{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T06:17:34Z","timestamp":1783145854529,"version":"3.54.6"},"reference-count":41,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1016\/j.tox.2005.02.008","type":"journal-article","created":{"date-parts":[[2005,4,4]],"date-time":"2005-04-04T09:29:06Z","timestamp":1112606946000},"page":"70-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Acrylamide tissue distribution and genotoxic effects in a common viral infection in mice"],"prefix":"10.1016","volume":"211","author":[{"given":"Lilianne","family":"Abramsson-Zetterberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennie","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils-Gunnar","family":"Ilb\u00e4ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2005.02.008_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/09553009514550041","article-title":"Flow cytometric analysis of micronucleus induction in mice by internal exposure to 137Cs at very low dose rates","volume":"67","author":"Abramsson-Zetterberg","year":"1995","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.tox.2005.02.008_bib2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1383-5718(02)00322-4","article-title":"The dose\u2013response relationship at very low doses of acrylamide is linear in the flow cytometer-based mouse micronucleus assay","volume":"535","author":"Abramsson-Zetterberg","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.tox.2005.02.008_bib3","first-page":"147","article-title":"Regulation of hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation","volume":"7","author":"Baumann","year":"1990","journal-title":"J. Mol. Biol. Med."},{"key":"10.1016\/j.tox.2005.02.008_bib4","series-title":"Textbook of Pediatric Infectious Diseases","first-page":"54","article-title":"Metabolic response of the host to infections","author":"Beisel","year":"1998"},{"key":"10.1016\/j.tox.2005.02.008_bib5","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/0041-008X(91)90036-E","article-title":"Formation of hemoglobin adducts of acrylamide and its epoxide metabolite glycidamide in the rat","volume":"111","author":"Bergmark","year":"1991","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2005.02.008_bib6","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1021\/tx00017a004","article-title":"Acrylamide is metabolized to glycidamide in the rat: evidence from hemoglobin adduct formation","volume":"3","author":"Callemann","year":"1990","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2005.02.008_bib7","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3109\/03602539608994018","article-title":"The metabolism and pharmacokinetics of acrylamide: implications for mechanisms of toxicity and human risk estimation","volume":"28","author":"Callemann","year":"1996","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.tox.2005.02.008_bib8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0041-008X(85)90352-7","article-title":"Distribution and binding of [14C]Acrylamide to macromolecules in SENCAR and Balb\/c mice following oral and topical administration","volume":"79","author":"Carlsson","year":"1985","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2005.02.008_bib9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1478-3231.1999.tb00015.x","article-title":"Altered expression of hepatic carcinogen metabolizing enzymes with liver injury in HBV transgenic mouse lineages expressing various amounts of hepatitis B surface antigen","volume":"19","author":"Chemin","year":"1999","journal-title":"Liver"},{"key":"10.1016\/j.tox.2005.02.008_bib10","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/carcin\/20.4.699","article-title":"Decreased expression of glutathione S-transferase M1 in HPV16-transfected human cervical keratinocytes in culture","volume":"20","author":"Chin","year":"1999","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.tox.2005.02.008_bib11","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0378-4274(98)00254-9","article-title":"Hepatitis B virus-induced liver injury and altered expression of carcinogen metabolising enzymes: the role of the HBx protein","volume":"102\u2013103","author":"Chomarat","year":"1998","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2005.02.008_bib12","doi-asserted-by":"crossref","unstructured":"Darnerud, P.-O., Wong, J., Bergman, \u00c5., Ilb\u00e4ck, N.-G., 2005. Common viral infection affects pentabrominated diphenyl ether (PBDE) distribution and metabolic and hormonal activities in mice. Toxicology, doi: 10.1016\/j.tox.2005.01.015.","DOI":"10.1016\/j.tox.2005.01.015"},{"key":"10.1016\/j.tox.2005.02.008_bib13","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0344-0338(11)81022-8","article-title":"Proliferation and maturation of human bone marrow cells in infectious diseases","volume":"186","author":"Dormer","year":"1990","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.tox.2005.02.008_bib14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/toxsci\/kfg165","article-title":"Risk assessment of acrylamide in foods","volume":"75","author":"Dybing","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2005.02.008_bib15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/rmv.368","article-title":"Viral induction of site-specific chromosome damage","volume":"13","author":"Fortunato","year":"2003","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.tox.2005.02.008_bib16","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1055\/s-2007-971990","article-title":"Acute infection: metabolic responses, effects on performance, interaction with exercise and myocarditis","volume":"19","author":"Friman","year":"1998","journal-title":"Rev. Int. J. Sports Med."},{"key":"10.1016\/j.tox.2005.02.008_bib17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0378-4274(00)00217-4","article-title":"Redistribution of accumulated 2,3,7,8-tetrachlorodibenzo-p-dioxin during coxsackievirus B3 infection in the mouse","volume":"116","author":"Funseth","year":"2000","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2005.02.008_bib18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0048-9697(01)00864-6","article-title":"Effects of coxsackievirus B3 infection on the acute-phase protein metallothionein and on cytochrome P450 involved in the detoxification processes of TCDD in the mouse","volume":"284","author":"Funseth","year":"2002","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2005.02.008_bib19","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/cyto.990130711","article-title":"Flow-cytometric enumeration of micronucleated polychromatic erythrocytes in mouse peripheral blood","volume":"13","author":"Graw\u00e9","year":"1992","journal-title":"Cytometry"},{"key":"10.1016\/j.tox.2005.02.008_bib20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1469-185X.1999.tb00042.x","article-title":"Toxic action\/toxicity","volume":"75","author":"Hathway","year":"2000","journal-title":"Biol. Rev. Philos. Soc."},{"key":"10.1016\/j.tox.2005.02.008_bib21","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/mutage\/7.4.257","article-title":"Flow cytometric micronucleus test with mouse peripheral erythrocytes","volume":"7","author":"Hayashi","year":"1992","journal-title":"Mutagenesis"},{"key":"10.1016\/j.tox.2005.02.008_bib22","series-title":"Viral Infections of the Heart","first-page":"82","article-title":"Animal models: immunological aspects","author":"Huber","year":"1993"},{"key":"10.1016\/j.tox.2005.02.008_bib23","series-title":"New Concepts in Viral Heart Disease","first-page":"115","article-title":"Detection and typing of enteroviruses by nucleic acid probes and monoclonal antibodies","author":"Hyypi\u00e4","year":"1988"},{"key":"10.1016\/j.tox.2005.02.008_bib24","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0300-483X(92)90023-8","article-title":"Altered distribution of 109Cadmium in mice during viral infection","volume":"71","author":"Ilb\u00e4ck","year":"1992","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2005.02.008_bib25","first-page":"117","article-title":"Effects of the antiviral WIN 54954 and the immune modulator LS2616 on cachectin\/TNF and \u03b3-interferon responses during viral heart disease","volume":"88","author":"Ilb\u00e4ck","year":"1993","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.tox.2005.02.008_bib26","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0300-483X(93)02776-D","article-title":"Changed distribution and immune effects of nickel augment viral-induced inflammatory heart lesions in mice","volume":"91","author":"Ilb\u00e4ck","year":"1994","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2005.02.008_bib27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0378-4274(96)03777-0","article-title":"Effects of methyl mercury on cytokines, inflammation and virus clearance in a common viral infection","volume":"89","author":"Ilb\u00e4ck","year":"1996","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2005.02.008_bib28","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/00006676-200303000-00017","article-title":"Trace element changes in the pancreas during viral infection in mice","volume":"26","author":"Ilb\u00e4ck","year":"2003","journal-title":"Pancreas"},{"key":"10.1016\/j.tox.2005.02.008_bib29","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.tox.2003.12.019","article-title":"Metallothionein is induced and trace element balance changed in target organs of a common viral infection","volume":"199","author":"Ilb\u00e4ck","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2005.02.008_bib30","doi-asserted-by":"crossref","first-page":"33395","DOI":"10.1074\/jbc.M003754200","article-title":"Modulation of glutathione S-transferase alpha by hepatitis B virus and the chemopreventive drug oltipraz","volume":"275","author":"Jaitovitch-Groisman","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2005.02.008_bib31","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/oem.56.3.181","article-title":"Mortality patterns among workers exposed to acrylamide: 1994 follow up","volume":"56","author":"March","year":"1999","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.tox.2005.02.008_bib32","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0041-008X(86)90373-X","article-title":"The distribution of [14C]acrylamide in male and pregnant swiss-webster mice studied by whole-body autoradiography","volume":"86","author":"Marlowe","year":"1986","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2005.02.008_bib33","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.3109\/03602539709002246","article-title":"Regulation of cytochromes P450 during inflammation and infection","volume":"29","author":"Morgan","year":"1997","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.tox.2005.02.008_bib34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1383-5718(02)00281-4","article-title":"Induction of micronuclei in mouse and rat by glycidamide, genotoxic metabolite of acrylamide","volume":"535","author":"Paulsson","year":"2003","journal-title":"Mutat. Res."},{"key":"10.1016\/j.tox.2005.02.008_bib35","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1006\/abio.1999.4267","article-title":"Simultaneous analysis of hemoglobin adducts of acrylamide and glycidamide by gas chromatography\u2013mass spectrometry","volume":"274","author":"Perez","year":"1999","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.tox.2005.02.008_bib36","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/carcin\/16.5.1161","article-title":"Formation of N-7-(2-carbamoyl-2-hydroxyethyl)guanine in DNA of the mouse and the rat following intraperitoneal administration of (14C)acrylamide","volume":"16","author":"Segerb\u00e4ck","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.tox.2005.02.008_bib37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1021\/tx00025a014","article-title":"Characterization and quantitation of urinary metabolites of [1,2 3-13C]acrylamide in rats and mice using 13C nuclear magnetic resonance spectroscopy","volume":"5","author":"Sumner","year":"1992","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2005.02.008_bib38","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/S0278-6915(03)00188-1","article-title":"Dietary intake of acrylamide in Sweden","volume":"41","author":"Svensson","year":"2003","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2005.02.008_bib39","unstructured":"WHO, 2003. Press release http:\/\/www.who.int\/fsf\/acrylamide#main#page.htm."},{"key":"10.1016\/j.tox.2005.02.008_bib40","first-page":"424","article-title":"Viral myocarditis. A review","volume":"101","author":"Woodruff","year":"1980","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tox.2005.02.008_bib41","first-page":"2749","article-title":"Glutathione S-transferase expression in hepatitis B virus-associated human hepatocellular carcinogenesis","volume":"57","author":"Zhou","year":"1997","journal-title":"Cancer Res."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X05001149?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X05001149?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:52:55Z","timestamp":1759531975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X05001149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":41,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["S0300483X05001149"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2005.02.008","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2005,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acrylamide tissue distribution and genotoxic effects in a common viral infection in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2005.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}