{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:58:08Z","timestamp":1777111088390,"version":"3.51.4"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Liliana Moreno Velasquez"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Travel Medicine and Infectious Disease"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.tmaid.2016.10.013","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T16:16:09Z","timestamp":1478189769000},"page":"52-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Delayed haemolysis secondary to treatment of severe malaria with intravenous artesunate: Report on the experience of a referral centre for tropical infections in Spain"],"prefix":"10.1016","volume":"15","author":[{"given":"Teresa","family":"Ald\u00e1miz-Echevarr\u00eda Lois","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"L\u00f3pez-Pol\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca F.","family":"Norman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Monge-Maillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rogelio","family":"L\u00f3pez-V\u00e9lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose A.","family":"Perez-Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tmaid.2016.10.013_bib1","series-title":"World Health organisation guidelines for the treatment of malaria","year":"2015"},{"key":"10.1016\/j.tmaid.2016.10.013_bib2","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/1475-2875-11-328","article-title":"Management of imported malaria in Europe","volume":"11","author":"Askling","year":"2012","journal-title":"Malar J"},{"key":"10.1016\/j.tmaid.2016.10.013_bib3","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.eimc.2013.12.014","article-title":"Diagn\u00f3stico y tratamiento de la malaria importada en Espa\u00f1a: recomendaciones del Grupo de Trabajo de Malaria de la Sociedad Espa\u00f1ola de Medicina Tropical y Salud Internacional (SEMTSI)","volume":"33","author":"Mu\u00f1oz","year":"2015","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"10.1016\/j.tmaid.2016.10.013_bib4","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0035-9203(01)90104-X","article-title":"A\u00a0meta-analysis using individual patient data of trials comparing artemether with quinine in the treatment of severe falciparum malaria","volume":"95","author":"Artemether-Quinine Meta-analysis Study Group","year":"2001","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.tmaid.2016.10.013_bib5","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(05)67176-0","article-title":"Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial","volume":"366","author":"Dondorp","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.tmaid.2016.10.013_bib6","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/S0140-6736(10)61924-1","article-title":"Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial","volume":"376","author":"Dondorp","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.tmaid.2016.10.013_bib7","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/cid\/civ575","article-title":"Intravenous artesunate reduces parasite clearance time, duration of intensive care, and hospital treatment in patients with severe malaria in Europe: the TropNet severe malaria study","volume":"61","author":"Kurth","year":"2015","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.tmaid.2016.10.013_bib8","series-title":"Prequalification programme: a United Nations programme managed by WHO","author":"World Health Organisation","year":"2010"},{"key":"10.1016\/j.tmaid.2016.10.013_bib9","unstructured":"RARE disease (orphan) designations. Disponible en: http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Brochure\/2011\/03\/WC500104234.pdf."},{"key":"10.1016\/j.tmaid.2016.10.013_bib10","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0140-6736(79)92952-0","article-title":"Cause of anaemia in malaria","volume":"1","author":"Woodruff","year":"1979","journal-title":"Lancet"},{"key":"10.1016\/j.tmaid.2016.10.013_bib11","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/0140-6736(93)92248-R","article-title":"Prolonged haemolytic anaemia in malaria and autoantiboidies against triosephosphate isomerase","volume":"342","author":"Ritter","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.tmaid.2016.10.013_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1475-2875-11-25","article-title":"Comparing changes in haematologic parameters occurring in patients included in randomised controlled trials of artesunate-amodiaquine vs single and combination treatments of uncomplicated falciparum in sub-Saharan Africa","volume":"11","author":"Swang","year":"2012","journal-title":"Malar J"},{"key":"10.1016\/j.tmaid.2016.10.013_bib13","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3201\/eid1705.101229","article-title":"Intravenous artesunate for severe malaria in travellers, Europe","volume":"17","author":"Soller","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.tmaid.2016.10.013_bib14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1182\/blood-2014-02-555953","article-title":"Postartesunate delayed haemolysis is a predictable event related to the lifesaving effect of artemisinins","volume":"124","author":"Jaur\u00e9guiberry","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.tmaid.2016.10.013_bib15","first-page":"753","article-title":"Update on cases of delayed haemolysis after parenteral artesunate therapy for malaria - United States, 2008 and 2013","volume":"63","author":"Pacskowski","year":"2014","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.tmaid.2016.10.013_bib16","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1475-2875-11-102","article-title":"Treatment outcome of intravenous artesunate in patients with severe malaria in the Netherlands and Belgium","volume":"11","author":"Kreeftmeijer-Vegter","year":"2012","journal-title":"Malar J"},{"key":"10.1016\/j.tmaid.2016.10.013_bib17","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1093\/infdis\/jit841","article-title":"Delayed haemolysis after treatment with parenteral artesunate in African children with severe malaria\u2013a double-center prospective study","volume":"209","author":"Rolling","year":"2014","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.tmaid.2016.10.013_bib18","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3201\/eid2105.141171","article-title":"French Artesunate Working Group. Delayed-onset hemolytic anemia in patients with travel-associated severe malaria treated with artesunate, France, 2011-2013","volume":"21","author":"Jaur\u00e9guiberry","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.tmaid.2016.10.013_bib19","unstructured":"Experts Group Meeting on delayed haemolytic anaemia following treatment with injectable artesunate; 19 Mars 2013; Wien, Austria. Disponible en: http:\/\/www.mmv.org\/sites\/default\/files\/uploads\/docs\/events\/2013\/InjectableArtesunateExpertGroupMeeting.pdf."},{"key":"10.1016\/j.tmaid.2016.10.013_bib20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.tox.2012.05.024","article-title":"Dihydroartemisinin inhibits the human erythroid cell differentiation by altering the cell cycle","volume":"300","author":"Finaurini","year":"2012","journal-title":"Toxicology"},{"key":"10.1016\/j.tmaid.2016.10.013_bib21","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.1182\/blood-2010-03-272781","article-title":"Inhibition of erythropoiesis in malaria anemia: role of hemosoin and hemosoingenerated 4-hydroxynonenal","volume":"116","author":"Skorokhod","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.tmaid.2016.10.013_bib22","article-title":"Delayed haemolysis after artesunate therapy in a cohort of patients with severe imported malaria due to Pasmodium falciparum","author":"G\u00f3mes-Junyent","year":"2015","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"10.1016\/j.tmaid.2016.10.013_bib23","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.tmaid.2015.03.003","article-title":"Delayed haemolysis after artesunate treatment of severe malaria - review of the literature and perspective","volume":"13","author":"Rolling","year":"2015","journal-title":"Travel Med Infect Dis"},{"key":"10.1016\/j.tmaid.2016.10.013_bib24","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/1475-2875-12-241","article-title":"Artesunate versus quinine in the treatment of severe imported malaria: comparative analysis of adverse events focussing on delayed haemolysis","volume":"12","author":"Rolling","year":"2013","journal-title":"Malar J"},{"key":"10.1016\/j.tmaid.2016.10.013_bib25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1475-2875-11-91","article-title":"Haemolytic anaemia in an HIV-infected patient with severe falciparum malaria after treatment with oral artemether-lumefantrine","volume":"11","author":"Corpolongo","year":"2012","journal-title":"Malar J"},{"key":"10.1016\/j.tmaid.2016.10.013_bib26","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0140-6736(13)60812-0","article-title":"Artemisinin therapy and severe delayed haemolysis","volume":"382","author":"Jarvis","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.tmaid.2016.10.013_bib27","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12936-015-0760-x","article-title":"Severe falciparum malaria treated with artesunate complicated by delayed onset haemolysis and acute kidney injury","volume":"14","author":"Plewes","year":"2015","journal-title":"Malar J"},{"key":"10.1016\/j.tmaid.2016.10.013_bib28","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.tmaid.2015.03.004","article-title":"Does post-artesunate delayed haemolysis change practice?","volume":"13","author":"Yansouni","year":"2015","journal-title":"Travel Med Infect Dis"}],"container-title":["Travel Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477893916301661?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477893916301661?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:01:39Z","timestamp":1761487299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1477893916301661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":28,"alternative-id":["S1477893916301661"],"URL":"https:\/\/doi.org\/10.1016\/j.tmaid.2016.10.013","relation":{},"ISSN":["1477-8939"],"issn-type":[{"value":"1477-8939","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Delayed haemolysis secondary to treatment of severe malaria with intravenous artesunate: Report on the experience of a referral centre for tropical infections in Spain","name":"articletitle","label":"Article Title"},{"value":"Travel Medicine and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tmaid.2016.10.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}