{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:34:04Z","timestamp":1777448044229,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Travel Medicine and Infectious Disease"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.tmaid.2010.04.006","type":"journal-article","created":{"date-parts":[[2010,5,22]],"date-time":"2010-05-22T05:09:51Z","timestamp":1274504991000},"page":"257-262","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["What role does the blood brain barrier play in acute mountain sickness?"],"prefix":"10.1016","volume":"8","author":[{"given":"Alex","family":"Baneke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tmaid.2010.04.006_bib1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0002-9343(79)90393-0","article-title":"Rales. Peripheral edema, retinal hemorrhage and acute mountain sickness","volume":"67","author":"Hackett","year":"1979","journal-title":"Am J Med"},{"issue":"6756","key":"10.1016\/j.tmaid.2010.04.006_bib2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1136\/bmj.301.6756.853","article-title":"Prevalence of acute mountain sickness in the Swiss Alps","volume":"301","author":"Maggiorini","year":"1990","journal-title":"BMJ"},{"issue":"22","key":"10.1016\/j.tmaid.2010.04.006_bib3","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1001\/jama.280.22.1920","article-title":"High-altitude cerebral edema evaluated with magnetic resonance imaging. Clinical correlation and pathophysiology","volume":"280","author":"Hackett","year":"1998","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.tmaid.2010.04.006_bib4","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1089\/1527029041352054","article-title":"High altitude cerebral oedema","volume":"5","author":"Hackett","year":"2004","journal-title":"High Altitude Medicine and Biology"},{"key":"10.1016\/j.tmaid.2010.04.006_bib5","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1242\/jeb.204.18.3161","article-title":"Frontiers of hypoxia research: acute mountain sickness","volume":"204","author":"Roach","year":"2004","journal-title":"J Exp Biol"},{"issue":"2","key":"10.1016\/j.tmaid.2010.04.006_bib6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1580\/1080-6032(1999)010[0097:TCEOHA]2.3.CO;2","article-title":"The cerebral etiology of high-altitude cerebral edema and acute mountain sickness","volume":"10","author":"Hackett","year":"1999","journal-title":"Wilderness Environ Med, Summer"},{"key":"10.1016\/j.tmaid.2010.04.006_bib7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1056\/NEJM196901232800402","article-title":"Acute mountain sickness","volume":"280","author":"Singh","year":"1969","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tmaid.2010.04.006_bib8","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-116-6-461","article-title":"Acetazolamide in the treatment of acute mountain sickness: clinical efficacy and effect on gas exchange","volume":"116","author":"Grissom","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.tmaid.2010.04.006_bib9","doi-asserted-by":"crossref","first-page":"H1485","DOI":"10.1152\/ajpheart.00645.2001","article-title":"Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation","volume":"282","author":"Mark","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"10.1016\/j.tmaid.2010.04.006_bib10","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/sj.jcbfm.9600404","article-title":"Magnetic resonance imaging evidence of cytotoxic cerebral edema in acute mountain sickness","volume":"27","author":"Kallenberg","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.tmaid.2010.04.006_bib11","series-title":"Hypoxia: women at altitude","first-page":"254","article-title":"Cerebral hemodynamics and high altitude cerebral edema","author":"Krasney","year":"1997"},{"issue":"25","key":"10.1016\/j.tmaid.2010.04.006_bib12","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1056\/NEJM198912213212504","article-title":"Dexamethasone in the treatment of acute mountain sickness","volume":"21","author":"Levine","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tmaid.2010.04.006_bib13","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1056\/NEJM197510022931407","article-title":"Brain edema","volume":"293","author":"Fishman","year":"1975","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.tmaid.2010.04.006_bib14","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1054\/jocn.2001.1031","article-title":"Ischaemic brain oedema","volume":"9","author":"Ropper","year":"2002","journal-title":"J Clin Neurosci"},{"issue":"1","key":"10.1016\/j.tmaid.2010.04.006_bib15","doi-asserted-by":"crossref","first-page":"C88","DOI":"10.1152\/ajpcell.00148.2007","article-title":"O\u2032Donnell ME. Hypoxia effects on cell volume and iron uptake of cerebral microvascular endothelial cells","volume":"294","author":"Brillault","year":"2008","journal-title":"Am J Pysiol Cell Physiol"},{"issue":"6","key":"10.1016\/j.tmaid.2010.04.006_bib16","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/BF00602819","article-title":"Sequential changes on 23Na MRI after cerebral infarction","volume":"35","author":"Shimizu","year":"1993","journal-title":"Neuroradiology"},{"issue":"1","key":"10.1016\/j.tmaid.2010.04.006_bib17","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/sj.jcbfm.9600513","article-title":"Hypoxia induced acute mountain sickness is associated with intracellular cerebral edema: a 3T magnetic resonance imaging study","volume":"28","author":"Schoonman","year":"2008","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.tmaid.2010.04.006_bib18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-4615-4711-2_13","article-title":"High altitude headache. Lessons from headaches at sea level","volume":"474","author":"Sanchez del Rio","year":"1999","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"10.1016\/j.tmaid.2010.04.006_bib19","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1089\/1527029041352108","article-title":"Acute mountain sickness: controversies and advances","volume":"5","author":"Bartsch","year":"2004","journal-title":"High Alt Med Biol"},{"issue":"1","key":"10.1016\/j.tmaid.2010.04.006_bib20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.mvr.2007.06.004","article-title":"Reoxygenation stress on blood-brain barrier paracellular permeability and edema in the rat","volume":"75","author":"Witt","year":"2008","journal-title":"Microvasc Res"},{"issue":"2","key":"10.1016\/j.tmaid.2010.04.006_bib21","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1212\/wnl.18.2.127","article-title":"The effects of graded hypoxia upon transient cerebral blood flow\u00a0and oxygen consumption","volume":"18","author":"Shimojyo","year":"1968","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.tmaid.2010.04.006_bib22","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1152\/jappl.1991.71.4.1447","article-title":"Cerebral metabolic and pressure flow responses during sustained hypoxia in awake sheep","volume":"71","author":"Iwamoto","year":"1991","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.tmaid.2010.04.006_bib23","series-title":"Hypoxia: into the next millenium","first-page":"368","article-title":"Can acute mountain sickness be induced by exercise?","author":"Bradwell","year":"1999"},{"issue":"4","key":"10.1016\/j.tmaid.2010.04.006_bib24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/00039899909602485","article-title":"Exercise-induced cerebral deoxygenation among untrained trekkers at moderate\u00a0altitudes","volume":"54","author":"Saito","year":"1999","journal-title":"Arch Environ Health"},{"issue":"2","key":"10.1016\/j.tmaid.2010.04.006_bib25","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1152\/jappl.2000.88.2.581","article-title":"Exercise exacerbates acute mountain sickness at simulated high altitude","volume":"88","author":"Roach","year":"2000","journal-title":"J Appl Physiol"},{"issue":"2","key":"10.1016\/j.tmaid.2010.04.006_bib26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1179\/016164103101201175","article-title":"Noninvasive assessment of cerebral oxygenation during high altitude trekking in the Nepal Himalayas (2850\u20135600\u00a0m)","volume":"25","author":"Hadolt","year":"2003","journal-title":"Neurol Res"},{"key":"10.1016\/j.tmaid.2010.04.006_bib27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1183\/09031936.00.15112300","article-title":"Theophylline improves acute mountain sickness","volume":"15","author":"Fischer","year":"2000","journal-title":"Eur Respir J"},{"issue":"2","key":"10.1016\/j.tmaid.2010.04.006_bib28","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1046\/j.1471-4159.1997.68020874.x","article-title":"Hypoxia dramatically increases the nonspecific transport of blood-borne proteins to the brain","volume":"68","author":"Plateel","year":"1997","journal-title":"J Neurochem"},{"issue":"6","key":"10.1016\/j.tmaid.2010.04.006_bib29","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000179188","article-title":"Microvascular permeability of the isolated rat heart to various solutes in well-oxygenated and\u00a0hypoxic conditions","volume":"16","author":"al-Haboubi","year":"1996","journal-title":"Int J Microcirc Clin Exp"},{"issue":"3","key":"10.1016\/j.tmaid.2010.04.006_bib30","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/cvr\/27.3.384","article-title":"Hypoxia induced disruption of the cardiac endothelial glycocalyx: implications for capillary permeability","volume":"27","author":"Ward","year":"1993","journal-title":"Cardiovasc Res"},{"issue":"11","key":"10.1016\/j.tmaid.2010.04.006_bib31","first-page":"1082","article-title":"Increase in blood\u2013brain barrier permeability by altitude decompression","volume":"58","author":"Chryssanthou","year":"1987","journal-title":"Aviat Space Environ Med"},{"issue":"3","key":"10.1016\/j.tmaid.2010.04.006_bib32","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/1523-1747.ep12286453","article-title":"Hypoxia regulates the expression of vascular permeability factor\/vascular endothelial growth factor (VPF\/VEGF) and its receptors in human skin","volume":"108","author":"Detmar","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.tmaid.2010.04.006_bib33","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1093\/brain\/awf257","article-title":"Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain","volume":"125","author":"Schoch","year":"2002","journal-title":"Brain: a Journal of Neurology"},{"key":"10.1016\/j.tmaid.2010.04.006_bib34","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.rmed.2006.06.014","article-title":"Change in plasma vascular endothelial growth factor during onset and recovery from acute mountain sickness","volume":"101","author":"Dorward","year":"2007","journal-title":"Respir Med"},{"issue":"5","key":"10.1016\/j.tmaid.2010.04.006_bib35","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1152\/japplphysiol.00589.2004","article-title":"Greater\u00a0free plasma VEGF and lower soluble VEGF receptor-1 in acute mountain sickness","volume":"98","author":"Tissot van Patot","year":"2005","journal-title":"J Appl Physiol"},{"issue":"1","key":"10.1016\/j.tmaid.2010.04.006_bib36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/sj.jcbfm.9600169","article-title":"Free radical-mediated damage to barrier function is not associated with altered brain morphology in high-altitude headache","volume":"26","author":"Bailey","year":"2006","journal-title":"J Cereb Blood Flow Metab"}],"container-title":["Travel Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147789391000044X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147789391000044X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:58:59Z","timestamp":1761487139000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147789391000044X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S147789391000044X"],"URL":"https:\/\/doi.org\/10.1016\/j.tmaid.2010.04.006","relation":{},"ISSN":["1477-8939"],"issn-type":[{"value":"1477-8939","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"What role does the blood brain barrier play in acute mountain sickness?","name":"articletitle","label":"Article Title"},{"value":"Travel Medicine and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tmaid.2010.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}