{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T19:59:27Z","timestamp":1760644767262,"version":"build-2065373602"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1016\/j.tox.2003.11.016","type":"journal-article","created":{"date-parts":[[2004,1,17]],"date-time":"2004-01-17T05:15:16Z","timestamp":1074316516000},"page":"15-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["CYP1A2 is not required for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunosuppression"],"prefix":"10.1016","volume":"197","author":[{"given":"R.J","family":"Smialowicz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.E","family":"Burgin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.C","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.J","family":"Diliberto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.W","family":"Setzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.S","family":"Birnbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2003.11.016_BIB1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/BF00293624","article-title":"Pharmacokinetics and biological activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. 1. Dose-dependent tissue distribution and induction of hepatic ethoxyresorufin O-deethylase in rats following a single injection","volume":"62","author":"Abraham","year":"1988","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2003.11.016_BIB2","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1210\/endo-126-6-3101","article-title":"Estradiol metabolism by complementary deoxyribonucleic acid-expressed human cytochrome P450s","volume":"126","author":"Aoyama","year":"1990","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2003.11.016_BIB3","first-page":"89","article-title":"CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is the major route of metabolism in humans","volume":"54","author":"Boobis","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.tox.2003.11.016_BIB4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/00008571-199608000-00002","article-title":"Role of CYP1A2 in caffeine metabolism: studies using mice deficient in CYP1A2","volume":"6","author":"Buters","year":"1996","journal-title":"Pharmacogenetics"},{"key":"10.1016\/j.tox.2003.11.016_BIB5","unstructured":"Davidson, A.C., Hinkley, D.V., 1997. Bootstrap Methods and Their Application. Cambridge University Press, Cambridge, UK, pp. 193\u2013202."},{"key":"10.1016\/j.tox.2003.11.016_BIB6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/taap.1995.1025","article-title":"Dose\u2013response relationships of tissue distribution and induction of CYP1A1 and CYP1A2 enzyme activities following acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice","volume":"130","author":"Diliberto","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2003.11.016_BIB7","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1006\/bbrc.1997.6973","article-title":"Role of CYP1A2 in hepatic sequestration of dioxin: studies using CYP1A2 knock-out mice","volume":"236","author":"Diliberto","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2003.11.016_BIB8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1006\/taap.1999.8720","article-title":"Effects of CYP1A2 on deposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,4,7,8-pentachlorodibenzofuran, and 2,2\u2032,4,4\u2032,5,5\u2032-hexachloro-biphenyl in CYP1A2 knockout and parental (C57BL\/6N and 129\/Sv) strains of mice","volume":"159","author":"Diliberto","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2003.11.016_BIB9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/toxsci\/61.2.241","article-title":"Subchronic exposure of [3H]-2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in female B6C3F1 mice: relationship of steady-state levels to disposition and metabolism","volume":"61","author":"Diliberto","year":"2001","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2003.11.016_BIB10","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0026-895X(25)09225-9","article-title":"Cytochrome P450 Nma, Nmb, and LM4 (1A2) are differentially expressed during development in rabbit olfactory mucosa and liver","volume":"42","author":"Ding","year":"1992","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tox.2003.11.016_BIB11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/10618600.1996.10474713","article-title":"A language for data analysis and graphics","volume":"5","author":"Ihaka","year":"1996","journal-title":"J. Comput. Graph. Stat."},{"key":"10.1016\/j.tox.2003.11.016_BIB12","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1006\/faat.1993.1106","article-title":"Estimation of octanol\u2013water partition coefficients and correlation with dermal absorption for several polyhalogenated aromatic hydrocarbons","volume":"21","author":"Jackson","year":"1993","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.tox.2003.11.016_BIB13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0300-483X(00)00330-9","article-title":"Sensitivity of the SRBC PFC assay vs. ELISA for detection of immunosuppression by TCDD and TCDD-like congeners","volume":"156","author":"Johnson","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2003.11.016_BIB14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/taap.1993.1132","article-title":"A physiologically based pharmacokinetic model for 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) in the rat: tissue distribution and CYP1A2 induction","volume":"121","author":"Kedderis","year":"1993","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2003.11.016_BIB15","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1006\/taap.1993.1066","article-title":"Acute inflammatory response to sheep red blood cell challenge in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): phenotypic and functional analysis of peritoneal exudate cells","volume":"119","author":"Kerkvliet","year":"1993","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2003.11.016_BIB16","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0272-0590(92)90047-L","article-title":"Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests","volume":"18","author":"Luster","year":"1992","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.tox.2003.11.016_BIB17","unstructured":"NIH, 1996. Policy on Humane Care and Use of Laboratory Animals. Public Health Service, Office for Protection from Research Risks, NIH, Rockville, MD."},{"key":"10.1016\/j.tox.2003.11.016_BIB18","doi-asserted-by":"crossref","first-page":"5134","DOI":"10.1073\/pnas.92.11.5134","article-title":"Neonatal lethality associated with respiratory distress in mice lacking cytochrome P4501A2","volume":"92","author":"Pineau","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tox.2003.11.016_BIB19","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0378-4274(98)00339-7","article-title":"Knockout animals in toxicology: assessment of toxin bioactivation pathways using mice deficient in xenobiotic metabolizing enzymes","volume":"102\u2013103","author":"Pineau","year":"1998","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2003.11.016_BIB20","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0026-895X(25)09094-7","article-title":"Stimulation of in vivo hepatic uptake and in vitro hepatic binding of [125I]2-lodo-3,7,8-trichlorodibenzo-p-dioxin by the administration of agonist for the Ah receptor","volume":"36","author":"Poland","year":"1989","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tox.2003.11.016_BIB21","unstructured":"RS\/1, 1997. RS\/1 Release 5.3. Domain Solutions Corp., Cambridge, MA."},{"key":"10.1016\/j.tox.2003.11.016_BIB22","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1006\/taap.1994.1029","article-title":"Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)on humoral immunity and lymphocyte subpopulations: differences between mice and rats","volume":"124","author":"Smialowicz","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2003.11.016_BIB23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/taap.2001.9167","article-title":"Protection of the CYP1A2 (\u2212\/\u2212) null mouse against uroporphyria and hepatic injury following exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"173","author":"Smith","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2003.11.016_BIB24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/jbt.2570040206","article-title":"TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) is a tight binding inhibitor of cytochrome P450-d","volume":"4","author":"Voorman","year":"1989","journal-title":"J. Biochem. Toxicol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X03005444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X03005444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:47:13Z","timestamp":1759531633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X03005444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["S0300483X03005444"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2003.11.016","relation":{},"ISSN":["0300-483X"],"issn-type":[{"type":"print","value":"0300-483X"}],"subject":[],"published":{"date-parts":[[2004,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CYP1A2 is not required for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immunosuppression","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2003.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}