{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:08:22Z","timestamp":1778670502576,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.tox.2005.09.002","type":"journal-article","created":{"date-parts":[[2005,10,18]],"date-time":"2005-10-18T16:49:23Z","timestamp":1129654163000},"page":"139-146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Characterization of anti-apoptotic action of TCDD as a defensive cellular stress response reaction against the cell damaging action of ultra-violet irradiation in an immortalized normal human mammary epithelial cell line, MCF10A"],"prefix":"10.1016","volume":"217","author":[{"given":"Sujin","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2005.09.002_bib1","first-page":"3360","article-title":"Two- and three-dimensional cell structures govern epidermal growth factor survival function in human bladder carcinoma cell lines","volume":"57","author":"Dangles","year":"1997","journal-title":"Cancer Res."},{"key":"10.1016\/j.tox.2005.09.002_bib2","first-page":"3314","article-title":"Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: correlation with increased transforming growth factor \u03b1 production","volume":"61","author":"Davis","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.tox.2005.09.002_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0041-008X(03)00012-7","article-title":"The aryl hydrocarbon receptor antagonist, 3\u2032 methoxy-4\u2032 nitroflavone, attenuates 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent regulation of growth factor signaling and apoptosis in the MCF-10A cell line","volume":"188","author":"Davis","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2005.09.002_bib4","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1091\/mbc.10.8.2493","article-title":"Radiation induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells leading to increased proliferation and protection from radiation induced cell death","volume":"10","author":"Dent","year":"1999","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.tox.2005.09.002_bib5","doi-asserted-by":"crossref","first-page":"17612","DOI":"10.1074\/jbc.274.25.17612","article-title":"Epidermal growth factor protects epithelial cells against Fas-induced apoptosis: requirement for Akt activation","volume":"274","author":"Gibson","year":"1999","journal-title":"J. Bio. Chem."},{"key":"10.1016\/j.tox.2005.09.002_bib6","first-page":"488","article-title":"Epidermal growth factor protects epithelial-derived cells from tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by inhibiting cytochrome C release","volume":"62","author":"Gibson","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.tox.2005.09.002_bib7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/toxsci\/58.1.127","article-title":"Various nitric oxide donors protect chick embryonic neurons from cyanide-induced apoptosis","volume":"58","author":"Jensen","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2005.09.002_bib8","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1074\/jbc.M008210200","article-title":"Epidermal growth factor receptor-dependent control of keratinocyte survival and Bcl-xL expression through a MEK-dependent pathway","volume":"276","author":"Jost","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2005.09.002_bib9","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1034\/j.1600-0773.2003.930406.x","article-title":"2 3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced activation of mitogen-activated protein kinase signaling pathway in Jurkat T cells","volume":"93","author":"Kwon","year":"2003","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2005.09.002_bib10","first-page":"1200","article-title":"Bacterial lipopolysaccharide antagonizes transforming growth factor beta 1-induced apoptosis in primary cultures of hepatocytes","volume":"23","author":"Martin-Sanz","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2005.09.002_bib11","first-page":"153","article-title":"Is the Ah receptor a stress response receptor, mediating cellular defense reactions?","volume":"1","author":"Matsumura","year":"2003","journal-title":"J. UOEH Suppl."},{"key":"10.1016\/j.tox.2005.09.002_bib12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0006-2952(03)00157-6","article-title":"On the significance of cellular stress response reactions in the toxic actions of dioxin","volume":"66","author":"Matsumura","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2005.09.002_bib13","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jbt.20041","article-title":"Studies on the mechanism of rapid activation of protein tyrosine phosphorylation activities, particularly c-Src kinase, by TCDD in MCF10A","volume":"18","author":"Mazina","year":"2004","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.tox.2005.09.002_bib14","doi-asserted-by":"crossref","first-page":"G1360","DOI":"10.1152\/ajpgi.2001.280.6.G1360","article-title":"Role of EGF receptor tyrosine kinase activity in anti-apoptotic effect of EGF on mouse hepatocytes","volume":"280","author":"Musallam","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.tox.2005.09.002_bib15","doi-asserted-by":"crossref","first-page":"C92","DOI":"10.1152\/ajpcell.2000.278.1.C92","article-title":"Induction of heme oxygenase-1 by hypoxia and free radicals in human dermal fibroblasts","volume":"278","author":"Panchenko","year":"2000","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.tox.2005.09.002_bib16","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/jbt.20040","article-title":"TCDD causes suppression of growth and differentiation of MCF10A, human mammary epithelial cells by interfering with their insulin receptor signaling through c-Src kinase and ERK activation","volume":"18","author":"Park","year":"2004","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.tox.2005.09.002_bib17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3109\/10428199509059662","article-title":"Apoptosis overview emphasizing the role of oxidative stress, DNA damage and signaling transduction pathways","volume":"19","author":"Payne","year":"1995","journal-title":"Leuk. Lymphoma."},{"key":"10.1016\/j.tox.2005.09.002_bib18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2486\/indhealth.41.127","article-title":"Short- and long-term morbidity and mortality in the population exposed to dioxin after the \u201cSeveso accident\u201d","volume":"41","author":"Pesatori","year":"2003","journal-title":"Ind. Health"},{"key":"10.1016\/j.tox.2005.09.002_bib19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/j.1749-6632.2002.tb04680.x","article-title":"CoCl2, a chemical inducer of hypoxia-inducible factor-1, and hypoxia reduce apoptotic cell death in hepatoma cell line HepG2","volume":"973","author":"Piret","year":"2002","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.tox.2005.09.002_bib20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bone.2003.06.004","article-title":"Reduction of c-Src activity by substituted 5,7-diphenyl-pyrrolo[2,3-d]-pyrimidines induces osteoclast apoptosis in vivo and in vitro","volume":"34","author":"Recchia","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.tox.2005.09.002_bib21","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1124\/mol.53.3.438","article-title":"PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen- activated protein kinase","volume":"53","author":"Reiners","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tox.2005.09.002_bib22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.toxlet.2003.12.019","article-title":"Tumor promoters as inhibitors of apoptosis in rat hepatocytes","volume":"149","author":"Schrenk","year":"2004","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2005.09.002_bib23","doi-asserted-by":"crossref","first-page":"31807","DOI":"10.1074\/jbc.M302580200","article-title":"Hepatitis B virus X protein activates a survival signaling by linking Src to phosphatidylinositol 3-kinase","volume":"278","author":"Shih","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2005.09.002_bib24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1039\/b201230h","article-title":"UV-induced DNA damage and repair: a review","volume":"1","author":"Sinha","year":"2002","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.tox.2005.09.002_bib25","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ijc.10983","article-title":"c-Raf controlled pathways in the protection of tumor cells from apoptosis","volume":"104","author":"Slater","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.tox.2005.09.002_bib26","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1470-2045(00)00193-5","article-title":"Apoptosis: implications of basic research for clinical oncology","volume":"2","author":"Tamm","year":"2001","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.tox.2005.09.002_bib27","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0898-6568(01)00206-6","article-title":"Evidence for involvement of c-Src in the anti-apoptotic action of nitric oxide in serum-deprived RINm5F cells","volume":"13","author":"Tejedo","year":"2001","journal-title":"Cell Signal."},{"key":"10.1016\/j.tox.2005.09.002_bib28","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0006-2952(03)00404-0","article-title":"Interaction of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with induced adipocyte differentiation in mouse embryonic fibroblasts (MEFs) involved tyrosine kinase c-Src","volume":"66","author":"Vogel","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2005.09.002_bib29","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1289\/ehp.02110625","article-title":"Serum dioxin concentrations and breast cancer risk in the Seveso Women's Health Study","volume":"110","author":"Warner","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2005.09.002_bib30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1382-6689(98)00040-4","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses apoptosis and leads to hyperphosphorylation of p53 in rat hepatocytes","volume":"6","author":"Woerner","year":"1998","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.tox.2005.09.002_bib31","first-page":"745","article-title":"Alpha 1-antitrypsin blocks the release of transforming growth factor-alpha from MCF-7 human breast cancer cells","volume":"82","author":"Yavelow","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X05004324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X05004324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:54:05Z","timestamp":1759532045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X05004324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":31,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0300483X05004324"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2005.09.002","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of anti-apoptotic action of TCDD as a defensive cellular stress response reaction against the cell damaging action of ultra-violet irradiation in an immortalized normal human mammary epithelial cell line, MCF10A","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2005.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}