{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:38:16Z","timestamp":1791837496283,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24wm0625310"],"award-info":[{"award-number":["JP24wm0625310"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020964","name":"Japan Science and Technology Agency Fusion Oriented REsearch for disruptive Science and Technology","doi-asserted-by":"publisher","award":["JPMJFR231P"],"award-info":[{"award-number":["JPMJFR231P"]}],"id":[{"id":"10.13039\/501100020964","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007333","name":"Alzheimer's Disease Neuroimaging Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007333","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.tjpad.2025.100228","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T19:47:39Z","timestamp":1749844059000},"page":"100228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["The coupling of global brain activity and cerebrospinal fluid flow as a potential predictive marker of brain amyloid-\u03b2 accumulation"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0260-0424","authenticated-orcid":false,"given":"Yuya","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5028-218X","authenticated-orcid":false,"given":"Koji","family":"Kamagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5562-1504","authenticated-orcid":false,"given":"Kaito","family":"Takabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5281-0464","authenticated-orcid":false,"given":"Rinako","family":"Iseki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9339-6950","authenticated-orcid":false,"given":"Christina","family":"Andica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5277-3249","authenticated-orcid":false,"given":"Akifumi","family":"Hagiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3056-0792","authenticated-orcid":false,"given":"Toshiaki","family":"Akashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1180-2629","authenticated-orcid":false,"given":"Osamu","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8491-0698","authenticated-orcid":false,"given":"Shigeki","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjpad.2025.100228_bib0001","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/alzrt187","article-title":"Evidence for impaired amyloid \u03b2 clearance in Alzheimer\u2019s disease","volume":"5","author":"Wildsmith","year":"2013","journal-title":"Alzheimer Res Ther"},{"key":"10.1016\/j.tjpad.2025.100228_bib0002","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.abb8739","article-title":"Glymphatic failure as a final common pathway to dementia","volume":"370","author":"Nedergaard","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.tjpad.2025.100228_bib0003","doi-asserted-by":"crossref","DOI":"10.1126\/science.1197623","article-title":"Decreased clearance of CNS \u03b2-amyloid in Alzheimer\u2019s disease","volume":"330","author":"Mawuenyega","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.tjpad.2025.100228_bib0004","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neurobiolaging.2023.03.005","article-title":"Annualized changes in rate of amyloid deposition and neurodegeneration are greater in participants who become amyloid positive than those who remain amyloid negative","volume":"127","author":"Groechel","year":"2023","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.tjpad.2025.100228_bib0005","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","article-title":"The Glymphatic System: A beginner\u2019s guide","volume":"40","author":"Jessen","year":"2015","journal-title":"Neurochem Res"},{"key":"10.1016\/j.tjpad.2025.100228_bib0006","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/jmri.28759","article-title":"Current understanding of the anatomy, physiology, and Magnetic resonance imaging of neurofluids: update from the 2022 \u201cISMRM Imaging neurofluids study group\u201d workshop in Rome","volume":"59","author":"Agarwal","year":"2024","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.tjpad.2025.100228_bib0007","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neubiorev.2018.03.028","article-title":"Interaction between blood-brain barrier and glymphatic system in solute clearance","volume":"90","author":"Verheggen","year":"2018","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.tjpad.2025.100228_bib0008","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1126\/science.1240514","article-title":"Garbage truck of the brain","volume":"340","author":"Nedergaard","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.tjpad.2025.100228_bib0009","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nrd.2018.109","article-title":"Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing","volume":"17","author":"Boland","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.tjpad.2025.100228_bib0010","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain","volume":"342","author":"Xie","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.tjpad.2025.100228_bib0011","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrneurol.2015.119","article-title":"Clearance systems in the brain\u2014implications for Alzheimer disease","volume":"11","author":"Tarasoff-Conway","year":"2015","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.tjpad.2025.100228_bib0012","doi-asserted-by":"crossref","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.tjpad.2025.100228_bib0013","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.neubiorev.2019.05.016","article-title":"Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson\u2019s disease","volume":"103","author":"Sundaram","year":"2019","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.tjpad.2025.100228_bib0014","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1126\/science.aax5440","article-title":"Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep","volume":"366","author":"Fultz","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.tjpad.2025.100228_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001233","article-title":"Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease\u2013related pathology","volume":"19","author":"Han","year":"2021","journal-title":"PLoS Biol"},{"key":"10.1016\/j.tjpad.2025.100228_bib0016","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.neuroimage.2018.04.045","article-title":"Contribution of systemic vascular effects to fMRI activity in white matter","volume":"176","author":"\u00d6zbay","year":"2018","journal-title":"NeuroImage"},{"key":"10.1016\/j.tjpad.2025.100228_bib0017","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1152\/japplphysiol.00954.2005","article-title":"Perivascular nerves and the regulation of cerebrovascular tone","volume":"100","author":"Hamel","year":"2006","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.tjpad.2025.100228_bib0018","doi-asserted-by":"crossref","first-page":"7788","DOI":"10.1038\/s41467-023-43627-y","article-title":"Resting-state global brain activity affects early \u03b2-amyloid accumulation in default mode network","volume":"14","author":"Han","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.tjpad.2025.100228_bib0019","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1002\/mds.28643","article-title":"Decoupling of global brain activity and cerebrospinal fluid flow in parkinson\u2019s disease cognitive decline","volume":"36","author":"Han","year":"2021","journal-title":"Mov Disord"},{"key":"10.1016\/j.tjpad.2025.100228_bib0020","article-title":"Reduced coupling between the global blood-oxygen-level-dependent signal and cerebrospinal fluid inflow is associated with the severity of small vessel disease","volume":"36","author":"Zhang","year":"2022","journal-title":"NeuroImage: Clin"},{"key":"10.1016\/j.tjpad.2025.100228_bib0021","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1177\/0271678X231164337","article-title":"Reduced coupling of global brain function and cerebrospinal fluid dynamics in Parkinson\u2019s disease","volume":"43","author":"Wang","year":"2023","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.tjpad.2025.100228_bib0022","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1212\/WNL.56.12.1746","article-title":"The Monro\u2013Kellie hypothesis","volume":"56","author":"Mokri","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2025.100228_bib0023","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13195-017-0283-5","article-title":"On the path to 2025: understanding the Alzheimer\u2019s disease continuum","volume":"9","author":"Aisen","year":"2017","journal-title":"Alzheimer Res Ther"},{"key":"10.1016\/j.tjpad.2025.100228_bib0024","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1016\/j.jalz.2013.05.1769","article-title":"The Alzheimer\u2019s Disease Neuroimaging Initiative: A review of papers published since its inception","volume":"9","author":"Weiner","year":"2013","journal-title":"Alzheimer Dement"},{"key":"10.1016\/j.tjpad.2025.100228_bib0025","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.jalz.2018.01.010","article-title":"CSF biomarkers of Alzheimer\u2019s disease concord with amyloid-\u03b2 PET and predict clinical progression: a study of fully automated immunoassays in BioFINDER and ADNI cohorts","volume":"14","author":"Hansson","year":"2018","journal-title":"Alzheimer Dement"},{"key":"10.1016\/j.tjpad.2025.100228_bib0026","doi-asserted-by":"crossref","first-page":"5888","DOI":"10.1038\/s41380-021-01263-2","article-title":"Alzheimer\u2019s disease profiled by fluid and imaging markers: tau PET best predicts cognitive decline","volume":"26","author":"Bucci","year":"2021","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.tjpad.2025.100228_bib0027","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13195-021-00836-1","article-title":"Validation of amyloid PET positivity thresholds in centiloids: a multisite PET study approach","volume":"13","author":"Royse","year":"2021","journal-title":"Alzheimer Res Ther"},{"key":"10.1016\/j.tjpad.2025.100228_bib0028","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.jalz.2015.05.001","article-title":"The Alzheimer\u2019s Disease Neuroimaging Initiative 2 PET Core: 2015","volume":"11","author":"Jagust","year":"2015","journal-title":"Alzheimer Dement"},{"key":"10.1016\/j.tjpad.2025.100228_bib0029","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/ana.23908","article-title":"Comparing positron emission tomography imaging and cerebrospinal fluid measurements of \u03b2-amyloid","volume":"74","author":"Landau","year":"2013","journal-title":"Ann Neurol"},{"key":"10.1016\/j.tjpad.2025.100228_bib0030","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuroimage.2008.09.037","article-title":"A new method for improving functional-to-structural MRI alignment using local Pearson correlation","volume":"44","author":"Saad","year":"2009","journal-title":"NeuroImage"},{"key":"10.1016\/j.tjpad.2025.100228_bib0031","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"NeuroImage"},{"key":"10.1016\/j.tjpad.2025.100228_bib0032","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1073\/pnas.0911855107","article-title":"Toward discovery science of human brain function","volume":"107","author":"Biswal","year":"2010","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.tjpad.2025.100228_bib0033","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2967\/jnumed.114.148981","article-title":"Measurement of longitudinal \u03b2-amyloid change with 18F-florbetapir PET and standardized uptake value ratios","volume":"56","author":"Landau","year":"2015","journal-title":"J Nucl Med"},{"key":"10.1016\/j.tjpad.2025.100228_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.116614","article-title":"Identifying and removing widespread signal deflections from fMRI data: rethinking the global signal regression problem","volume":"212","author":"Aquino","year":"2020","journal-title":"NeuroImage"},{"key":"10.1016\/j.tjpad.2025.100228_bib0035","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.neuroimage.2011.09.088","article-title":"Inflow effects on functional MRI","volume":"62","author":"Gao","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.tjpad.2025.100228_bib0036","doi-asserted-by":"crossref","first-page":"919","DOI":"10.3390\/cells11050919","article-title":"Waste clearance in the brain and neuroinflammation: A novel perspective on biomarker and drug target discovery in Alzheimer\u2019s disease","volume":"11","author":"Uchida","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.tjpad.2025.100228_bib0037","doi-asserted-by":"crossref","first-page":"873","DOI":"10.3233\/JAD-150897","article-title":"Cerebrospinal fluid markers of Alzheimer\u2019s Disease pathology and microglial activation are associated with altered white matter microstructure in asymptomatic adults at risk for Alzheimer\u2019s disease","volume":"50","author":"Melah","year":"2016","journal-title":"J Alzheimer Dis"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580725001712?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580725001712?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:40:07Z","timestamp":1762674007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580725001712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":37,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S2274580725001712"],"URL":"https:\/\/doi.org\/10.1016\/j.tjpad.2025.100228","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The coupling of global brain activity and cerebrospinal fluid flow as a potential predictive marker of brain amyloid-\u03b2 accumulation","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjpad.2025.100228","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Masson SAS on behalf of SERDI Publisher.","name":"copyright","label":"Copyright"}],"article-number":"100228"}}