{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:50:25Z","timestamp":1787237425427,"version":"build-2736575974"},"reference-count":79,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.tjpad.2025.100452","type":"journal-article","created":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T01:03:10Z","timestamp":1767229390000},"page":"100452","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multi-omics integration reveals shared genetic architecture between metabolic markers and gray matter atrophy in Alzheimer\u2019s Disease"],"prefix":"10.1016","volume":"13","author":[{"given":"Piaoran","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3660-3770","authenticated-orcid":false,"given":"Huaigui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjpad.2025.100452_bib0001","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.tjpad.2025.100452_bib0002","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3233\/JAD-150047","article-title":"Voxel level survival analysis of grey matter volume and incident mild cognitive impairment or Alzheimer's Disease","volume":"46","author":"Zeifman","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2025.100452_bib0003","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","article-title":"Alzheimer disease","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.tjpad.2025.100452_bib0004","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/247150","article-title":"Synapses and dendritic spines as pathogenic targets in Alzheimer's disease","volume":"2012","author":"Yu","year":"2012","journal-title":"Neural Plast"},{"key":"10.1016\/j.tjpad.2025.100452_bib0005","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.parkreldis.2021.09.025","article-title":"A multiparametric MRI study of structural brain damage in dementia with lewy bodies: a comparison with Alzheimer's disease","volume":"91","author":"Caso","year":"2021","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.tjpad.2025.100452_bib0006","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/WNN.0000000000000245","article-title":"different patterns of gray matter volume reduction in early-onset and late-onset Alzheimer Disease","volume":"33","author":"Chishiki","year":"2020","journal-title":"Cognit Behav Neurol"},{"key":"10.1016\/j.tjpad.2025.100452_bib0007","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nrn3475","article-title":"Power failure: why small sample size undermines the reliability of neuroscience","volume":"14","author":"Button","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.tjpad.2025.100452_bib0008","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuroimage.2018.10.077","article-title":"Voxel-based meta-analysis via permutation of subject images (PSI): theory and implementation for SDM","volume":"186","author":"Albajes-Eizagirre","year":"2019","journal-title":"Neuroimage"},{"key":"10.1016\/j.tjpad.2025.100452_bib0009","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40035-015-0027-z","article-title":"Voxel-based meta-analysis of grey matter changes in Alzheimer's disease","volume":"4","author":"Wang","year":"2015","journal-title":"Transl Neurodegener"},{"key":"10.1016\/j.tjpad.2025.100452_bib0010","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1038\/s41588-021-00921-z","article-title":"A genome-wide association study with 1126,563 individuals identifies new risk loci for Alzheimer's disease","volume":"53","author":"Wightman","year":"2021","journal-title":"Nat Genet"},{"key":"10.1016\/j.tjpad.2025.100452_bib0011","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1111\/febs.16344","article-title":"Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise","volume":"290","author":"Yin","year":"2023","journal-title":"FEBS J"},{"key":"10.1016\/j.tjpad.2025.100452_bib0012","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pneurobio.2013.06.004","article-title":"Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies","volume":"108","author":"Chen","year":"2013","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.tjpad.2025.100452_bib0013","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/MOL.0000000000000862","article-title":"Omega-3 fatty acids and cognitive function","volume":"34","author":"Welty","year":"2023","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.tjpad.2025.100452_bib0014","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/09637486.2018.1508426","article-title":"Association between serum cholesterol levels and Alzheimer's disease in China: a case-control study","volume":"70","author":"Chen","year":"2019","journal-title":"Int J Food Sci Nutr"},{"key":"10.1016\/j.tjpad.2025.100452_bib0015","article-title":"Diabetes mellitus and the risk of Alzheimer's disease: a nationwide population-based study","volume":"9","author":"Huang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.tjpad.2025.100452_bib0016","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/s41576-018-0016-z","article-title":"From genome-wide associations to candidate causal variants by statistical fine-mapping","volume":"19","author":"Schaid","year":"2018","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.tjpad.2025.100452_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110173","article-title":"Imaging transcriptomics: convergent cellular, transcriptomic, and molecular neuroimaging signatures in the healthy adult human brain","volume":"37","author":"Martins","year":"2021","journal-title":"Cell Rep"},{"key":"10.1016\/j.tjpad.2025.100452_bib0018","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/s42003-024-06665-w","article-title":"Transcriptomic decoding of regional cortical vulnerability to major depressive disorder","volume":"7","author":"Zhu","year":"2024","journal-title":"Communications biology"},{"key":"10.1016\/j.tjpad.2025.100452_bib0019","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/s41386-022-01474-3","article-title":"Transcriptional signatures of the cortical morphometric similarity network gradient in first-episode, treatment-naive major depressive disorder","volume":"48","author":"Xue","year":"2023","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.tjpad.2025.100452_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117526","article-title":"Genes associated with gray matter volume alterations in schizophrenia","volume":"225","author":"Ji","year":"2021","journal-title":"Neuroimage"},{"key":"10.1016\/j.tjpad.2025.100452_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.908650","article-title":"Alzheimer's Disease-related genes identified by linking spatial patterns of pathology and gene expression","volume":"16","author":"Mullins","year":"2022","journal-title":"Front Neurosci"},{"key":"10.1016\/j.tjpad.2025.100452_bib0022","doi-asserted-by":"crossref","first-page":"fcac216","DOI":"10.1093\/braincomms\/fcac216","article-title":"Alzheimer-prone brain regions, metabolism and risk-gene expression are strongly correlated","volume":"4","author":"Ye","year":"2022","journal-title":"Brain Commun"},{"key":"10.1016\/j.tjpad.2025.100452_bib0023","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1093\/cercor\/bhac211","article-title":"Genetic mechanisms underlying gray matter volume changes in patients with drug-naive first-episode schizophrenia","volume":"33","author":"Xu","year":"2023","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.tjpad.2025.100452_bib0024","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jad.2023.01.051","article-title":"Transcriptional substrates of brain structural and functional impairments in drug-naive first-episode patients with major depressive disorder","volume":"325","author":"Fang","year":"2023","journal-title":"J Affect Disord"},{"key":"10.1016\/j.tjpad.2025.100452_bib0025","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41586-021-04064-3","article-title":"The power of genetic diversity in genome-wide association studies of lipids","volume":"600","author":"Graham","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.tjpad.2025.100452_bib0026","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1038\/s41588-023-01462-3","article-title":"GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification","volume":"55","author":"Lagou","year":"2023","journal-title":"Nat Genet"},{"key":"10.1016\/j.tjpad.2025.100452_bib0027","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/s41588-021-00852-9","article-title":"The trans-ancestral genomic architecture of glycemic traits","volume":"53","author":"Chen","year":"2021","journal-title":"Nat Genet"},{"key":"10.1016\/j.tjpad.2025.100452_bib0028","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.tjpad.2025.100452_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2024.120551","article-title":"Homotopic functional connectivity disruptions in schizophrenia and their associated gene expression","volume":"289","author":"Cai","year":"2024","journal-title":"Neuroimage"},{"key":"10.1016\/j.tjpad.2025.100452_bib0030","first-page":"557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ (Clinical research ed)"},{"key":"10.1016\/j.tjpad.2025.100452_bib0031","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nature11405","article-title":"An anatomically comprehensive atlas of the adult human brain transcriptome","volume":"489","author":"Hawrylycz","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.tjpad.2025.100452_bib0032","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuroimage.2019.01.011","article-title":"A practical guide to linking brain-wide gene expression and neuroimaging data","volume":"189","author":"Arnatkeviciute","year":"2019","journal-title":"Neuroimage"},{"key":"10.1016\/j.tjpad.2025.100452_bib0033","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/978-1-62703-059-5_23","article-title":"Partial least squares methods: partial least squares correlation and partial least square regression","volume":"930","author":"Abdi","year":"2013","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.tjpad.2025.100452_bib0034","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jad.2024.11.021","article-title":"Brain connectivity and transcriptomic similarity inform abnormal morphometric similarity patterns in first-episode, treatment-na\u00efve major depressive disorder","volume":"370","author":"Xue","year":"2025","journal-title":"J Affect Disord"},{"key":"10.1016\/j.tjpad.2025.100452_bib0035","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/s41380-018-0023-7","article-title":"Synaptic and transcriptionally downregulated genes are associated with cortical thickness differences in autism","volume":"24","author":"Romero-Garcia","year":"2019","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.tjpad.2025.100452_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117038","article-title":"Generative modeling of brain maps with spatial autocorrelation","volume":"220","author":"Burt","year":"2020","journal-title":"Neuroimage"},{"key":"10.1016\/j.tjpad.2025.100452_bib0037","doi-asserted-by":"crossref","first-page":"7647","DOI":"10.1038\/s41467-024-52121-y","article-title":"Investigating the shared genetic architecture between depression and subcortical volumes","volume":"15","author":"Liu","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.tjpad.2025.100452_bib0038","article-title":"Genome-wide analysis identifies novel shared loci between depression and white matter microstructure","author":"Zhao","year":"2025","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.tjpad.2025.100452_bib0039","first-page":"0688","article-title":"Genome-wide pleiotropy analysis reveals shared genetic associations between type 2 diabetes mellitus and subcortical brain volumes","volume":"8","author":"Zhao","year":"2025","journal-title":"Research (Washington, DC)"},{"key":"10.1016\/j.tjpad.2025.100452_bib0040","doi-asserted-by":"crossref","unstructured":"Liu H., Xie Y., Ji Y., et al. Identification of genetic architecture shared between schizophrenia and Alzheimer's disease. Transl Psychiatry. 2025;15:150. doi:https:\/\/doi.org\/10.1038\/s41398-025-03348-w.","DOI":"10.1038\/s41398-025-03348-w"},{"key":"10.1016\/j.tjpad.2025.100452_bib0041","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","article-title":"Functional mapping and annotation of genetic associations with FUMA","volume":"8","author":"Watanabe","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.tjpad.2025.100452_bib0042","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1093\/brain\/awad038","article-title":"Identification of novel genomic risk loci shared between common epilepsies and psychiatric disorders","volume":"146","author":"Karadag","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.tjpad.2025.100452_bib0043","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1176\/appi.ajp.20220660","article-title":"Characterizing the shared genetic underpinnings of schizophrenia and cardiovascular disease risk factors","volume":"180","author":"R\u00f8devand","year":"2023","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.tjpad.2025.100452_bib0044","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ng.2892","article-title":"A general framework for estimating the relative pathogenicity of human genetic variants","volume":"46","author":"Kircher","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.tjpad.2025.100452_bib0045","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1101\/gr.137323.112","article-title":"Annotation of functional variation in personal genomes using RegulomeDB","volume":"22","author":"Boyle","year":"2012","journal-title":"Genome Res"},{"key":"10.1016\/j.tjpad.2025.100452_bib0046","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature14248","article-title":"Integrative analysis of 111 reference human epigenomes","volume":"518","author":"Roadmap Epigenomics","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.tjpad.2025.100452_bib0047","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ng.3538","article-title":"Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets","volume":"48","author":"Zhu","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.tjpad.2025.100452_bib0048","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.tjpad.2025.100452_bib0049","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1515\/jpm-2014-0268","article-title":"MR imaging of the fetal brain at 1.5T and 3.0T field strengths: comparing specific absorption rate (SAR) and image quality","volume":"43","author":"Krishnamurthy","year":"2015","journal-title":"J Perinat Med"},{"key":"10.1016\/j.tjpad.2025.100452_bib0050","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s40279-023-01927-9","article-title":"The perils of misinterpreting and misusing \"Publication Bias\" in meta-analyses: an education review on funnel plot-based methods","volume":"54","author":"Afonso","year":"2024","journal-title":"Sports Med"},{"key":"10.1016\/j.tjpad.2025.100452_bib0051","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/cne.25521","article-title":"On the evolution of polysensory superior temporal sulcus and middle temporal gyrus: a key component of the semantic system in the human brain","volume":"531","author":"Petrides","year":"2023","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.tjpad.2025.100452_bib0052","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev-psych-022321-035256","article-title":"Speech computations of the human superior temporal gyrus","volume":"73","author":"Bhaya-Grossman","year":"2022","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.tjpad.2025.100452_bib0053","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1080\/13803395.2018.1446513","article-title":"Connected speech and language in mild cognitive impairment and Alzheimer's disease: a review of picture description tasks","volume":"40","author":"Mueller","year":"2018","journal-title":"J Clin Exp Neuropsychol"},{"key":"10.1016\/j.tjpad.2025.100452_bib0054","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.tics.2017.05.008","article-title":"A Closer Look at the Hippocampus and Memory","volume":"21","author":"Voss","year":"2017","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.tjpad.2025.100452_bib0055","doi-asserted-by":"crossref","first-page":"8142","DOI":"10.1523\/JNEUROSCI.1319-17.2017","article-title":"A Role for the Left Angular Gyrus in Episodic Simulation and Memory","volume":"37","author":"Thakral","year":"2017","journal-title":"J Neurosci"},{"key":"10.1016\/j.tjpad.2025.100452_bib0056","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1093\/brain\/awad181","article-title":"The functional role of the precuneus","volume":"146","author":"Dadario","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.tjpad.2025.100452_bib0057","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0254623","article-title":"Volume of the right supramarginal gyrus is associated with a maintenance of emotion recognition ability","volume":"16","author":"Wada","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.tjpad.2025.100452_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2022.103168","article-title":"Changes in brain connectivity linked to multisensory processing of pain modulation in migraine with acupuncture treatment","volume":"36","author":"Liu","year":"2022","journal-title":"NeuroImage Clinical"},{"key":"10.1016\/j.tjpad.2025.100452_bib0059","article-title":"The thalamus: structure, function, and neurotherapeutics","volume":"22","author":"Marcuse","year":"2025","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.tjpad.2025.100452_bib0060","doi-asserted-by":"crossref","first-page":"4594","DOI":"10.1016\/j.cub.2020.08.104","article-title":"Transient disruption of the inferior parietal lobule impairs the ability to attribute intention to action","volume":"30","author":"Patri","year":"2020","journal-title":"Curr Biol"},{"key":"10.1016\/j.tjpad.2025.100452_bib0061","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pscychresns.2014.10.017","article-title":"Medial frontal gyrus alterations in schizophrenia: relationship with duration of illness and executive dysfunction","volume":"231","author":"Frascarelli","year":"2015","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.tjpad.2025.100452_bib0062","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147488","article-title":"Effect of copper and zinc on the single molecule self-affinity of Alzheimer's amyloid-beta peptides","volume":"11","author":"Hane","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.tjpad.2025.100452_bib0063","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3233\/JAD-180802","article-title":"Understanding the amyloid hypothesis in Alzheimer's disease","volume":"68","author":"Paroni","year":"2019","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2025.100452_bib0064","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.220188","article-title":"Neuronal signalling of zinc: from detection and modulation to function","volume":"12","author":"Zhang","year":"2022","journal-title":"Open Biol"},{"key":"10.1016\/j.tjpad.2025.100452_bib0065","doi-asserted-by":"crossref","first-page":"e838","DOI":"10.1038\/tp.2016.83","article-title":"Obesity and age-related alterations in the gene expression of zinc-transporter proteins in the human brain","volume":"6","author":"Olesen","year":"2016","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.tjpad.2025.100452_bib0066","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.86944","article-title":"Loss of Ptpmt1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice","volume":"12","author":"Zheng","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.tjpad.2025.100452_bib0067","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.3233\/JAD-170585","article-title":"Mitochondria and mitochondrial cascades in Alzheimer's Disease","volume":"62","author":"Swerdlow","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2025.100452_bib0068","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1007\/s12035-020-01926-1","article-title":"The role of Mitochondria in Neurodegenerative Diseases: the Lesson from Alzheimer's Disease and Parkinson's Disease","volume":"57","author":"Monzio Compagnoni","year":"2020","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.tjpad.2025.100452_bib0069","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tins.2017.01.002","article-title":"Mitophagy and Alzheimer's disease: cellular and molecular mechanisms","volume":"40","author":"Kerr","year":"2017","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.tjpad.2025.100452_bib0070","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006338","article-title":"Neurotoxicity of amyloid beta-protein: synaptic and network dysfunction","volume":"2","author":"Mucke","year":"2012","journal-title":"Cold Spring Harb Perspect Med."},{"key":"10.1016\/j.tjpad.2025.100452_bib0071","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1007\/s00018-014-1706-0","article-title":"Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer's disease","volume":"71","author":"Kam","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.tjpad.2025.100452_bib0072","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3233\/JAD-210405","article-title":"Blood triglyceride and high-density lipoprotein levels are associated with plasma Amyloid-\u03b2 transport: a population-based cross-sectional study","volume":"84","author":"Wei","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2025.100452_bib0073","article-title":"Triglyceride-glucose index, Alzheimer's disease plasma biomarkers, and dementia in older adults: the MIND-China study","volume":"15","author":"Tian","year":"2023","journal-title":"Alzheimers Dement (Amst)"},{"key":"10.1016\/j.tjpad.2025.100452_bib0074","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0092-8674(90)90442-H","article-title":"Recent insights in phosphatidylinositol signaling","volume":"63","author":"Majerus","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.tjpad.2025.100452_bib0075","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1007\/s13311-022-01293-w","article-title":"Nuclear pore dysfunction in neurodegeneration","volume":"19","author":"Spead","year":"2022","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.tjpad.2025.100452_bib0076","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ceb.2016.12.006","article-title":"Nuclear pore complexes and regulation of gene expression","volume":"46","author":"Raices","year":"2017","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.tjpad.2025.100452_bib0077","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1080\/19491034.2017.1395542","article-title":"Nuclear pore complexes as hubs for gene regulation","volume":"9","author":"MA","year":"2018","journal-title":"Nucleus"},{"key":"10.1016\/j.tjpad.2025.100452_bib0078","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.neuron.2018.07.039","article-title":"Tau protein disrupts nucleocytoplasmic transport in Alzheimer's disease","volume":"99","author":"Eftekharzadeh","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.tjpad.2025.100452_bib0079","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13195-025-01683-0","article-title":"Multi-omics analyses identify gut microbiota-fecal metabolites-brain-cognition pathways in the Alzheimer's disease continuum","volume":"17","author":"Zhao","year":"2025","journal-title":"Alzheimers Res Ther"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580725003930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580725003930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T20:25:47Z","timestamp":1776198347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580725003930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":79,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2274580725003930"],"URL":"https:\/\/doi.org\/10.1016\/j.tjpad.2025.100452","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-omics integration reveals shared genetic architecture between metabolic markers and gray matter atrophy in Alzheimer\u2019s Disease","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjpad.2025.100452","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Masson SAS on behalf of SERDI Publisher.","name":"copyright","label":"Copyright"}],"article-number":"100452"}}