{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:38:29Z","timestamp":1791434309695,"version":"4.3.3"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T00:00:00Z","timestamp":1613779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006447","name":"Universit\u00e4t Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Travel Medicine and Infectious Disease"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.tmaid.2021.101995","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T20:29:55Z","timestamp":1614025795000},"page":"101995","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":135,"special_numbering":"C","title":["COVID-19 sequelae in adults aged less than 50 years: A systematic review"],"prefix":"10.1016","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9754-620X","authenticated-orcid":false,"given":"Sandra","family":"Willi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"L\u00fcthold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8923-5812","authenticated-orcid":false,"given":"Adam","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadescha Viviane","family":"H\u00e4nggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donik\u00eb","family":"Sejdiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7546-9538","authenticated-orcid":false,"given":"Camila","family":"Scaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3838-587X","authenticated-orcid":false,"given":"Nicole","family":"Bender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3951-1807","authenticated-orcid":false,"given":"Kaspar","family":"Staub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Schlagenhauf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tmaid.2021.101995_bib1","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1001\/jama.2020.17709","article-title":"As their numbers grow, COVID-19 \u201clong haulers\u201d stump experts","volume":"324","author":"Rubin","year":"2020","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.tmaid.2021.101995_bib2","series-title":"Covidence systematic review software","author":"Veritas Health Innovation","year":"2020"},{"key":"10.1016\/j.tmaid.2021.101995_bib3","author":"World Health Organization"},{"key":"10.1016\/j.tmaid.2021.101995_bib4","series-title":"The newcastle\u2013ottawa Scale (NOS) for assessing the quality of non-randomized studies in meta-analysis","author":"Wells","year":"2000"},{"key":"10.1016\/j.tmaid.2021.101995_bib5","author":"JAMA"},{"key":"10.1016\/j.tmaid.2021.101995_bib6","doi-asserted-by":"crossref","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"151","author":"Moher","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.tmaid.2021.101995_bib7","article-title":"Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: a cross-sectional evaluation","author":"Halpin","year":"2020","journal-title":"J Med Virol"},{"key":"10.1016\/j.tmaid.2021.101995_bib8","article-title":"Post-discharge health status and symptoms in patients with severe COVID-19","author":"Weerahandi","year":"2020","journal-title":"MedRxiv Prepr Serv Heal Sci"},{"key":"10.1016\/j.tmaid.2021.101995_bib9","author":"Townsend"},{"key":"10.1016\/j.tmaid.2021.101995_bib10","article-title":"Patient outcomes after hospitalisation with COVID-19 and implications for follow-up; results from a prospective UK cohort","author":"Arnold","year":"2020","journal-title":"MedRxiv"},{"key":"10.1016\/j.tmaid.2021.101995_bib11","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/jama.2020.12603","article-title":"Group for the GAC-19 P-ACS. Persistent symptoms in patients after acute COVID-19","volume":"324","author":"Carf\u00ec","year":"2020","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.tmaid.2021.101995_bib12","doi-asserted-by":"crossref","DOI":"10.15585\/mmwr.mm6930e1","article-title":"Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network \u2014 United States, March\u2013June 2020","volume":"69","author":"Tenforde","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.tmaid.2021.101995_bib13","article-title":"Post-COVID-19 Functional Status: relation to age, smoking, hospitalization and comorbidities","author":"Mohamed-Hussein","year":"2020","journal-title":"MedRxiv"},{"key":"10.1016\/j.tmaid.2021.101995_bib14","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2020.25.36.2001542","article-title":"Reduced maximal aerobic capacity after COVID-19 in young adult recruits, Switzerland","volume":"25","author":"Crameri","year":"2020","journal-title":"Euro Surveill"},{"key":"10.1016\/j.tmaid.2021.101995_bib15","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01754-2020","article-title":"Functional characteristics of patients with SARS-CoV-2 pneumonia at 30\u2005days post-infection","volume":"56","author":"Frija-Masson","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.tmaid.2021.101995_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2020.100463","article-title":"Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery","volume":"25","author":"Zhao","year":"2020","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.tmaid.2021.101995_bib17","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3233\/XST-200685","article-title":"Analysis of thin-section CT in patients with coronavirus disease (COVID-19) after hospital discharge","volume":"28","author":"Wei","year":"2020","journal-title":"J X Ray Sci Technol"},{"key":"10.1016\/j.tmaid.2021.101995_bib18","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3348\/kjr.2020.0215","article-title":"Prediction of the development of pulmonary fibrosis using serial thin-section CT and clinical features in patients discharged after treatment for COVID-19 pneumonia","volume":"21","author":"Yu","year":"2020","journal-title":"Korean J Radiol"},{"key":"10.1016\/j.tmaid.2021.101995_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2020.109121","article-title":"Preliminary detection of lung hypoperfusion in discharged Covid-19 patients during recovery","volume":"129","author":"Patelli","year":"2020","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.tmaid.2021.101995_bib20","doi-asserted-by":"crossref","first-page":"e150","DOI":"10.1016\/j.jinf.2020.06.003","article-title":"Anormal pulmonary function and residual CT abnormalities in rehabilitating COVID-19 patients after discharge","volume":"81","author":"You","year":"2020","journal-title":"J Infect"},{"key":"10.1016\/j.tmaid.2021.101995_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.idcr.2020.e00868","article-title":"Spontaneous pneumothorax following COVID-19 pneumonia","volume":"21","author":"Hollingshead","year":"2020","journal-title":"IDCases"},{"key":"10.1016\/j.tmaid.2021.101995_bib22","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12931-020-01385-1","article-title":"The pulmonary sequalae in discharged patients with COVID-19: a short-term observational study","volume":"21","author":"Liu","year":"2020","journal-title":"Respir Res"},{"key":"10.1016\/j.tmaid.2021.101995_bib23","article-title":"Persisting pulmonary impairment following severe SARS-CoV-2 infection, preliminary results from the CovILD study","volume":"7","author":"Sahanic","year":"2020","journal-title":"Cover. COVID \u2013 Best Abstr"},{"key":"10.1016\/j.tmaid.2021.101995_bib24","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-020-01429-6","article-title":"Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase","author":"Huang","year":"2020","journal-title":"Respir Res"},{"key":"10.1016\/j.tmaid.2021.101995_bib25","article-title":"Pericarditis and myocarditis long after SARS-CoV-2 infection: a cross-sectional descriptive study in health-care workers","author":"Eiros","year":"2020","journal-title":"MedRxiv"},{"key":"10.1016\/j.tmaid.2021.101995_bib26","doi-asserted-by":"crossref","DOI":"10.1001\/jamacardio.2020.3557","article-title":"Outcomes of cardiovascular magnetic resonance imaging in patients recently recovered from coronavirus disease 2019 (COVID-19)","author":"Puntmann","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.tmaid.2021.101995_bib27","doi-asserted-by":"crossref","DOI":"10.1001\/jamacardio.2020.4916","article-title":"Cardiovascular magnetic resonance findings in competitive athletes recovering from COVID-19 infection","author":"Rajpal","year":"2020","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.tmaid.2021.101995_bib28","doi-asserted-by":"crossref","first-page":"e624","DOI":"10.1016\/S2352-3026(20)30175-7","article-title":"Sudden severe thrombocytopenia in a patient in the recovery stage of COVID-19","volume":"7","author":"Chen","year":"2020","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.tmaid.2021.101995_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2020.100484","article-title":"Cerebral micro-structural changes in COVID-19 patients \u2013 an MRI-based 3-month follow-up study: a brief title: cerebral changes in COVID-19","volume":"25","author":"Lu","year":"2020","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.tmaid.2021.101995_bib30","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s11739-020-02418-9","article-title":"Bilateral lower limb weakness: a cerebrovascular consequence of covid-19 or a complication associated with it?","volume":"15","author":"Morjaria","year":"2020","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.tmaid.2021.101995_bib31","article-title":"Bidirectional associations between COVID-19 and psychiatric disorder: a study of 62,354 COVID-19 cases","author":"Taquet","year":"2020","journal-title":"MedRxiv"},{"key":"10.1016\/j.tmaid.2021.101995_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2020.07.037","article-title":"Anxiety and depression in COVID-19 survivors: role of inflammatory and clinical predictors","author":"Mazza","year":"2020","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.tmaid.2021.101995_bib33","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1177\/1945892420930954","article-title":"Prevalence and recovery from olfactory and gustatory dysfunctions in covid-19 infection: a prospective multicenter study","volume":"34","author":"Chary","year":"2020","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.tmaid.2021.101995_bib34","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.bjorl.2020.05.001","article-title":"Incomplete and late recovery of sudden olfactory dysfunction in COVID-19","volume":"86","author":"Kosugi","year":"2020","journal-title":"Braz J Otorhinolaryngol"},{"key":"10.1016\/j.tmaid.2021.101995_bib35","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1007\/s00405-020-05965-1","article-title":"Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study","volume":"277","author":"Lechien","year":"2020","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"key":"10.1016\/j.tmaid.2021.101995_bib36","article-title":"Subacute thyroiditis in a patient infected with SARS-COV-2: an endocrine complication linked to the COVID-19 pandemic","author":"Ruggeri","year":"2020","journal-title":"Hormones"},{"key":"10.1016\/j.tmaid.2021.101995_bib37","first-page":"105","article-title":"Subacute thyroiditis after sars-COV-2 infection","author":"Brancatella","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.tmaid.2021.101995_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.00229","article-title":"SARS-CoV-2 dissemination through peripheral nerves explains multiple organ injury","volume":"14","author":"Fenrich","year":"2020","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.tmaid.2021.101995_bib39","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.2217\/fon-2020-0300","article-title":"Clinical sequelae of the novel coronavirus: does COVID-19 infection predispose patients to cancer?","volume":"16","author":"Hays","year":"2020","journal-title":"Future Oncol"},{"key":"10.1016\/j.tmaid.2021.101995_bib40","series-title":"Report of the WHO-China joint mission on coronavirus disease 2019 (COVID-19)","author":"World Health Organization","year":"2020"},{"key":"10.1016\/j.tmaid.2021.101995_bib41","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/21641846.2020.1778227","article-title":"Post-viral fatigue and COVID-19: lessons from past epidemics","volume":"8","author":"Islam","year":"2020","journal-title":"Fatigue Biomed Heal Behav"},{"key":"10.1016\/j.tmaid.2021.101995_bib42","article-title":"COVID-19 after effects: concerns for singers","author":"Helding","year":"2020","journal-title":"J Voice"},{"key":"10.1016\/j.tmaid.2021.101995_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.hrthm.2020.06.026","article-title":"COVID-19 cardiac injury: implications for long-term surveillance and outcomes in survivors","author":"Mitrani","year":"2020","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.tmaid.2021.101995_bib44","article-title":"COVID-19: dealing with a potential risk factor for chronic neurological disorders","author":"Schirinzi","year":"2020","journal-title":"J Neurol"},{"key":"10.1016\/j.tmaid.2021.101995_bib45","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1111\/ene.14329","article-title":"Neurological manifestations and neuro-invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2","volume":"27","author":"Vonck","year":"2020","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.tmaid.2021.101995_bib46","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1007\/s10072-020-04575-3","article-title":"Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients","volume":"41","author":"Yachou","year":"2020","journal-title":"Neurol Sci"},{"key":"10.1016\/j.tmaid.2021.101995_bib47","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S2215-0366(20)30203-0","article-title":"Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic","volume":"7","author":"Rogers","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.tmaid.2021.101995_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.wjorl.2020.05.004","article-title":"Is SARS-CoV-2 (COVID-19) postviral olfactory dysfunction (PVOD) different from other PVOD?","author":"Imam","year":"2020","journal-title":"World J Otorhinolaryngol Head Neck Surg"},{"key":"10.1016\/j.tmaid.2021.101995_bib49","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s12020-020-02349-7","article-title":"Possible long-term endocrine-metabolic complications in COVID-19: lesson from the SARS model","volume":"68","author":"Mongio\u00ec","year":"2020","journal-title":"Endocrine"},{"key":"10.1016\/j.tmaid.2021.101995_bib50","article-title":"SARS-CoV-2 and male infertility: possible multifaceted pathology","author":"Dutta","year":"2020","journal-title":"Reprod Sci"}],"container-title":["Travel Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477893921000363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477893921000363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:06:18Z","timestamp":1761487578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1477893921000363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":50,"alternative-id":["S1477893921000363"],"URL":"https:\/\/doi.org\/10.1016\/j.tmaid.2021.101995","relation":{},"ISSN":["1477-8939"],"issn-type":[{"value":"1477-8939","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"COVID-19 sequelae in adults aged less than 50 years: A systematic review","name":"articletitle","label":"Article Title"},{"value":"Travel Medicine and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tmaid.2021.101995","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101995"}}