{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:46:00Z","timestamp":1787856360622,"version":"build-2784847793"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD16\/0027\/0020"],"award-info":[{"award-number":["RD16\/0027\/0020"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Travel Medicine and Infectious Disease"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.tmaid.2022.102286","type":"journal-article","created":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T02:10:20Z","timestamp":1645841420000},"page":"102286","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Imported fascioliasis in Spain: Report of 12 cases from the +REDIVI collaborative network (2009\u20132019)"],"prefix":"10.1016","volume":"47","author":[{"given":"Diego","family":"Torr\u00fas-Tendero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6501-9867","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Ramos-Rinc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0546-1354","authenticated-orcid":false,"given":"Fernando","family":"Salvador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9125-7706","authenticated-orcid":false,"given":"Jara","family":"Llenas-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Arsuaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Crespillo-And\u00fajar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8735-4124","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"P\u00e9rez-Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tmaid.2022.102286_bib1","first-page":"141","article-title":"Fasciola, lymnaeids and human fasciolosis, with a global overview on disease transmission, epidemiology, evolutionary genetics, molecular epidemiology and control","volume":"69","author":"Mas-Coma","year":"2009","journal-title":"Adv Parasitol"},{"issue":"13","key":"10.1016\/j.tmaid.2022.102286_bib2","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1017\/S0031182018000914","article-title":"Human fascioliasis infection sources, their diversity, incidence factors, analytical methods and prevention measures","volume":"145","author":"Mas-Coma","year":"2018","journal-title":"Parasitology"},{"key":"10.1016\/j.tmaid.2022.102286_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0001-706X(97)00669-4","article-title":"Presence of very high prevalence and intensity of infection with Fasciola hepatica among Aymara children from the Northern Bolivian Altiplano","volume":"66","author":"Esteban","year":"1997","journal-title":"Acta Trop"},{"key":"10.1016\/j.tmaid.2022.102286_bib4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0035-9203(99)90289-4","article-title":"High endemicity of human fascioliasis between lake Titicaca and La Paz valley, Bolivia","volume":"93","author":"Esteban","year":"1999","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"6 Pt A","key":"10.1016\/j.tmaid.2022.102286_bib5","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.tmaid.2014.09.006","article-title":"Fascioliasis: a worldwide parasitic disease of importance in travel medicine","volume":"12","author":"Ashrafi","year":"2014","journal-title":"Trav Med Infect Dis"},{"key":"10.1016\/j.tmaid.2022.102286_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.tmaid.2017.09.001","article-title":"Helminthic infections in returning travelers and migrants with eosinophilia: diagnostic value of medical history, eosinophil count and IgE","volume":"20","author":"Salzer","year":"2017","journal-title":"Trav Med Infect Dis"},{"key":"10.1016\/j.tmaid.2022.102286_bib7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1079\/JOH2005296","article-title":"Epidemiology of fascioliasis in human endemic areas","volume":"79","author":"Mas-Coma","year":"2005","journal-title":"Journal of Helmintology"},{"key":"10.1016\/j.tmaid.2022.102286_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/00005792-199501000-00002","article-title":"Fascioliasis in developed countries: a review of classic and aberrant forms of the disease","volume":"74","author":"Arjona","year":"1995","journal-title":"Medicine"},{"key":"10.1016\/j.tmaid.2022.102286_bib9","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0210-5705(01)70204-X","article-title":"Fascioliasis hepatobiliar. Estudio de una serie de 37 pacientes","volume":"24","author":"Cosme","year":"2001","journal-title":"Gastroenterol Hepatol"},{"key":"10.1016\/j.tmaid.2022.102286_bib10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.eimc.2019.08.004","article-title":"Incidencia y distribuci\u00f3n geogr\u00e1fica de pacientes hospitalizados con fascioliasis en Espa\u00f1a","volume":"38","author":"Guerrero-Espejo","year":"2020","journal-title":"Enferm Infecc Microbiol Cl\u00edn"},{"key":"10.1016\/j.tmaid.2022.102286_bib11","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/tax035","article-title":"6-year review of +Redivi: a prospective registry of imported infectious diseases in Spain","volume":"24","author":"P\u00e9rez-Molina","year":"2017","journal-title":"J Trav Med"},{"key":"10.1016\/j.tmaid.2022.102286_bib12","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/tay139","article-title":"Sentinel surveillance in travel medicine: 20 years of Geosentinel Publications (1999-2018)","volume":"25","author":"Wilder-Smith","year":"2018","journal-title":"J Trav Med"},{"key":"10.1016\/j.tmaid.2022.102286_bib13","doi-asserted-by":"crossref","first-page":"824","DOI":"10.2214\/AJR.07.2127","article-title":"Hepatobiliary fascioliasis: sonographic and CT findings in 87 patients during the initial phase and long-term follow-up","volume":"189","author":"Kabaalioglu","year":"2007","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.tmaid.2022.102286_bib14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00330-002-1470-7","article-title":"Human fascioliasis: MR imaging findings of hepatic lesions","volume":"13","author":"Cevikol","year":"2003","journal-title":"Eur Radiol"},{"key":"10.1016\/j.tmaid.2022.102286_bib15","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/QCO.0b013e3283567b7e","article-title":"New developments in epidemiology, diagnosis, and treatment of fascioliasis","volume":"25","author":"Cabada","year":"2012","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.tmaid.2022.102286_bib16","first-page":"13","article-title":"Fasciola hepatica infection in a 65 year-old woman","volume":"4","author":"Bernard","year":"2010","journal-title":"Gastrointest Radiol"},{"key":"10.1016\/j.tmaid.2022.102286_bib17","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.cgh.2012.02.013","article-title":"The variable presentations and broadening geographic distribution of hepatic fascioliasis","volume":"10","author":"Rowan","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.tmaid.2022.102286_bib18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/jtm.12205","article-title":"Fasciola hepatica in a German traveler returning from Thailand","volume":"22","author":"Salzer","year":"2015","journal-title":"J Trav Med"},{"key":"10.1016\/j.tmaid.2022.102286_bib19","doi-asserted-by":"crossref","first-page":"186","DOI":"10.5694\/mja15.00010","article-title":"Fascioliasis in Australian travellers to bali","volume":"203","author":"Figtree","year":"2015","journal-title":"Med J Aust"},{"key":"10.1016\/j.tmaid.2022.102286_bib20","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1007\/s11605-017-3477-z","article-title":"Fasciola hepatica-a \"diver\" in the biliary tree","volume":"21","author":"Martins","year":"2017","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.tmaid.2022.102286_bib21","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/tay012","article-title":"Prolonged antibiotic use leading to Clostridium difficile colitis in an ill returned traveller with acute fascioliasis","volume":"25","author":"Kain","year":"2018","journal-title":"J Trav Med"},{"key":"10.1016\/j.tmaid.2022.102286_bib22","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/tropej\/fmz043","article-title":"A case of fasciolosis in a 11-year-old Syrian immigrant boy","volume":"66","author":"Velev","year":"2020","journal-title":"J Trop Pediatr"},{"key":"10.1016\/j.tmaid.2022.102286_bib23","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4269\/ajtmh.19-0671","article-title":"Case report: first molecular diagnosis of liver abscesses due to Fasciola hepatica acute infection imported from vietnam","volume":"102","author":"L'Ollivier","year":"2020","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.tmaid.2022.102286_bib24","first-page":"389","article-title":"La Infecci\u00f3n por Fasciola hepatica en el Per\u00fa: una Enfermedad Emergente","volume":"27","author":"Marcos","year":"2007","journal-title":"Rev Gastroenterol Peru"},{"key":"10.1016\/j.tmaid.2022.102286_bib25","doi-asserted-by":"crossref","first-page":"749","DOI":"10.4269\/ajtmh.1999.60.749","article-title":"Short report: immunodiagnosis of human fascioliasis using recombinant Fasciola hepatica cathepsin L1 cysteine proteinase","volume":"60","author":"O'Neill","year":"1999","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.tmaid.2022.102286_bib26","first-page":"158","article-title":"Fas2-ELISA y la T\u00e9cnica de Sedimentaci\u00f3n R\u00e1pida de Lumbreras en el diagn\u00f3stico de la infecci\u00f3n por Fasciola hepatica","volume":"13","author":"Maco","year":"2002","journal-title":"Rev M\u00e9d Hered"},{"key":"10.1016\/j.tmaid.2022.102286_bib27","doi-asserted-by":"crossref","first-page":"977","DOI":"10.4269\/ajtmh.2007.76.977","article-title":"Evaluation of Fas2-ELISA for the serological detection of Fasciola hepatica infection in humans","volume":"76","author":"Espinoza","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.tmaid.2022.102286_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002414","article-title":"The diagnosis of human fascioliasis by enzyme-linked immunosorbent assay (ELISA) using recombinant cathepsin L protease","volume":"7","author":"Gonzales Santana","year":"2013","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.tmaid.2022.102286_bib29","doi-asserted-by":"crossref","first-page":"852","DOI":"10.4269\/ajtmh.16-0253","article-title":"Development of two FhSAP2 recombinant-based assays for immunodiagnosis of human chronic fascioliasis","volume":"95","author":"Shin","year":"2016","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.tmaid.2022.102286_bib30","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4269\/ajtmh.2008.78.222","article-title":"Natural history, clinicoradiologic correlates, and response to triclabendazole in acute massive fascioliasis","volume":"78","author":"Marcos","year":"2008","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.tmaid.2022.102286_bib31","first-page":"206","article-title":"MRI findings of hepatobiliairy fascioliasis","volume":"91","author":"Vanheste","year":"2008","journal-title":"J Belg Radiol"},{"key":"10.1016\/j.tmaid.2022.102286_bib32","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.7863\/ultra.33.12.2105","article-title":"Sonographic findings of hepatobiliary fascioliasis accompanied by extrahepatic expansion and ectopic lesions","volume":"33","author":"Teke","year":"2014","journal-title":"J Ultrasound Med"},{"key":"10.1016\/j.tmaid.2022.102286_bib33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.clinimag.2015.11.002","article-title":"CT findings of human Fasciola hepatica infection: case reports and review of the literature","volume":"40","author":"Patel","year":"2016","journal-title":"Clin Imag"},{"key":"10.1016\/j.tmaid.2022.102286_bib34","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1556\/EuJMI.1.2011.1.10","article-title":"Imported parasitic infections in Serbia","volume":"1","author":"Daki\u0107","year":"2011","journal-title":"Eur J Microbiol Immunol"},{"key":"10.1016\/j.tmaid.2022.102286_bib35","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.4269\/ajtmh.20-0139","article-title":"Early postnatal and preschool age infection by Fasciola spp.: report of five cases from Vietnam and worldwide review","volume":"103","author":"Van De","year":"2020","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.tmaid.2022.102286_bib36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.actatropica.2015.12.023","article-title":"Epidemiological analysis of human fascioliasis in northeastern Punjab, Pakistan","volume":"156","author":"Qureshi","year":"2016","journal-title":"Acta Trop"},{"key":"10.1016\/j.tmaid.2022.102286_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/B978-0-12-800099-1.00002-8","article-title":"Neurological and ocular fascioliasis in humans","volume":"84","author":"Mas-Coma","year":"2014","journal-title":"Adv Parasitol"},{"key":"10.1016\/j.tmaid.2022.102286_bib38","first-page":"268","article-title":"Comportamiento cl\u00ednico-terap\u00e9utico de Fasciola hepatica en una serie de 87 pacientes","volume":"63","author":"Garc\u00e9s","year":"2011","journal-title":"Rev Cubana Med Trop"},{"key":"10.1016\/j.tmaid.2022.102286_bib39","first-page":"271","article-title":"Evaluation of circulating Fasciola antigens in specific diagnosis of fascioliasis","volume":"31","author":"Hassam","year":"2001","journal-title":"J Egypt Soc Parasitol"},{"key":"10.1016\/j.tmaid.2022.102286_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001812","article-title":"Field evaluation of a coproantigen detection test for fascioliasis diagnosis and surveillance in human hiperendemic areas of Andean countries","volume":"6","author":"Valero","year":"2012","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.tmaid.2022.102286_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001376","article-title":"Development and evaluation of a new lateral flow immunoassay for serodiagnosis of human fasciolosis","volume":"5","author":"Sern\u00e1ndez-Mart\u00ednez","year":"2011","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.tmaid.2022.102286_bib42","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1017\/S0031182014000869","article-title":"Diagnosis of human fascioliasis by stool and blood techniques: update for the present global scenario","volume":"141","author":"Mas-Coma","year":"2014","journal-title":"Parasitology"},{"key":"10.1016\/j.tmaid.2022.102286_bib43","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11686-020-00302-2","article-title":"Use of the PCR in a combined methodological approach for the study of human fascioliasis in a endemic area","volume":"66","author":"Carnevale","year":"2021","journal-title":"Acta Parasitol"},{"key":"10.1016\/j.tmaid.2022.102286_bib44","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1517\/13543784.14.12.1513","article-title":"Triclabendazole for the treatment of fasciolasis and paragonimiasis","volume":"14","author":"Keiser","year":"2005","journal-title":"Expet Opin Invest Drugs"},{"key":"10.1016\/j.tmaid.2022.102286_bib45","series-title":"Report of the WHO Informal Meeting on use of triclabendazole in fascioliasis control","first-page":"17","author":"World Health Organization","year":"2007"},{"key":"10.1016\/j.tmaid.2022.102286_bib46","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/trstmh\/trz093","article-title":"Triclabendazole in the treatment of human fascioliasis: a review","volume":"113","author":"Ghandi","year":"2019","journal-title":"Trans Roy Soc Trop Med Hyg"},{"key":"10.1016\/j.tmaid.2022.102286_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001720","article-title":"Administration of triclabendazole is safe and effective in controlling fascioliasis in an endemic community of the Bolivian Altiplano","volume":"6","author":"Villegas","year":"2012","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.tmaid.2022.102286_bib48","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1046\/j.1365-2036.2003.01419.x","article-title":"Double-blind, randomized, placebo-controlled study of nitazoxanide in the treatment of fascioliasis in adults and children from northern Peru","volume":"17","author":"Favennec","year":"2003","journal-title":"Aliment Pharmacol Ther"}],"container-title":["Travel Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477893922000321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477893922000321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:07:29Z","timestamp":1761487649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1477893922000321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":48,"alternative-id":["S1477893922000321"],"URL":"https:\/\/doi.org\/10.1016\/j.tmaid.2022.102286","relation":{},"ISSN":["1477-8939"],"issn-type":[{"value":"1477-8939","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Imported fascioliasis in Spain: Report of 12 cases from the +REDIVI collaborative network (2009\u20132019)","name":"articletitle","label":"Article Title"},{"value":"Travel Medicine and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tmaid.2022.102286","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102286"}}