{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:08:46Z","timestamp":1788966526478,"version":"build-2803163510"},"reference-count":71,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ2097"],"award-info":[{"award-number":["2024JJ2097"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ20100"],"award-info":[{"award-number":["2025JJ20100"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071216"],"award-info":[{"award-number":["82071216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371434"],"award-info":[{"award-number":["82371434"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20300"],"award-info":[{"award-number":["U22A20300"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3603700"],"award-info":[{"award-number":["2023YFC3603700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019081","name":"Science and Technology Program of Hunan Province","doi-asserted-by":"publisher","award":["2021SK1020"],"award-info":[{"award-number":["2021SK1020"]}],"id":[{"id":"10.13039\/501100019081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011790","name":"Xiangya Hospital, Central South University","doi-asserted-by":"publisher","award":["2022LNJJ16"],"award-info":[{"award-number":["2022LNJJ16"]}],"id":[{"id":"10.13039\/501100011790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.tjpad.2026.100566","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:46:24Z","timestamp":1775893584000},"page":"100566","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multidimensional modeling of biological aging: integrating gait, eye movement, rest-state functional connectivity, and plasma biomarkers in non-dementia older adults"],"prefix":"10.1016","volume":"13","author":[{"given":"Jingyi","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meidan","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuewen","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beisha","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3393-8578","authenticated-orcid":false,"given":"Bin","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-7790","authenticated-orcid":false,"given":"Shilin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjpad.2026.100566_bib0001","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.maturitas.2020.05.018","article-title":"The World health organization (WHO) approach to healthy ageing","volume":"139","author":"Rudnicka","year":"2020","journal-title":"Maturitas"},{"key":"10.1016\/j.tjpad.2026.100566_bib0002","first-page":"814","article-title":"World Population Ageing 1950-2050. Brief article book review","volume":"28","author":"McNicoll","year":"2002","journal-title":"Popul Dev Rev"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100566_bib0003","doi-asserted-by":"crossref","first-page":"835","DOI":"10.5604\/12321966.1129943","article-title":"Biological psychological and social determinants of old age: bio-psycho-social aspects of human aging","volume":"21","author":"Dziechcia\u017c","year":"2014","journal-title":"Ann Agric Env Med"},{"issue":"2","key":"10.1016\/j.tjpad.2026.100566_bib0004","article-title":"A model for estimating biological age from physiological biomarkers of healthy aging: cross-sectional study","volume":"5","author":"Husted","year":"2022","journal-title":"JMIR Aging"},{"issue":"3","key":"10.1016\/j.tjpad.2026.100566_bib0005","doi-asserted-by":"crossref","DOI":"10.11613\/BM.2019.030501","article-title":"Hallmarks of senescence and aging","volume":"29","author":"Dodig","year":"2019","journal-title":"Biochem Med"},{"issue":"12","key":"10.1016\/j.tjpad.2026.100566_bib0006","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/s41576-022-00511-7","article-title":"Measuring biological age using omics data","volume":"23","author":"Rutledge","year":"2022","journal-title":"Nat Rev Genet"},{"issue":"3","key":"10.1016\/j.tjpad.2026.100566_bib0007","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s43587-021-00044-4","article-title":"Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy","volume":"1","author":"Elliott","year":"2021","journal-title":"Nat Aging"},{"issue":"10","key":"10.1016\/j.tjpad.2026.100566_bib0008","doi-asserted-by":"crossref","DOI":"10.2196\/19209","article-title":"A biological age model designed for health promotion interventions: protocol for an interdisciplinary study for model development","volume":"9","author":"Husted","year":"2020","journal-title":"JMIR Res Protoc"},{"issue":"8","key":"10.1016\/j.tjpad.2026.100566_bib0009","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1038\/s41380-019-0626-7","article-title":"Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort","volume":"26","author":"Elliott","year":"2021","journal-title":"Mol Psychiatry"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100566_bib0010","doi-asserted-by":"crossref","first-page":"56","DOI":"10.14283\/jpad.2019.50","article-title":"Revisiting the hallmarks of aging to identify markers of biological age","volume":"7","author":"Guerville","year":"2020","journal-title":"J Prev Alzheimers Dis"},{"issue":"3","key":"10.1016\/j.tjpad.2026.100566_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.108891","article-title":"A biological age model based on physical examination data to predict mortality in a Chinese population","volume":"27","author":"Jia","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.tjpad.2026.100566_bib0012","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ebiom.2017.03.046","article-title":"Biological age predictors","volume":"21","author":"Jylh\u00e4v\u00e4","year":"2017","journal-title":"EBioMedicine"},{"issue":"2","key":"10.1016\/j.tjpad.2026.100566_bib0013","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41591-023-02784-9","article-title":"Validation of biomarkers of aging","volume":"30","author":"Moqri","year":"2024","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.tjpad.2026.100566_bib0014","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/s43587-023-00557-0","article-title":"Causality-enriched epigenetic age uncouples damage and adaptation","volume":"4","author":"Ying","year":"2024","journal-title":"Nat Aging"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100566_bib0015","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.pmr.2017.06.005","article-title":"Normal changes in gait and mobility problems in the elderly","volume":"28","author":"Cruz-Jimenez","year":"2017","journal-title":"Phys Med Rehabil Clin N Am"},{"issue":"2","key":"10.1016\/j.tjpad.2026.100566_bib0016","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000342206","article-title":"Decline in gait performance detected by an electronic walkway system in 907 older adults of the population-based KORA-Age study","volume":"59","author":"Autenrieth","year":"2013","journal-title":"Gerontology"},{"issue":"9","key":"10.1016\/j.tjpad.2026.100566_bib0017","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1093\/gerona\/glz015","article-title":"Of aging mice and men: gait speed decline is a translatable trait, with species-specific underlying properties","volume":"74","author":"Bair","year":"2019","journal-title":"J Gerontol Biol Sci Med Sci"},{"issue":"5","key":"10.1016\/j.tjpad.2026.100566_bib0018","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/ggi.14150","article-title":"Age-related changes in gait speeds and asymmetry during circular gait and straight-line gait in older individuals aged 60-79\u2009years","volume":"21","author":"Hirono","year":"2021","journal-title":"Geriatr Gerontol Int"},{"issue":"6","key":"10.1016\/j.tjpad.2026.100566_bib0019","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1093\/gerona\/glab346","article-title":"Relative trajectories of gait and cognitive decline in aging","volume":"77","author":"Jayakody","year":"2022","journal-title":"J Gerontol Biol Sci Med Sci"},{"issue":"11","key":"10.1016\/j.tjpad.2026.100566_bib0020","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1093\/gerona\/glu052","article-title":"Neuroimaging of mobility in aging: a targeted review","volume":"69","author":"Holtzer","year":"2014","journal-title":"J Gerontol Biol Sci Med Sci"},{"issue":"2","key":"10.1016\/j.tjpad.2026.100566_bib0021","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/npr2.12163","article-title":"Effects of age and sex on eye movement characteristics","volume":"41","author":"Takahashi","year":"2021","journal-title":"Neuropsychopharmacol Rep"},{"issue":"3","key":"10.1016\/j.tjpad.2026.100566_bib0022","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1080\/13825585.2022.2039587","article-title":"The impact of aging and repetition on eye movements and recognition memory","volume":"30","author":"Mazloum-Farzaghi","year":"2023","journal-title":"Neuropsychol Dev Cogn B Aging Neuropsychol Cogn"},{"issue":"5","key":"10.1016\/j.tjpad.2026.100566_bib0023","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0459-19.2020","article-title":"Aging effects and test-retest reliability of inhibitory control for saccadic eye movements","volume":"7","author":"P\u0142omecka","year":"2020","journal-title":"eNeuro"},{"issue":"5","key":"10.1016\/j.tjpad.2026.100566_bib0024","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1080\/13825585.2016.1237613","article-title":"Saccadic eye movements: what do they tell us about aging cognition?","volume":"24","author":"Noiret","year":"2017","journal-title":"Neuropsychol Dev Cogn B Aging Neuropsychol Cogn"},{"issue":"10","key":"10.1016\/j.tjpad.2026.100566_bib0025","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1080\/13607863.2021.1972931","article-title":"Cognitive training modified age-related brain changes in older adults with subjective memory decline","volume":"26","author":"Yin","year":"2022","journal-title":"Aging Ment Health"},{"issue":"9","key":"10.1016\/j.tjpad.2026.100566_bib0026","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1162\/jocn_a_01616","article-title":"The aging brain and Executive functions revisited: implications from meta-analytic and functional-connectivity evidence","volume":"33","author":"Heckner","year":"2021","journal-title":"J Cogn Neurosci"},{"issue":"10","key":"10.1016\/j.tjpad.2026.100566_bib0027","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19102937","article-title":"Cellular senescence and neurodegenerative disease","volume":"19","author":"Kritsilis","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.tjpad.2026.100566_bib0028","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"10.1016\/j.tjpad.2026.100566_bib0029","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/brain\/awac128","article-title":"Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease","volume":"146","author":"Stevenson-Hoare","year":"2023","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100566_bib0030","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s13195-022-01093-6","article-title":"Diagnostic value of plasma p-tau181, NfL, and GFAP in a clinical setting cohort of prevalent neurodegenerative dementias","volume":"14","author":"Baiardi","year":"2022","journal-title":"Alzheimers Res Ther"},{"issue":"10","key":"10.1016\/j.tjpad.2026.100566_bib0031","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0895-4356(88)90034-0","article-title":"A chinese version of the mini-mental state examination; impact of illiteracy in a Shanghai dementia survey","volume":"41","author":"Katzman","year":"1988","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100566_bib0032","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/alz.12629","article-title":"Mild cognitive impairment among rural-dwelling older adults in China: a community-based study","volume":"19","author":"Cong","year":"2023","journal-title":"Alzheimers Dement"},{"issue":"2","key":"10.1016\/j.tjpad.2026.100566_bib0033","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1002\/alz.13517","article-title":"A detection model of cognitive impairment via the integrated gait and eye movement analysis from a large Chinese community cohort","volume":"20","author":"Lin","year":"2024","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.tjpad.2026.100566_bib0034","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1146\/annurev-physiol-022516-034255","article-title":"Neuromuscular junction formation, aging, and disorders","volume":"80","author":"Li","year":"2018","journal-title":"Annu Rev Physiol"},{"issue":"5","key":"10.1016\/j.tjpad.2026.100566_bib0035","article-title":"Aging and sarcopenia in the elderly","volume":"23","author":"Musculoskeletal","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100566_bib0036","doi-asserted-by":"crossref","first-page":"M192","DOI":"10.1093\/gerona\/52A.4.M192","article-title":"Correlates of performance-based measures of muscle function in the elderly: the Cardiovascular Health Study","volume":"52","author":"Hirsch","year":"1997","journal-title":"J Gerontol Biol Sci Med Sci"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100566_bib0037","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1212\/WNL.0000000000004153","article-title":"Slowing gait and risk for cognitive impairment: the hippocampus as a shared neural substrate","volume":"89","author":"Rosso","year":"2017","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.tjpad.2026.100566_bib0038","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1093\/gerona\/glp075","article-title":"A novel aging phenotype of slow gait, impaired executive function, and depressive symptoms: relationship to blood pressure and other cardiovascular risks","volume":"64","author":"Hajjar","year":"2009","journal-title":"J Gerontol Biol Sci Med Sci"},{"key":"10.1016\/j.tjpad.2026.100566_bib0039","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.gaitpost.2017.04.013","article-title":"Validity and repeatability of inertial measurement units for measuring gait parameters","volume":"55","author":"Washabaugh","year":"2017","journal-title":"Gait Post"},{"issue":"5","key":"10.1016\/j.tjpad.2026.100566_bib0040","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1080\/13607863.2021.1913471","article-title":"Executive function deficits in mild cognitive impairment: evidence from saccade tasks","volume":"26","author":"Chehrehnegar","year":"2022","journal-title":"Aging Ment Health"},{"issue":"11","key":"10.1016\/j.tjpad.2026.100566_bib0041","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1007\/s40520-019-01121-w","article-title":"Behavioral and cognitive markers of mild cognitive impairment: diagnostic value of saccadic eye movements and Simon task","volume":"31","author":"Chehrehnegar","year":"2019","journal-title":"Aging Clin Exp Res"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100566_bib0042","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3233\/JAD-180082","article-title":"Prodromal Alzheimer's disease demonstrates increased errors at a simple and automated anti-saccade task","volume":"65","author":"Holden","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2026.100566_bib0043","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1146\/annurev-vision-082114-035349","article-title":"Visual guidance of smooth pursuit eye movements","volume":"1","author":"Lisberger","year":"2015","journal-title":"Annu Rev Vis Sci"},{"issue":"6614","key":"10.1016\/j.tjpad.2026.100566_bib0044","doi-asserted-by":"crossref","first-page":"eabo7257","DOI":"10.1126\/science.abo7257","article-title":"Molecular and cellular evolution of the primate dorsolateral prefrontal cortex","volume":"377","author":"Ma","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.tjpad.2026.100566_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2017.11.004","article-title":"Brodmann area 10: collating, integrating and high level processing of nociception and pain","volume":"161","author":"Peng","year":"2018","journal-title":"Prog Neurobiol"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100566_bib0046","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tins.2015.11.002","article-title":"Neural basis of strategic decision making","volume":"39","author":"Lee","year":"2016","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.tjpad.2026.100566_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2022.103028","article-title":"Modulation of dorsolateral prefrontal cortex functional connectivity after intermittent theta-burst stimulation in depression: combining findings from fNIRS and fMRI","volume":"34","author":"Struckmann","year":"2022","journal-title":"Neuroimage Clin"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100566_bib0048","doi-asserted-by":"crossref","DOI":"10.1117\/1.NPh.9.4.045007","article-title":"Acquisition time for functional near-infrared spectroscopy resting-state functional connectivity in assessing autism","volume":"9","author":"Wu","year":"2022","journal-title":"Neurophotonics"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100566_bib0049","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1016\/j.neuroimage.2010.10.069","article-title":"A quantitative comparison of NIRS and fMRI across multiple cognitive tasks","volume":"54","author":"Cui","year":"2011","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.tjpad.2026.100566_bib0050","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41582-021-00616-3","article-title":"Blood GFAP as an emerging biomarker in brain and spinal cord disorders","volume":"18","author":"Abdelhak","year":"2022","journal-title":"Nat Rev Neurol"},{"issue":"7","key":"10.1016\/j.tjpad.2026.100566_bib0051","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1474-4422(16)00070-3","article-title":"CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis","volume":"15","author":"Olsson","year":"2016","journal-title":"Lancet Neurol"},{"issue":"6","key":"10.1016\/j.tjpad.2026.100566_bib0052","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tins.2015.04.003","article-title":"Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker","volume":"38","author":"Yang","year":"2015","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.tjpad.2026.100566_bib0053","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev.ne.19.030196.001155","article-title":"Neuronal intermediate filaments","volume":"19","author":"Lee","year":"1996","journal-title":"Annu Rev Neurosci"},{"issue":"5","key":"10.1016\/j.tjpad.2026.100566_bib0054","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0197-4580(93)90100-P","article-title":"GFAP mRNA increases with age in rat and human brain","volume":"14","author":"Nichols","year":"1993","journal-title":"Neurobiol Aging"},{"issue":"5","key":"10.1016\/j.tjpad.2026.100566_bib0055","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41582-024-00955-x","article-title":"Neurofilaments as biomarkers in neurological disorders - towards clinical application","volume":"20","author":"Khalil","year":"2024","journal-title":"Nat Rev Neurol"},{"issue":"10","key":"10.1016\/j.tjpad.2026.100566_bib0056","doi-asserted-by":"crossref","DOI":"10.1172\/JCI158453","article-title":"Biological aging processes underlying cognitive decline and neurodegenerative disease","volume":"132","author":"Gonzales","year":"2022","journal-title":"J Clin Invest"},{"issue":"8","key":"10.1016\/j.tjpad.2026.100566_bib0057","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.jacc.2019.11.062","article-title":"Biological versus chronological aging: JACC Focus Seminar","volume":"75","author":"Hamczyk","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.tjpad.2026.100566_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101807","article-title":"Sedentary behavior and the biological hallmarks of aging","volume":"83","author":"Raffin","year":"2023","journal-title":"Ageing Res Rev"},{"issue":"18","key":"10.1016\/j.tjpad.2026.100566_bib0059","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1016\/j.cell.2023.08.003","article-title":"Biomarkers of aging for the identification and evaluation of longevity interventions","volume":"186","author":"Moqri","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.tjpad.2026.100566_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101679","article-title":"Telomere length and brain aging: a systematic review and meta-analysis","volume":"80","author":"Gampawar","year":"2022","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.tjpad.2026.100566_bib0061","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ceb.2017.12.001","article-title":"Telomeres and aging","volume":"52","author":"Shay","year":"2018","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.tjpad.2026.100566_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101743","article-title":"Epigenetic clock: a promising biomarker and practical tool in aging","volume":"81","author":"Duan","year":"2022","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.tjpad.2026.100566_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102546","article-title":"Epigenetic clocks and programmatic aging","volume":"101","author":"Gems","year":"2024","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.tjpad.2026.100566_bib0064","series-title":"Applied regression analysis: a research tool","author":"Rawlings","year":"1998"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100566_bib0065","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/00401706.1970.10488634","article-title":"Ridge regression: biased estimation for nonorthogonal problems","volume":"12","author":"Hoerl","year":"1970","journal-title":"Technometrics"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100566_bib0066","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.2517-6161.1996.tb02080.x","article-title":"Regression shrinkage and selection via the lasso","volume":"58","author":"Tibshirani","year":"1996","journal-title":"J R Stat Soc B"},{"issue":"8","key":"10.1016\/j.tjpad.2026.100566_bib0067","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/procel\/pwae011","article-title":"DNA methylation clocks for estimating biological age in Chinese cohorts","volume":"15","author":"Zheng","year":"2024","journal-title":"Protein Cell"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100566_bib0068","doi-asserted-by":"crossref","DOI":"10.3390\/cells12010032","article-title":"A blood-based molecular clock for biological age estimation","volume":"12","author":"Paparazzo","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100566_bib0069","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13073-025-01558-x","article-title":"Proteomic landscape of multidimensional aging phenotypes","volume":"17","author":"Cao","year":"2025","journal-title":"Genome Med"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100566_bib0070","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1038\/s41467-025-58819-x","article-title":"Health octo tool matches personalized health with rate of aging","volume":"16","author":"Salimi","year":"2025","journal-title":"Nat Commun"},{"issue":"11","key":"10.1016\/j.tjpad.2026.100566_bib0071","doi-asserted-by":"crossref","DOI":"10.3390\/s24113613","article-title":"Optimizing rare disease gait classification through data balancing and generative AI: insights from hereditary cerebellar ataxia","volume":"24","author":"Trabassi","year":"2024","journal-title":"Sensors"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580726000907?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580726000907?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:41:08Z","timestamp":1780339268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580726000907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":71,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2274580726000907"],"URL":"https:\/\/doi.org\/10.1016\/j.tjpad.2026.100566","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multidimensional modeling of biological aging: integrating gait, eye movement, rest-state functional connectivity, and plasma biomarkers in non-dementia older adults","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjpad.2026.100566","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS on behalf of SERDI Publisher.","name":"copyright","label":"Copyright"}],"article-number":"100566"}}