{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:50:36Z","timestamp":1767916236489,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Travel Medicine and Infectious Disease"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.tmaid.2018.05.002","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T19:21:22Z","timestamp":1526498482000},"page":"44-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Travel-related leptospirosis in the Netherlands 2009\u20132016: An epidemiological report and case series"],"prefix":"10.1016","volume":"24","author":[{"given":"Sophia G.","family":"de Vries","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maud M.I.","family":"Bekedam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin J.","family":"Visser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelis","family":"Stijnis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter P.A.M.","family":"van Thiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mich\u00e8le","family":"van Vugt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Goorhuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri F.P.","family":"Wagenaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin P.","family":"Grobusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marga G.A.","family":"Goris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tmaid.2018.05.002_bib1","series-title":"Human leptospirosis: guidance for diagnosis, surveillance and control","author":"World Health Organization","year":"2003"},{"issue":"2","key":"10.1016\/j.tmaid.2018.05.002_bib2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1128\/CMR.14.2.296-326.2001","volume":"14","author":"Levett","year":"2001","journal-title":"Leptospirosis. Clin Microbiol Rev"},{"issue":"9","key":"10.1016\/j.tmaid.2018.05.002_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003843","article-title":"Environmental and behavioural determinants of leptospirosis transmission: a systematic review","volume":"9","author":"Mwachui","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"10.1016\/j.tmaid.2018.05.002_bib4","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1365-2672.2009.04220.x","article-title":"Leptospirosis: risks during recreational activities","volume":"107","author":"Monahan","year":"2009","journal-title":"J Appl Microbiol"},{"key":"10.1016\/j.tmaid.2018.05.002_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.tmaid.2017.03.010","article-title":"Infections associated with adventure travel: a systematic review","volume":"16","author":"Gundacker","year":"2017","journal-title":"Travel Med Infect Dis"},{"issue":"10","key":"10.1016\/j.tmaid.2018.05.002_bib6","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.trstmh.2010.07.002","article-title":"Climate change, flooding, urbanisation and leptospirosis: fuelling the fire?","volume":"104","author":"Lau","year":"2010","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"9","key":"10.1016\/j.tmaid.2018.05.002_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003898","article-title":"Global morbidity and mortality of leptospirosis: a systematic review","volume":"9","author":"Costa","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"12","key":"10.1016\/j.tmaid.2018.05.002_bib8","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S1473-3099(03)00830-2","article-title":"Leptospirosis: a zoonotic disease of global importance","volume":"3","author":"Bharti","year":"2003","journal-title":"Lancet Infect Dis"},{"issue":"2","key":"10.1016\/j.tmaid.2018.05.002_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004482","article-title":"Early indicators of fatal leptospirosis during the 2010 epidemic in Puerto Rico","volume":"10","author":"Sharp","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"10.1016\/j.tmaid.2018.05.002_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3201\/eid1801.101892","article-title":"Outbreak of leptospirosis after flood, the Philippines, 2009","volume":"18","author":"Amilasan","year":"2012","journal-title":"Emerg Infect Dis"},{"issue":"132","key":"10.1016\/j.tmaid.2018.05.002_bib11","first-page":"2","article-title":"Establishment of valid laboratory case definition for human leptospirosis","volume":"3","author":"Goris","year":"2012","journal-title":"J Bacteriol Parasitol"},{"issue":"9","key":"10.1016\/j.tmaid.2018.05.002_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007093","article-title":"Development and validation of a real-time PCR for detection of pathogenic leptospira species in clinical materials","volume":"4","author":"Ahmed","year":"2009","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.tmaid.2018.05.002_bib13","article-title":"Diagnostic accuracy of real-time PCR assays targeting 16S rRNA and lipL32 genes for human leptospirosis in Thailand: a case-control study","volume":"6","author":"Thaipadungpanit","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.tmaid.2018.05.002_bib14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.tmaid.2009.12.002","article-title":"Leptospirosis: an emerging disease in travellers","volume":"8","author":"Lau","year":"2010","journal-title":"Travel Med Infect Dis"},{"key":"10.1016\/j.tmaid.2018.05.002_bib15","series-title":"UNWTO tourism highlights","year":"2016"},{"issue":"3","key":"10.1016\/j.tmaid.2018.05.002_bib16","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3201\/eid1903.111260","article-title":"Human leptospirosis trends, The Netherlands, 1925-2008","volume":"19","author":"Goris","year":"2013","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"10.1016\/j.tmaid.2018.05.002_bib17","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4269\/ajtmh.12-0551","article-title":"Acute and potentially life-threatening tropical diseases in western travelers\u2013a GeoSentinel multicenter study, 1996-2011","volume":"88","author":"Jensenius","year":"2013","journal-title":"Am J Trop Med Hyg"},{"issue":"7","key":"10.1016\/j.tmaid.2018.05.002_bib18","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.3201\/eid1107.041172","article-title":"Leptospirosis in Germany, 1962-2003","volume":"11","author":"Jansen","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.tmaid.2018.05.002_bib19","series-title":"Trendrapport toerisme, recreatie en vrije tijd 2016","year":"2016"},{"issue":"17","key":"10.1016\/j.tmaid.2018.05.002_bib20","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2016.21.17.30211","article-title":"Marked increase in leptospirosis infections in humans and dogs in The Netherlands, 2014","volume":"21","author":"Pijnacker","year":"2016","journal-title":"Euro Surveill"},{"key":"10.1016\/j.tmaid.2018.05.002_bib21","first-page":"51","article-title":"History of notification [in Dutch]","volume":"4","author":"van Vliet","year":"2009","journal-title":"Tijdschrift voor Infectieziekten"},{"key":"10.1016\/j.tmaid.2018.05.002_bib22","series-title":"LCI-richtlijn leptospirose [guideline for leptospirosis]","author":"National Coordinating Body for Infectious Diseases (LCI)","year":"2011"},{"issue":"10","key":"10.1016\/j.tmaid.2018.05.002_bib23","first-page":"464","article-title":"Suspected leptospiral meningitis in adults: report of four cases and review of the literature","volume":"73","author":"van Samkar","year":"2015","journal-title":"Neth J Med"},{"issue":"5","key":"10.1016\/j.tmaid.2018.05.002_bib24","first-page":"215","article-title":"Severe pulmonary manifestation of leptospirosis","volume":"70","author":"Helmerhorst","year":"2012","journal-title":"Neth J Med"},{"key":"10.1016\/j.tmaid.2018.05.002_bib25","unstructured":"Centraal Bureau voor de Statistiek. Lange vakanties buitenland; bestemmingen naar vakantiekenmerken. Available at: http:\/\/statline.cbs.nl\/Statweb\/publication\/?DM=SLNL&PA=71086NED&D1=a&D2=39-41&D3=a&HDR=T&STB=G1,G2&VW=T. Accessed 26 July 2017."},{"issue":"4","key":"10.1016\/j.tmaid.2018.05.002_bib26","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/jtm.12035","article-title":"Travel-related leptospirosis: a series of 15 imported cases","volume":"20","author":"van de Werve","year":"2013","journal-title":"J Travel Med"},{"issue":"12","key":"10.1016\/j.tmaid.2018.05.002_bib27","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1093\/qjmed\/hcs145","article-title":"Leptospirosis and Weil's disease in the UK","volume":"105","author":"Forbes","year":"2012","journal-title":"Qjm"},{"issue":"3","key":"10.1016\/j.tmaid.2018.05.002_bib28","doi-asserted-by":"crossref","first-page":"459","DOI":"10.4269\/ajtmh.2010.09-0239","article-title":"Travel-related leptospirosis in Israel: a nationwide study","volume":"82","author":"Leshem","year":"2010","journal-title":"Am J Trop Med Hyg"},{"issue":"4","key":"10.1016\/j.tmaid.2018.05.002_bib29","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1469-0691.2011.03474.x","article-title":"Emergence, control and re-emerging leptospirosis: dynamics of infection in the changing world","volume":"17","author":"Hartskeerl","year":"2011","journal-title":"Clin Microbiol Infect"},{"issue":"2","key":"10.1016\/j.tmaid.2018.05.002_bib30","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3201\/eid1702.101109","article-title":"Leptospirosis in Hawaii, USA, 1999-2008","volume":"17","author":"Katz","year":"2011","journal-title":"Emerg Infect Dis"},{"issue":"7","key":"10.1016\/j.tmaid.2018.05.002_bib31","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.881847","article-title":"Electrocardiographic changes in hospitalized patients with leptospirosis over a 10-year period","volume":"17","author":"Skerk","year":"2011","journal-title":"Med Sci Monit"},{"issue":"3","key":"10.1016\/j.tmaid.2018.05.002_bib32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1590\/S0066-782X2002000300002","article-title":"Electrocardiographic alterations in patients hospitalized with leptospirosis in the Brazilian city of Salvador","volume":"78","author":"Sacramento","year":"2002","journal-title":"Arq Bras Cardiol"},{"issue":"9","key":"10.1016\/j.tmaid.2018.05.002_bib33","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.trstmh.2012.06.007","article-title":"Cardiac involvement in leptospirosis","volume":"106","author":"Navinan","year":"2012","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.tmaid.2018.05.002_bib34","first-page":"810","article-title":"On a laboratory Leptospira ballum infection; orchitis as a complication","volume":"91","author":"Kappeler","year":"1961","journal-title":"Schweiz Med Wochenschr"},{"issue":"3","key":"10.1016\/j.tmaid.2018.05.002_bib35","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1001\/archinte.1958.00260150094011","article-title":"Leptospirosis (ballum) contracted from Swiss albino mice","volume":"101","author":"Stoenner","year":"1958","journal-title":"AMA Arch Intern Med"},{"issue":"3","key":"10.1016\/j.tmaid.2018.05.002_bib36","first-page":"163","article-title":"A case of leptospirosis ballum in California","volume":"93","author":"Boak","year":"1960","journal-title":"Calif Med"},{"issue":"6","key":"10.1016\/j.tmaid.2018.05.002_bib37","first-page":"51","article-title":"Leptospirosis ballum contracted from pet mice","volume":"118","author":"Friedmann","year":"1973","journal-title":"Calif Med"},{"issue":"6514","key":"10.1016\/j.tmaid.2018.05.002_bib38","first-page":"174","article-title":"Leptospirosis hardjo epididymitis","volume":"292","author":"Hoghton","year":"1986","journal-title":"Br Med J"},{"issue":"1","key":"10.1016\/j.tmaid.2018.05.002_bib39","first-page":"20","article-title":"Estandarizaci\u00f3n y validaci\u00f3n de una prueba de PCR para el diagn\u00f3stico precoz de Leptospirosis humana","volume":"24","author":"C\u00e9spedes","year":"2007","journal-title":"Rev Peru Med Exp Salud P\u00fablica"}],"container-title":["Travel Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477893918300929?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477893918300929?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:03:34Z","timestamp":1761487414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1477893918300929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":39,"alternative-id":["S1477893918300929"],"URL":"https:\/\/doi.org\/10.1016\/j.tmaid.2018.05.002","relation":{},"ISSN":["1477-8939"],"issn-type":[{"value":"1477-8939","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Travel-related leptospirosis in the Netherlands 2009\u20132016: An epidemiological report and case series","name":"articletitle","label":"Article Title"},{"value":"Travel Medicine and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tmaid.2018.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}