{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:16:33Z","timestamp":1789488993037,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Prevention of Alzheimer's Disease"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.tjpad.2026.100641","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T12:33:32Z","timestamp":1786019612000},"page":"100641","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stages of objective memory impairment (SOMI) as a predictor of clinical progression in the A4 study"],"prefix":"10.1016","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8415-2922","authenticated-orcid":false,"given":"Priyanka","family":"Kumari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Lipton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4317-7282","authenticated-orcid":false,"given":"Andrew J.","family":"Aschenbrenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reisa","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6026-2238","authenticated-orcid":false,"given":"Michael C.","family":"Donohue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Grober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.tjpad.2026.100641_bib45","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1038\/s41591-024-02988-7","article-title":"Revised criteria for the diagnosis and staging of Alzheimer\u2019s disease","volume":"30","author":"Jack","year":"2024","journal-title":"Nature medic"},{"issue":"5","key":"10.1016\/j.tjpad.2026.100641_bib46","doi-asserted-by":"crossref","first-page":"e662","DOI":"10.1212\/WNL.0000000000011222","article-title":"Association of \u03b2-amyloid level, clinical progression, and longitudinal cognitive change in normal older individuals","volume":"96","author":"Van der Kall","year":"2021","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.tjpad.2026.100641_bib47","article-title":"Cognitive decline across five cognitive batteries: sample size implications for clinical trials","volume":"11","author":"Zammit","year":"2025","journal-title":"Alzheim Demen Translat Res Clinic Interven"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100641_bib48","article-title":"Alzheimer\u2019s disease neuroimaging initiative. objective subtle cognitive decline and plasma phosphorylated tau181: Early markers of Alzheimer\u2019s disease\u2010related declines","volume":"13","author":"Thomas","year":"2021","journal-title":"Alzheim Dement: Diagn, Assess Dis Monitor"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100641_bib49","article-title":"Alzheimer\u2019s Disease Neuroimaging Initiative. Subtle cognitive impairment as a marker of Alzheimer\u2019s pathologies and clinical progression in cognitively normal individuals","volume":"13","author":"Shen","year":"2021","journal-title":"Alzheim Demen: Diag, Assess Dis Monitor"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100641_bib50","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s11065-017-9345-5","article-title":"Detectable neuropsychological differences in early preclinical Alzheimer\u2019s disease: a meta-analysis","volume":"27","author":"Duke Han","year":"2017","journal-title":"Neuropsychol rev"},{"issue":"5","key":"10.1016\/j.tjpad.2026.100641_bib51","doi-asserted-by":"crossref","DOI":"10.1002\/alz.71458","article-title":"Minor neuropsychological deficits and stage 2 of Alzheimer\u2019s disease","volume":"22","author":"Stark","year":"2026","journal-title":"Alzheim Dement"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100641_bib52","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/87565648709540361","article-title":"Genuine memory deficits in dementia","volume":"3","author":"Grober","year":"1987","journal-title":"Develop neuropsychol"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100641_bib53","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3233\/JAD-2010-091150","article-title":"The amnestic syndrome of hippocampal type in Alzheimer\u2019s disease: an MRI study","volume":"22","author":"Sarazin","year":"2010","journal-title":"J Alzheim Dis"},{"issue":"6","key":"10.1016\/j.tjpad.2026.100641_bib54","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S1474-4422(14)70090-0","article-title":"Advancing research diagnostic criteria for Alzheimer\u2019s disease: The IWG-2 criteria","volume":"13","author":"Dubois","year":"2014","journal-title":"Lancet Neurol"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100641_bib55","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1212\/WNL.54.4.827","article-title":"Memory impairment on free and cued selective reminding predicts dementia","volume":"54","author":"Grober","year":"2000","journal-title":"Neurology"},{"issue":"22","key":"10.1016\/j.tjpad.2026.100641_bib56","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1212\/WNL.0b013e3181df0959","article-title":"Validity of the free and cued selective reminding test in predicting dementia: the 3C study","volume":"74","author":"Auriacombe","year":"2010","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.tjpad.2026.100641_bib57","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.jalz.2016.12.014","article-title":"Free and cued selective reminding test\u2013accuracy for the differential diagnosis of Alzheimer\u2019s and neurodegenerative diseases: A large\u2010scale biomarker\u2010characterized monocenter cohort study (ClinAD)","volume":"13","author":"Teichmann","year":"2017","journal-title":"Alzheim Dement"},{"issue":"14","key":"10.1016\/j.tjpad.2026.100641_bib58","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1212\/WNL.0b013e31828ab2c9","article-title":"Screening for predementia AD: time-dependent operating characteristics of episodic memory tests","volume":"80","author":"Derby","year":"2013","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100641_bib59","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/alz.12431","article-title":"Cognitive decline as an outcome and marker of progression toward dementia, in early preventive trials","volume":"18","author":"Mura","year":"2022","journal-title":"Alzheim Dement"},{"key":"10.1016\/j.tjpad.2026.100641_bib60","first-page":"161","article-title":"Temporal unfolding of declining episodic memory on the Free and Cued Selective Reminding Test in the predementia phase of Alzheimer\u2019s disease: Implications for clinical trials. Alzheimer\u2019s & Dementia: Diagnosis","volume":"10","author":"Grober","year":"2018","journal-title":"Assess Dis Monit"},{"issue":"22","key":"10.1016\/j.tjpad.2026.100641_bib61","doi-asserted-by":"crossref","first-page":"e2279","DOI":"10.1212\/WNL.0000000000207276","article-title":"Association of stages of objective memory impairment with incident symptomatic cognitive impairment in cognitively normal individuals","volume":"100","author":"Grober","year":"2023","journal-title":"Neurology"},{"issue":"7\u20138","key":"10.1016\/j.tjpad.2026.100641_bib62","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1017\/S1355617725101240","article-title":"Assessing stages of objective memory impairment and neuroimaging as risk factors of incident cognitive impairment","volume":"31","author":"Petersen","year":"2025","journal-title":"J Int Neuropsych Soc"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100641_bib63","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3233\/JAD-200946","article-title":"Stages of objective memory impairment predict Alzheimer\u2019s Disease neuropathology: Comparison with the Clinical Dementia Rating Scale\u2013Sum of Boxes","volume":"80","author":"Grober","year":"2021","journal-title":"JAlzheim Dis"},{"issue":"12","key":"10.1016\/j.tjpad.2026.100641_bib64","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1056\/NEJMoa2305032","article-title":"Trial of solanezumab in preclinical Alzheimer\u2019s disease","volume":"389","author":"Sperling","year":"2023","journal-title":"New England J Med"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100641_bib65","doi-asserted-by":"crossref","first-page":"802","DOI":"10.14283\/jpad.2024.122","article-title":"Amyloid and tau prediction of cognitive and functional decline in unimpaired older individuals: longitudinal data from the A4 and LEARN studies","volume":"11","author":"Sperling","year":"2024","journal-title":"J Prevent Alzheim Dis"},{"issue":"9","key":"10.1016\/j.tjpad.2026.100641_bib66","first-page":"1797","article-title":"Plasma p-tau231 and p-tau217 as state markers of amyloid-\u03b2 pathology in preclinical Alzheimer\u2019s disease","volume":"28","author":"Mil\u00e0-Alom\u00e0","year":"2022","journal-title":"Nature med"},{"key":"10.1016\/j.tjpad.2026.100641_bib67","doi-asserted-by":"crossref","unstructured":"Buckley RF, Townsend DL, Birkenbihl CJ, Cuppels M, Coughlan GT, Seto MT, Brown JA, Properzi MJ, Honig MC, Li A, Schultz AP. The prognostic value of blood-based p-tau217 levels on progression to clinical impairment. medRxiv. 2026 Jan 1.","DOI":"10.64898\/2026.02.06.26345770"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100641_bib68","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1038\/s41467-026-71269-3","article-title":"Plasma phosphorylated tau 217 and longitudinal trajectories of A\u03b2, tau, and cognition in cognitively unimpaired older adults","volume":"17","author":"Yang","year":"2026","journal-title":"Nature Comm"},{"issue":"3","key":"10.1016\/j.tjpad.2026.100641_bib69","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1002\/alz.13679","article-title":"Predictors and outcomes of fluctuations in the clinical dementia rating scale","volume":"20","author":"Wilks","year":"2024","journal-title":"Alzheim Demen"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100641_bib70","first-page":"324","volume":"30","author":"Malek-Ahmadi","year":"2016","journal-title":"Reversion from mild cognitive impairment to normal cognition: a meta-analysis. Alzheim Dis Associat Disord"},{"issue":"6","key":"10.1016\/j.tjpad.2026.100641_bib71","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1212\/WNL.38.6.900","article-title":"Screening for dementia by memory testing","volume":"38","author":"Grober","year":"1988","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.tjpad.2026.100641_bib72","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/j.1532-5415.2008.01652.x","article-title":"Free and cued selective reminding distinguishes Alzheimer\u2019s disease from vascular dementia","volume":"56","author":"Grober","year":"2008","journal-title":"J American Geriat Soc"},{"issue":"8","key":"10.1016\/j.tjpad.2026.100641_bib73","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/jamaneurol.2014.803","article-title":"The preclinical Alzheimer cognitive composite: measuring amyloid-related decline","volume":"71","author":"Donohue","year":"2014","journal-title":"JAMA Neurol"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100641_bib74","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/01688638708405063","article-title":"norms and alternate-form reliability of two scoring systems","volume":"9","author":"Abikoff","year":"1987","journal-title":"J Clinic Experim Neuropsych"},{"issue":"3","key":"10.1016\/j.tjpad.2026.100641_bib75","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0004-9514(05)70034-9","article-title":"Mini-Mental State Examination (MMSE)","volume":"51","author":"Galea","year":"2005","journal-title":"Aust J Physiother"},{"issue":"5","key":"10.1016\/j.tjpad.2026.100641_bib76","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/JCP.0000000000000941","article-title":"Digit symbol substitution test: the case for sensitivity over specificity in neuropsychological testing","volume":"38","author":"Jaeger","year":"2018","journal-title":"J clinic psychopharmacol"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100641_bib77","doi-asserted-by":"crossref","first-page":"823","DOI":"10.14283\/jpad.2024.134","article-title":"Longitudinal phospho-tau217 predicts amyloid positron emission tomography in asymptomatic Alzheimer\u2019s disease","volume":"11","author":"Rissman","year":"2024","journal-title":"J Preven Alzheim Dis"},{"issue":"13","key":"10.1016\/j.tjpad.2026.100641_bib78","doi-asserted-by":"crossref","first-page":"e1327","DOI":"10.1212\/WNL.0000000000200046","article-title":"Associations of stages of objective memory impairment with amyloid PET and structural MRI: The A4 study","volume":"98","author":"Grober","year":"2022","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100641_bib79","article-title":"Neuroimaging correlates of stages of objective memory impairment (SOMI) system","volume":"13","author":"Grober","year":"2021","journal-title":"Alzheim Dement: Diagn, Assess Dis Monitor"},{"issue":"1","key":"10.1016\/j.tjpad.2026.100641_bib80","doi-asserted-by":"crossref","first-page":"112","DOI":"10.14283\/jpad.2022.98","article-title":"Associations of stages of objective memory impairment with cerebrospinal fluid and neuroimaging biomarkers of Alzheimer\u2019s disease","volume":"10","author":"Petersen","year":"2023","journal-title":"J preven Alzheim Dis"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100641_bib81","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/alz.12433","article-title":"Diversity in Alzheimer\u2019s disease drug trials: the importance of eligibility criteria","volume":"18","author":"Franzen","year":"2022","journal-title":"Alzheim Dement"},{"issue":"3","key":"10.1016\/j.tjpad.2026.100641_bib82","first-page":"266","article-title":"The free and cued selective reminding test: evidence of psychometric adequacy","volume":"51","author":"Grober","year":"2009","journal-title":"Psychol Sci Quart"},{"issue":"9","key":"10.1016\/j.tjpad.2026.100641_bib83","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1001\/jamaneurol.2024.2619","article-title":"Plasma phosphorylated tau 217 and A\u03b242\/40 to predict early brain A\u03b2 accumulation in people without cognitive impairment","volume":"81","author":"Janelidze","year":"2024","journal-title":"JAMA Neurol"},{"issue":"4","key":"10.1016\/j.tjpad.2026.100641_bib84","article-title":"Digital memory assessments and plasma pTau217 enable efficient preclinical Alzheimer\u2019s trials","volume":"13","author":"Vanderlip","year":"2026","journal-title":"J Prevent Alzheim Dis"}],"container-title":["The Journal of Prevention of Alzheimer's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580726001652?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2274580726001652?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:53:38Z","timestamp":1789487618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2274580726001652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2274580726001652"],"URL":"https:\/\/doi.org\/10.1016\/j.tjpad.2026.100641","relation":{},"ISSN":["2274-5807"],"issn-type":[{"value":"2274-5807","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stages of objective memory impairment (SOMI) as a predictor of clinical progression in the A4 study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Prevention of Alzheimer's Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tjpad.2026.100641","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Masson SAS on behalf of SERDI Publisher.","name":"copyright","label":"Copyright"}],"article-number":"100641"}}