025.100133_bib0053","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1212\/WNL.0000000000002914","article-title":"The ARIC-PET amyloid imaging study: brain amyloid differences by age, race, sex, and APOE","volume":"87","author":"Gottesman","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2025.100133_bib0054","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1001\/jamaneurol.2022.3157","article-title":"Racial and ethnic differences in amyloid PET positivity in individuals with mild cognitive impairment or dementia: a secondary analysis of the imaging dementia\u2013Evidence for amyloid scanning (IDEAS) cohort study","volume":"79","author":"Wilkins","year":"2022","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.tjpad.2025.100133_bib0055","doi-asserted-by":"crossref","first-page":"E1491","DOI":"10.1212\/WNL.0000000000011599","article-title":"Amyloid PET imaging in self-identified Non-Hispanic black participants of the Anti-Amyloid in asymptomatic Alzheimer's Disease (A4) study","volume":"96","author":"Deters","year":"2021","journal-title":"Neurology"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580725000779?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580725000779?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T22:46:03Z","timestamp":1786488363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580725000779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S2274580725000779"],"URL":"https:\/\/doi.org\/10.1016\/j.tjpad.2025.100133","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.11.12.24316919","asserted-by":"object"}]},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sample size estimates for biomarker-based outcome measures in clinical trials in autosomal dominant Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjpad.2025.100133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Masson SAS on behalf of SERDI Publisher.","name":"copyright","label":"Copyright"}],"article-number":"100133"}}