{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:46:12Z","timestamp":1790178372200,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010969","name":"Alzheimer Netherlands","doi-asserted-by":"publisher","award":["WE.03-2024-24"],"award-info":[{"award-number":["WE.03-2024-24"]}],"id":[{"id":"10.13039\/501100010969","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer&apos;s Association","doi-asserted-by":"publisher","award":["AARG-22-972229"],"award-info":[{"award-number":["AARG-22-972229"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016036","name":"Health~Holland","doi-asserted-by":"publisher","award":["LSHM20106"],"award-info":[{"award-number":["LSHM20106"]}],"id":[{"id":"10.13039\/100016036","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["101032288"],"award-info":[{"award-number":["101032288"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development","doi-asserted-by":"publisher","award":["73305095007"],"award-info":[{"award-number":["73305095007"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development","doi-asserted-by":"publisher","award":["733050817"],"award-info":[{"award-number":["733050817"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development","doi-asserted-by":"publisher","award":["10510032120003"],"award-info":[{"award-number":["10510032120003"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022812","name":"Stichting Het Heinsius-Houbolt Fonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.tjpad.2026.100481","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:05:01Z","timestamp":1768871101000},"page":"100481","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["No longitudinal association between hearing loss and Alzheimer\u2019s disease pathology"],"prefix":"10.1016","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8710-6427","authenticated-orcid":false,"given":"Jordi H.C.","family":"Boons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3082-9285","authenticated-orcid":false,"given":"Phuong Thuy","family":"Nguyen Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9694-3945","authenticated-orcid":false,"given":"Anna","family":"van Houwelingen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Arfan","family":"Ikram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gertjan","family":"Dingemanse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4658-2176","authenticated-orcid":false,"given":"Meike W.","family":"Vernooij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Goedegebure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5739-466X","authenticated-orcid":false,"given":"Julia","family":"Neitzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjpad.2026.100481_bib0001","doi-asserted-by":"crossref","unstructured":"World Health Organization. Global status report on the public health response to dementia. 2021.","DOI":"10.1016\/S2468-2667(21)00215-2"},{"key":"10.1016\/j.tjpad.2026.100481_bib0002","unstructured":"Gauthier S WCSSMJR-NP. World Alzheimer report 2022: Life after diagnosis: navigating treatment, care and support. London, England; 2022."},{"key":"10.1016\/j.tjpad.2026.100481_bib0003","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the Lancet standing commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.tjpad.2026.100481_bib0004","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.769405","article-title":"Hearing loss and cognition: what we know and where we need to go","volume":"13","author":"Powell","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.tjpad.2026.100481_bib0005","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1097\/MAO.0000000000004308","article-title":"Conductive hearing loss associates with dementia, and middle ear reconstruction mitigates this association: a multinational database study","volume":"45","author":"Urdang","year":"2024","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.tjpad.2026.100481_bib0006","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1002\/alz.13539","article-title":"Modeling the temporal evolution of plasma p-tau in relation to amyloid beta and tau PET","volume":"20","author":"Cogswell","year":"2024","journal-title":"Alzheimer 19s Dement"},{"key":"10.1016\/j.tjpad.2026.100481_bib0007","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201911170","article-title":"Cerebrospinal fluid and plasma biomarker trajectories with increasing amyloid deposition in Alzheimer\u2019s disease","volume":"11","author":"Palmqvist","year":"2019","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.tjpad.2026.100481_bib0008","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1002\/alz.13157","article-title":"Longitudinal changes in Alzheimer\u2019s-related plasma biomarkers and brain amyloid","volume":"19","author":"Bilgel","year":"2023","journal-title":"Alzheimer 19s Dement"},{"key":"10.1016\/j.tjpad.2026.100481_bib0009","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/jamaneurol.2023.5319","article-title":"Diagnostic accuracy of a plasma phosphorylated tau 217 immunoassay for Alzheimer disease pathology","volume":"81","author":"Ashton","year":"2024","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.tjpad.2026.100481_bib0010","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer\u2019s disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.tjpad.2026.100481_bib0011","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer\u2019s disease: alzheimer\u2019s association workgroup","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimer 19s Dement"},{"key":"10.1016\/j.tjpad.2026.100481_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102647","article-title":"Association between adult-onset hearing loss and dementia biomarkers: a systematic review","volume":"104","author":"Lasica","year":"2025","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.tjpad.2026.100481_bib0013","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1001\/jamaoto.2023.0824","article-title":"Association of hearing loss with anatomical and functional connectivity in patients with mild cognitive impairment","volume":"149","author":"An","year":"2023","journal-title":"JAMA Otolaryngol 13Head Neck Surg"},{"key":"10.1016\/j.tjpad.2026.100481_bib0014","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1136\/jnnp-2022-329726","article-title":"Distinct disease mechanisms may underlie cognitive decline related to hearing loss in different age groups","volume":"94","author":"van \u2019t Hooft","year":"2023","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.tjpad.2026.100481_bib0015","article-title":"Sensory impairment and beta-amyloid deposition in the Baltimore longitudinal study of aging","volume":"15","author":"Yesantharao","year":"2023","journal-title":"Alzheimer 19s Dement: Diagn Assess Dis Monit"},{"key":"10.1016\/j.tjpad.2026.100481_bib0016","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-14466-6","article-title":"Worsening hearing was associated with higher \u03b2-amyloid and tau burden in age-related hearing loss","volume":"12","author":"Zheng","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.tjpad.2026.100481_bib0017","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1093\/gerona\/glad159","article-title":"Hearing, \u03b2-Amyloid deposition and cognitive test performance in black and white older adults: the ARIC-PET study","volume":"78","author":"Deal","year":"2023","journal-title":"J Gerontol: A"},{"key":"10.1016\/j.tjpad.2026.100481_bib0018","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3233\/JAD-215121","article-title":"No influence of age-related hearing loss on brain amyloid-\u03b2","volume":"85","author":"Sarant","year":"2022","journal-title":"J Alzheimer 19s Dis"},{"key":"10.1016\/j.tjpad.2026.100481_bib0019","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/jnnp-2019-321897","article-title":"Pure tone audiometry and cerebral pathology in healthy older adults","volume":"91","author":"Parker","year":"2020","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.tjpad.2026.100481_bib0020","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.18632\/aging.101971","article-title":"Age-related hearing loss accelerates cerebrospinal fluid tau levels and brain atrophy: a longitudinal study","volume":"11","author":"Xu","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.tjpad.2026.100481_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104336","article-title":"Hearing impairment is associated with cognitive decline, brain atrophy and tau pathology","volume":"86","author":"Wang","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.tjpad.2026.100481_bib0022","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/s10072-023-07143-7","article-title":"Age-related hearing loss is not linked to cerebrospinal fluid levels of \u03b2-amyloid or p-tau181","volume":"45","author":"Mart\u00ednez-Dubarbie","year":"2024","journal-title":"Neurol Sci"},{"key":"10.1016\/j.tjpad.2026.100481_bib0023","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/lary.28859","article-title":"The association between early age-related hearing loss and brain \u03b2-Amyloid","volume":"131","author":"Golub","year":"2021","journal-title":"Laryngoscope"},{"key":"10.1016\/j.tjpad.2026.100481_bib0024","doi-asserted-by":"crossref","first-page":"e382","DOI":"10.1097\/MAO.0000000000003454","article-title":"The laterality of early age-related hearing loss and brain \u03b2-amyloid","volume":"43","author":"Irace","year":"2022","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.tjpad.2026.100481_bib0025","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/s43587-024-00592-5","article-title":"GDF1 ameliorates cognitive impairment induced by hearing loss","volume":"4","author":"Pan","year":"2024","journal-title":"Nat Aging"},{"key":"10.1016\/j.tjpad.2026.100481_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114413","article-title":"Hearing loss and impaired short-term memory in an Alzheimer\u2019s disease mouse model of amyloid-beta pathology","volume":"365","author":"Jafari","year":"2023","journal-title":"Exp Neurol"},{"key":"10.1016\/j.tjpad.2026.100481_bib0027","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/gbb.12370","article-title":"Reduced acoustic startle response and peripheral hearing loss in the 5xFAD mouse model of Alzheimer\u2019s disease","volume":"16","author":"O\u2019Leary","year":"2017","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.tjpad.2026.100481_bib0028","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2025.39209","article-title":"Hearing loss, brain structure, cognition, and dementia risk in the framingham heart study","volume":"8","author":"Kolo","year":"2025","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.tjpad.2026.100481_bib0029","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s10654-015-0105-7","article-title":"The rotterdam scan study: design update 2016 and main findings","volume":"30","author":"Ikram","year":"2015","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.tjpad.2026.100481_bib0030","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10654-023-01094-1","article-title":"The rotterdam study. design update and major findings between 2020 and 2024","volume":"39","author":"Ikram","year":"2024","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.tjpad.2026.100481_bib0031","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s10654-007-9199-x","article-title":"The rotterdam study: objectives and design update","volume":"22","author":"Hofman","year":"2007","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.tjpad.2026.100481_bib0032","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s10654-017-0321-4","article-title":"The Rotterdam Study: 2018 update on objectives, design and main results","volume":"32","author":"Ikram","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.tjpad.2026.100481_bib0033","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/brain\/awac354","article-title":"Diabetes and hypertension are related to amyloid-beta burden in the population-based Rotterdam Study","volume":"146","author":"van Arendonk","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.tjpad.2026.100481_bib0034","unstructured":"International Organization for Standardization (ISO). ISO 8253-1:2010. acoustics\u2014audiometric test methods\u2014part 1: pure-tone air and bone conduction audiometry. Geneva, Switzerland; 2010."},{"key":"10.1016\/j.tjpad.2026.100481_bib0035","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1017\/S002221510005564X","article-title":"Modern masking techniques and their application to the diagnosis of functional deafness","volume":"73","author":"Hood","year":"1959","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.tjpad.2026.100481_bib0036","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2471\/BLT.19.230367","article-title":"Hearing loss grades and the International classification of functioning, disability and health","volume":"97","author":"Olusanya","year":"2019","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.tjpad.2026.100481_bib0037","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.tjpad.2026.100481_bib0038","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.nicl.2017.04.025","article-title":"Optimized classification of 18F-Florbetaben PET scans as positive and negative using an SUVR quantitative approach and comparison to visual assessment","volume":"15","author":"Bullich","year":"2017","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.tjpad.2026.100481_bib0039","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1474-4422(08)70001-2","article-title":"Imaging of amyloid \u03b2 in Alzheimer\u2019s disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism","volume":"7","author":"Rowe","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.tjpad.2026.100481_bib0040","unstructured":"Purves D AGFD et al., editors. The auditory cortex. neuroscience. 2nd edition. Sunderland (MA): Sinauer Associates; 2001."},{"key":"10.1016\/j.tjpad.2026.100481_bib0041","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s00259-016-3601-4","article-title":"Quantitation of PET signal as an adjunct to visual interpretation of florbetapir imaging","volume":"44","author":"Pontecorvo","year":"2017","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.tjpad.2026.100481_bib0042","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13195-021-00836-1","article-title":"Validation of amyloid PET positivity thresholds in centiloids: a multisite PET study approach","volume":"13","author":"Royse","year":"2021","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.tjpad.2026.100481_bib0043","unstructured":"UNESCO Institute for Statistics. International Standard Classification of Education (ISCED) 2011. Montreal; 2012."},{"key":"10.1016\/j.tjpad.2026.100481_bib0044","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jad.2022.09.145","article-title":"The role of cognitive and brain reserve in late-life depressive events: the Rotterdam Study","volume":"320","author":"Zijlmans","year":"2023","journal-title":"J Affect Disord"},{"key":"10.1016\/j.tjpad.2026.100481_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2021.09.024","article-title":"Cross-modal connectivity effects in age-related hearing loss","volume":"111","author":"Ponticorvo","year":"2022","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.tjpad.2026.100481_bib0046","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/ggi.15052","article-title":"Neural correlates of age-related hearing loss: an MRI and FDG-PET study","volume":"25","author":"Sakurai","year":"2025","journal-title":"Geriatr Gerontol Int"},{"key":"10.1016\/j.tjpad.2026.100481_bib0047","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.neuroimage.2014.11.023","article-title":"Decreased auditory GABA+ concentrations in presbycusis demonstrated by edited magnetic resonance spectroscopy","volume":"106","author":"Gao","year":"2015","journal-title":"Neuroimage"},{"key":"10.1016\/j.tjpad.2026.100481_bib0048","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002156","article-title":"Human apoE isoforms differentially regulate brain amyloid-\u03b2 Peptide clearance","volume":"3","author":"Castellano","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.tjpad.2026.100481_bib0049","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.43.8.1467","article-title":"Association of apolipoprotein E allele \u03f54 with late-onset familial and sporadic Alzheimer\u2019s disease","volume":"43","author":"Saunders","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2026.100481_bib0050","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neurobiolaging.2024.01.006","article-title":"APOE-\u03b54 is not associated with pure-tone hearing thresholds, visual acuity or cognition, cross-sectionally or over 3 years of follow up in the canadian longitudinal study on aging","volume":"138","author":"Mick","year":"2024","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.tjpad.2026.100481_bib0051","article-title":"Clinical features and potential mechanisms relating neuropathological biomarkers and blood-brain barrier in patients with Alzheimer\u2019s disease and hearing loss","volume":"14","author":"Zhang","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.tjpad.2026.100481_bib0052","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neurobiolaging.2025.07.003","article-title":"Evaluating the link between hearing loss and Alzheimer\u2019s disease neuropathology: a systematic review and meta-analysis","volume":"154","author":"Chandra","year":"2025","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.tjpad.2026.100481_bib0053","doi-asserted-by":"crossref","DOI":"10.3390\/cells11091418","article-title":"Induction of accelerated aging in a mouse model","volume":"11","author":"Cai","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.tjpad.2026.100481_bib0054","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00401-016-1662-x","article-title":"Alzheimer\u2019s disease: experimental models and reality","volume":"133","author":"Drummond","year":"2017","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.tjpad.2026.100481_bib0055","first-page":"353","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Sci (1979)"},{"key":"10.1016\/j.tjpad.2026.100481_bib0056","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.neuron.2020.08.003","article-title":"How can hearing loss cause dementia?","volume":"108","author":"Griffiths","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.tjpad.2026.100481_bib0057","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1037\/a0014802","article-title":"Aging, hearing acuity, and the attentional costs of effortful listening","volume":"24","author":"Tun","year":"2009","journal-title":"Psychol Aging"},{"key":"10.1016\/j.tjpad.2026.100481_bib0058","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.0963-7214.2005.00356.x","article-title":"Hearing loss in older adulthood","volume":"14","author":"Wingfield","year":"2005","journal-title":"Curr Dir Psychol Sci"},{"key":"10.1016\/j.tjpad.2026.100481_bib0059","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1111\/jgs.15506","article-title":"American geriatrics society and national institute on aging bench-to-bedside conference: sensory impairment and cognitive decline in older adults","volume":"66","author":"Whitson","year":"2018","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.tjpad.2026.100481_bib0060","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neurobiolaging.2024.10.003","article-title":"Hearing loss and its relation to longitudinal changes in white matter microstructure in older adults: the Rotterdam study","volume":"145","author":"Boons","year":"2025","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.tjpad.2026.100481_bib0061","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1136\/jnnp-2023-333101","article-title":"Peripheral hearing loss at age 70 predicts brain atrophy and associated cognitive change","volume":"95","author":"Parker","year":"2024","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.tjpad.2026.100481_bib0062","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7874\/jao.2023.00626","article-title":"Trends in distributions of hearing threshold levels by ages: a comparison of the ISO 7029 and newly available country-specific data","volume":"28","author":"Jin","year":"2024","journal-title":"J Audiol Otol"},{"key":"10.1016\/j.tjpad.2026.100481_bib0063","article-title":"Establishment of reference audiometric norms for the elderly population: a community-based study on mean and median hearing thresholds","volume":"11","author":"Yang","year":"2025","journal-title":"Heliyon"},{"key":"10.1016\/j.tjpad.2026.100481_bib0064","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/AUD.0000000000001420","article-title":"Hearing loss prevalence, years lived with disability, and hearing aid use in the united states from 1990 to 2019: findings from the global burden of disease study","volume":"45","author":"Haile","year":"2024","journal-title":"Ear Hear"},{"key":"10.1016\/j.tjpad.2026.100481_bib0065","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/lary.26150","article-title":"Prevalence of age-related hearing loss, including sex differences, in older adults in a large cohort study","volume":"127","author":"Homans","year":"2017","journal-title":"Laryngoscope"},{"key":"10.1016\/j.tjpad.2026.100481_bib0066","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/ageing\/afq168","article-title":"Central auditory function in early Alzheimer\u2019s disease and in mild cognitive impairment","volume":"40","author":"Idrizbegovic","year":"2011","journal-title":"Age Ageing"},{"key":"10.1016\/j.tjpad.2026.100481_bib0067","doi-asserted-by":"crossref","DOI":"10.1177\/2040622318811000","article-title":"Sensorial frailty: age-related hearing loss and the risk of cognitive impairment and dementia in later life","volume":"10","author":"Panza","year":"2019","journal-title":"Ther Adv Chronic Dis"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580726000051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580726000051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T02:55:55Z","timestamp":1773975355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580726000051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S2274580726000051"],"URL":"https:\/\/doi.org\/10.1016\/j.tjpad.2026.100481","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"No longitudinal association between hearing loss and Alzheimer\u2019s disease pathology","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjpad.2026.100481","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Masson SAS on behalf of SERDI Publisher.","name":"copyright","label":"Copyright"}],"article-number":"100481"}}