{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:56:28Z","timestamp":1791395788922,"version":"4.3.3"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T00:00:00Z","timestamp":1529280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development","doi-asserted-by":"publisher","award":["205200003"],"award-info":[{"award-number":["205200003"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Travel Medicine and Infectious Disease"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.tmaid.2018.06.005","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T19:11:42Z","timestamp":1529435502000},"page":"87-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Carriage of Blastocystis spp. in travellers - A prospective longitudinal study"],"prefix":"10.1016","volume":"27","author":[{"given":"Jarne M.","family":"van Hattem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maris S.","family":"Arcilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Schultsz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin C.","family":"Bootsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nienke","family":"Verhaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjoerd P.","family":"Rebers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Goorhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin P.","family":"Grobusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Penders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno D.","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"van Gool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldert","family":"Bart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry J.","family":"van Genderen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian C.","family":"Melles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicky","family":"Molhoek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid M.","family":"Oude Lashof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen E.","family":"Stobberingh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri A.","family":"Verbrugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.tmaid.2018.06.005_bib1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1128\/CMR.00022-08","article-title":"New insights on classification, identification, and clinical relevance of Blastocystis spp","volume":"21","author":"Tan","year":"2008","journal-title":"Clin Microbiol Rev"},{"issue":"3","key":"10.1016\/j.tmaid.2018.06.005_bib2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1017\/S0950268815001697","article-title":"Molecular epidemiology and genetic diversity of Blastocystis infection in humans in Italy","volume":"144","author":"Mattiucci","year":"2016","journal-title":"Epidemiol Infect"},{"issue":"6 Pt B","key":"10.1016\/j.tmaid.2018.06.005_bib3","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.parint.2016.04.004","article-title":"Blastocystis phylogeny among various isolates from humans to insects","volume":"65","author":"Yoshikawa","year":"2016","journal-title":"Parasitol Int"},{"key":"10.1016\/j.tmaid.2018.06.005_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2016.05.015","article-title":"Current status of Blastocystis: a personal view","author":"Stensvold","year":"2016","journal-title":"Parasitol Int"},{"issue":"4","key":"10.1016\/j.tmaid.2018.06.005_bib5","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.protis.2013.05.003","article-title":"Genetic diversity of blastocystis in livestock and zoo animals","volume":"164","author":"Alfellani","year":"2013","journal-title":"Protist"},{"issue":"4","key":"10.1016\/j.tmaid.2018.06.005_bib6","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1128\/CMR.9.4.563","article-title":"Blastocystis hominis revisited","volume":"9","author":"Stenzel","year":"1996","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"10.1016\/j.tmaid.2018.06.005_bib7","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/MOG.0000000000000135","article-title":"The intestinal protozoa: emerging impact on global health and development","volume":"31","author":"Turkeltaub","year":"2015","journal-title":"Curr Opin Gastroenterol"},{"issue":"3\u20134","key":"10.1016\/j.tmaid.2018.06.005_bib8","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.vetpar.2014.04.006","article-title":"Molecular epidemiology of Blastocystis in pigs and their in-contact humans in Southeast Queensland, Australia, and Cambodia","volume":"203","author":"Wang","year":"2014","journal-title":"Vet Parasitol"},{"issue":"1\u20132","key":"10.1016\/j.tmaid.2018.06.005_bib9","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.vetpar.2009.12.032","article-title":"Molecular characterization of Blastocystis isolates from zoo animals and their animal-keepers","volume":"169","author":"Parkar","year":"2010","journal-title":"Vet Parasitol"},{"issue":"Pt 3","key":"10.1016\/j.tmaid.2018.06.005_bib10","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1017\/S0031182006001582","article-title":"Direct characterization of Blastocystis from faeces by PCR and evidence of zoonotic potential","volume":"134","author":"Parkar","year":"2007","journal-title":"Parasitology"},{"issue":"8740","key":"10.1016\/j.tmaid.2018.06.005_bib11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0140-6736(91)91301-A","article-title":"Blastocystis hominis: Commensal or pathogen?","volume":"337","year":"1991","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.tmaid.2018.06.005_bib12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/clinids\/21.1.97","article-title":"Is Blastocystis hominis a cause of diarrhea in travelers? A prospective controlled study in Nepal","volume":"21","author":"Shlim","year":"1995","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.tmaid.2018.06.005_bib13","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/clinids\/21.1.104","article-title":"Is there any reason to continue treating Blastocystis infections?","volume":"21","author":"Markell","year":"1995","journal-title":"Clin Infect Dis"},{"issue":"12","key":"10.1016\/j.tmaid.2018.06.005_bib14","first-page":"1543","article-title":"Questionable clinical significance of Blastocystis hominis infection","volume":"84","author":"Sun","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.tmaid.2018.06.005_bib15","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1186\/1471-2334-13-389","article-title":"Diagnosis and subtype analysis of Blastocystis sp. in 442 patients in a hospital setting in The Netherlands","volume":"13","author":"Bart","year":"2013","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.tmaid.2018.06.005_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2016.01.010","article-title":"Eradication of Blastocystis in humans: really necessary for all?","author":"Kurt","year":"2016","journal-title":"Parasitol Int"},{"key":"10.1016\/j.tmaid.2018.06.005_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.tmaid.2017.08.003","article-title":"Travel-related acquisition of diarrhoeagenic bacteria, enteral viruses and parasites in a prospective cohort of 98 Dutch travellers","volume":"19","author":"van Hattem","year":"2017","journal-title":"Trav Med Infect Dis"},{"issue":"8","key":"10.1016\/j.tmaid.2018.06.005_bib18","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1111\/j.1469-0691.2010.03414.x","article-title":"Controlled study on enteropathogens in travellers returning from the tropics with and without diarrhoea","volume":"17","author":"Paschke","year":"2011","journal-title":"Clin Microbiol Infect"},{"issue":"1","key":"10.1016\/j.tmaid.2018.06.005_bib19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0163-4453(97)91025-2","article-title":"The role of Blastocystis hominis as a possible intestinal pathogen in travellers","volume":"35","author":"Jelinek","year":"1997","journal-title":"J Infect"},{"issue":"1","key":"10.1016\/j.tmaid.2018.06.005_bib20","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S1473-3099(16)30319-X","article-title":"Import and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae by international travellers (COMBAT study): a prospective, multicentre cohort study","volume":"17","author":"Arcilla","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.tmaid.2018.06.005_bib21","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1186\/1471-2458-14-410","article-title":"The Carriage of Multiresistant Bacteria after Travel (COMBAT) prospective cohort study: methodology and design","volume":"14","author":"Arcilla","year":"2014","journal-title":"BMC Publ Health"},{"issue":"4","key":"10.1016\/j.tmaid.2018.06.005_bib22","first-page":"519","article-title":"Epidemiological and diagnostic features of blastocystis infection in symptomatic patients in izmir province","volume":"9","author":"Dagci","year":"2014","journal-title":"Turkey. Iran J Parasitol"},{"issue":"12","key":"10.1016\/j.tmaid.2018.06.005_bib23","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/molbev\/mst197","article-title":"MEGA6: molecular evolutionary genetics analysis version 6.0","volume":"30","author":"Tamura","year":"2013","journal-title":"Mol Biol Evol"},{"issue":"3","key":"10.1016\/j.tmaid.2018.06.005_bib24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.pt.2007.01.004","article-title":"Terminology for Blastocystis subtypes\u2013a consensus","volume":"23","author":"Stensvold","year":"2007","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.tmaid.2018.06.005_bib25","series-title":"MedCalc statistical software version 16.4.3 (MedCalc software bvba, Ostend, Belgium","year":"2016"},{"issue":"5","key":"10.1016\/j.tmaid.2018.06.005_bib26","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s10096-015-2312-2","article-title":"Low prevalence of Blastocystis sp. in active ulcerative colitis patients","volume":"34","author":"Rossen","year":"2015","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"4","key":"10.1016\/j.tmaid.2018.06.005_bib27","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ijpara.2008.07.006","article-title":"Subtype distribution of Blastocystis isolates from synanthropic and zoo animals and identification of a new subtype","volume":"39","author":"Stensvold","year":"2009","journal-title":"Int J Parasitol"},{"issue":"1","key":"10.1016\/j.tmaid.2018.06.005_bib28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00436-003-0995-2","article-title":"Polymerase chain reaction-based genotype classification among human Blastocystis hominis populations isolated from different countries","volume":"92","author":"Yoshikawa","year":"2004","journal-title":"Parasitol Res"},{"issue":"1","key":"10.1016\/j.tmaid.2018.06.005_bib29","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1128\/JCM.43.1.348-355.2005","article-title":"Molecular phylogenies of Blastocystis isolates from different hosts: implications for genetic diversity, identification of species, and zoonosis","volume":"43","author":"Noel","year":"2005","journal-title":"J Clin Microbiol"},{"issue":"1","key":"10.1016\/j.tmaid.2018.06.005_bib30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.protis.2005.12.001","article-title":"DNA barcoding of blastocystis","volume":"157","author":"Scicluna","year":"2006","journal-title":"Protist"},{"issue":"2","key":"10.1016\/j.tmaid.2018.06.005_bib31","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1080\/19490976.2015.1019693","article-title":"Characterization of the human gut microbiome during travelers' diarrhea","volume":"6","author":"Youmans","year":"2015","journal-title":"Gut Microb"},{"issue":"5","key":"10.1016\/j.tmaid.2018.06.005_bib32","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.pt.2018.02.004","article-title":"Associations between gut microbiota and common luminal intestinal parasites","volume":"34","author":"Stensvold","year":"2018","journal-title":"Trends Parasitol"},{"issue":"2","key":"10.1016\/j.tmaid.2018.06.005_bib33","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s004360050528","article-title":"Irregular shedding of Blastocystis hominis","volume":"85","author":"Vennila","year":"1999","journal-title":"Parasitol Res"},{"issue":"3","key":"10.1016\/j.tmaid.2018.06.005_bib34","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00436-010-2095-4","article-title":"Clinical efficacy of Saccharomyces boulardii or metronidazole in symptomatic children with Blastocystis hominis infection","volume":"108","author":"Dinleyici","year":"2011","journal-title":"Parasitol Res"},{"issue":"5","key":"10.1016\/j.tmaid.2018.06.005_bib35","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/MPG.0b013e31823a29a7","article-title":"No advantage for antibiotic treatment over placebo in Blastocystis hominis-positive children with recurrent abdominal pain","volume":"54","author":"Heyland","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"1","key":"10.1016\/j.tmaid.2018.06.005_bib36","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/1574-6941.12396","article-title":"The microbial eukaryote Blastocystis is a prevalent and diverse member of the healthy human gut microbiota","volume":"90","author":"Scanlan","year":"2014","journal-title":"FEMS Microbiol Ecol"}],"container-title":["Travel Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477893918301388?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477893918301388?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:03:27Z","timestamp":1761487407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1477893918301388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":36,"alternative-id":["S1477893918301388"],"URL":"https:\/\/doi.org\/10.1016\/j.tmaid.2018.06.005","relation":{},"ISSN":["1477-8939"],"issn-type":[{"value":"1477-8939","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carriage of Blastocystis spp. in travellers - A prospective longitudinal study","name":"articletitle","label":"Article Title"},{"value":"Travel Medicine and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tmaid.2018.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}