{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:13:35Z","timestamp":1793294015230,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.tjpad.2026.100547","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T12:21:00Z","timestamp":1775046060000},"page":"100547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Increase in healthcare utilization and Medicare payment with progression of preclinical Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"13","author":[{"given":"Julie","family":"Beyrer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1126-5712","authenticated-orcid":false,"given":"Zachary","family":"Sheff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9526-5356","authenticated-orcid":false,"given":"Nalin","family":"Payakachat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Chandler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Fei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Kubisiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0514-0196","authenticated-orcid":false,"given":"Angelina","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4390-5168","authenticated-orcid":false,"given":"Karen C.","family":"Holdridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Yaari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2896-5838","authenticated-orcid":false,"given":"Paul","family":"Aisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2640-2094","authenticated-orcid":false,"given":"Michael S.","family":"Rafii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reisa A.","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjpad.2026.100547_bib0001","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer\u2019s Association Workgroup","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimer\u2019s Dement"},{"key":"10.1016\/j.tjpad.2026.100547_bib0002","unstructured":"Food and Drug Administration. Early Alzheimer\u2019s Disease: Developing Drugs for Treatment [Draft Guidance Document]. 2024. March 12. https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/early-alzheimers-disease-developing-drugs-treatment."},{"key":"10.1016\/j.tjpad.2026.100547_bib0003","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13195-017-0283-5","article-title":"On the path to 2025: understanding the Alzheimer's disease continuum","volume":"9","author":"Aisen","year":"2017","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.tjpad.2026.100547_bib0004","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer\u2019s disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.tjpad.2026.100547_bib0005","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimer\u2019s Dement"},{"key":"10.1016\/j.tjpad.2026.100547_bib0006","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jalz.2019.09.085","article-title":"Neuropsychological decline up to 20 years before incident mild cognitive impairment","volume":"16","author":"Caselli","year":"2020","journal-title":"Alzheimer\u2019s Dement"},{"issue":"22","key":"10.1016\/j.tjpad.2026.100547_bib0007","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1016\/j.cell.2023.09.023","article-title":"Accelerating Alzheimer's therapeutic development: The past and future of clinical trials","volume":"186","author":"Boxer","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.tjpad.2026.100547_bib0008","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/alz.12694","article-title":"Global estimates on the number of persons across the Alzheimer's disease continuum","volume":"19","author":"Gustavsson","year":"2023","journal-title":"Alzheimer\u2019s Dement"},{"key":"10.1016\/j.tjpad.2026.100547_bib0009","unstructured":"Alzheimer's Disease International. World Alzheimer Report 2015: The Global Impact of Dementia, https:\/\/www.alzint.org\/u\/WorldAlzheimerReport2015.pdf; 2015 [accessed 22 April 2025]."},{"issue":"3","key":"10.1016\/j.tjpad.2026.100547_bib0010","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1001\/jamaneurol.2021.5216","article-title":"Prevalence estimates of amyloid abnormality across the Alzheimer disease clinical spectrum","volume":"79","author":"Jansen","year":"2022","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.tjpad.2026.100547_bib0011","doi-asserted-by":"crossref","first-page":"802","DOI":"10.14283\/jpad.2024.122","article-title":"Amyloid and tau prediction of cognitive and functional decline in unimpaired older individuals: longitudinal data from the A4 and LEARN studies","volume":"11","author":"Sperling","year":"2024","journal-title":"J Prev Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2026.100547_bib0012","unstructured":"United States Census Bureau. Age and sex composition in the United States: 2023. https:\/\/www.census.gov\/data\/tables\/2023\/demo\/age-and-sex\/2023-age-sex-composition.html, 2023 [accessed 22 April 2025]."},{"issue":"9","key":"10.1016\/j.tjpad.2026.100547_bib0013","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1001\/jamaneurol.2021.2161","article-title":"Global prevalence of young-onset dementia: a systematic review and meta-analysis","volume":"78","author":"Hendriks","year":"2021","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.tjpad.2026.100547_bib0014","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1212\/WNL.0000000000004826","article-title":"Practice guideline update summary: Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology","volume":"90","author":"Petersen","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2026.100547_bib0015","series-title":"Presented at the Alzheimer\u2019s Association International Conference","article-title":"Estimating preclinical Alzheimer\u2019s disease populations by P-tau217 in the United States, Japan, Germany, and China","author":"Sheff","year":"2025"},{"key":"10.1016\/j.tjpad.2026.100547_bib0016","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1002\/alz.13809","article-title":"2024 Alzheimer's disease facts and figures","volume":"20","year":"2024","journal-title":"Alzheimer\u2019s Dement"},{"issue":"9","key":"10.1016\/j.tjpad.2026.100547_bib0017","first-page":"1065","article-title":"Assessing out-of-pocket expenses and indirect costs for the Alzheimer disease continuum in the United States","volume":"29","author":"Monfared","year":"2023","journal-title":"J Manag Care Spec Pharm"},{"key":"10.1016\/j.tjpad.2026.100547_bib0018","doi-asserted-by":"crossref","first-page":"glaf030","DOI":"10.1093\/gerona\/glaf030","article-title":"Incremental healthcare costs of dementia and cognitive impairment in community-dwelling older adults: a prospective cohort study","author":"Sheets","year":"2025","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.tjpad.2026.100547_bib0019","doi-asserted-by":"crossref","first-page":"5852","DOI":"10.1002\/alz.13476","article-title":"Health care utilization and costs in the years preceding dementia identification","volume":"19","author":"Kumar","year":"2023","journal-title":"Alzheimer\u2019s Dement"},{"key":"10.1016\/j.tjpad.2026.100547_bib0020","article-title":"Disease progression and costs at the 3-year follow-up of the GERAS-US study","volume":"15","author":"Chandler","year":"2023","journal-title":"Alzheimer\u2019s Dement (Amst)"},{"key":"10.1016\/j.tjpad.2026.100547_bib0021","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3233\/JAD-231166","article-title":"Potential impact of slowing disease progression in early symptomatic Alzheimer's disease on patient quality of life, caregiver time, and total societal costs: estimates based on findings from GERAS-US study","volume":"100","author":"Chandler","year":"2024","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2026.100547_bib0022","doi-asserted-by":"crossref","first-page":"303","DOI":"10.14283\/jpad.2024.23","article-title":"Health economic considerations in the deployment of an Alzheimer\u2019s prevention therapy","volume":"11","author":"Mattke","year":"2024","journal-title":"J Prev Alzheimer\u2019s Dis"},{"key":"10.1016\/j.tjpad.2026.100547_bib0023","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1056\/NEJMoa2305032","article-title":"A4 Study Team. Trial of solanezumab in preclinical Alzheimer\u2019s disease","volume":"389","author":"Sperling","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tjpad.2026.100547_bib0024","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1001\/jamaneurol.2020.0387","article-title":"Association of factors with elevated amyloid burden in clinically normal older individuals","volume":"77","author":"Sperling","year":"2020","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.tjpad.2026.100547_bib0025","unstructured":"MD Clarity. RCM Glossary - Per member per month (PMPM). https:\/\/www.mdclarity.com\/glossary\/per-member-per-month-pmpm [accessed on November 3, 2025]."},{"key":"10.1016\/j.tjpad.2026.100547_bib0026","unstructured":"CMS, Centers for Medicare & Medicaid Services, 2021, Historical National Health Expenditure Data, https:\/\/www.cms.gov\/data-research\/statistics-trends-and-reports\/national-health-expenditure-data, 2021 [accessed on May 1, 2023]."},{"key":"10.1016\/j.tjpad.2026.100547_bib0027","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000353859","article-title":"Association between frailty and dementia: a population-based study","volume":"60","author":"Kulmala","year":"2014","journal-title":"Gerontology"},{"key":"10.1016\/j.tjpad.2026.100547_bib0028","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1186\/s12913-018-3689-2","article-title":"Validation of the JEN frailty index in the National Long-Term Care Survey community population: identifying functionally impaired older adults from claims data","volume":"18","author":"Kinosian","year":"2018","journal-title":"BMC Health Serv Res"},{"key":"10.1016\/j.tjpad.2026.100547_bib0029","article-title":"Applying managed fee-for-service delivery models to improve care for dually eligible beneficiaries","volume":"12","author":"Bratesman","year":"2002","journal-title":"Robert Wood Johnson Found Medic\/Medicaid Integration Program"},{"key":"10.1016\/j.tjpad.2026.100547_bib0030","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jval.2010.10.022","article-title":"The economic burden of Medicare-eligible patients by multiple sclerosis type","volume":"14","author":"Gilden","year":"2011","journal-title":"Value Health"},{"key":"10.1016\/j.tjpad.2026.100547_bib0031","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1111\/jgs.12974","article-title":"Effects of home-based primary care on Medicare costs in high-risk elders","volume":"62","author":"De Jonge","year":"2014","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.tjpad.2026.100547_bib0032","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3233\/JAD-220415","article-title":"Clinical and economic assessment in early-stage dementia by severity and amyloid-\u03b2 status: A 5-year retrospective claims study of GERAS-US Patients","volume":"91","author":"Chandler","year":"2023","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2026.100547_bib0033","doi-asserted-by":"crossref","first-page":"271","DOI":"10.5034\/inquiryjrnl_43.3.271","article-title":"Economic profiling of physician specialists: use of outlier treatment and episode attribution rules","volume":"43","author":"Thomas","year":"2006","journal-title":"Inquiry"},{"key":"10.1016\/j.tjpad.2026.100547_bib0034","first-page":"782","article-title":"Real-world health care costs and resource utilization associated with mild cognitive impairment in the United States: A retrospective cohort study of commercial and Medicare data","volume":"31","author":"Frech","year":"2025","journal-title":"J Manag Care Spec Pharm"},{"key":"10.1016\/j.tjpad.2026.100547_bib0035","doi-asserted-by":"crossref","first-page":"983","DOI":"10.14283\/jpad.2024.68","article-title":"Economic impact of progression from mild cognitive impairment to Alzheimer disease in the United States","volume":"11","author":"Frech","year":"2024","journal-title":"J Prev Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2026.100547_bib0036","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/WAD.0000000000000070","article-title":"Diagnostic pathways to Alzheimer Disease: Costs incurred in a Medicare population","volume":"29","author":"Gilden","year":"2015","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1016\/j.tjpad.2026.100547_bib0037","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1177\/13872877251322978","article-title":"Diagnostic journey and management of patients with mild cognitive impairment and Alzheimer's disease dementia: A multinational, real-world survey","volume":"104","author":"Vasileva-Metodiev","year":"2025","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2026.100547_bib0038","unstructured":"U.S. Census Bureau. Educational attainment in the United States: 2021. https:\/\/www.census.gov\/data\/tables\/2021\/demo\/educational-attainment\/cps-detailed-tables.html, 2021 [accessed on 23 August 2025]."},{"key":"10.1016\/j.tjpad.2026.100547_bib0039","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.jalz.2019.04.001","article-title":"Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype","volume":"15","author":"Vermunt","year":"2019","journal-title":"Alzheimer\u2019s Dement"},{"key":"10.1016\/j.tjpad.2026.100547_bib0040","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s12877-025-05898-6","article-title":"Association between comorbidity indices and nursing home admission in patients with Alzheimer's disease: a longitudinal observational study using the MEMORA cohort","volume":"25","author":"Temedda","year":"2025","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.tjpad.2026.100547_bib0041","doi-asserted-by":"crossref","first-page":"M173","DOI":"10.1093\/gerona\/57.3.M173","article-title":"Prevalence and impact of medical comorbidity in Alzheimer\u2019s disease","volume":"57","author":"Doraiswamy","year":"2002","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.tjpad.2026.100547_bib0042","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s11606-018-4377-y","article-title":"Underdiagnosis of dementia: an observational study of patterns in diagnosis and awareness in US older adults","volume":"33","author":"Amjad","year":"2018","journal-title":"J Gen Intern Med"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580726000713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580726000713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:42:20Z","timestamp":1780339340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580726000713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2274580726000713"],"URL":"https:\/\/doi.org\/10.1016\/j.tjpad.2026.100547","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increase in healthcare utilization and Medicare payment with progression of preclinical Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjpad.2026.100547","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Eli Lilly and Company. Published by Elsevier Masson SAS on behalf of SERDI Publisher.","name":"copyright","label":"Copyright"}],"article-number":"100547"}}