{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:30:54Z","timestamp":1791264654501,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["20202640-0022937"],"award-info":[{"award-number":["20202640-0022937"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Travel Medicine and Infectious Disease"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.tmaid.2023.102586","type":"journal-article","created":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T12:11:47Z","timestamp":1685967107000},"page":"102586","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Dengue clinical features and harbingers of severity in the diabetic patient: A retrospective cohort study on Reunion island, 2019"],"prefix":"10.1016","volume":"54","author":[{"given":"Azizah","family":"Issop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Bertolotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves-Marie","family":"Diarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-christophe","family":"Ma\u00efza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric","family":"Jarlet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Cogne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric","family":"Doussiet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric","family":"Magny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Maillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Belot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Cadic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathys","family":"Carras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Chane-Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romane","family":"Crouzet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hirschinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Cecilia","family":"Etoa N\u2019Doko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azizah","family":"Issop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Legros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamitiana","family":"Randriamanana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Rosolen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nolwenn","family":"Sautereau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Nob\u00e9court","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"G\u00e9rardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tmaid.2023.102586_bib1","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s40121-021-00470-2","article-title":"The global trends and regional differences in incidence of dengue infection from 1990 to 2019: an analysis from the Global Burden of Diseases of Study","volume":"10","author":"Du","year":"2021","journal-title":"Infect Dis Ther"},{"key":"10.1016\/j.tmaid.2023.102586_bib2","unstructured":"European Center for Disease Prevention and Control. Dengue worldwide overview. https:\/\/www.ecdc.europa.eu\/en\/dengue-monthly. [Accessed 4 April 2023]."},{"key":"10.1016\/j.tmaid.2023.102586_bib3","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1007\/s40121-022-00647-3","article-title":"Climate change and cascading risks from infectious disease","volume":"11","author":"Semenza","year":"2022","journal-title":"Infect Dis Ther"},{"key":"10.1016\/j.tmaid.2023.102586_bib4","doi-asserted-by":"crossref","DOI":"10.2807\/ese.15.39.19676-en","article-title":"First two autochthonous dengue virus infections in metropolitan France, September 2010","volume":"15","author":"La Ruche","year":"2010","journal-title":"Euro Surveill"},{"key":"10.1016\/j.tmaid.2023.102586_bib5","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2022.27.44.2200818","article-title":"Autochthonous dengue in mainland France, 2022: geographical extension and incidence increase","volume":"27","author":"Cochet","year":"2022","journal-title":"Euro Surveill"},{"key":"10.1016\/j.tmaid.2023.102586_bib6","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1365-3156.2010.02671.x","article-title":"Spatially disaggregated disease transmission risk: land use, land cover and risk of dengue transmission on the island of Ohau","volume":"16","author":"Vanwambecke","year":"2011","journal-title":"Trop Med Int Health"},{"key":"10.1016\/j.tmaid.2023.102586_bib7","series-title":"DENGUE. Point epidemiologique hebdomadaire, La Reunion","first-page":"6","year":"2021"},{"key":"10.1016\/j.tmaid.2023.102586_bib8","series-title":"Dengue guidelines for diagnosis, treatment, prevention and control","year":"2009"},{"key":"10.1016\/j.tmaid.2023.102586_bib9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1056\/NEJM199912163412507","article-title":"Infections in patients with diabetes mellitus","volume":"341","author":"Joshi","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tmaid.2023.102586_bib10","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.2337\/diacare.24.6.1044","article-title":"Diabetes and the risk of infection-related mortality in the U.S","volume":"24","author":"Bertoni","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.tmaid.2023.102586_bib11","doi-asserted-by":"crossref","first-page":"510","DOI":"10.2337\/diacare.26.2.510","article-title":"Quantifying the risk of infectious diseases for people with diabetes","volume":"26","author":"Shah","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.tmaid.2023.102586_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003741","article-title":"Is diabetes a risk factor for a severe clinical presentation of dengue? - review and meta-analysis","volume":"9","author":"Htun","year":"2015","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.tmaid.2023.102586_bib13","doi-asserted-by":"crossref","first-page":"e1641","DOI":"10.1371\/journal.pntd.0001641","article-title":"Diabetes with hypertension as risk factors for adult dengue hemorrhagic fever in a predominantly dengue serotype 2 epidemic: a case control study","volume":"6","author":"Pang","year":"2012","journal-title":"PLoS Neglected Trop Dis"},{"key":"10.1016\/j.tmaid.2023.102586_bib15","series-title":"Proceeding of the second Berkeley symposium on mathematical statistics and probability","first-page":"159","article-title":"On median tests for linear hypotheses","author":"Brown","year":"1951"},{"key":"10.1016\/j.tmaid.2023.102586_bib16","series-title":"Advances in economics sixth world congress","first-page":"171","article-title":"Quantile regression, censoring, and the structure of wages","author":"Chamberlain","year":"1994"},{"issue":"7","key":"10.1016\/j.tmaid.2023.102586_bib17","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/aje\/kwh090","article-title":"A modified Poisson regression approach to prospective studies with binary data","volume":"159","author":"Zou","year":"2004","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.tmaid.2023.102586_bib18","doi-asserted-by":"crossref","first-page":"m441","DOI":"10.1136\/bmj.m441","article-title":"Calculating the sample size required for developing a clinical prediction model","volume":"368","author":"Riley","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.tmaid.2023.102586_bib19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijid.2017.12.018","article-title":"Prevalence of comorbidities in Chikungunya : a systematic review and meta-analysis","volume":"67","author":"Badawi","year":"2018","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.tmaid.2023.102586_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200200","article-title":"Prevalence of comorbidities in dengue fever and West Nile virus: a systematic review and meta-analysis","volume":"13","author":"Badawi","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.tmaid.2023.102586_bib21","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.2337\/dc20-2676","article-title":"Diabetes and overweight\/obesity are independent, nonadditive risk factors for in-hospital severity of COVID-19: an international, multicenter, retrospective meta-analysis","volume":"44","author":"Longmore","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/j.tmaid.2023.102586_bib22","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.diabres.2004.07.013","article-title":"Prevalence of type 2 diabetes and central adiposity in La r\u00e9union island, the REDIA study","volume":"67","author":"Favier","year":"2005","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.tmaid.2023.102586_bib23","first-page":"e4895","article-title":"Dengue with hemorrhagic and acute pancreatitis: case report and review","volume":"11","author":"Correa","year":"2019","journal-title":"Cureus"},{"key":"10.1016\/j.tmaid.2023.102586_bib24","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/cid\/cit458","article-title":"Case definitions, diagnostic algorithms, and priorities in encephalitis : consensus statement of the International Encephalitis Consortium","volume":"57","author":"Venkatesan","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.tmaid.2023.102586_bib25","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.3201\/eid1312.061265","article-title":"Risk factors for West Nile virus neuroinvasive disease, California","volume":"13","author":"Jean","year":"2005","journal-title":"Emerg Infect Dis 2007"},{"key":"10.1016\/j.tmaid.2023.102586_bib26","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.2337\/dc08-0779","article-title":"Anemia, diabetes, and chronic kidney disease","volume":"32","author":"Mehdi","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.tmaid.2023.102586_bib27","series-title":"HAL-R\u00e9union. Archive ouverte de l'Universit\u00e9 de La R\u00e9union, ed. Sciences du Vivant [q-bio] Dumas-03831531, v1","first-page":"79","article-title":"[Facteurs de risque de d\u00e9c\u00e8s ou de th\u00e9rapeutique invasive chez les patients suspects de dengue durant l\u2019\u00e9pid\u00e9mie \u00e0 La R\u00e9union en 2019]","author":"Crouzet","year":"2022"},{"key":"10.1016\/j.tmaid.2023.102586_bib28","first-page":"20","article-title":"The usefulness of peripheral blood cell counts to distinguish COVID-19 from dengue during acute infection","volume":"7","author":"Osuna-Ramos","year":"2022","journal-title":"Trav Med Infect Dis"},{"key":"10.1016\/j.tmaid.2023.102586_bib29","article-title":"Neutrophil extracellular traps in dengue are mainly generated NOX-independently","volume":"12","author":"Garisha","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.tmaid.2023.102586_bib30","doi-asserted-by":"crossref","first-page":"R65","DOI":"10.1530\/JME-20-0128","article-title":"NETosis contributes to the pathogenesis of diabetes and its complications","volume":"65","author":"Njeim","year":"2020","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.tmaid.2023.102586_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcv.2018.01.001","article-title":"Renal manifestations of dengue virus infections","volume":"101","author":"Gurugama","year":"2018","journal-title":"J Clin Virol"},{"key":"10.1016\/j.tmaid.2023.102586_bib32","article-title":"Incidence, characteristics and risk factors of acute kidney injury among dengue patients: a retrospective analysis","volume":"10","author":"Mallhi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.tmaid.2023.102586_bib33","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.diabet.2007.10.002","article-title":"High prevalence of chronic kidney disease in La R\u00e9union island and its association with the metabolic syndrome in the non-diabetic population: La R\u00e9union Diabetes (REDIA) Study","volume":"33","author":"Stengel","year":"2007","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.tmaid.2023.102586_bib34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/08037051.2016.1182854","article-title":"Prevalence, treatment, and control of hypertension in La R\u00e9union: the REDIA population-based cohort study","volume":"26","author":"Cournot","year":"2017","journal-title":"Blood Pres"},{"key":"10.1016\/j.tmaid.2023.102586_bib35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3132\/dvdr.2008.034","article-title":"Apoptosis, vascular leakage and increased risk of severe dengue in a type 2 diabetes mellitus patient","volume":"5","author":"Limonta","year":"2008","journal-title":"Diabetes Vasc Dis Res"},{"key":"10.1016\/j.tmaid.2023.102586_bib36","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.142805","article-title":"Hyperglycemia exacerbates dengue virus infection by facilitating poly(A)-binding protein-mediated viral translation","volume":"7","author":"Shen","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.tmaid.2023.102586_bib37","article-title":"Study on dengue severity in diabetic and non-diabetic population of tertiary care hospital by assessing inflammatory indicators","volume":"82","author":"Singh","year":"2022","journal-title":"Ann Med Surg (Lond)"},{"key":"10.1016\/j.tmaid.2023.102586_bib38","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/01.CIR.98.12.1164","article-title":"Activated platelets induce monocyte chemotactic protein-1 secretion and surface expression of intercellular adhesion molecule-1 on endothelial cells","volume":"98","author":"Gawaz","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.tmaid.2023.102586_bib39","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jmii.2017.12.005","article-title":"Diabetic patients suffering dengue are at risk for development of dengue shock syndrome\/severe dengue: emphasizing the impacts of co-existing comorbidity(ies) and glycemic control on dengue severity","volume":"53","author":"Lee","year":"2020","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.tmaid.2023.102586_bib40","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/S1473-3099(20)30601-0","article-title":"Risk predictors of progression to severe diseases during the febrile phase of dengue: a systematic review and meta-analysis","volume":"21","author":"Sangkaew","year":"2021","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.tmaid.2023.102586_bib41","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.jmii.2021.03.009","article-title":"Clinical characteristics and risk factors for intracranial haemorrhage or infarction in patients with dengue","volume":"54","author":"Chang","year":"2021","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.tmaid.2023.102586_bib42","doi-asserted-by":"crossref","first-page":"239","DOI":"10.7883\/yoken.JJID.2017.457","article-title":"A multicenter study of clinical presentations and predictive factors for severe manifestations of dengue in adults","volume":"71","author":"Temprasertrudee","year":"2018","journal-title":"Jpn J Infect Dis"}],"container-title":["Travel Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477893923000467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477893923000467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:08:57Z","timestamp":1761487737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1477893923000467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":41,"alternative-id":["S1477893923000467"],"URL":"https:\/\/doi.org\/10.1016\/j.tmaid.2023.102586","relation":{},"ISSN":["1477-8939"],"issn-type":[{"value":"1477-8939","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dengue clinical features and harbingers of severity in the diabetic patient: A retrospective cohort study on Reunion island, 2019","name":"articletitle","label":"Article Title"},{"value":"Travel Medicine and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tmaid.2023.102586","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102586"}}