{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T07:02:07Z","timestamp":1794294127009,"version":"4.9.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine Reviews"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.tmrv.2021.06.001","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T13:21:53Z","timestamp":1623763313000},"page":"22-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Anemia-Induced Bleeding in Patients with Platelet Disorders"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2233-7010","authenticated-orcid":false,"given":"Swarni","family":"Thakar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9664-7882","authenticated-orcid":false,"given":"Nadia","family":"Gabarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Radford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore E.","family":"Warkentin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tmrv.2021.06.001_bib0001","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1056\/NEJMoa1212772","article-title":"A no-prophylaxis platelet-transfusion strategy for hematologic cancers","volume":"368","author":"Stanworth","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0002","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1001\/jama.1983.03340090057031","article-title":"The relation of blood platelets to hemorrhagic disease: description of a method for determining the bleeding time and coagulation time and report of three cases of hemorrhagic disease relieved by transfusion","volume":"250","author":"Duke","year":"1983","journal-title":"JAMA J Am Med Assoc"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0003","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.V64.6.1200.1200","article-title":"Potentiation by red blood cells of shear-induced platelet aggregation: relative importance of chemical and physical mechanisms","volume":"64","author":"Reimers","year":"1984","journal-title":"Blood"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0004","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00109-017-1542-4","article-title":"The expansive role of oxylipins on platelet biology","volume":"95","author":"Yeung","year":"2017","journal-title":"J Mol Med"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0005","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1073\/pnas.93.4.1480","article-title":"cGMP mediates the vascular and platelet actions of nitric oxide: Confirmation using an inhibitor of the soluble guanylyl cyclase","volume":"93","author":"Moro","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0006","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1056\/NEJM199303043280907","article-title":"Platelet-endothelium interactions","volume":"328","author":"Ware","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0007","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1182\/blood.V56.5.937.937","article-title":"Experimental thrombocytopenia and capillary ultrastructure","volume":"56","author":"Shepro","year":"1980","journal-title":"Blood"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0008","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1182\/blood.V46.4.567.567","article-title":"Ultrastructural changes of endothelium associated with thrombocytopenia","volume":"46","author":"Kitchens","year":"1975","journal-title":"Blood"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0009","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1080\/09537104.2017.1378807","article-title":"Endothelial alterations in a canine model of immune thrombocytopenia","volume":"30","author":"LeVine","year":"2019","journal-title":"Platelets"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0010","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1182\/blood.V67.1.203.203","article-title":"Human thrombocytopenia is associated with structural abnormalities of the endothelium that are ameliorated by glucocorticosteroid administration","volume":"67","author":"Kitchens","year":"1986","journal-title":"Blood"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0011","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1365-2141.1994.tb04737.x","article-title":"The contribution of the haematocrit to thrombocytopenic bleeding in experimental animals","volume":"86","author":"Blajchman","year":"1994","journal-title":"Br J Haematol"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0012","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1126\/science.7352265","article-title":"Red blood cells: their dual role in thrombus formation","volume":"207","author":"Turitto","year":"1980","journal-title":"Science (80- )"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0013","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1001\/jama.1910.04330140029009","article-title":"The relation of blood platelets to hemorrhagic disease: description of a method for determining the bleeding time and coagulation time and report of three cases of hemorrhagic disease relieved by transfusion","volume":"55","author":"Duke","year":"1910","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0014","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1046\/j.1537-2995.2001.41080977.x","article-title":"Anemia-induced increase in the bleeding time: implications for treatment of nonsurgical blood loss","volume":"41","author":"Valeri","year":"2001","journal-title":"Transfusion"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0015","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0022-5223(19)34841-X","article-title":"Hematologic changes during and after cardiopulmonary bypass and their relationship to the bleeding time and nonsurgical blood loss","volume":"104","author":"Khuri","year":"1992","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0016","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/ajcp\/108.5.579","article-title":"The volume of blood shed during the bleeding time correlates with the peripheral venous hematocrit","volume":"108","author":"Crowley","year":"1997","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0017","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1182\/blood-2017-01-757930","article-title":"Laboratory predictors of bleeding and the effect of platelet and RBC transfusions on bleeding outcomes in the PLADO trial","volume":"130","author":"Uhl","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0018","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1111\/trf.15335","article-title":"Can we transfuse wisely in patients undergoing chemotherapy for acute leukemia or autologous stem cell transplantation?","volume":"59","author":"Lamarche","year":"2019","journal-title":"Transfusion"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0019","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1111\/trf.13658","article-title":"Red blood cell transfusion triggers in acute leukemia: a randomized pilot study","volume":"56","author":"DeZern","year":"2016","journal-title":"Transfusion"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0020","unstructured":"Webert KE, Cook RJ, Couban S, Carruthers J, Lee K-A, Blajchman MA, et\u00a0al. A multicenter pilot-randomized controlled trial of the feasibility of an augmented red blood cell transfusion strategy for patients treated with induction chemotherapy for acute leukemia or stem cell transplantation. Transfusion. 10.1111\/j.1537-2995.2007.01485.x."},{"key":"10.1016\/j.tmrv.2021.06.001_bib0021","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1200\/JCO.19.01836","article-title":"Liberal versus restrictive red blood cell transfusion thresholds in hematopoietic cell transplantation: a randomized, open label, phase III, noninferiority trial","volume":"38","author":"Tay","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0022","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD011305.pub2","article-title":"Restrictive versus liberal red blood cell transfusion strategies for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support","author":"Estcourt","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0023","unstructured":"ISRCTN - ISRCTN96390716: Red cell transfusion in acute myeloid leukaemia (REAL). https:\/\/www.isrctn.com\/ISRCTN96390716 (accessed April 27, 2021). 10.1186\/ISRCTN17438123."},{"key":"10.1016\/j.tmrv.2021.06.001_bib0024","unstructured":"TRANSfusion in patients with onco-hematological malignancies resuscitated from septic shock - full text view - ClinicalTrials.gov. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03837171 (accessed April 27, 2021)."},{"key":"10.1016\/j.tmrv.2021.06.001_bib0025","unstructured":"ISRCTN - ISRCTN17438123: A small pilot feasibility study for a possible randomised control trial comparing clinical outcomes and quality of life following two different transfusion strategies in children undergoing allogeneic hematopoietic stem cell transplant (HSCT). https:\/\/www.isrctn.com\/ISRCTN17438123 (accessed April 27, 2021)."},{"key":"10.1016\/j.tmrv.2021.06.001_bib0026","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1046\/j.1537-2995.1998.38111299056308.x","article-title":"The hemostatic effect of packed red cell transfusion in patients with anemia","volume":"38","author":"Ho","year":"2008","journal-title":"Transfusion"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0027","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/bjh.16291","article-title":"The association between haemorrhage and markers of endothelial insufficiency and inflammation in patients with hypoproliferative thrombocytopenia: a cohort study","volume":"189","author":"Ypma","year":"2020","journal-title":"Br J Haematol"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0028","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1001\/jama.1959.03000320029007","article-title":"Bleeding tendency in uremia","volume":"169","author":"O'Grady","year":"1959","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0029","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0025-7125(16)32437-3","article-title":"Bleeding in uremia","volume":"56","author":"Rabiner","year":"1972","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0030","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000166955","article-title":"Uremia as a cause of bleeding","volume":"5","author":"Andrassy","year":"1985","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0031","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000166482","article-title":"Biochemical abnormalities of platelets in renal failure. Evidence for decreased platelet serotonin, adenosine diphosphate and Mg-dependent adenosine triphosphatase","volume":"1","author":"Eknoyan","year":"1981","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0032","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1182\/blood.V75.7.1498.1498","article-title":"High von Willebrand factor concentration compensates a relative adhesion defect in uremic blood","volume":"75","author":"Zwaginga","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0033","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1159\/000057479","article-title":"Nitric oxide\/L-arginine in uremia","volume":"25","author":"Aiello","year":"1999","journal-title":"Miner Electrolyte Metab"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0034","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2141.1985.tb02974.x","article-title":"Low haematocrit and prolonged bleeding time in uraemic patients: effect of red cell transfusions","volume":"59","author":"Fernandez","year":"1985","journal-title":"Br J Haematol"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0035","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0140-6736(82)90050-2","article-title":"Uraemic bleeding: role of anaemia and beneficial effect of red cell transfusions","volume":"320","author":"Livio","year":"1982","journal-title":"Lancet"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0036","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1053\/j.ajkd.2003.10.037","article-title":"Inflammation, endothelial dysfunction, and platelet activation in patients with chronic kidney disease: the Chronic Renal Impairment in Birmingham (CRIB) study","volume":"43","author":"Landray","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0037","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2215\/CJN.06790712","article-title":"Antiplatelet therapy in the management of cardiovascular disease in patients with CKD: what is the evidence?","volume":"8","author":"Jain","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0038","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2215\/CJN.06790712","article-title":"Antiplatelet therapy in the management of cardiovascular disease in patients with CKD: what is the evidence?","volume":"8","author":"Jain","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0039","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1182\/asheducation-2013.1.268","article-title":"Inherited platelet disorders including Glanzmann thrombasthenia and Bernard-Soulier syndrome","volume":"2013","author":"Diz-K\u00fc\u00e7\u00fckkaya","year":"2013","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0040","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3324\/haematol.2010.039883","article-title":"Bernard-Soulier syndrome","volume":"96","author":"Berndt","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0041","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2020-240374","article-title":"Successful management of severe gastrointestinal bleeding from jejunal angiodysplasia in a patient with Bernard-Soulier syndrome","volume":"14","author":"Vekaria","year":"2021","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0042","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/MBC.0b013e328358e8fd","article-title":"Recurrent jejunal bleeding due to angiodysplasia in a Bernard-Soulier patient","volume":"24","author":"Otrock","year":"2013","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0043","first-page":"113","article-title":"Intractable gastrointestinal bleeding from angiodysplasia in a patient of Bernard-Soulier syndrome: report of a case","volume":"54","author":"Okita","year":"2005","journal-title":"Hiroshima J Med Sci"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0044","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0887-7963(03)00037-3","article-title":"Gastrointestinal bleeding, angiodysplasia, cardiovascular disease, and acquired von Willebrand syndrome","volume":"17","author":"Warkentin","year":"2003","journal-title":"Transfus Med Rev"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0045","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0140-6736(92)92434-H","article-title":"Aortic stenosis and bleeding gastrointestinal angiodysplasia: is acquired von Willebrand's disease the link?","volume":"340","author":"Warkentin","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0046","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1182\/blood.V87.10.4235.bloodjournal87104235","article-title":"Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion","volume":"87","author":"Tsai","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0047","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1056\/NEJMp030055","article-title":"Aortic Stenosis, von Willebrand factor, and bleeding","volume":"349","author":"Sadler","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0048","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1056\/NEJMoa022831","article-title":"Acquired von Willebrand syndrome in aortic stenosis","volume":"349","author":"Vincentelli","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0049","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1056\/NEJM200209123471122","article-title":"Gastrointestinal angiodysplasia and aortic stenosis","volume":"347","author":"Warkentin","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0050","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/ageing\/afp019","article-title":"Heyde syndrome: A common diagnosis in older patients with severe aortic stenosis","volume":"38","author":"Massyn","year":"2009","journal-title":"Age Ageing"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0051","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/jama.2015.12","article-title":"Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial","volume":"313","author":"Holcomb","year":"2015","journal-title":"JAMA - J Am Med Assoc"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0052","first-page":"261","article-title":"Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma: Packed red blood cells the answer?","volume":"65","author":"Kashuk","year":"2008","journal-title":"J Trauma - Inj Infect Crit Care"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0053","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00134-019-05884-8","article-title":"Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine","volume":"46","author":"Vlaar","year":"2020","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0054","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/10428190802714024","article-title":"Hemorrhagic complications in patients with advanced hematological malignancies followed at home: an Italian experience","volume":"50","author":"Cartoni","year":"2009","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0055","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/j.1537-2995.2009.02154.x","article-title":"Pilot trials in transfusion medicine","volume":"49","author":"Arnold","year":"2009","journal-title":"Transfusion"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0056","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/trf.16126","article-title":"Exploring the components of bleeding outcomes in transfusion trials for patients with hematologic malignancy","volume":"61","author":"Balitsky","year":"2021","journal-title":"Transfusion"},{"key":"10.1016\/j.tmrv.2021.06.001_bib0057","doi-asserted-by":"crossref","DOI":"10.1186\/1472-6963-14-89","article-title":"Patient engagement in research: a systematic review","volume":"14","author":"Domecq","year":"2014","journal-title":"BMC Health Serv Res"}],"container-title":["Transfusion Medicine Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887796321000225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887796321000225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:19:39Z","timestamp":1760138379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887796321000225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0887796321000225"],"URL":"https:\/\/doi.org\/10.1016\/j.tmrv.2021.06.001","relation":{},"ISSN":["0887-7963"],"issn-type":[{"value":"0887-7963","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anemia-Induced Bleeding in Patients with Platelet Disorders","name":"articletitle","label":"Article Title"},{"value":"Transfusion Medicine Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tmrv.2021.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}