{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:38:34Z","timestamp":1791293914654,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01LM012535"],"award-info":[{"award-number":["R01LM012535"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 LM013463"],"award-info":[{"award-number":["R01 LM013463"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19 AG074879"],"award-info":[{"award-number":["U19 AG074879"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Korea Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI19C0149"],"award-info":[{"award-number":["HI19C0149"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Korea Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI18C0630"],"award-info":[{"award-number":["HI18C0630"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG072177"],"award-info":[{"award-number":["U01AG072177"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U19 AG024904"],"award-info":[{"award-number":["U19 AG024904"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG010133"],"award-info":[{"award-number":["P30 AG010133"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG068057"],"award-info":[{"award-number":["U01 AG068057"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG057739"],"award-info":[{"award-number":["R01 AG057739"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["T32 AG071444"],"award-info":[{"award-number":["T32 AG071444"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG068193"],"award-info":[{"award-number":["R01 AG068193"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG019771"],"award-info":[{"award-number":["R01 AG019771"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG072976"],"award-info":[{"award-number":["P30 AG072976"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002551","name":"Seoul National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002551","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020206","name":"Korea Dementia Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2014M3C7A1046042"],"award-info":[{"award-number":["2014M3C7A1046042"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2022-00165636"],"award-info":[{"award-number":["RS-2022-00165636"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2023-KH136195"],"award-info":[{"award-number":["RS-2023-KH136195"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.tjpad.2025.100368","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T19:25:12Z","timestamp":1758137112000},"page":"100368","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations of circulating c-reactive protein levels with central Alzheimer\u2019s disease biomarkers"],"prefix":"10.1016","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8280-3963","authenticated-orcid":false,"given":"Hye Ji","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3159-4510","authenticated-orcid":false,"given":"Min Soo","family":"Byun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0860-0946","authenticated-orcid":false,"given":"Dahyun","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6613-4680","authenticated-orcid":false,"given":"Hyejin","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5952-3373","authenticated-orcid":false,"given":"Gijung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangyong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Hyung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0855-8637","authenticated-orcid":false,"given":"Musung","family":"Keum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1444-1099","authenticated-orcid":false,"given":"Bo Kyung","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Kyeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyoon","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1640-2090","authenticated-orcid":false,"given":"Yun-Sang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5893-3124","authenticated-orcid":false,"given":"Jun-Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9643-2008","authenticated-orcid":false,"given":"Koung Mi","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul-Ho","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1371-8209","authenticated-orcid":false,"given":"Yen-Ning","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1376-8532","authenticated-orcid":false,"given":"Andrew J.","family":"Saykin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangsik","family":"Nho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8976-8320","authenticated-orcid":false,"given":"Dong Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjpad.2025.100368_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clinbiochem.2019.04.006","article-title":"Towards salivary C-reactive protein as a viable biomarker of systemic inflammation","volume":"68","author":"Pay","year":"2019","journal-title":"Clin Biochem"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100368_bib0002","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.clim.2005.08.004","article-title":"C-reactive protein: ligands, receptors and role in inflammation","volume":"117","author":"Marnell","year":"2005","journal-title":"Clin Immunol"},{"issue":"4","key":"10.1016\/j.tjpad.2025.100368_bib0003","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3109\/07853890009011772","article-title":"Function of C-reactive protein","volume":"32","author":"Du Clos","year":"2000","journal-title":"Ann Med"},{"issue":"12","key":"10.1016\/j.tjpad.2025.100368_bib0004","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1016\/j.immuni.2022.10.016","article-title":"Emerging roles of innate and adaptive immunity in Alzheimer's disease","volume":"55","author":"Chen","year":"2022","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.tjpad.2025.100368_bib0005","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer's disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.tjpad.2025.100368_bib0006","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jocn.2022.11.016","article-title":"Peripheral high levels of CRP predict progression from normal cognition to dementia: a systematic review and meta-analysis","volume":"107","author":"Long","year":"2023","journal-title":"J Clin Neurosci"},{"issue":"1","key":"10.1016\/j.tjpad.2025.100368_bib0007","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/0891988709351832","article-title":"Decreased C-reactive protein levels in Alzheimer disease","volume":"23","author":"O'Bryant","year":"2010","journal-title":"J Geriatr Psychiatry Neurol"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100368_bib0008","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/ana.10265","article-title":"Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study","volume":"52","author":"Schmidt","year":"2002","journal-title":"Ann Neurol"},{"issue":"6","key":"10.1016\/j.tjpad.2025.100368_bib0009","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1001\/archneur.65.6.776","article-title":"Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease","volume":"65","author":"Locascio","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.tjpad.2025.100368_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2020.111004","article-title":"C-reactive protein as a predictor of mild cognitive impairment conversion into Alzheimer's disease dementia","volume":"138","author":"Fernandes","year":"2020","journal-title":"Exp Gerontol"},{"issue":"6","key":"10.1016\/j.tjpad.2025.100368_bib0011","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.3597","article-title":"Association of chronic low-grade inflammation with risk of Alzheimer disease in APOE4 carriers","volume":"1","author":"Tao","year":"2018","journal-title":"JAMA Netw Open"},{"issue":"3","key":"10.1016\/j.tjpad.2025.100368_bib0012","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11883-007-0019-2","article-title":"Genetic determinants of C-reactive protein","volume":"9","author":"Danik","year":"2007","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.tjpad.2025.100368_bib0013","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bbi.2021.03.015","article-title":"Peripheral inflammatory biomarkers predict the deposition and progression of amyloid-\u03b2 in cognitively unimpaired older adults","volume":"95","author":"Oberlin","year":"2021","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.tjpad.2025.100368_bib0014","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.exger.2018.04.014","article-title":"Chronically raised C-reactive protein is inversely associated with cortical \u03b2-amyloid in older adults with subjective memory complaints","volume":"108","author":"Hooper","year":"2018","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.tjpad.2025.100368_bib0015","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bbi.2021.12.008","article-title":"Associations of circulating C-reactive proteins, APOE \u03b54, and brain markers for Alzheimer's disease in healthy samples across the lifespan","volume":"100","author":"Wang","year":"2022","journal-title":"Brain Behav Immun"},{"issue":"6","key":"10.1016\/j.tjpad.2025.100368_bib0016","doi-asserted-by":"crossref","first-page":"851","DOI":"10.4306\/pi.2017.14.6.851","article-title":"Korean Brain aging study for the early diagnosis and prediction of Alzheimer's Disease: methodology and baseline sample characteristics","volume":"14","author":"Byun","year":"2017","journal-title":"Psychiatry Investig"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100368_bib0017","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ana.23931","article-title":"Mild cognitive impairment due to Alzheimer disease in the community","volume":"74","author":"Petersen","year":"2013","journal-title":"Ann Neurol"},{"issue":"1","key":"10.1016\/j.tjpad.2025.100368_bib0018","doi-asserted-by":"crossref","first-page":"P47","DOI":"10.1093\/geronb\/57.1.P47","article-title":"Development of the Korean version of the consortium to establish a registry for Alzheimer's Disease assessment packet (CERAD-K): clinical and neuropsychological assessment batteries","volume":"57","author":"Lee","year":"2002","journal-title":"J Gerontol: B"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100368_bib0019","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1212\/01.WNL.0000130531.90205.EF","article-title":"Memory impairment, but not cerebrovascular disease, predicts progression of MCI to dementia","volume":"63","author":"DeCarli","year":"2004","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.tjpad.2025.100368_bib0020","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S1474-4422(14)70194-2","article-title":"Age-specific population frequencies of cerebral \u03b2-amyloidosis and neurodegeneration among people with normal cognitive function aged 50-89 years: a cross-sectional study","volume":"13","author":"Jack","year":"2014","journal-title":"Lancet Neurol"},{"issue":"3","key":"10.1016\/j.tjpad.2025.100368_bib0021","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jalz.2016.08.005","article-title":"Defining imaging biomarker cut points for brain aging and Alzheimer's disease","volume":"13","author":"Jack","year":"2017","journal-title":"Alzheimers Dement"},{"issue":"10","key":"10.1016\/j.tjpad.2025.100368_bib0022","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1093\/clinchem\/28.10.2121","article-title":"Turbidimetric immunoassay of serum C-reactive protein","volume":"28","author":"Otsuji","year":"1982","journal-title":"Clin Chem"},{"issue":"8","key":"10.1016\/j.tjpad.2025.100368_bib0023","first-page":"439","article-title":"High-sensitivity C-reactive protein: clinical importance","volume":"29","author":"Bassuk","year":"2004","journal-title":"Curr Probl Cardiol"},{"key":"10.1016\/j.tjpad.2025.100368_bib0024","series-title":"C reactive protein, in statpearls","author":"Nehring","year":"2024"},{"issue":"8750","key":"10.1016\/j.tjpad.2025.100368_bib0025","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/0140-6736(91)92823-K","article-title":"Apolipoprotein E genotyping by one-stage PCR","volume":"337","author":"Wenham","year":"1991","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.tjpad.2025.100368_bib0026","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1002\/alz.12568","article-title":"C-reactive protein levels and risk of dementia-observational and genetic studies of 111,242 individuals from the general population","volume":"18","author":"Hegazy","year":"2022","journal-title":"Alzheimers Dement"},{"issue":"4","key":"10.1016\/j.tjpad.2025.100368_bib0027","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1093\/ije\/dyt093","article-title":"Use of allele scores as instrumental variables for mendelian randomization","volume":"42","author":"Burgess","year":"2013","journal-title":"Int J Epidemiol"},{"issue":"9","key":"10.1016\/j.tjpad.2025.100368_bib0028","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.2337\/db14-1603","article-title":"HDL cholesterol and risk of type 2 diabetes: a mendelian randomization study","volume":"64","author":"Haase","year":"2015","journal-title":"Diabetes"},{"issue":"11","key":"10.1016\/j.tjpad.2025.100368_bib0029","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1161\/CIRCULATIONAHA.105.591271","article-title":"Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level","volume":"113","author":"Kathiresan","year":"2006","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.tjpad.2025.100368_bib0030","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12872-022-02610-z","article-title":"CRP levels are significantly associated with CRP genotype and estrogen use in the Lifestyle, Biomarker and Atherosclerosis (LBA) study","volume":"22","author":"Frans\u00e9n","year":"2022","journal-title":"BMC Cardiovasc Disord"},{"issue":"4","key":"10.1016\/j.tjpad.2025.100368_bib0031","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41409-019-0679-x","article-title":"Cubic splines to model relationships between continuous variables and outcomes: a guide for clinicians","volume":"55","author":"Gauthier","year":"2020","journal-title":"Bone Marrow Transpl"},{"issue":"19","key":"10.1016\/j.tjpad.2025.100368_bib0032","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1002\/sim.1545","article-title":"Estimating regression models with unknown break-points","volume":"22","author":"Muggeo","year":"2003","journal-title":"Stat Med"},{"issue":"1","key":"10.1016\/j.tjpad.2025.100368_bib0033","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1527-3466.2006.00033.x","article-title":"C-reactive protein (CRP)-lowering agents","volume":"24","author":"Prasad","year":"2006","journal-title":"Cardiovasc Drug Rev"},{"issue":"4","key":"10.1016\/j.tjpad.2025.100368_bib0034","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/cvr\/cvae034","article-title":"Effect of lipid-lowering therapies on C-reactive protein levels: a comprehensive meta-analysis of randomized controlled trials","volume":"120","author":"Xie","year":"2024","journal-title":"Cardiovasc, Res"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100368_bib0035","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00702-014-1263-6","article-title":"Cerebrospinal fluid and plasma C-reactive protein and aggression in personality-disordered subjects: a pilot study","volume":"122","author":"Coccaro","year":"2015","journal-title":"J Neural Transm (Vienna)"},{"issue":"6","key":"10.1016\/j.tjpad.2025.100368_bib0036","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/s41380-018-0096-3","article-title":"What does plasma CRP tell us about peripheral and central inflammation in depression?","volume":"25","author":"Felger","year":"2020","journal-title":"Mol Psychiatry"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100368_bib0037","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0969-2126(99)80023-9","article-title":"The physiological structure of human C-reactive protein and its complex with phosphocholine","volume":"7","author":"Thompson","year":"1999","journal-title":"Structure"},{"issue":"3","key":"10.1016\/j.tjpad.2025.100368_bib0038","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1128\/IAI.69.3.1747-1754.2001","article-title":"Expression of C-reactive protein in the human respiratory tract","volume":"69","author":"Gould","year":"2001","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.tjpad.2025.100368_bib0039","first-page":"120","article-title":"Radioimmunoassay of human C-reactive protein and levels in normal sera","volume":"87","author":"Claus","year":"1976","journal-title":"J Lab Clin Med"},{"issue":"3","key":"10.1016\/j.tjpad.2025.100368_bib0040","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1586\/1744666X.4.3.379","article-title":"C-reactive protein at the interface between innate immunity and inflammation","volume":"4","author":"Peisajovich","year":"2008","journal-title":"Expert Rev Clin Immunol"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100368_bib0041","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1046\/j.1365-2567.2002.01481.x","article-title":"C-reactive protein-mediated phagocytosis and phospholipase D signalling through the high-affinity receptor for immunoglobulin G (FcgammaRI)","volume":"107","author":"Bodman-Smith","year":"2002","journal-title":"Immunology"},{"issue":"9","key":"10.1016\/j.tjpad.2025.100368_bib0042","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1084\/jem.192.9.1353","article-title":"C-reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity","volume":"192","author":"Gershov","year":"2000","journal-title":"J Exp Med"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100368_bib0043","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/art.20846","article-title":"Reversal of ongoing proteinuria in autoimmune mice by treatment with C-reactive protein","volume":"52","author":"Rodriguez","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.tjpad.2025.100368_bib0044","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/hmg\/ddh021","article-title":"Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus","volume":"13","author":"Russell","year":"2004","journal-title":"Hum Mol Genet"},{"issue":"3\u20134","key":"10.1016\/j.tjpad.2025.100368_bib0045","first-page":"221","article-title":"C-reactive protein (CRP) and autoimmune disease: facts and conjectures","volume":"11","author":"Szalai","year":"2004","journal-title":"Clin Dev Immunol"},{"issue":"11","key":"10.1016\/j.tjpad.2025.100368_bib0046","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1161\/STROKEAHA.118.022317","article-title":"C-reactive protein, plasma amyloid-\u03b2 levels, and their interaction with magnetic resonance imaging markers","volume":"49","author":"Hilal","year":"2018","journal-title":"Stroke"},{"issue":"10","key":"10.1016\/j.tjpad.2025.100368_bib0047","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1002\/hbm.22073","article-title":"Correlation between high-sensitivity C-reactive protein and brain gray matter volume in healthy elderly subjects","volume":"34","author":"Taki","year":"2013","journal-title":"Hum Brain Mapp"},{"issue":"2\u20133","key":"10.1016\/j.tjpad.2025.100368_bib0048","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jchemneu.2005.07.003","article-title":"Systemic inflammation induces apoptosis with variable vulnerability of different brain regions","volume":"30","author":"Semmler","year":"2005","journal-title":"J Chem Neuroanat"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100368_bib0049","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1046\/j.1471-4159.2000.0750634.x","article-title":"The inhibitory effects of interleukin-6 on synaptic plasticity in the rat hippocampus are associated with an inhibition of mitogen-activated protein kinase ERK","volume":"75","author":"Tancredi","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.tjpad.2025.100368_bib0050","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.atherosclerosis.2017.08.008","article-title":"Genetic and environmental influences on stability and change in baseline levels of C-reactive protein: a longitudinal twin study","volume":"265","author":"Sas","year":"2017","journal-title":"Atherosclerosis"},{"issue":"8","key":"10.1016\/j.tjpad.2025.100368_bib0051","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1373\/49.8.1258","article-title":"Preanalytic and analytic sources of variations in C-reactive protein measurement: implications for cardiovascular disease risk assessment","volume":"49","author":"Ledue","year":"2003","journal-title":"Clin Chem"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100368_bib0052","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1373\/clinchem.2008.117754","article-title":"Impact of genetic and environmental factors on hsCRP concentrations and response to therapeutic agents","volume":"55","author":"Shen","year":"2009","journal-title":"Clin Chem"},{"issue":"3","key":"10.1016\/j.tjpad.2025.100368_bib0053","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0021-9150(00)00586-4","article-title":"Familial and genetic determinants of systemic markers of inflammation: the NHLBI family heart study","volume":"154","author":"Pankow","year":"2001","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.tjpad.2025.100368_bib0054","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/HJH.0b013e328011753e","article-title":"C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic\/beta-adrenergic pathway loci","volume":"25","author":"Wessel","year":"2007","journal-title":"J Hypertens"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580725003103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580725003103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:46:31Z","timestamp":1778867191000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580725003103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S2274580725003103"],"URL":"https:\/\/doi.org\/10.1016\/j.tjpad.2025.100368","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations of circulating c-reactive protein levels with central Alzheimer\u2019s disease biomarkers","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjpad.2025.100368","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Masson SAS on behalf of SERDI Publisher.","name":"copyright","label":"Copyright"}],"article-number":"100368"}}