{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T18:35:41Z","timestamp":1769020541088,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfusion Medicine Reviews"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.tmrv.2008.09.005","type":"journal-article","created":{"date-parts":[[2008,12,4]],"date-time":"2008-12-04T12:13:50Z","timestamp":1228392830000},"page":"55-61","source":"Crossref","is-referenced-by-count":56,"title":["The Age of Red Blood Cells in Premature Infants (ARIPI) Randomized Controlled Trial: Study Design"],"prefix":"10.1016","volume":"23","author":[{"given":"Dean","family":"Fergusson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Hutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora L.","family":"Hogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"LeBel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morris A.","family":"Blajchman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason C.","family":"Ford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Hebert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Kakadekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lajos","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koravangattu","family":"Sankaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stan","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Smyth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuppuchipalayam","family":"Ramesh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole Rouvinez","family":"Bouali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Tinmouth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tmrv.2008.09.005_bib1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0955-3886(97)00043-X","article-title":"The red cell storage lesion and its implication for transfusion","volume":"18","author":"Chin-Yee","year":"1997","journal-title":"Transfus Sci"},{"key":"10.1016\/j.tmrv.2008.09.005_bib2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1537-2995.1985.25385219897.x","article-title":"The membrane and the lesions of storage in preserved red cells","volume":"25","author":"Wolfe","year":"1985","journal-title":"Transfusion"},{"key":"10.1016\/j.tmrv.2008.09.005_bib3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0887-7963(88)70030-9","article-title":"Red cell membrane changes during storage","volume":"2","author":"Card","year":"1988","journal-title":"Transfus Med Rev"},{"key":"10.1016\/j.tmrv.2008.09.005_bib4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1053\/tmrv.2001.22613","article-title":"The clinical consequences of the red cell storage lesion","volume":"15","author":"Tinmouth","year":"2001","journal-title":"Transfus Med Rev"},{"key":"10.1016\/j.tmrv.2008.09.005_bib5","doi-asserted-by":"crossref","first-page":"17058","DOI":"10.1073\/pnas.0707958104","article-title":"S-nitrosohemoglobin deficiency: A mechanism for loss of physiological activity in banked blood","volume":"104","author":"Reynolds","year":"2007","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.tmrv.2008.09.005_bib6","doi-asserted-by":"crossref","first-page":"17063","DOI":"10.1073\/pnas.0708160104","article-title":"Evolution of adverse changes in stored RBCs","volume":"104","author":"Bennett-Guerrero","year":"2007","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.tmrv.2008.09.005_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0003-4975(10)63624-7","article-title":"Transfusion of 2,3-DPG-enriched red blood cells to improve cardiac function","volume":"26","author":"Dennis","year":"1978","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.tmrv.2008.09.005_bib8","article-title":"A model of transfusion related acute lung injury (TRALI)","volume":"153","author":"Allard","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.tmrv.2008.09.005_bib9","series-title":"Pediatric transfusion practice","first-page":"129","article-title":"Additive solutions and product age in neonatal red blood cell transfusion","author":"Strauss","year":"2002"},{"key":"10.1016\/j.tmrv.2008.09.005_bib10","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1053\/tmrv.2003.50009","article-title":"Risks associated with transfusion of cellular blood components in Canada","volume":"17","author":"Kleinman","year":"2003","journal-title":"Transfus Med Rev"},{"key":"10.1016\/j.tmrv.2008.09.005_bib11","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1001\/jama.289.15.1950","article-title":"Clinical outcomes following institution of universal leukoreduction of blood transfusions for premature infants","volume":"289","author":"Fergusson","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.tmrv.2008.09.005_bib12","first-page":"197A","article-title":"Changing transfusion practices in the NICU","author":"Boulton","year":"1995","journal-title":"Pediatr Res"},{"key":"10.1016\/j.tmrv.2008.09.005_bib13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0887-7963(05)80109-9","article-title":"Small volume red blood cell transfusions for neonatal patients","volume":"9","author":"Hume","year":"1995","journal-title":"Transfus Med Rev Trans Med Rev"},{"key":"10.1016\/j.tmrv.2008.09.005_bib14","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1542\/peds.91.3.523","article-title":"National survey of neonatal transfusion practices: I. Red blood cell therapy","volume":"91","author":"Levy","year":"1993","journal-title":"Pediatrics"},{"key":"10.1016\/j.tmrv.2008.09.005_bib15","first-page":"530","article-title":"National survey of neonatal transfusion practices: II. Blood component therapy","volume":"91","author":"Strauss","year":"1993","journal-title":"Pediatrics"},{"key":"10.1016\/j.tmrv.2008.09.005_bib16","first-page":"410A","article-title":"Variation in the incidence of necrotizing enterocolitis (NEC) in very-low-birth-weight infants among Canadian neonatal intensive care units","volume":"47","author":"Lee","year":"2000","journal-title":"Pediatr Res"},{"key":"10.1016\/j.tmrv.2008.09.005_bib17","first-page":"371A","article-title":"Variations in the site-specific rates of bronchopulmonary dysplasia (BPD) among infants admitted to 17 neonatal intensive care units (NICUs) in Canada\u2014Implications for bench marking","volume":"47","author":"Ohlsson","year":"2000","journal-title":"Pediatr Res"},{"key":"10.1016\/j.tmrv.2008.09.005_bib18","first-page":"722","article-title":"Restoration in vivo of erythrocyte adenosine triphosphate, 2.3-diphosphoglycerate, potassium ion, and sodium ion concentrations following the transfusion of acid-citrate-dextrose-stored human red blood cells","volume":"73","author":"Valeri","year":"1969","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.tmrv.2008.09.005_bib19","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1152\/jappl.1971.31.6.823","article-title":"Physiologic effects of 2,3-DPG-depleted red cells with high affinity for oxygen","volume":"31","author":"Valeri","year":"1971","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.tmrv.2008.09.005_bib20","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1056\/NEJM197407112910204","article-title":"Current status of red-cell preservation and availability in relation to the development National Blood Policy","volume":"291","author":"Chaplin","year":"1974","journal-title":"N Engl J Med."},{"key":"10.1016\/j.tmrv.2008.09.005_bib21","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1172\/JCI105987","article-title":"Hemoglobin function in stored blood","volume":"48","author":"Bunn","year":"1969","journal-title":"J Clin Invest."},{"key":"10.1016\/j.tmrv.2008.09.005_bib22","first-page":"733","article-title":"The basis of defective oxygen delivery from stored blood","volume":"137","author":"Sugerman","year":"1970","journal-title":"Surg Gynecol Obstet"},{"key":"10.1016\/j.tmrv.2008.09.005_bib23","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1423-0410.1971.tb01807.x","article-title":"The physiologic effect of transfusing preserved red cells with low 2,3-diphosphoglycerate and high affinity for oxygen","volume":"20","author":"Valeri","year":"1971","journal-title":"Vox Sang"},{"key":"10.1016\/j.tmrv.2008.09.005_bib24","first-page":"96S","article-title":"Plasma from stored red cells activate human pulmonary endothelial cells","volume":"38","author":"Silliman","year":"1998","journal-title":"Transfusion"},{"key":"10.1016\/j.tmrv.2008.09.005_bib25","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1172\/JCI1841","article-title":"Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model","volume":"101","author":"Silliman","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.tmrv.2008.09.005_bib26","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1006\/jsre.2001.6306","article-title":"Influence of storage on red blood cell rheological properties","volume":"102","author":"Berezina","year":"2002","journal-title":"J Surg Res"},{"key":"10.1016\/j.tmrv.2008.09.005_bib27","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1001\/jama.269.23.3024","article-title":"Effect of stored-blood transfusion on oxygen delivery in patients with sepsis","volume":"269","author":"Marik","year":"1993","journal-title":"JAMA"},{"key":"10.1016\/j.tmrv.2008.09.005_bib28","first-page":"124","article-title":"Age of transfused red blood cells is associated with ICU length of stay","volume":"17","author":"Martin","year":"1994","journal-title":"Clin Invest Med"},{"key":"10.1016\/j.tmrv.2008.09.005_bib29","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1007\/BF03012772","article-title":"Association of mortality with age of blood transfused in septic ICU patients","volume":"44","author":"Purdy","year":"1997","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.tmrv.2008.09.005_bib30","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S0002-9610(99)00239-1","article-title":"Age of transfused blood is an independent risk factor for postinjury multiple organ failure","volume":"178","author":"Zallen","year":"1999","journal-title":"Am J Surg"},{"key":"10.1016\/j.tmrv.2008.09.005_bib31","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1046\/j.1537-2995.1999.39070701.x","article-title":"Transfusion and postoperative pneumonia in coronary artery bypass graft surgery: Effect of the length of storage of transfused red cells","volume":"39","author":"Vamvakas","year":"1999","journal-title":"Transfusion"},{"key":"10.1016\/j.tmrv.2008.09.005_bib32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1046\/j.1537-2995.2000.40010101.x","article-title":"Transfusion and postoperative pneumonia in coronary artery bypass graft surgery: Effect of the length of storage of transfused red cells","volume":"40","author":"Vamvakas","year":"2000","journal-title":"Transfusion"},{"key":"10.1016\/j.tmrv.2008.09.005_bib33","first-page":"S247","article-title":"Age of stored red cells does not influence indices of oxygenation after transfusion to critically ill patients: Randomized controlled trial","volume":"27","author":"Walsh","year":"2001","journal-title":"Eur Soc Intensive Care Med"},{"key":"10.1016\/j.tmrv.2008.09.005_bib34","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1001\/archsurg.137.6.711","article-title":"Increased rate of infection associated with transfusion of old blood after severe injury","volume":"137","author":"Offner","year":"2002","journal-title":"Arch Surg"},{"key":"10.1016\/j.tmrv.2008.09.005_bib35","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1097\/00000542-200304000-00005","article-title":"Influence of erythrocyte concentrate storage time on postsurgical morbidity in cardiac surgery patients","volume":"98","author":"Leal-Noval","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1016\/j.tmrv.2008.09.005_bib36","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0022-3476(96)70150-6","article-title":"Changing patterns of red blood cell transfusion in very-low-birth-weight infants","volume":"129","author":"Widness","year":"1996","journal-title":"J Pediar"},{"key":"10.1016\/j.tmrv.2008.09.005_bib37","first-page":"545","article-title":"Perinatal hematology","author":"Bifano","year":"1995","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.tmrv.2008.09.005_bib38","first-page":"1781","article-title":"Guidelines for transfusion of erythrocytes to neonates and premature infants","volume":"147","author":"Fetus and Newborn Committee (Canadian Paediatric Society)","year":"1992","journal-title":"CMAJ"},{"key":"10.1016\/j.tmrv.2008.09.005_bib39","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0887-7963(05)80108-7","article-title":"Symposium on neonatal transfusions","volume":"9","author":"Hume","year":"1995","journal-title":"Transfus Med Rev"},{"key":"10.1016\/j.tmrv.2008.09.005_bib40","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0022-3476(00)70104-1","article-title":"Feasibility and safety of AS-3 red blood cells for neonatal transfusions","volume":"136","author":"Strauss","year":"2000","journal-title":"J Pediatr"},{"key":"10.1016\/j.tmrv.2008.09.005_bib41","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1046\/j.1537-2995.1996.361097017172.x","article-title":"AS-1 red blood cells for neonatal transfusions: A randomized trial assessing donor exposure and safety","volume":"36","author":"Strauss","year":"1996","journal-title":"Transfusion"},{"key":"10.1016\/j.tmrv.2008.09.005_bib42","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0022-3476(94)70132-6","article-title":"Prospective, randomized trial of the safety and efficacy of a limited donor exposure transfusion program for premature neonates","volume":"125","author":"Liu","year":"1994","journal-title":"J Pediatr"},{"key":"10.1016\/j.tmrv.2008.09.005_bib43","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S0022-3476(95)70561-9","article-title":"Reducing blood donor exposures in low-birth-weight infants by the use of older, unwashed packed red blood cells","volume":"126","author":"Lee","year":"1995","journal-title":"J Pediatr"},{"key":"10.1016\/j.tmrv.2008.09.005_bib44","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0140-6736(54)90978-2","article-title":"Defective gas-transport function of stored red blood cells","volume":"1","author":"Valtis","year":"1954","journal-title":"Lancet"},{"key":"10.1016\/j.tmrv.2008.09.005_bib45","doi-asserted-by":"crossref","first-page":"f214","DOI":"10.1136\/fn.78.3.F214","article-title":"Antioxidant activity, packed cell transfusions, and outcome in premature infants","volume":"78","author":"Silvers","year":"1998","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1016\/j.tmrv.2008.09.005_bib46","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0378-3782(01)00115-3","article-title":"The role of blood transfusions and iron intake on retinopathy of prematurity","volume":"62","author":"Dani","year":"2001","journal-title":"Early Hum Dev."},{"key":"10.1016\/j.tmrv.2008.09.005_bib47","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1093\/oxfordjournals.aje.a114754","article-title":"An outbreak of necrotizing enterocolitis. Association with transfusions of packed red blood cells","volume":"126","author":"McGrady","year":"1987","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.tmrv.2008.09.005_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000658-197801000-00001","article-title":"Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging","volume":"187","author":"Bell","year":"1978","journal-title":"Ann Surg"},{"key":"10.1016\/j.tmrv.2008.09.005_bib49","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3476(78)80282-0","article-title":"Incidence and evolution of subependymal and intraventricular hemorrhage. A study of infants with birth weights less than 1500 gm","volume":"92","author":"Papile","year":"1978","journal-title":"J Pediatr"},{"key":"10.1016\/j.tmrv.2008.09.005_bib50","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.blre.2007.07.003","article-title":"Transfusion-related immunomodulation (TRIM): An update","volume":"21","author":"Vamvakas","year":"2007","journal-title":"Blood Rev."},{"key":"10.1016\/j.tmrv.2008.09.005_bib51","first-page":"13","article-title":"Introduction to sample size determination and power analysis for clinical trials","volume":"1","author":"Lachin","year":"1980","journal-title":"Controlled Clin Trials"}],"container-title":["Transfusion Medicine Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887796308000758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887796308000758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T02:07:14Z","timestamp":1684721234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887796308000758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S0887796308000758"],"URL":"https:\/\/doi.org\/10.1016\/j.tmrv.2008.09.005","relation":{},"ISSN":["0887-7963"],"issn-type":[{"value":"0887-7963","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}