{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:23:35Z","timestamp":1773321815578,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["K24DC015544"],"award-info":[{"award-number":["K24DC015544"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["ICI23\/00032"],"award-info":[{"award-number":["ICI23\/00032"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["AC19\/00103"],"award-info":[{"award-number":["AC19\/00103"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI14\/01126"],"award-info":[{"award-number":["PI14\/01126"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI21\/00791"],"award-info":[{"award-number":["PI21\/00791"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["INT19\/00016"],"award-info":[{"award-number":["INT19\/00016"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI19\/00882"],"award-info":[{"award-number":["PI19\/00882"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI18\/00335"],"award-info":[{"award-number":["PI18\/00335"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["INT23\/00048"],"award-info":[{"award-number":["INT23\/00048"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI23\/01786"],"award-info":[{"award-number":["PI23\/01786"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["CP20\/00038"],"award-info":[{"award-number":["CP20\/00038"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI18\/00435"],"award-info":[{"award-number":["PI18\/00435"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI22\/00611"],"award-info":[{"award-number":["PI22\/00611"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["INT21\/00073"],"award-info":[{"award-number":["INT21\/00073"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["JR20\/0018"],"award-info":[{"award-number":["JR20\/0018"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI17\/01019"],"award-info":[{"award-number":["PI17\/01019"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI24\/01087"],"award-info":[{"award-number":["PI24\/01087"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI21\/01395"],"award-info":[{"award-number":["PI21\/01395"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["CD23\/00235"],"award-info":[{"award-number":["CD23\/00235"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI17\/01896"],"award-info":[{"award-number":["PI17\/01896"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI22\/00758"],"award-info":[{"award-number":["PI22\/00758"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI20\/01473"],"award-info":[{"award-number":["PI20\/01473"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI22\/00307"],"award-info":[{"award-number":["PI22\/00307"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["CM23\/00176"],"award-info":[{"award-number":["CM23\/00176"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010552","name":"Department of Health","doi-asserted-by":"publisher","award":["SLT006\/17\/125"],"award-info":[{"award-number":["SLT006\/17\/125"]}],"id":[{"id":"10.13039\/501100010552","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["CM23\/00176"],"award-info":[{"award-number":["CM23\/00176"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2021 SGR 00979"],"award-info":[{"award-number":["2021 SGR 00979"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RF1NS050915"],"award-info":[{"award-number":["RF1NS050915"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007353","name":"Fondation J\u00e9r\u00f4me Lejeune","doi-asserted-by":"publisher","award":["PDC-2023-51"],"award-info":[{"award-number":["PDC-2023-51"]}],"id":[{"id":"10.13039\/100007353","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007353","name":"Fondation J\u00e9r\u00f4me Lejeune","doi-asserted-by":"publisher","award":["202307"],"award-info":[{"award-number":["202307"]}],"id":[{"id":"10.13039\/100007353","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020199","name":"Fundaci\u00f3n Espa\u00f1ola para el Fomento de la Investigaci\u00f3n de la Esclerosis Lateral Amiotr\u00f3fica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019583","name":"Charles and Helen Schwab Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019583","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016608","name":"Rainwater Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015496","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003607","name":"Association for Frontotemporal Degeneration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["U19AG063911"],"award-info":[{"award-number":["U19AG063911"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG073482"],"award-info":[{"award-number":["R01AG073482"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG071756"],"award-info":[{"award-number":["R01AG071756"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R56AG075744"],"award-info":[{"award-number":["R56AG075744"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["P01AG019724"],"award-info":[{"award-number":["P01AG019724"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["U24AG057437"],"award-info":[{"award-number":["U24AG057437"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG078457"],"award-info":[{"award-number":["R01AG078457"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["RF1AG077557"],"award-info":[{"award-number":["RF1AG077557"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG038791"],"award-info":[{"award-number":["R01AG038791"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100021066","name":"Gates Ventures","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002565","name":"Alzheimer's Drug Discovery Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"'la Caixa' Foundation","doi-asserted-by":"publisher","award":["23S06157-001"],"award-info":[{"award-number":["23S06157-001"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P01AG019724"],"award-info":[{"award-number":["P01AG019724"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARG-22-923680"],"award-info":[{"award-number":["AARG-22-923680"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AACSF-21-850193"],"award-info":[{"award-number":["AACSF-21-850193"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARF-22-924456"],"award-info":[{"award-number":["AARF-22-924456"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015595","name":"GHR Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005595","name":"University of California","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.tjpad.2026.100486","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:47:16Z","timestamp":1769215636000},"page":"100486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential role of MRI to optimize clinical trial design for progressive supranuclear palsy and corticobasal degeneration"],"prefix":"10.1016","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1503-4775","authenticated-orcid":false,"given":"Jes\u00fas","family":"Garc\u00eda-Castro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8304-6711","authenticated-orcid":false,"given":"Lawren","family":"VandeVrede","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6026-2238","authenticated-orcid":false,"given":"Michael C.","family":"Donohue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6776-6559","authenticated-orcid":false,"given":"L\u00eddia","family":"Vaqu\u00e9-Alc\u00e1zar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7652-8029","authenticated-orcid":false,"given":"Sara","family":"Rubio-Guerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1021-4653","authenticated-orcid":false,"given":"Judit","family":"Selma-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary W.","family":"Heuer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2202-3521","authenticated-orcid":false,"given":"Alejandra O.","family":"Morcillo-Nieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Franquesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2656-8748","authenticated-orcid":false,"given":"Oriol","family":"Dols-Icardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9958-0951","authenticated-orcid":false,"given":"Alexandre","family":"Bejanin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6109-6371","authenticated-orcid":false,"given":"Olivia","family":"Belbin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Fortea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3819-3245","authenticated-orcid":false,"given":"Daniel","family":"Alcolea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Carmona-Iragui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7636-9758","authenticated-orcid":false,"given":"Carla","family":"Abdelnour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Barroeta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1567-617X","authenticated-orcid":false,"given":"Miguel","family":"Santos-Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1795-1833","authenticated-orcid":false,"given":"Mar\u00eda Belen","family":"S\u00e1nchez Saudin\u00f3s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9886-4792","authenticated-orcid":false,"given":"Isabel","family":"Sala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Lle\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Gorno-Tempini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2518-2520","authenticated-orcid":false,"given":"Maria Luisa","family":"Mandelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4096-6390","authenticated-orcid":false,"given":"Rema","family":"Raman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0901-4711","authenticated-orcid":false,"given":"Anne-Marie A","family":"Wills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eden","family":"Barragan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Litvan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad","family":"Boeve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brad","family":"Dickerson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murray","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward D.","family":"Huey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Irwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Pantelyat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5944-8497","authenticated-orcid":false,"given":"Carmela","family":"Tartaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1308-646X","authenticated-orcid":false,"given":"Julio C.","family":"Rojas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam L.","family":"Boxer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5418-2052","authenticated-orcid":false,"given":"Ignacio","family":"Ill\u00e1n-Gala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.tjpad.2026.100486_bib0001","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s13311-020-00888-5","article-title":"Four-repeat tauopathies: current management and future treatments","volume":"17","author":"VandeVrede","year":"2020","journal-title":"Neurotherapeutics"},{"issue":"10","key":"10.1016\/j.tjpad.2026.100486_bib0002","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41582-021-00541-5","article-title":"Evolving concepts in progressive supranuclear palsy and other 4-repeat tauopathies","volume":"17","author":"Stamelou","year":"2021","journal-title":"Nat Rev Neurol"},{"issue":"7880","key":"10.1016\/j.tjpad.2026.100486_bib0003","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41586-021-03911-7","article-title":"Structure-based classification of tauopathies","volume":"598","author":"Shi","year":"2021","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100486_bib0004","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1001\/archneur.1964.00460160003001","article-title":"Progressive supranuclear palsy: a heterogeneous degeneration involving the brain stem, basal ganglia and cerebellum with vertical gaze and pseudobulbar palsy","volume":"10","author":"Steele","year":"1964","journal-title":"Nuchal Dyst Dement Arch Neurol"},{"key":"10.1016\/j.tjpad.2026.100486_bib0005","first-page":"23","article-title":"Corticodentatonigral degeneration with neuronal achromasia: a progressive disorder of late adult life","volume":"92","author":"Rebeiz","year":"1967","journal-title":"Trans Am Neurol Assoc"},{"issue":"6","key":"10.1016\/j.tjpad.2026.100486_bib0006","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/mds.26987","article-title":"Clinical diagnosis of progressive supranuclear palsy: the movement disorder society criteria: MDS clinical diagnostic criteria for PSP","volume":"32","author":"H\u00f6glinger","year":"2017","journal-title":"Mov Disord"},{"issue":"5","key":"10.1016\/j.tjpad.2026.100486_bib0007","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1212\/WNL.0b013e31827f0fd1","article-title":"Criteria for the diagnosis of corticobasal degeneration","volume":"80","author":"Armstrong","year":"2013","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100486_bib0008","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000009734","article-title":"Clinical and pathologic features of cognitive-predominant corticobasal degeneration","volume":"95","author":"Sakae","year":"2020","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100486_bib0009","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1212\/01.wnl.0000191307.69661.c3","article-title":"Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP","volume":"66","author":"Josephs","year":"2006","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.tjpad.2026.100486_bib0010","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000207397","article-title":"Clinicoradiologic and neuropathologic evaluation of Corticobasal syndrome","volume":"101","author":"Shir","year":"2023","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.tjpad.2026.100486_bib0011","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/S1474-4422(17)30157-6","article-title":"Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches","volume":"16","author":"Boxer","year":"2017","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.tjpad.2026.100486_bib0012","doi-asserted-by":"crossref","DOI":"10.1002\/mds.30261","article-title":"Clinical diagnosis of progressive supranuclear palsy (PSP): a clinicopathological comparison of patients with confirmed PSP and clinical mimics","author":"Wrigley","year":"2025","journal-title":"Mov Disord"},{"issue":"6","key":"10.1016\/j.tjpad.2026.100486_bib0013","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/mds.28007","article-title":"Automated MRI classification in progressive supranuclear palsy: a large international cohort study","volume":"35","author":"Nigro","year":"2020","journal-title":"Mov Disord"},{"issue":"8","key":"10.1016\/j.tjpad.2026.100486_bib0014","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/mds.29866","article-title":"Magnetic resonance imaging measures to track atrophy progression in progressive supranuclear palsy in clinical trials","volume":"39","author":"Quattrone","year":"2024","journal-title":"Mov Disord"},{"issue":"5","key":"10.1016\/j.tjpad.2026.100486_bib0015","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1001\/jamaneurol.2025.0112","article-title":"Automated imaging differentiation for parkinsonism","volume":"82","author":"Vaillancourt","year":"2025","journal-title":"JAMA Neurol"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100486_bib0016","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.9588","article-title":"Diagnostic accuracy of magnetic resonance imaging measures of brain atrophy across the spectrum of progressive supranuclear palsy and corticobasal degeneration","volume":"5","author":"Ill\u00e1n-Gala","year":"2022","journal-title":"JAMA Netw Open"},{"issue":"19","key":"10.1016\/j.tjpad.2026.100486_bib0017","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1212\/WNL.0000000000003305","article-title":"Progression of brain atrophy in PSP and CBS over 6 months and 1 year","volume":"87","author":"Dutt","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2026.100486_bib0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.parkreldis.2020.01.019","article-title":"Magnetic resonance parkinsonism index for evaluating disease progression rate in progressive supranuclear palsy: a longitudinal 2-year study","volume":"72","author":"Quattrone","year":"2020","journal-title":"Park Relat Disord"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100486_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/WNL.47.1.1","article-title":"Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop","volume":"47","author":"Litvan","year":"1996","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.tjpad.2026.100486_bib0020","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of primary progressive aphasia and its variants","volume":"76","author":"Gorno-Tempini","year":"2011","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.tjpad.2026.100486_bib0021","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S1474-4422(14)70088-2","article-title":"Davunetide in patients with progressive supranuclear palsy: a randomised, double-blind, placebo-controlled phase 2\/3 trial","volume":"13","author":"Boxer","year":"2014","journal-title":"Lancet Neurol"},{"issue":"6","key":"10.1016\/j.tjpad.2026.100486_bib0022","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1093\/brain\/awm032","article-title":"A clinical rating scale for progressive supranuclear palsy","volume":"130","author":"Golbe","year":"2007","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.tjpad.2026.100486_bib0023","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/mds.28470","article-title":"A modified progressive supranuclear palsy rating scale","volume":"36","author":"Gr\u00f6tsch","year":"2021","journal-title":"Mov Disord"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100486_bib0024","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/alz.12033","article-title":"Utility of the global CDR\u00ae plus NACC FTLD rating and development of scoring rules: data from the ARTFL\/LEFFTDS Consortium","volume":"16","author":"Miyagawa","year":"2020","journal-title":"Alzheimer 19s Dement"},{"issue":"6","key":"10.1016\/j.tjpad.2026.100486_bib0025","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/mds.26973","article-title":"Longitudinal magnetic resonance imaging in progressive supranuclear palsy: a new combined score for clinical trials: PSP MRI atrophy Score","volume":"32","author":"H\u00f6glinger","year":"2017","journal-title":"Mov Disord"},{"issue":"5","key":"10.1016\/j.tjpad.2026.100486_bib0026","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1001\/jamaneurol.2023.0488","article-title":"Evaluation of plasma phosphorylated Tau217 for differentiation between alzheimer disease and frontotemporal lobar degeneration subtypes among patients with corticobasal syndrome","volume":"80","author":"VandeVrede","year":"2023","journal-title":"JAMA Neurol"},{"issue":"6","key":"10.1016\/j.tjpad.2026.100486_bib0027","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/mds.28011","article-title":"Copathology in progressive supranuclear palsy: does it matter?","volume":"35","author":"Jecmenica Lukic","year":"2020","journal-title":"Mov Disord"},{"issue":"3","key":"10.1016\/j.tjpad.2026.100486_bib0028","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/jnen\/nlz141","article-title":"Primary tau pathology, not copathology, correlates with clinical symptoms in PSP and CBD","volume":"79","author":"Robinson","year":"2020","journal-title":"J Neuropathol Exp Neurol"},{"issue":"2","key":"10.1016\/j.tjpad.2026.100486_bib0029","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer","volume":"62","author":"Fischl","year":"2012","journal-title":"NeuroImage"},{"key":"10.1016\/j.tjpad.2026.100486_bib0030","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neuroimage.2015.02.065","article-title":"Bayesian segmentation of brainstem structures in MRI","volume":"113","author":"Iglesias","year":"2015","journal-title":"NeuroImage"},{"issue":"3","key":"10.1016\/j.tjpad.2026.100486_bib0031","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"NeuroImage"},{"issue":"6","key":"10.1016\/j.tjpad.2026.100486_bib0032","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","article-title":"The sva package for removing batch effects and other unwanted variation in high-throughput experiments","volume":"28","author":"Leek","year":"2012","journal-title":"Bioinformatics"},{"issue":"11","key":"10.1016\/j.tjpad.2026.100486_bib0033","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v098.i11","article-title":"cutpointr : improved estimation and validation of optimal cutpoints in R","volume":"98","author":"Thiele","year":"2021","journal-title":"J Stat Soft"},{"issue":"13","key":"10.1016\/j.tjpad.2026.100486_bib0034","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v082.i13","article-title":"lmerTest package: tests in linear mixed effects models","volume":"82","author":"Kuznetsova","year":"2017","journal-title":"J Stat Soft"},{"issue":"26","key":"10.1016\/j.tjpad.2026.100486_bib0035","doi-asserted-by":"crossref","first-page":"772","DOI":"10.21105\/joss.00772","article-title":"ggeffects: tidy data frames of marginal effects from regression models","volume":"3","author":"L\u00fcdecke","year":"2018","journal-title":"JOSS"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100486_bib0036","doi-asserted-by":"crossref","first-page":"264","DOI":"10.32614\/RJ-2022-022","article-title":"Power and sample size for longitudinal models in R \u2013 the longpower package and shiny app","volume":"14","author":"Iddi","year":"2022","journal-title":"R J"},{"issue":"10","key":"10.1016\/j.tjpad.2026.100486_bib0037","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/mds.26694","article-title":"on behalf of the AL-108-231 investigators. minimal clinically important worsening on the progressive supranuclear palsy rating scale","volume":"31","author":"Hewer","year":"2016","journal-title":"Mov Disord"},{"issue":"8","key":"10.1016\/j.tjpad.2026.100486_bib0038","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1002\/mds.27619","article-title":"Sensitivity and specificity of diagnostic criteria for progressive supranuclear palsy","volume":"34","author":"Ali","year":"2019","journal-title":"Mov Disord"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100486_bib0039","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1093\/brain\/awad396","article-title":"Clinical dimensions along the non-fluent variant primary progressive aphasia spectrum","volume":"147","author":"Ill\u00e1n-Gala","year":"2024","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.tjpad.2026.100486_bib0040","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00401-020-02158-2","article-title":"Distribution patterns of tau pathology in progressive supranuclear palsy","volume":"140","author":"Kovacs","year":"2020","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.tjpad.2026.100486_bib0041","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroimage.2014.12.035","article-title":"Reliability and statistical power analysis of cortical and subcortical freesurfer metrics in a large sample of healthy elderly","volume":"108","author":"Liem","year":"2015","journal-title":"NeuroImage"},{"issue":"2","key":"10.1016\/j.tjpad.2026.100486_bib0042","article-title":"Test-retest reliability of freesurfer-derived volume, area and cortical thickness from MPRAGE and MP2RAGE brain MRI images","volume":"2","author":"Knussmann","year":"2022","journal-title":"Neuroimage: Rep"},{"key":"10.1016\/j.tjpad.2026.100486_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117012","article-title":"FastSurfer - a fast and accurate deep learning based neuroimaging pipeline","volume":"219","author":"Henschel","year":"2020","journal-title":"NeuroImage"},{"issue":"9","key":"10.1016\/j.tjpad.2026.100486_bib0044","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1002\/hbm.25398","article-title":"For the alzheimer\u2019s disease neuroimaging initiative. beware of white matter hyperintensities causing systematic errors in freesurfer gray matter segmentations!","volume":"42","author":"Dadar","year":"2021","journal-title":"Hum Brain Mapp"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100486_bib0045","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.trci.2016.12.001","article-title":"North American alzheimer\u2019s disease neuroimaging initiative, et al. cross-validation of optimized composites for preclinical alzheimer\u2019s disease","volume":"3","author":"Donohue","year":"2017","journal-title":"A&D Transl Res Clin Interv"},{"issue":"3","key":"10.1016\/j.tjpad.2026.100486_bib0046","article-title":"Cut-points and gray zones: the challenges of integrating alzheimer\u2019s disease plasma biomarkers into clinical practice","volume":"21","author":"Hazan","year":"2025","journal-title":"Alzheimer 19s Dement"},{"issue":"6","key":"10.1016\/j.tjpad.2026.100486_bib0047","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1038\/s41591-024-02937-4","article-title":"Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS","volume":"30","author":"Chatterjee","year":"2024","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100486_bib0048","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/mds.25815","article-title":"Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial","volume":"29","author":"H\u00f6glinger","year":"2014","journal-title":"Mov Disord"},{"issue":"7","key":"10.1016\/j.tjpad.2026.100486_bib0049","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000214040","article-title":"\u03b1-synuclein seed amplifications assay in a cohort with cognitive impairment: performance and interactions with CSF and plasma biomarkers","volume":"105","author":"Esteller-Gauxax","year":"2025","journal-title":"Neurology"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580726000105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580726000105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:38:16Z","timestamp":1773261496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580726000105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S2274580726000105"],"URL":"https:\/\/doi.org\/10.1016\/j.tjpad.2026.100486","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential role of MRI to optimize clinical trial design for progressive supranuclear palsy and corticobasal degeneration","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjpad.2026.100486","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS on behalf of SERDI Publisher.","name":"copyright","label":"Copyright"}],"article-number":"100486"}}