{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:35:34Z","timestamp":1791531334830,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010814","name":"Anhui Province Department of Education","doi-asserted-by":"publisher","award":["2024AH040242"],"award-info":[{"award-number":["2024AH040242"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014980","name":"Wannan Medical College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014980","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.tjpad.2025.100306","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T03:55:44Z","timestamp":1753242944000},"page":"100306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cortical microstructure in familial frontotemporal dementia associated with MAPT, GRN, and C9orf72 pathogenic variants: Looking beyond atrophy"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2857-1382","authenticated-orcid":false,"given":"Lijuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1800-7061","authenticated-orcid":false,"given":"Si","family":"Cen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2265-4705","authenticated-orcid":false,"given":"Pengcheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8712-9493","authenticated-orcid":false,"given":"Pusheng","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-500X","authenticated-orcid":false,"given":"Wencai","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjpad.2025.100306_bib0001","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"Rascovsky","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.tjpad.2025.100306_bib0002","doi-asserted-by":"crossref","first-page":"6045","DOI":"10.1002\/alz.14158","article-title":"Association of cortical morphology, white matter hyperintensity, and glymphatic function in frontotemporal dementia variants","volume":"20","author":"Xiao","year":"2024","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.tjpad.2025.100306_bib0003","doi-asserted-by":"crossref","first-page":"e1154","DOI":"10.1212\/WNL.0000000000200860","article-title":"Differences in motor features of C9orf72, MAPT, or GRN variant carriers with familial frontotemporal lobar degeneration","volume":"99","author":"Tipton","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2025.100306_bib0004","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1007\/s00415-019-09363-4","article-title":"An update on genetic frontotemporal dementia","volume":"266","author":"Greaves","year":"2019","journal-title":"J Neurol"},{"key":"10.1016\/j.tjpad.2025.100306_bib0005","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S0140-6736(13)60630-3","article-title":"Genetics of dementia","volume":"383","author":"Loy","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.tjpad.2025.100306_bib0006","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1038\/s41591-022-01942-9","article-title":"Temporal order of clinical and biomarker changes in familial frontotemporal dementia","volume":"28","author":"Staffaroni","year":"2022","journal-title":"Nat Med"},{"key":"10.1016\/j.tjpad.2025.100306_bib0007","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/S0140-6736(15)00461-4","article-title":"Frontotemporal dementia","volume":"386","author":"Bang","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.tjpad.2025.100306_bib0008","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-pathmechdis-051222-120750","article-title":"Neurodegenerative disease tauopathies","volume":"19","author":"Creekmore","year":"2024","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.tjpad.2025.100306_bib0009","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.nicl.2015.01.011","article-title":"Longitudinal gray matter contraction in three variants of primary progressive aphasia: a tenser-based morphometry study","volume":"8","author":"Brambati","year":"2015","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.tjpad.2025.100306_bib0010","doi-asserted-by":"crossref","first-page":"e140","DOI":"10.1212\/WNL.0000000000009760","article-title":"Longitudinal structural and metabolic changes in frontotemporal dementia","volume":"95","author":"Bejanin","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2025.100306_bib0011","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13195-015-0132-3","article-title":"Diffusion imaging changes in grey matter in Alzheimer's disease: a potential marker of early neurodegeneration","volume":"7","author":"Weston","year":"2015","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.tjpad.2025.100306_bib0012","doi-asserted-by":"crossref","first-page":"7813","DOI":"10.1038\/s41380-021-01290-z","article-title":"Association of cortical microstructure with amyloid-\u03b2 and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults","volume":"26","author":"Rodriguez-Vieitez","year":"2021","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.tjpad.2025.100306_bib0013","doi-asserted-by":"crossref","first-page":"e2565","DOI":"10.1212\/WNL.0000000000010727","article-title":"Cortical microstructure in the amyotrophic lateral sclerosis-frontotemporal dementia continuum","volume":"95","author":"Illan-Gala","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2025.100306_bib0014","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jalz.2017.09.013","article-title":"Cortical microstructural changes along the Alzheimer's disease continuum","volume":"14","author":"Montal","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.tjpad.2025.100306_bib0015","doi-asserted-by":"crossref","first-page":"7048","DOI":"10.1002\/alz.14176","article-title":"Spatial and temporal patterns of cortical mean diffusivity in Alzheimer's disease and suspected non-Alzheimer's disease pathophysiology","volume":"20","author":"Sun","year":"2024","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.tjpad.2025.100306_bib0016","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13195-023-01208-7","article-title":"Association of cortical and subcortical microstructure with disease severity: impact on cognitive decline and language impairments in frontotemporal lobar degeneration","volume":"15","author":"Ding","year":"2023","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.tjpad.2025.100306_bib0017","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/brain\/awz031","article-title":"Cortical microstructure in the behavioural variant of frontotemporal dementia: looking beyond atrophy","volume":"142","author":"Ill\u00e1n-Gala","year":"2019","journal-title":"Brain"},{"key":"10.1016\/j.tjpad.2025.100306_bib0018","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1002\/mds.28779","article-title":"Neurofilament light chain as a biomarker for cognitive decline in Parkinson Disease","volume":"36","author":"Aamodt","year":"2021","journal-title":"Mov Disord"},{"key":"10.1016\/j.tjpad.2025.100306_bib0019","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12916-024-03418-8","article-title":"Peripheral GFAP and NfL as early biomarkers for dementia: longitudinal insights from the UK Biobank","volume":"22","author":"Wang","year":"2024","journal-title":"BMC Med"},{"key":"10.1016\/j.tjpad.2025.100306_bib0020","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1001\/jamaneurol.2022.5250","article-title":"Serum glial fibrillary acidic protein compared with neurofilament light chain as a biomarker for disease progression in multiple sclerosis","volume":"80","author":"Meier","year":"2023","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.tjpad.2025.100306_bib0021","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jalz.2019.06.4947","article-title":"The longitudinal evaluation of familial frontotemporal dementia subjects protocol: framework and methodology","volume":"16","author":"Boeve","year":"2020","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.tjpad.2025.100306_bib0022","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/alz.12011","article-title":"Genetic screening of a large series of North American sporadic and familial frontotemporal dementia cases","volume":"16","author":"Ramos","year":"2020","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.tjpad.2025.100306_bib0023","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jalz.2019.08.196","article-title":"Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration","volume":"16","author":"Olney","year":"2020","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.tjpad.2025.100306_bib0024","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"Free Surfer","volume":"62","author":"Fischl","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.tjpad.2025.100306_bib0025","doi-asserted-by":"crossref","first-page":"11050","DOI":"10.1073\/pnas.200033797","article-title":"Measuring the thickness of the human cerebral cortex from magnetic resonance images","volume":"97","author":"Fischl","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.tjpad.2025.100306_bib0026","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jalz.2019.05.013","article-title":"Use of the CDR\u00ae plus NACC FTLD in mild FTLD: data from the ARTFL\/LEFFTDS consortium","volume":"16","author":"Miyagawa","year":"2020","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.tjpad.2025.100306_bib0027","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuroimage.2017.08.047","article-title":"Harmonization of multi-site diffusion tensor imaging data","volume":"161","author":"Fortin","year":"2017","journal-title":"Neuroimage"},{"key":"10.1016\/j.tjpad.2025.100306_bib0028","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/brain\/awad428","article-title":"Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer's disease","volume":"147","author":"Spotorno","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.tjpad.2025.100306_bib0029","doi-asserted-by":"crossref","first-page":"e2026","DOI":"10.1212\/WNL.0000000000009405","article-title":"Cortical microstructural correlates of astrocytosis in autosomal-dominant Alzheimer disease","volume":"94","author":"Vilaplana","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2025.100306_bib0030","doi-asserted-by":"crossref","first-page":"e2565","DOI":"10.1212\/WNL.0000000000010727","article-title":"Cortical microstructure in the amyotrophic lateral sclerosis-frontotemporal dementia continuum","volume":"95","author":"Ill\u00e1n-Gala","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2025.100306_bib0031","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/mds.29761","article-title":"Cortical macro- and microstructural changes in Parkinson's Disease with probable rapid eye movement sleep behavior disorder","volume":"39","author":"Pardo","year":"2024","journal-title":"Mov Disord"},{"key":"10.1016\/j.tjpad.2025.100306_bib0032","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13195-022-00974-0","article-title":"Cortical microstructure in primary progressive aphasia: a multicenter study","volume":"14","author":"Ill\u00e1n-Gala","year":"2022","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.tjpad.2025.100306_bib0033","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.tjpad.2025.100306_bib0034","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/mdc3.12677","article-title":"C9orf72 and its relevance in Parkinsonism and Movement disorders: a comprehensive review of the literature","volume":"5","author":"Bourinaris","year":"2018","journal-title":"Mov Disord Clin Pract"},{"key":"10.1016\/j.tjpad.2025.100306_bib0035","article-title":"Portuguese version of the CDR plus NACC FTLD: validation studies","volume":"14","author":"Lima","year":"2022","journal-title":"Alzheimers Dement (Amst)"},{"key":"10.1016\/j.tjpad.2025.100306_bib0036","doi-asserted-by":"crossref","DOI":"10.3390\/cells10061537","article-title":"Neurofilament light chain (NfL) in blood-A biomarker predicting unfavourable outcome in the acute phase and improvement in the late phase after stroke","volume":"10","author":"Pekny","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.tjpad.2025.100306_bib0037","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1093\/brain\/awae145","article-title":"Meso-cortical pathway damage in cognition, apathy and gait in cerebral small vessel disease","volume":"147","author":"Li","year":"2024","journal-title":"Brain"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580725002493?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580725002493?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T15:15:25Z","timestamp":1762614925000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580725002493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":37,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S2274580725002493"],"URL":"https:\/\/doi.org\/10.1016\/j.tjpad.2025.100306","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cortical microstructure in familial frontotemporal dementia associated with MAPT, GRN, and C9orf72 pathogenic variants: Looking beyond atrophy","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjpad.2025.100306","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Masson SAS on behalf of SERDI Publisher.","name":"copyright","label":"Copyright"}],"article-number":"100306"}}