{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:56:26Z","timestamp":1792756586864,"version":"4.5.0"},"reference-count":98,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2018\\u201305,761"],"award-info":[{"award-number":["RGPIN-2018\\u201305,761"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["GS9\\u2013171,369"],"award-info":[{"award-number":["GS9\\u2013171,369"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015569","name":"Canadian Consortium on Neurodegeneration in Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs Program","doi-asserted-by":"publisher","award":["CRC-2022\\u201300,240"],"award-info":[{"award-number":["CRC-2022\\u201300,240"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.tjpad.2025.100364","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T19:50:30Z","timestamp":1756497030000},"page":"100364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["APOE \u03b54-related differences in brain structure, function, and connectivity at midlife: A scoping review"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4927-6740","authenticated-orcid":false,"given":"Rikki","family":"Lissaman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1048-3250","authenticated-orcid":false,"given":"Sidra","family":"Anjum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4977-060X","authenticated-orcid":false,"given":"Andrea","family":"Quaiattini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Natasha","family":"Rajah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4852","key":"10.1016\/j.tjpad.2025.100364_bib0060","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E: cholesterol transport protein with expanding role in cell biology","volume":"240","author":"Mahley","year":"1988","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.tjpad.2025.100364_bib0061","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00109-016-1427-y","article-title":"Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders","volume":"94","author":"Mahley","year":"2016","journal-title":"J Mol Med"},{"issue":"8","key":"10.1016\/j.tjpad.2025.100364_bib0077","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1016\/S0021-9258(18)34702-1","article-title":"Human apolipoprotein E. The complete amino acid sequence","volume":"257","author":"Rall","year":"1982","journal-title":"J Biol Chem"},{"issue":"17","key":"10.1016\/j.tjpad.2025.100364_bib0094","doi-asserted-by":"crossref","first-page":"9077","DOI":"10.1016\/S0021-9258(19)52510-8","article-title":"Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms","volume":"256","author":"Weisgraber","year":"1981","journal-title":"J Biol Chem"},{"key":"10.1016\/j.tjpad.2025.100364_bib0042","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nbd.2014.08.025","article-title":"Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer\u2019s diseases","volume":"72","author":"Huang","year":"2014","journal-title":"Neurobiol Dis"},{"issue":"5123","key":"10.1016\/j.tjpad.2025.100364_bib0009","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.tjpad.2025.100364_bib0003","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.neuron.2019.01.056","article-title":"A quarter century of APOE and Alzheimer\u2019s disease: progress to date and the path forward","volume":"101","author":"Belloy","year":"2019","journal-title":"Neuron"},{"issue":"16","key":"10.1016\/j.tjpad.2025.100364_bib0023","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"issue":"9","key":"10.1016\/j.tjpad.2025.100364_bib0033","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/mp.2011.52","article-title":"APOE and Alzheimer disease: a major gene with semi-dominant inheritance","volume":"16","author":"Genin","year":"2011","journal-title":"Mol Psychiatry"},{"issue":"3","key":"10.1016\/j.tjpad.2025.100364_bib0045","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1001\/jamaneurol.2021.5216","article-title":"Prevalence estimates of amyloid abnormality across the Alzheimer disease clinical spectrum","volume":"79","author":"Jansen","year":"2022","journal-title":"JAMA Neurol"},{"issue":"19","key":"10.1016\/j.tjpad.2025.100364_bib0046","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1001\/jama.2015.4668","article-title":"Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis","volume":"313","author":"Jansen","year":"2015","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.tjpad.2025.100364_bib0084","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1001\/jamaneurol.2020.0387","article-title":"Association of factors with elevated amyloid burden in clinically normal older individuals","volume":"77","author":"Sperling","year":"2020","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.tjpad.2025.100364_bib0012","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","article-title":"The neuropathological diagnosis of Alzheimer\u2019s disease","volume":"14","author":"DeTure","year":"2019","journal-title":"Mol Neurodegener"},{"issue":"3","key":"10.1016\/j.tjpad.2025.100364_bib0041","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3233\/JAD-2009-1163","article-title":"Impact of APOE on the healthy aging brain: a voxel-based MRI and DTI study","volume":"18","author":"Honea","year":"2009","journal-title":"J Alzheimer\u2019s Dis: JAD"},{"issue":"4","key":"10.1016\/j.tjpad.2025.100364_bib0052","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0292576","article-title":"Impact of APOE-\u03b5 alleles on brain structure and cognitive function in healthy older adults: a VBM and DTI replication study","volume":"19","author":"Lacey","year":"2024","journal-title":"PLOS ONE"},{"key":"10.1016\/j.tjpad.2025.100364_bib0058","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1007\/s11682-019-00069-9","article-title":"Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity","volume":"14","author":"Lyall","year":"2019","journal-title":"Brain Imaging Behav"},{"issue":"5","key":"10.1016\/j.tjpad.2025.100364_bib0008","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1159\/000109150","article-title":"Neuroimaging and APOE genotype: a systematic qualitative review","volume":"24","author":"Cherbuin","year":"2007","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"3","key":"10.1016\/j.tjpad.2025.100364_bib0031","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s11065-014-9263-8","article-title":"Imaging brain effects of APOE4 in cognitively normal individuals across the lifespan","volume":"24","author":"Fouquet","year":"2014","journal-title":"Neuropsychol Rev"},{"key":"10.1016\/j.tjpad.2025.100364_bib0005","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuroscience.2017.05.048","article-title":"Disrupted white matter structural networks in healthy older adult APOE \u03b54 carriers \u2013 An international multicenter DTI study","volume":"357","author":"Cavedo","year":"2017","journal-title":"Neuroscience"},{"issue":"9","key":"10.1016\/j.tjpad.2025.100364_bib0038","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/mp.2010.90","article-title":"The APOE \u025b4 allele modulates brain white matter integrity in healthy adults","volume":"16","author":"Heise","year":"2011","journal-title":"Mol Psychiatry"},{"issue":"1","key":"10.1016\/j.tjpad.2025.100364_bib0039","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41398-024-02848-5","article-title":"A comprehensive analysis of APOE genotype effects on human brain structure in the UK Biobank","volume":"14","author":"Heise","year":"2024","journal-title":"Transl Psychiatry"},{"issue":"6","key":"10.1016\/j.tjpad.2025.100364_bib0059","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.neurobiolaging.2014.01.006","article-title":"Alzheimer\u2019s disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936","volume":"35","author":"Lyall","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.tjpad.2025.100364_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101133","article-title":"Risk for Alzheimer\u2019s disease: a review of long-term episodic memory encoding and retrieval fMRI studies","volume":"62","author":"McDonough","year":"2020","journal-title":"Ageing Res Rev"},{"issue":"7","key":"10.1016\/j.tjpad.2025.100364_bib0030","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1093\/brain\/awt127","article-title":"Lack of reliable evidence for a distinctive \u03b54-related cognitive phenotype that is independent from clinical diagnostic status: findings from the Australian Imaging, Biomarkers and Lifestyle Study","volume":"136","author":"Foster","year":"2013","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100364_bib0083","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1212\/WNL.50.2.355","article-title":"Apolipoprotein E genotype influences cognitive \u201cphenotype\u201d in patients with Alzheimer\u2019s disease but not in healthy control subjects","volume":"50","author":"Smith","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2025.100364_bib0070","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cortex.2018.03.025","article-title":"APOE genotype and cognition in healthy individuals at-risk of Alzheimer\u2019s disease: a review","volume":"104","author":"O\u2019Donoghue","year":"2018","journal-title":"Cortex"},{"issue":"4","key":"10.1016\/j.tjpad.2025.100364_bib0011","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jalz.2009.07.003","article-title":"Temporal lobe functional activity and connectivity in young adult APOE \u03b54 carriers","volume":"6","author":"Dennis","year":"2010","journal-title":"Alzheimer\u2019s Dement"},{"issue":"15","key":"10.1016\/j.tjpad.2025.100364_bib0025","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1097\/01.wnr.0000234745.27571.d1","article-title":"Functional magnetic resonance imaging and magnetoencephalography differences associated with APOE\u03b54 in young healthy adults","volume":"17","author":"Filbey","year":"2006","journal-title":"NeuroReport"},{"issue":"17","key":"10.1016\/j.tjpad.2025.100364_bib0026","doi-asserted-by":"crossref","first-page":"7209","DOI":"10.1073\/pnas.0811879106","article-title":"Distinct patterns of brain activity in young carriers of the APOE-\u03b54 allele","volume":"106","author":"Filippini","year":"2009","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.tjpad.2025.100364_bib0040","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neurobiolaging.2018.08.026","article-title":"Increased posterior default mode network activity and structural connectivity in young adult APOE-\u03b54 carriers: a multimodal imaging investigation","volume":"73","author":"Hodgetts","year":"2019","journal-title":"Neurobiol Aging"},{"issue":"6259","key":"10.1016\/j.tjpad.2025.100364_bib0051","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1126\/science.aac8128","article-title":"Reduced grid-cell\u2013like representations in adults at genetic risk for Alzheimer\u2019s disease","volume":"350","author":"Kunz","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.tjpad.2025.100364_bib0082","doi-asserted-by":"crossref","DOI":"10.1038\/srep16322","article-title":"APOE-\u03b54 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults","volume":"5","author":"Shine","year":"2015","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.tjpad.2025.100364_bib0027","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.1408-24.2024","article-title":"Precuneus activity during retrieval is positively associated with amyloid burden in cognitively normal older APOE4 carriers","volume":"45","author":"Fischer","year":"2025","journal-title":"J Neurosci"},{"issue":"6","key":"10.1016\/j.tjpad.2025.100364_bib0010","doi-asserted-by":"crossref","first-page":"fcae376","DOI":"10.1093\/braincomms\/fcae376","article-title":"Cerebral hyperactivation across the Alzheimer\u2019s disease pathological cascade","volume":"6","author":"Corriveau-Lecavalier","year":"2024","journal-title":"Brain Commun"},{"issue":"11","key":"10.1016\/j.tjpad.2025.100364_bib0044","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.tics.2011.09.004","article-title":"Lifespan brain activity, \u03b2-amyloid, and Alzheimer\u2019s disease","volume":"15","author":"Jagust","year":"2011","journal-title":"Trends Cogn Sci (Regul Ed)"},{"issue":"9","key":"10.1016\/j.tjpad.2025.100364_bib0073","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.tins.2023.06.003","article-title":"More than just risk for Alzheimer\u2019s disease: APOE \u03b54\u2019s impact on the aging brain","volume":"46","author":"Palmer","year":"2023","journal-title":"Trends Neurosci"},{"issue":"3","key":"10.1016\/j.tjpad.2025.100364_bib0087","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurobiolaging.2010.11.011","article-title":"The effects of APOE on brain activity do not simply reflect the risk of Alzheimer\u2019s disease","volume":"33","author":"Trachtenberg","year":"2012","journal-title":"Neurobiol Aging"},{"issue":"1","key":"10.1016\/j.tjpad.2025.100364_bib0088","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.neuroimage.2011.07.059","article-title":"The effects of APOE on the functional architecture of the resting brain","volume":"59","author":"Trachtenberg","year":"2012","journal-title":"NeuroImage"},{"issue":"4","key":"10.1016\/j.tjpad.2025.100364_bib0037","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jalz.2008.02.006","article-title":"Revision of the apolipoprotein E compensatory mechanism recruitment hypothesis","volume":"4","author":"Han","year":"2008","journal-title":"Alzheimer\u2019s Dement"},{"key":"10.1016\/j.tjpad.2025.100364_bib0092","article-title":"The apolipoprotein e antagonistic pleiotropy hypothesis: review and recommendations","volume":"2011","author":"Tuminello","year":"2011","journal-title":"Int J Alzheimer\u2019s Dis"},{"key":"10.1016\/j.tjpad.2025.100364_bib0097","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cortex.2016.12.016","article-title":"Sex and APOE: a memory advantage in male APOE \u03b54 carriers in midlife","volume":"88","author":"Zokaei","year":"2017","journal-title":"Cortex"},{"issue":"6","key":"10.1016\/j.tjpad.2025.100364_bib0081","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1097\/WCO.0000000000000262","article-title":"Does apolipoprotein E genotype influence cognition in middle-aged individuals?","volume":"28","author":"Salvato","year":"2015","journal-title":"Curr, Opin, Neurol"},{"issue":"4","key":"10.1016\/j.tjpad.2025.100364_bib0013","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.tins.2024.02.001","article-title":"The \u201cmiddle-aging\u201d brain","volume":"47","author":"Dohm-Hansen","year":"2024","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.tjpad.2025.100364_bib0055","series-title":"Encyclopedia of the human brain","first-page":"95","article-title":"Brain health and episodic memory function at midlife: exploring the effects of sex differences and menopause status","author":"LaPlume","year":"2025"},{"issue":"1","key":"10.1016\/j.tjpad.2025.100364_bib0053","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/0165025414533223","article-title":"Midlife as a pivotal period in the life course: balancing growth and decline at the crossroads of youth and old age","volume":"39","author":"Lachman","year":"2015","journal-title":"Int J Behav Dev"},{"key":"10.1016\/j.tjpad.2025.100364_bib0075","series-title":"Cognitive neuroscience of aging: linking cognitive and cerebral aging","first-page":"363","article-title":"The middle-aged brain: a cognitive neuroscience perspective","author":"Park","year":"2016"},{"key":"10.1016\/j.tjpad.2025.100364_bib0086","first-page":"1","article-title":"Menopause as a biological and psychological transition","author":"Thurston","year":"2025","journal-title":"Nat Rev Psychol"},{"issue":"3","key":"10.1016\/j.tjpad.2025.100364_bib0054","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1017\/S1355617716000990","article-title":"The elusive nature of APOE \u03b54 in mid-adulthood: understanding the cognitive profile","volume":"23","author":"Lancaster","year":"2017","journal-title":"J Int Neuropsychol Soc"},{"key":"10.1016\/j.tjpad.2025.100364_bib0036","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.arr.2017.03.004","article-title":"Functional neuroimaging findings in healthy middle-aged adults at risk of Alzheimer\u2019s disease","volume":"36","author":"Habib","year":"2017","journal-title":"Ageing Res Rev"},{"issue":"7","key":"10.1016\/j.tjpad.2025.100364_bib0090","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann, Intern, Med"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100364_bib0089","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.neurobiolaging.2010.03.009","article-title":"The effects of APOE-\u03b54 on the BOLD response","volume":"33","author":"Trachtenberg","year":"2012","journal-title":"Neurobiol Aging"},{"issue":"5","key":"10.1016\/j.tjpad.2025.100364_bib0057","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1007\/s00415-020-10383-8","article-title":"Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals","volume":"268","author":"Liu","year":"2021","journal-title":"J Neurol"},{"issue":"4","key":"10.1016\/j.tjpad.2025.100364_bib0063","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.3233\/JAD-200238","article-title":"Hippocampal subfield volumes in middle-aged adults at risk of dementia","volume":"75","author":"McKeever","year":"2020","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100364_bib0069","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/jnnp-2019-321652","article-title":"Association between midlife dementia risk factors and longitudinal brain atrophy: the PREVENT-dementia study","volume":"91","author":"O\u2019Brien","year":"2020","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"10.1016\/j.tjpad.2025.100364_bib0068","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1002\/alz.13733","article-title":"Entorhinal-based path integration selectively predicts midlife risk of Alzheimer\u2019s disease","volume":"20","author":"Newton","year":"2024","journal-title":"Alzheimer\u2019s Dement"},{"issue":"4","key":"10.1016\/j.tjpad.2025.100364_bib0071","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1017\/S1355617714000113","article-title":"Amyloid burden, neuronal function, and cognitive decline in middle-aged adults at risk for Alzheimer\u2019s disease","volume":"20","author":"Okonkwo","year":"2014","journal-title":"J Int Neuropsychol Soc"},{"issue":"5","key":"10.1016\/j.tjpad.2025.100364_bib0007","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/gerona\/63.5.501","article-title":"Total and regional gray matter volume is not related to APOE*E4 status in a community sample of middle-aged individuals","volume":"63","author":"Cherbuin","year":"2008","journal-title":"J Gerontol: A"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100364_bib0028","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1162\/netn_a_00220","article-title":"Inferring excitation-inhibition dynamics using a maximum entropy model unifying brain structure and function","volume":"6","author":"Fortel","year":"2022","journal-title":"Netw Neurosci"},{"issue":"12","key":"10.1016\/j.tjpad.2025.100364_bib0029","doi-asserted-by":"crossref","first-page":"6350","DOI":"10.1093\/cercor\/bhaa190","article-title":"Connectome signatures of hyperexcitation in cognitively intact middle-aged female APOE-\u03b54 carriers","volume":"30","author":"Fortel","year":"2020","journal-title":"Cereb Cortex"},{"issue":"S9","key":"10.1016\/j.tjpad.2025.100364_bib0065","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1002\/alz.13403","article-title":"Sex and APOE \u03b54 carrier effects on atrophy, amyloid PET, and tau PET burden in early-onset Alzheimer\u2019s disease","volume":"19","author":"Nemes","year":"2023","journal-title":"Alzheimer\u2019s Dement"},{"key":"10.1016\/j.tjpad.2025.100364_bib0066","doi-asserted-by":"crossref","DOI":"10.3389\/frdem.2023.1303256","article-title":"Elevated gonadotropin levels are associated with increased biomarker risk of Alzheimer\u2019s disease in midlife women","volume":"2","author":"Nerattini","year":"2023","journal-title":"Front Dement"},{"issue":"22","key":"10.1016\/j.tjpad.2025.100364_bib0072","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1212\/WNL.0b013e3182583047","article-title":"Family history of Alzheimer disease predicts hippocampal atrophy in healthy middle-aged adults","volume":"78","author":"Okonkwo","year":"2012","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.tjpad.2025.100364_bib0074","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1212\/WNL.0b013e3181f11deb","article-title":"Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men","volume":"75","author":"Panizzon","year":"2010","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.tjpad.2025.100364_bib0080","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jalz.2017.02.008","article-title":"The midlife cognitive profiles of adults at high risk of late-onset Alzheimer\u2019s disease: the PREVENT study","volume":"13","author":"Ritchie","year":"2017","journal-title":"Alzheimer\u2019s Dement"},{"issue":"Suppl 3","key":"10.1016\/j.tjpad.2025.100364_bib0024","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3233\/JAD-2011-0002","article-title":"Presence of ApoE \u03b54 allele associated with thinner frontal cortex in middle age","volume":"26","author":"Fennema-Notestine","year":"2011","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100364_bib0078","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/ana.410440226","article-title":"Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer\u2019s disease","volume":"44","author":"Reiman","year":"1998","journal-title":"Ann, Neurol"},{"issue":"11","key":"10.1016\/j.tjpad.2025.100364_bib0020","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1177\/0269881113499828","article-title":"Nicotine effects on attentional reorienting in mid-age adults, and interactions with apolipoprotein E status","volume":"27","author":"Evans","year":"2013","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.tjpad.2025.100364_bib0076","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.nicl.2017.03.016","article-title":"Family history and APOE4 risk for Alzheimer\u2019s disease impact the neural correlates of episodic memory by early midlife","volume":"14","author":"Rajah","year":"2017","journal-title":"NeuroImage: Clin"},{"key":"10.1016\/j.tjpad.2025.100364_bib0017","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neurobiolaging.2020.03.006","article-title":"Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia","volume":"91","author":"Dounavi","year":"2020","journal-title":"Neurobiol Aging"},{"issue":"8","key":"10.1016\/j.tjpad.2025.100364_bib0018","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1007\/s00415-022-11061-7","article-title":"Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-dementia study","volume":"269","author":"Dounavi","year":"2022","journal-title":"J Neurol"},{"issue":"5","key":"10.1016\/j.tjpad.2025.100364_bib0019","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/nbm.3502","article-title":"Structural and resting-state MRI detects regional brain differences in young and mid-age healthy APOE-e4 carriers compared with non-APOE-e4 carriers","volume":"29","author":"Dowell","year":"2016","journal-title":"NMR Biomed"},{"key":"10.1016\/j.tjpad.2025.100364_bib0022","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1038\/s41598-020-59272-0","article-title":"Mid age APOE \u03b54 carriers show memory-related functional differences and disrupted structure-function relationships in hippocampal regions","volume":"10","author":"Evans","year":"2020","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100364_bib0034","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055902","article-title":"Functional network endophenotypes unravel the effects of apolipoprotein E epsilon 4 in middle-aged adults","volume":"8","author":"Goveas","year":"2013","journal-title":"PLOS ONE"},{"issue":"22","key":"10.1016\/j.tjpad.2025.100364_bib0048","doi-asserted-by":"crossref","first-page":"6069","DOI":"10.1523\/JNEUROSCI.0959-06.2006","article-title":"The influence of Alzheimer disease family history and apolipoprotein E \u03b54 on mesial temporal lobe activation","volume":"26","author":"Johnson","year":"2006","journal-title":"J Neurosci"},{"issue":"10","key":"10.1016\/j.tjpad.2025.100364_bib0047","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1001\/archpsyc.64.10.1163","article-title":"Effect of Alzheimer disease risk on brain function during self-appraisal in healthy middle-aged adults","volume":"64","author":"Johnson","year":"2007","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.tjpad.2025.100364_bib0056","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cortex.2014.04.006","article-title":"Aberrant functional connectivity in Papez circuit correlates with memory performance in cognitively intact middle-aged APOE4 carriers","volume":"57","author":"Li","year":"2014","journal-title":"Cortex"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100364_bib98","doi-asserted-by":"crossref","first-page":"fcae046","DOI":"10.1093\/braincomms\/fcae046","article-title":"Dementia risk and thalamic nuclei volumetry in healthy midlife adults: The PREVENT Dementia study","volume":"6","author":"Shah","year":"2024","journal-title":"Brain Commun"},{"key":"10.1016\/j.tjpad.2025.100364_bib0091","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1741-7015-4-1","article-title":"Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer\u2019s Disease: a cross-sectional study","volume":"4","author":"Trivedi","year":"2006","journal-title":"BMC Med"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100364_bib0095","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/brain\/awn254","article-title":"The influence of parental history of Alzheimer\u2019s disease and apolipoprotein E 4 on the BOLD signal during recognition memory","volume":"132","author":"Xu","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.tjpad.2025.100364_bib0043","series-title":"The human nervous system","first-page":"896","article-title":"Chapter 24\u2014Hippocampal formation","author":"Insausti","year":"2012"},{"issue":"1","key":"10.1016\/j.tjpad.2025.100364_bib0096","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13195-020-00612-7","article-title":"Imaging biomarkers in neurodegeneration: current and future practices","volume":"12","author":"Young","year":"2020","journal-title":"Alzheimer\u2019s Res Ther"},{"issue":"7","key":"10.1016\/j.tjpad.2025.100364_bib0021","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.neurobiolaging.2014.01.145","article-title":"Cognitive and neural signatures of the APOE E4 allele in mid-aged adults","volume":"35","author":"Evans","year":"2014","journal-title":"Neurobiol Aging"},{"issue":"3","key":"10.1016\/j.tjpad.2025.100364_bib0079","doi-asserted-by":"crossref","first-page":"fcae189","DOI":"10.1093\/braincomms\/fcae189","article-title":"The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia","volume":"6","author":"Ritchie","year":"2024","journal-title":"Brain Commun"},{"key":"10.1016\/j.tjpad.2025.100364_bib0049","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.neuroimage.2018.05.052","article-title":"Disrupted topology of the resting state structural connectome in middle-aged APOE \u03b54 carriers","volume":"178","author":"Korthauer","year":"2018","journal-title":"NeuroImage"},{"key":"10.1016\/j.tjpad.2025.100364_bib0035","first-page":"91","article-title":"Functional neuroimaging studies in normal aging","author":"Guidotti Breting","year":"2012","journal-title":"In: Pardon, M.-C. & Bondi, M.W., editors. Behavioral neurobiology of aging Springer"},{"issue":"9","key":"10.1016\/j.tjpad.2025.100364_bib0006","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1093\/brain\/awae156","article-title":"The vascular contribution of apolipoprotein E to Alzheimer\u2019s disease","volume":"147","author":"Chen","year":"2024","journal-title":"Brain"},{"issue":"12","key":"10.1016\/j.tjpad.2025.100364_bib0001","doi-asserted-by":"crossref","first-page":"e2806","DOI":"10.1002\/brb3.2806","article-title":"Evidence of emerging BBB changes in mid-age apolipoprotein E epsilon-4 carriers","volume":"12","author":"Alruwais","year":"2022","journal-title":"Brain Behav"},{"issue":"11","key":"10.1016\/j.tjpad.2025.100364_bib0015","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1177\/0271678X211020863","article-title":"Evidence of cerebral hemodynamic dysregulation in middle-aged APOE \u03b54 carriers: the PREVENT-dementia study","volume":"41","author":"Dounavi","year":"2021","journal-title":"J Cereb Blood Flow Metab"},{"issue":"10","key":"10.1016\/j.tjpad.2025.100364_bib0016","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1177\/0271678X231173587","article-title":"Differential association of cerebral blood flow and anisocytosis in APOE \u03b54 carriers at midlife","volume":"43","author":"Dounavi","year":"2023","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.tjpad.2025.100364_bib0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jalz.2014.05.1755","article-title":"Reduced cerebrovascular reactivity in young adults carrying the APOE \u03b54 allele","volume":"11","author":"Suri","year":"2015","journal-title":"Alzheimer\u2019s Dement"},{"issue":"5","key":"10.1016\/j.tjpad.2025.100364_bib0004","doi-asserted-by":"crossref","DOI":"10.1038\/nrn3475","article-title":"Power failure: why small sample size undermines the reliability of neuroscience","volume":"14","author":"Button","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.tjpad.2025.100364_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102510","article-title":"The effects of APOEe4 allele on cerebral structure, function, and related interactions with cognition in young adults","volume":"101","author":"Kucikova","year":"2024","journal-title":"Ageing Res Rev"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100364_bib0064","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/ejn.13801","article-title":"Neurogenomics \u2013 Towards a more rigorous science","volume":"47","author":"Mitchell","year":"2017","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.tjpad.2025.100364_bib0002","doi-asserted-by":"crossref","DOI":"10.1001\/jamaneurol.2023.3599","article-title":"APOE genotype and Alzheimer disease risk across age, sex, and population ancestry","author":"Belloy","year":"2023","journal-title":"JAMA Neurol"},{"issue":"10","key":"10.1016\/j.tjpad.2025.100364_bib0067","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1001\/jamaneurol.2017.2188","article-title":"Apolipoprotein E genotype and sex risk factors for Alzheimer disease: a meta-analysis","volume":"74","author":"Neu","year":"2017","journal-title":"JAMA Neurol"},{"issue":"8","key":"10.1016\/j.tjpad.2025.100364_bib0032","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.045211","article-title":"Sex-dependent effect of APOE on Alzheimer\u2019s disease and other age-related neurodegenerative disorders","volume":"13","author":"Gamache","year":"2020","journal-title":"Dis Model Mech"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100364_bib0093","doi-asserted-by":"crossref","DOI":"10.1111\/jne.13209","article-title":"Role of estrogen in women\u2019s Alzheimer\u2019s disease risk as modified by APOE","volume":"35","author":"Valencia-Olvera","year":"2023","journal-title":"J Neuroendocr"},{"issue":"1","key":"10.1016\/j.tjpad.2025.100364_bib0014","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/nyas.14268","article-title":"The importance of diversity in cognitive neuroscience","volume":"1464","author":"Dotson","year":"2020","journal-title":"Ann N Y Acad Sci"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580725003061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580725003061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T12:38:29Z","timestamp":1786019909000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580725003061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":98,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2274580725003061"],"URL":"https:\/\/doi.org\/10.1016\/j.tjpad.2025.100364","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"APOE \u03b54-related differences in brain structure, function, and connectivity at midlife: A scoping review","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjpad.2025.100364","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Masson SAS on behalf of SERDI Publisher.","name":"copyright","label":"Copyright"}],"article-number":"100364"}}