{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:52:23Z","timestamp":1790293943221,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Travel Medicine and Infectious Disease"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.tmaid.2023.102608","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T16:40:10Z","timestamp":1687279210000},"page":"102608","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Host biomarkers for early identification of severe imported Plasmodium falciparum malaria"],"prefix":"10.1016","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0194-7736","authenticated-orcid":false,"given":"L.","family":"Balerdi-Sarasola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Parolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Fleitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Subir\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Rodr\u00edguez-Valero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Almuedo-Riera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Letona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"\u00c1lvarez-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Eugenia","family":"Valls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Vera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mayor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Camprub\u00ed-Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tmaid.2023.102608_bib2","article-title":"Diagnosis and treatment of imported malaria in Spain: recommendations from the malaria working group of the Spanish society of tropical medicine and international Health (SEMTSI)","volume":"33","author":"Mu\u00f1oz","year":"2015","journal-title":"Enfermedades Infecciosas y Microbiologia Clinica. Elsevier Doyma"},{"key":"10.1016\/j.tmaid.2023.102608_bib3","unstructured":"Ecdc. SURVEILLANCE REPORT malaria."},{"issue":"7854","key":"10.1016\/j.tmaid.2023.102608_bib4","article-title":"Risk factors for mortality from imported falciparum malaria in the United Kingdom over 20 years: an observational study","volume":"344","author":"Checkley","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.tmaid.2023.102608_bib5","article-title":"Is availability of artesunate associated with the prognosis of imported malaria in Spain?","volume":"37","author":"Camprub\u00ed","year":"2020","journal-title":"Travel Medicine and Infectious Disease. Elsevier Inc."},{"key":"10.1016\/j.tmaid.2023.102608_bib6","author":"Espinosa-Vega"},{"key":"10.1016\/j.tmaid.2023.102608_bib7","first-page":"49","article-title":"Prevalence, anti-malarial chemoprophylaxis and causes of deaths for severe imported malaria: a systematic review and meta-analysis","author":"Mahittikorn","year":"2022","journal-title":"Trav Med Infect Dis"},{"key":"10.1016\/j.tmaid.2023.102608_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.tmaid.2017.12.002","article-title":"Time delays in the diagnosis and treatment of malaria in non-endemic countries: a systematic review","volume":"21","author":"Bastaki","year":"2018","journal-title":"Trav Med Infect Dis"},{"issue":"8","key":"10.1016\/j.tmaid.2023.102608_bib9","doi-asserted-by":"crossref","DOI":"10.1093\/jtm\/taab159","article-title":"Pandemic-related delay of falciparum malaria diagnosis in a traveller leading to cerebral malaria","volume":"28","author":"Schubert","year":"2021","journal-title":"J Trav Med"},{"issue":"9487","key":"10.1016\/j.tmaid.2023.102608_bib10","article-title":"Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial","volume":"366","author":"White","year":"2005","journal-title":"Lancet"},{"issue":"9753","key":"10.1016\/j.tmaid.2023.102608_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(10)61924-1","article-title":"Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial","volume":"376","author":"Dondorp","year":"2010","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.tmaid.2023.102608_bib12","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciab133","article-title":"Intravenous artesunate for the treatment of severe imported malaria: implementation, efficacy, and safety in 1391 patients","volume":"73","author":"Roussel","year":"2021","journal-title":"Clin Infect Dis"},{"issue":"8","key":"10.1016\/j.tmaid.2023.102608_bib13","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jiz292","article-title":"Severity of Plasmodium falciparum and non-falciparum malaria in travelers and migrants: a nationwide observational study over 2 decades in Sweden","volume":"220","author":"W\u00e5ngdahl","year":"2019","journal-title":"J Infect Dis"},{"key":"10.1016\/j.tmaid.2023.102608_bib14","volume":"391","author":"Ashley","year":"2018"},{"issue":"Suppl 1","key":"10.1016\/j.tmaid.2023.102608_bib15","first-page":"7","article-title":"Severe malaria","volume":"19","year":"2014","journal-title":"Trop Med Int Health"},{"issue":"2","key":"10.1016\/j.tmaid.2023.102608_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.medmal.2018.08.003","article-title":"Management of severe imported malaria in adults","volume":"50","author":"Bruneel","year":"2020","journal-title":"Med Maladies Infect"},{"key":"10.1016\/j.tmaid.2023.102608_bib17","author":"Health Organization"},{"issue":"1","key":"10.1016\/j.tmaid.2023.102608_bib18","doi-asserted-by":"crossref","DOI":"10.1186\/1475-2875-12-50","article-title":"A clinicopathological correlation of the expression of the angiopoietin-Tie-2 receptor pathway in the brain of adults with Plasmodium falciparum malaria","volume":"12","author":"Prapansilp","year":"2013","journal-title":"Malar J"},{"issue":"2","key":"10.1016\/j.tmaid.2023.102608_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/nm1351","article-title":"Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation","volume":"12","author":"Fiedler","year":"2006","journal-title":"Nat Med"},{"issue":"44","key":"10.1016\/j.tmaid.2023.102608_bib20","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0805782105","article-title":"Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria","volume":"105","author":"Yeo","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.tmaid.2023.102608_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004912","article-title":"Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children","volume":"4","author":"Lovegrove","year":"2009","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.tmaid.2023.102608_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017440","article-title":"Combinations of host biomarkers predict mortality among Ugandan children with severe malaria: a retrospective case-control study","volume":"6","author":"Erdman","year":"2011","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.tmaid.2023.102608_bib23","doi-asserted-by":"crossref","DOI":"10.1111\/tmi.12787","article-title":"Triggering receptor expressed on myeloid cells 1 (TREM-1) and cytokine gene variants in complicated and uncomplicated malaria","volume":"21","author":"Adukpo","year":"2016","journal-title":"Trop Med Int Health"},{"issue":"1","key":"10.1016\/j.tmaid.2023.102608_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2875-9-255","article-title":"Neopterin and procalcitonin are suitable biomarkers for exclusion of severe Plasmodium falciparum disease at the initial clinical assessment of travellers with imported malaria","volume":"9","author":"Te Witt","year":"2010","journal-title":"Malar J"},{"issue":"10","key":"10.1016\/j.tmaid.2023.102608_bib25","doi-asserted-by":"crossref","DOI":"10.1007\/s00134-016-4356-x","article-title":"Imported falciparum malaria in adults: host- and parasite-related factors associated with severity. The French prospective multicenter PALUREA cohort study","volume":"42","author":"Bruneel","year":"2016","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.tmaid.2023.102608_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-01556-0","article-title":"C-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis","volume":"11","author":"Wilairatana","year":"2021","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.tmaid.2023.102608_bib27","article-title":"C-reactive protein as a prognostic marker of Plasmodiumfalciparum malaria severity","volume":"56","author":"Bhardwaj","year":"2019","journal-title":"J Vector Borne Dis"},{"issue":"5","key":"10.1016\/j.tmaid.2023.102608_bib28","doi-asserted-by":"crossref","DOI":"10.1093\/trstmh\/trab167","article-title":"Elevated admission C-reactive protein to albumin ratios are associated with disease severity and respiratory complications in adults with imported falciparum malaria","volume":"116","author":"Hoffmeister","year":"2022","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"654","key":"10.1016\/j.tmaid.2023.102608_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abn5040","article-title":"Improving the diagnosis of severe malaria in African children using platelet counts and plasma PfHRP2 concentrations","volume":"14","author":"Watson","year":"2022","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.tmaid.2023.102608_bib30","series-title":"Se","author":"Lampah","year":"2014"},{"key":"10.1016\/j.tmaid.2023.102608_bib31","doi-asserted-by":"crossref","DOI":"10.1186\/1475-2875-11-328","article-title":"Management of imported malaria in Europe","volume":"11","author":"Askling","year":"2012","journal-title":"Malar J"},{"key":"10.1016\/j.tmaid.2023.102608_bib32","series-title":"R: A language and environment for statistical computing","year":"2021"},{"issue":"85","key":"10.1016\/j.tmaid.2023.102608_bib33","article-title":"Scikit-learn: machine learning in Python","volume":"12","author":"Pedregosa Fabianpedregosa","year":"2011","journal-title":"J Mach Learn Res"},{"issue":"1","key":"10.1016\/j.tmaid.2023.102608_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12936-016-1624-8","article-title":"Systematic review of the role of angiopoietin-1 and angiopoietin-2 in Plasmodium species infections: biomarkers or therapeutic targets?","volume":"15","author":"De Jong","year":"2016","journal-title":"Malar J"},{"issue":"148","key":"10.1016\/j.tmaid.2023.102608_bib35","article-title":"Host immune response in returning travellers infected with malaria","volume":"11","author":"MacMullin","year":"2012","journal-title":"Malar J"},{"key":"10.1016\/j.tmaid.2023.102608_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.tmaid.2021.102076","article-title":"A comparative study of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) blood levels and peripheral blood parasitemia as parameters of disease severity in individuals with imported falciparum malaria","volume":"42","author":"Kwak","year":"2021","journal-title":"Trav Med Infect Dis"},{"key":"10.1016\/j.tmaid.2023.102608_bib37","first-page":"1","volume":"24","author":"Roussel","year":"2017"},{"issue":"8","key":"10.1016\/j.tmaid.2023.102608_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0020204","article-title":"Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2","volume":"2","author":"Dondorp","year":"2005","journal-title":"PLoS Med"},{"issue":"12","key":"10.1016\/j.tmaid.2023.102608_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41596-020-0357-x","article-title":"Tutorial: design and fabrication of nanoparticle-based lateral-flow immunoassays","volume":"15","author":"Parolo","year":"2020","journal-title":"Nat Protoc"},{"key":"10.1016\/j.tmaid.2023.102608_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103867","article-title":"A diagnostic platform for rapid, simultaneous quantification of procalcitonin and C-reactive protein in human serum","volume":"76","author":"Cao","year":"2022","journal-title":"EBioMedicine"}],"updated-by":[{"DOI":"10.1016\/j.tmaid.2024.102752","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000}}],"container-title":["Travel Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477893923000686?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1477893923000686?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T12:44:41Z","timestamp":1725799481000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1477893923000686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":39,"alternative-id":["S1477893923000686"],"URL":"https:\/\/doi.org\/10.1016\/j.tmaid.2023.102608","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.tmaid.2024.102752","asserted-by":"object"}]},"ISSN":["1477-8939"],"issn-type":[{"value":"1477-8939","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Host biomarkers for early identification of severe imported Plasmodium falciparum malaria","name":"articletitle","label":"Article Title"},{"value":"Travel Medicine and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tmaid.2023.102608","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102608"}}