{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:38:54Z","timestamp":1789141134757,"version":"build-2803163510"},"reference-count":76,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.tjpad.2026.100597","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T09:46:42Z","timestamp":1779702402000},"page":"100597","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between obstructive sleep apnea severity and glymphatic-related DTI-ALPS alterations in newly diagnosed, Drug-Na\u00efve Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"13","author":[{"given":"Wenxue","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurui","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tjpad.2026.100597_bib0001","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.3233\/JAD-221288","article-title":"Alzheimer's Disease biomarkers and complement proteins mediate the impact of sleep fragmentation on cognitive impairment in obstructive sleep apnea patients without dementia","volume":"95","author":"Yang","year":"2023","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2026.100597_bib0002","first-page":"45","article-title":"Does sleep apnea exacerbate adverse driving behaviors and accident risk in drivers with preclinical markers of Alzheimer's disease?","author":"Vakulin","year":"2022","journal-title":"Sleep"},{"key":"10.1016\/j.tjpad.2026.100597_bib0003","article-title":"Exploring the combined effects of sleep apnea and APOE-e4 on biomarkers of Alzheimer's disease","volume":"14","author":"Turner","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.tjpad.2026.100597_bib0004","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1002\/lary.28558","article-title":"Risk of Alzheimer's disease in obstructive sleep apnea patients with or without treatment: real-world evidence","volume":"130","author":"Tsai","year":"2020","journal-title":"Laryngoscope"},{"key":"10.1016\/j.tjpad.2026.100597_bib0005","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.1038735","article-title":"Associations between risk of Alzheimer's disease and obstructive sleep apnea, intermittent hypoxia, and arousal responses: a pilot study","volume":"13","author":"Tsai","year":"2022","journal-title":"Front Neurol"},{"key":"10.1016\/j.tjpad.2026.100597_bib0006","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.sleh.2024.08.012","article-title":"Mediating role of obstructive sleep apnea in altering slow-wave activity and elevating Alzheimer's disease risk: pilot study from a northern Taiwan cohort","volume":"11","author":"Tsai","year":"2025","journal-title":"Sleep Health"},{"key":"10.1016\/j.tjpad.2026.100597_bib0007","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1007\/s12035-020-02031-z","article-title":"Circulating MicroRNA profile associated with obstructive sleep apnea in Alzheimer's Disease","volume":"57","author":"Targa","year":"2020","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.tjpad.2026.100597_bib0008","first-page":"176","article-title":"Alzheimer's Disease in patients with obstructive sleep apnea syndrome","volume":"19","author":"Siachpazidou","year":"2020","journal-title":"Tanaffos"},{"key":"10.1016\/j.tjpad.2026.100597_bib0009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0221255","article-title":"Obstructive sleep apnea may increase the risk of Alzheimer's disease","volume":"14","author":"Przybylska-Kuc","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.tjpad.2026.100597_bib0010","first-page":"44","article-title":"Alzheimer's disease neuropathology in the hippocampus and brainstem of people with obstructive sleep apnea","author":"Owen","year":"2021","journal-title":"Sleep"},{"key":"10.1016\/j.tjpad.2026.100597_bib0011","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41440-023-01440-6","article-title":"Obstructive sleep apnea and non-dipper: epiphenomena or risks of Alzheimer's disease?: a review from the HOPE Asia Network","volume":"47","author":"Nagai","year":"2024","journal-title":"Hypertens Res"},{"key":"10.1016\/j.tjpad.2026.100597_bib0012","doi-asserted-by":"crossref","DOI":"10.1002\/alz.71144","article-title":"Racial, ethnic and sex-specific mechanisms of obstructive sleep apnea and Alzheimer's disease risk","volume":"22","author":"Murali","year":"2026","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.tjpad.2026.100597_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105054","article-title":"Obstructive sleep apnea and its treatment in aging: effects on Alzheimer's disease biomarkers, cognition, brain structure and neurophysiology","volume":"145","author":"Mullins","year":"2020","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.tjpad.2026.100597_bib0014","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1552535","article-title":"An investigation on Alzheimer's disease with obstructive sleep apnea: alterations of cognitive function, roles of cyclin-dependent kinase 5 and changes of brain structure","volume":"17","author":"Luo","year":"2025","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.tjpad.2026.100597_bib0015","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13195-024-01446-3","article-title":"Older adults at greater risk for Alzheimer's disease show stronger associations between sleep apnea severity in REM sleep and verbal memory","volume":"16","author":"Lui","year":"2024","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.tjpad.2026.100597_bib0016","article-title":"Older adults at greater risk for Alzheimer's disease show stronger associations between sleep apnea severity and verbal memory","author":"Lui","year":"2023","journal-title":"Res Sq"},{"key":"10.1016\/j.tjpad.2026.100597_bib0017","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.sleep.2019.01.003","article-title":"Obstructive sleep apnea may induce orexinergic system and cerebral beta-amyloid metabolism dysregulation: is it a further proof for Alzheimer's disease risk?","volume":"56","author":"Liguori","year":"2019","journal-title":"Sleep Med"},{"key":"10.1016\/j.tjpad.2026.100597_bib0018","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40035-025-00510-8","article-title":"Targeting the glymphatic system: abeta accumulation and phototherapy strategies across different stages of Alzheimer's disease","volume":"14","author":"Zhao","year":"2025","journal-title":"Transl Neurodegener"},{"key":"10.1016\/j.tjpad.2026.100597_bib0019","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12984-025-01738-1","article-title":"Effects of intermittent theta-burst stimulation on cognition and glymphatic system activity in mild cognitive impairment and very mild Alzheimer's disease: a randomized controlled trial","volume":"22","author":"Yang","year":"2025","journal-title":"J Neuroeng Rehabil"},{"key":"10.1016\/j.tjpad.2026.100597_bib0020","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13550-025-01339-y","article-title":"Glymphatic system dysfunction mediates amyloid deposition and cognitive impairment in Alzheimer's disease: a PET\/MRI multimodality imaging study","volume":"16","author":"Xue","year":"2025","journal-title":"EJNMMI Res"},{"key":"10.1016\/j.tjpad.2026.100597_bib0021","doi-asserted-by":"crossref","DOI":"10.1111\/ene.70384","article-title":"The relationship between cerebral small vessel disease, sleep quality, and cognitive impairment among community-dwelling older adults: exploring the role of glymphatic function","volume":"32","author":"Zhou","year":"2025","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.tjpad.2026.100597_bib0022","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.2147\/NSS.S548253","article-title":"Glymphatic system in adolescents with major depressive disorder: no dysfunction and No association with poor sleep quality","volume":"17","author":"Zhang","year":"2025","journal-title":"Nat Sci Sleep"},{"key":"10.1016\/j.tjpad.2026.100597_bib0023","unstructured":"X. Zeng, Y. Li, F.N. Yang, G. Del Mauro, J. Yu, R. Lu, J. Zhuo, L. Rowland, W. Emerson, Z. Wang, Sleep effects on brain, cognition, and mental health during adolescence are mediated by the glymphatic system, ArXiv, (2025)."},{"key":"10.1016\/j.tjpad.2026.100597_bib0024","doi-asserted-by":"crossref","DOI":"10.1007\/s00213-026-07004-z","article-title":"Glymphatic system dysfunction: a link between sleep disorders and neurodegeneration","author":"Yang","year":"2026","journal-title":"Psychopharmacol (Berl)"},{"key":"10.1016\/j.tjpad.2026.100597_bib0025","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.neuroscience.2025.09.008","article-title":"Glymphatic-meningeal lymphatic system, a new therapeutic target for sleep disorders","volume":"585","author":"Xiao","year":"2025","journal-title":"Neuroscience"},{"key":"10.1016\/j.tjpad.2026.100597_bib0026","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jsmc.2025.06.008","article-title":"The glymphatic system and sleep dysfunction in Parkinson's Disease","volume":"20","author":"Urso","year":"2025","journal-title":"Sleep Med Clin"},{"key":"10.1016\/j.tjpad.2026.100597_bib0027","first-page":"15","article-title":"Brain age acceleration on MRI due to poor sleep: associations, mechanisms, and clinical implications","author":"Toraih","year":"2025","journal-title":"Brain Sci"},{"key":"10.1016\/j.tjpad.2026.100597_bib0028","doi-asserted-by":"crossref","first-page":"34830","DOI":"10.1021\/acsnano.5c10519","article-title":"Engineering near-infrared-II nanoprobes reveal dexmedetomidine potentiating brain waste clearance in healthy and sleep-restricted mice","volume":"19","author":"Sun","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.tjpad.2026.100597_bib0029","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000213955","article-title":"Continuous positive airway pressure and progression of enlarged perivascular spaces in adults with obstructive sleep apnea","volume":"105","author":"Sommer","year":"2025","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2026.100597_bib0030","article-title":"Association of parasagittal dural space calcification with body mass index, non-rapid eye movement sleep and sleep apnea","author":"Siow","year":"2025","journal-title":"Sleep"},{"key":"10.1016\/j.tjpad.2026.100597_bib0031","doi-asserted-by":"crossref","DOI":"10.1002\/cns3.70024","article-title":"Increased extra-axial cerebrospinal fluid volume in children with Angelman syndrome: links to sleep problems and seizures","author":"Chen","year":"2025","journal-title":"Ann Child Neurol Soc"},{"key":"10.1016\/j.tjpad.2026.100597_bib0032","article-title":"Synthetic disaggregators enhance Central-peripheral amyloid-beta clearance in Alzheimer's disease","author":"Tang","year":"2026","journal-title":"Adv Mater"},{"key":"10.1016\/j.tjpad.2026.100597_bib0033","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s11325-025-03479-w","article-title":"Tracking glymphatic dysfunction in isolated rapid eye movement sleep behavior disorder: a longitudinal neuroimaging study","volume":"29","author":"Byun","year":"2025","journal-title":"Sleep Breath"},{"key":"10.1016\/j.tjpad.2026.100597_bib0034","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000214042","article-title":"Association of DTI-ALPS glymphatic index with differential phenoconversion in isolated REM sleep behavior disorder: a multi-cohort MRI study","volume":"105","author":"Ayral","year":"2025","journal-title":"Neurology"},{"key":"10.1016\/j.tjpad.2026.100597_bib0035","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2025.1607723","article-title":"Glymphatic system function in patients with ischemic stroke evaluated by the DTI-ALPS method: a comprehensive review","volume":"16","author":"Zeng","year":"2025","journal-title":"Front Neurol"},{"key":"10.1016\/j.tjpad.2026.100597_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2026.134157","article-title":"Neurite orientation dispersion and density imaging (NODDI) and DTI-ALPS index reveal white matter microstructural abnormalities and glymphatic-like dysfunction linked to cognitive impairment in non-stroke atrial fibrillation patients","volume":"449","author":"Yue","year":"2026","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.tjpad.2026.100597_bib0037","doi-asserted-by":"crossref","DOI":"10.1186\/s12883-026-04669-z","article-title":"Glymphatic dysfunction and its association with clinical symptom severity in narcolepsy type 1: a case-control DTI-ALPS study","author":"Xiaoxi","year":"2026","journal-title":"BMC Neurol"},{"key":"10.1016\/j.tjpad.2026.100597_bib0038","doi-asserted-by":"crossref","first-page":"31","DOI":"10.25259\/JCIS_142_2024","article-title":"Evaluation of the glymphatic system using the DTI-ALPS index in type 2 diabetes mellitus-induced cognitive impairment","volume":"15","author":"Wang","year":"2025","journal-title":"J Clin Imaging Sci"},{"key":"10.1016\/j.tjpad.2026.100597_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2025.111640","article-title":"Glymphatic dysfunction impairs cognitive function via disrupted white matter network efficiency in primary insomnia: a DTI-ALPS mediation study","volume":"233","author":"Wang","year":"2025","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.tjpad.2026.100597_bib0040","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1186\/s12888-025-07432-9","article-title":"Glymphatic alteration in NAFLD patient: a preliminary magnetic resonance imaging study based on DTI-ALPS","volume":"25","author":"Shu","year":"2025","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.tjpad.2026.100597_bib0041","doi-asserted-by":"crossref","first-page":"9705","DOI":"10.62347\/QFOR5108","article-title":"Association between diffusion tensor imaging analysis along the perivascular space (DTI-ALPS)-based glial-lymphatic dysfunction and cognitive impairment in non-small cell lung cancer","volume":"17","author":"Shao","year":"2025","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.tjpad.2026.100597_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2025.106835","article-title":"Extending the ALPS index: associating whole-brain patterns with glymphatic-related diffusion metrics in multiple sclerosis","volume":"104","author":"Santaniello","year":"2025","journal-title":"Mult Scler Relat Disord"},{"key":"10.1016\/j.tjpad.2026.100597_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2026.121705","article-title":"ALPS index and choroid plexus volume as indirect MRI biomarkers of glymphatic function for predicting cognitive decline in Parkinson's disease","volume":"326","author":"Ruan","year":"2026","journal-title":"Neuroimage"},{"key":"10.1016\/j.tjpad.2026.100597_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2025.108571","article-title":"The association between decreased ALPS index and emphysema as well as cognitive function in patients with COPD","volume":"251","author":"Lian","year":"2026","journal-title":"Respir Med"},{"key":"10.1016\/j.tjpad.2026.100597_bib0045","article-title":"The left DTI-ALPS index: a potential glymphatic mediator of cognitive and motor dysfunction in Parkinson's disease","volume":"12","author":"Li","year":"2025","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.tjpad.2026.100597_bib0046","article-title":"APOE4 modulates the association between DTI-ALPS index and Alzheimer's pathologies","volume":"21","author":"Kang","year":"2025","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.tjpad.2026.100597_bib0047","doi-asserted-by":"crossref","first-page":"e611","DOI":"10.5114\/pjr\/209785","article-title":"Assessing glymphatic dysfunction using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) index in gliomas and metastases","volume":"90","author":"Jayanna","year":"2025","journal-title":"Pol J Radiol"},{"key":"10.1016\/j.tjpad.2026.100597_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2025.125709","article-title":"Lower vascular cerebral flow and cerebral perfusion may be associated with impairment of the glymphatic system in multiple sclerosis: a cross-sectional DTI-ALPS MRI study","volume":"480","author":"Jakimovski","year":"2026","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.tjpad.2026.100597_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2023.101790","article-title":"The association of obstructive sleep apnea with blood and cerebrospinal fluid biomarkers of Alzheimer's dementia - A systematic review and meta-analysis","volume":"70","author":"Yeo","year":"2023","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.tjpad.2026.100597_bib0050","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1007\/s11764-024-01608-0","article-title":"The prevalence of mild cognitive impairment in breast cancer patients receiving chemotherapy according to the criteria of the National Institute on Aging-Alzheimer's Association (NIA-AA)","volume":"19","author":"Albers","year":"2025","journal-title":"J Cancer Surviv"},{"key":"10.1016\/j.tjpad.2026.100597_bib0051","first-page":"13","article-title":"Montreal cognitive assessment (MoCA) norms for older patients with a depressive disorder","author":"Scheenen","year":"2025","journal-title":"Med Sci (Basel)"},{"key":"10.1016\/j.tjpad.2026.100597_bib0052","doi-asserted-by":"crossref","first-page":"94","DOI":"10.20344\/amp.8859","article-title":"Alzheimer's Disease Assessment scale - cognitive subscale (ADAS-Cog): normative data for the Portuguese population","volume":"31","author":"Nogueira","year":"2018","journal-title":"Acta Med Port"},{"key":"10.1016\/j.tjpad.2026.100597_bib0053","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13195-024-01399-7","article-title":"Relationships of change in clinical dementia Rating (CDR) on patient outcomes and probability of progression: observational analysis","volume":"16","author":"Tariot","year":"2024","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.tjpad.2026.100597_bib0054","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s11325-020-02210-1","article-title":"Predictive ability of the International Classification of Sleep Disorders-3 in identifying risk of obstructive sleep apnea among recently unemployed adults","volume":"25","author":"Silva","year":"2021","journal-title":"Sleep Breath"},{"key":"10.1016\/j.tjpad.2026.100597_bib0055","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.21037\/jtd-22-1446","article-title":"Performance of the activities and participation component of international classification of functioning, disability and health sleep disorders brief core set in patients with obstructive sleep apnea","volume":"15","author":"Huang","year":"2023","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.tjpad.2026.100597_bib0056","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2463\/mrms.rev.2023-0175","article-title":"Diffusion tensor image analysis ALong the perivascular space (DTI-ALPS): revisiting the meaning and significance of the method","volume":"23","author":"Taoka","year":"2024","journal-title":"Magn Reson Med Sci"},{"key":"10.1016\/j.tjpad.2026.100597_bib0057","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s11604-023-01463-6","article-title":"Glymphatic system impairment in sleep disruption: diffusion tensor image analysis along the perivascular space (DTI-ALPS)","volume":"41","author":"Saito","year":"2023","journal-title":"Jpn J Radiol"},{"key":"10.1016\/j.tjpad.2026.100597_bib0058","article-title":"Alzheimer's disease biomarkers in patients with obstructive sleep apnea hypopnea syndrome and effects of surgery: a prospective cohort study","volume":"14","author":"Kong","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.tjpad.2026.100597_bib0059","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jocn.2022.06.004","article-title":"Association between obstructive sleep apnea and Alzheimer's disease-related blood and cerebrospinal fluid biomarkers: a meta-analysis","volume":"102","author":"Kang","year":"2022","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.tjpad.2026.100597_bib0060","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8091361","article-title":"Alterations in Alzheimer's Disease-associated gene expression in severe obstructive sleep apnea patients","volume":"8","author":"Li","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.tjpad.2026.100597_bib0061","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00405-020-05948-2","article-title":"Biomarkers of Alzheimer's disease in severe obstructive sleep apnea-hypopnea syndrome in the Chinese population","volume":"278","author":"Kong","year":"2021","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1016\/j.tjpad.2026.100597_bib0062","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s44294-025-00076-w","article-title":"Sex differences in sleep apnea and Alzheimer's Disease: role of cerebrovascular dysfunction","volume":"3","author":"Greenlund","year":"2025","journal-title":"NPJ Womens Health"},{"key":"10.1016\/j.tjpad.2026.100597_bib0063","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3233\/JAD-231385","article-title":"Obstructive sleep apnea and Alzheimer's Disease pathology: is sleep architecture the missing key?","volume":"98","author":"Gills","year":"2024","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2026.100597_bib0064","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1007\/s00415-019-09668-4","article-title":"Prevalence of obstructive sleep apnea in Alzheimer's disease patients","volume":"267","author":"Gaeta","year":"2020","journal-title":"J Neurol"},{"key":"10.1016\/j.tjpad.2026.100597_bib0065","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3233\/ADR-210004","article-title":"The importance of diagnosing and the clinical potential of treating obstructive sleep apnea to delay mild cognitive impairment and Alzheimer's disease: a special focus on cognitive performance","volume":"5","author":"Fernandes","year":"2021","journal-title":"J Alzheimers Dis Rep"},{"key":"10.1016\/j.tjpad.2026.100597_bib0066","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3233\/JAD-215734","article-title":"Nocturnal hypoxia and sleep fragmentation may drive neurodegenerative processes: the compared effects of obstructive sleep apnea syndrome and periodic limb movement disorder on Alzheimer's Disease biomarkers","volume":"88","author":"Fernandes","year":"2022","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2026.100597_bib0067","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3233\/JAD-201066","article-title":"Decoding causal links between sleep apnea and Alzheimer's disease","volume":"80","author":"Ferini-Strambi","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2026.100597_bib0068","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3233\/JAD-180640","article-title":"Risk of Alzheimer's disease in obstructive sleep Apnea syndrome: amyloid-beta and tau imaging","volume":"66","author":"Elias","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.tjpad.2026.100597_bib0069","first-page":"45","article-title":"Adverse driving behaviors are associated with sleep apnea severity and age in cognitively normal older adults at risk for Alzheimer's disease","author":"Doherty","year":"2022","journal-title":"Sleep"},{"key":"10.1016\/j.tjpad.2026.100597_bib0070","first-page":"44","article-title":"Obstructive sleep apnea and Alzheimer's disease-related cerebrospinal fluid biomarkers in mild cognitive impairment","author":"Diaz-Roman","year":"2021","journal-title":"Sleep"},{"key":"10.1016\/j.tjpad.2026.100597_bib0071","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s40675-018-0131-6","article-title":"Dynamic contributions of slow wave sleep and REM sleep to cognitive longevity","volume":"4","author":"Scullin","year":"2018","journal-title":"Curr Sleep Med Rep"},{"key":"10.1016\/j.tjpad.2026.100597_bib0072","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsaf418","article-title":"Circadian alterations in isolated REM sleep behavior disorder: associations with clinical, glymphatic and, dopaminergic imaging markers","author":"Roura","year":"2026","journal-title":"Sleep"},{"key":"10.1016\/j.tjpad.2026.100597_bib0073","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41531-025-00962-9","article-title":"Parkinson's disease with possible REM sleep behavior disorder correlated with more severe glymphatic system dysfunction","volume":"11","author":"Ma","year":"2025","journal-title":"NPJ Parkinsons Dis"},{"key":"10.1016\/j.tjpad.2026.100597_bib0074","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/ane.13573","article-title":"Glymphatic dysfunction in isolated REM sleep behavior disorder","volume":"145","author":"Lee","year":"2022","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.tjpad.2026.100597_bib0075","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s12035-025-05495-z","article-title":"Analysis of AQP4 SNPs and their association with REM sleep behavior disorder and hallucinations in Parkinson's Disease","volume":"63","author":"Agliardi","year":"2025","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.tjpad.2026.100597_bib0076","doi-asserted-by":"crossref","DOI":"10.3389\/frsle.2024.1322995","article-title":"From macro to micro: slow-wave sleep and its pivotal health implications","volume":"3","author":"Ishii","year":"2024","journal-title":"Front Sleep"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580726001226?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580726001226?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T06:04:51Z","timestamp":1783922691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580726001226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":76,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2274580726001226"],"URL":"https:\/\/doi.org\/10.1016\/j.tjpad.2026.100597","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between obstructive sleep apnea severity and glymphatic-related DTI-ALPS alterations in newly diagnosed, Drug-Na\u00efve Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjpad.2026.100597","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Masson SAS on behalf of SERDI Publisher.","name":"copyright","label":"Copyright"}],"article-number":"100597"}}