{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:10:22Z","timestamp":1759533022082,"version":"build-2065373602"},"reference-count":28,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1016\/j.tox.2003.12.005","type":"journal-article","created":{"date-parts":[[2004,1,27]],"date-time":"2004-01-27T05:23:12Z","timestamp":1075180992000},"page":"155-163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Histological and lipid peroxidation changes after administration of 2-acetylaminofluorene in a rat liver injury model following selective periportal and pericentral damage"],"prefix":"10.1016","volume":"196","author":[{"given":"Fragiska","family":"Sigala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Kostopanagiotou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioanna","family":"Andreadou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Kavatzas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelos","family":"Felekouras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Sigalas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Bastounis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efstathios","family":"Papalambros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2003.12.005_BIB1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/hep.510240331","article-title":"Selective enhancement in lipid peroxidation in plasma membrane in two experimental model of liver regenarations: partial hepatectomy and acute CCL4 administration","volume":"24","author":"Aguilar Delfin","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2003.12.005_BIB2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0014-2999(02)02431-7","article-title":"Reduction of myocardial infarct size in rabbits by a novel indole derivative with antioxidant and free radical scavenging properties","volume":"453","author":"Andreadou","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.tox.2003.12.005_BIB3","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/S0022-3565(25)24399-3","article-title":"Mechanism of hepatotoxicity to periportal regions of the liver lobule dye to allyl alcohol: role of oxygen and lipid peroxidation","volume":"238","author":"Badr","year":"1986","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2003.12.005_BIB4","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/hep.1840050619","article-title":"Hepatotoxicity due to allyl alcohol in the mice depends on alcohol dehydrogenase","volume":"5","author":"Belinsky","year":"1985","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2003.12.005_BIB5","first-page":"5712","article-title":"Loss of lipid peroxidation as a histochemical marker for preneoplastic hepatocellular foci of rats","volume":"44","author":"Benedetti","year":"1984","journal-title":"Cancer Res."},{"key":"10.1016\/j.tox.2003.12.005_BIB6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/15287399209531663","article-title":"Hepatotoxic interactions of ethanol with allyl alcohol or carbon tetrachloride in rats","volume":"37","author":"Berman","year":"1992","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.tox.2003.12.005_BIB7","first-page":"1606","article-title":"Activation, proliferation and differentiation of progenitor cells into hepatocytes in the d-galactosamine model of liver regeneration","volume":"143","author":"Dabeva","year":"1993","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tox.2003.12.005_BIB8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0304-3835(95)04009-S","article-title":"Early initiating and promoting effects in 2-AAF-induced rat liver carcinogenesis: an immunohistochemical study","volume":"98","author":"Hadjiolov","year":"1995","journal-title":"Cancer Lett."},{"key":"10.1016\/j.tox.2003.12.005_BIB9","first-page":"1100","article-title":"Balance between oxidative damage and proliferative potential in an experimental rat model of CCl4-induced cirrhosis: protective role of adenosine administration","volume":"26","author":"Hernandez-Munoz","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2003.12.005_BIB10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0009-2797(95)03638-3","article-title":"Cytotoxicity of aromatic amines in rat liver and oxidative stress","volume":"98","author":"Hillesheim","year":"1995","journal-title":"Chem. -Biol. Interact."},{"key":"10.1016\/j.tox.2003.12.005_BIB11","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1046\/j.1440-1746.2000.02207.x","article-title":"Reactive oxygen and mechanisms of inflammatory liver injury","volume":"15","author":"Jaeschke","year":"2000","journal-title":"J. Gastroener. Hepatol."},{"key":"10.1016\/j.tox.2003.12.005_BIB12","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0005-2728(95)00019-F","article-title":"A metabolite of carcinogenic 2-actylaminofluorene, 2-nitrosofluorene, induces redox cycling in mitochondria","volume":"1229","author":"Klohn","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.tox.2003.12.005_BIB13","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/0006-2952(90)90370-Z","article-title":"Lipid peroxidation and protein thiol depletion are not involved in the cytotoxicity of N-hydroxy-2-acetyleminofluorene in isolated rat hepatocytes","volume":"40","author":"Kroese","year":"1990","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2003.12.005_BIB14","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/hep.1840130422","article-title":"Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride","volume":"13","author":"Lindroos","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2003.12.005_BIB15","first-page":"166","article-title":"Pathological changes of hepatic artery and portal vein after ally-alcohol and carbon tetrachloride administration","volume":"19","author":"Papalambros","year":"2000","journal-title":"Int. Angiol."},{"key":"10.1016\/j.tox.2003.12.005_BIB16","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3346\/jkms.1999.14.5.531","article-title":"Transforming growth factor-b1 protein, proliferation and apoptosis of oval cells in acetylaminofluorene-induced rat liver regeneration","volume":"14","author":"Park","year":"1999","journal-title":"J. Kor. Med. Sci."},{"key":"10.1016\/j.tox.2003.12.005_BIB17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0041-008X(92)90367-2","article-title":"Involvement of nonparenchymal cells in oxygen-dependent hepatic injury by allyl alcohol","volume":"115","author":"Przybocki","year":"1992","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2003.12.005_BIB18","first-page":"517","article-title":"Analysis of cell cycle compartments of hepatocytes after partial hepatectomy","volume":"9","author":"Rabes","year":"1976","journal-title":"Cell Tissue Kinet."},{"key":"10.1016\/j.tox.2003.12.005_BIB19","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1007\/BF01918671","article-title":"Mechanism of allyl alcohol-induced hepatic necrosis","volume":"28","author":"Reid","year":"1972","journal-title":"Experientia"},{"key":"10.1016\/j.tox.2003.12.005_BIB20","first-page":"1114","article-title":"Cell behavior in the Acetylaminofluorene-treated regenerating rat liver: light and electron microscopic observations","volume":"145","author":"Sarraf","year":"1994","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.tox.2003.12.005_BIB21","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1530-0277.1992.tb00681.x","article-title":"Protective effect of oral acetylcysteine against the hepatorenal toxicity of carbon tetrachloride potentiated by ethyl alcohol","volume":"16","author":"Simko","year":"1992","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.tox.2003.12.005_BIB22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0009-2797(76)90159-9","article-title":"Biochemical changes after hepatic injury by allyl-alcohol and N-hydroxyl-Z-acetylaminofluorence","volume":"15","author":"Thorgeirsson","year":"1976","journal-title":"Chem. -Biol. Interact."},{"key":"10.1016\/j.tox.2003.12.005_BIB23","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/carcin\/12.6.985","article-title":"Dose-depedent effect of 2-acetylaminofluorence on hepatic foci development and cell proliferation in rats","volume":"12","author":"Tinawech","year":"1991","journal-title":"Carcinogenesis"},{"issue":"5","key":"10.1016\/j.tox.2003.12.005_BIB24","first-page":"657","article-title":"Cellular analysis of \u03b1-Fetoprotein gene activation during carbon tetrachloride and d-galactosamine-induced acute liver injury in rats","volume":"59","author":"Tournier","year":"1988","journal-title":"Lab. Investig."},{"key":"10.1016\/j.tox.2003.12.005_BIB25","first-page":"R19","article-title":"Metabolism of allyl alcohol leads to lipid peroxidation in mice","volume":"329","author":"Wendell","year":"1985","journal-title":"Arch. Pharmacol."},{"key":"10.1016\/j.tox.2003.12.005_BIB26","unstructured":"Willis, E.D., 1987. Evaluation of lipid peroxidation in lipid and biological membranes. In: Snell, K., Mullock, B. (Eds.), Biochemical Toxicology: A Practical Approach. IRL Press, Oxford, pp. 127\u2013152."},{"key":"10.1016\/j.tox.2003.12.005_BIB27","first-page":"1702","article-title":"Participation of small intraportal stem cells in the restitutive response of the liver to periportal necrosis induced by allyl alcohol","volume":"21","author":"Yavorkovsky","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2003.12.005_BIB28","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0006-291X(91)92020-K","article-title":"Expression of hepatocyte growth factor mRNA in regenerating rat liver after partial hepatectomy","volume":"177","author":"Zarnegor","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X03005493?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X03005493?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:47:42Z","timestamp":1759531662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X03005493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":28,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S0300483X03005493"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2003.12.005","relation":{},"ISSN":["0300-483X"],"issn-type":[{"type":"print","value":"0300-483X"}],"subject":[],"published":{"date-parts":[[2004,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histological and lipid peroxidation changes after administration of 2-acetylaminofluorene in a rat liver injury model following selective periportal and pericentral damage","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2003.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}