{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:02:42Z","timestamp":1791194562166,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004182","name":"Nordisk Ministerr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004182","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["QLK4-CT-2002-0603"],"award-info":[{"award-number":["QLK4-CT-2002-0603"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.tox.2006.03.015","type":"journal-article","created":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T10:46:34Z","timestamp":1144233994000},"page":"144-155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":220,"title":["Mechanisms underlying the anti-androgenic effects of diethylhexyl phthalate in fetal rat testis"],"prefix":"10.1016","volume":"223","author":[{"given":"Julie","family":"Borch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stine Broeng","family":"Metzdorff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Vinggaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Brokken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majken","family":"Dalgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2006.03.015_bib1","first-page":"397","article-title":"Pathogenesis of male reproductive tract lesions from gestation through adulthood following in utero exposure to di(n-butyl) phthalate","volume":"31","author":"Barlow","year":"2003","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.tox.2006.03.015_bib2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/toxsci\/kfg087","article-title":"Quantitative changes in gene expression in fetal rat testes following exposure to di(n-butyl) phthalate","volume":"73","author":"Barlow","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2006.03.015_bib3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1006\/taap.1995.1164","article-title":"Effects of ammonium perfluorooctanoate on Leydig cell function: in vitro, in vivo, and ex vivo studies","volume":"134","author":"Biegel","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2006.03.015_bib4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4158\/EP.7.4.279","article-title":"Use of insulin-sensitizing agents in patients with polycystic ovary syndrome","volume":"7","author":"Bloomgarden","year":"2001","journal-title":"Endocr. Pract."},{"key":"10.1016\/j.tox.2006.03.015_bib5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.reprotox.2003.10.011","article-title":"Steroidogenesis in fetal male rats is reduced by DEHP and DINP, but endocrine effects of DEHP are not modulated by DEHA in fetal, prepubertal and adult male rats","volume":"18","author":"Borch","year":"2004","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2006.03.015_bib6","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.toxlet.2005.10.020","article-title":"Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis","volume":"163","author":"Borch","year":"2006","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2006.03.015_bib7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0014-5793(99)00268-9","article-title":"PPARgamma activators down-regulate the expression of PPARgamma in 3T3-L1 adipocytes","volume":"447","author":"Camp","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tox.2006.03.015_bib8","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1161\/01.CIR.101.20.2411","article-title":"CLA-1\/SR-BI is expressed in atherosclerotic lesion macrophages and regulated by activators of peroxisome proliferator-activated receptors","volume":"101","author":"Chinetti","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.tox.2006.03.015_bib9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/toxsci\/kfi011","article-title":"Peroxisome proliferator-activated receptors: mediators of phthalate ester-induced effects in the male reproductive tract?","volume":"83","author":"Corton","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2006.03.015_bib10","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/0031-9384(95)02065-9","article-title":"Hormonal imprinting: neonatal treatment of rats with the peroxysome proliferator clofibrate irreversibly affects sexual behaviour","volume":"58","author":"Csaba","year":"1995","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.tox.2006.03.015_bib11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1034\/j.1600-0773.2000.pto860208.x","article-title":"Toxicity study of di(2-ethylhexyl) phthalate (DEHP) in combination with acetone in rats","volume":"86","author":"Dalgaard","year":"2000","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2006.03.015_bib12","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1006\/rtph.1999.1296","article-title":"A cancer risk assessment of di(2-ethylhexyl)phthalate: application of the new U.S. EPA risk assessment guidelines","volume":"29","author":"Doull","year":"1999","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.tox.2006.03.015_bib13","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1210\/endo.143.7.8895","article-title":"Effect of peroxisome proliferators on Leydig cell peripheral-type benzodiazepine receptor gene expression, hormone-stimulated cholesterol transport, and steroidogenesis: role of the peroxisome proliferator-activator receptor alpha","volume":"143","author":"Gazouli","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2006.03.015_bib14","unstructured":"Hass, U., Filinska, M., Pedersen, S., Dalgaard, M., Kledal, T.S.A., 2004. Effects of finasteride and DEHP on anogenital distance and nipple retention after perinatal exposure in rats. Poster at 32nd Conference of the European Teratology Society. Abstr. Reprod. Toxicol. 18, 707\u2013756."},{"key":"10.1016\/j.tox.2006.03.015_bib15","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.reprotox.2004.11.005","article-title":"Antiandrogenic effects in male rats perinatally exposed to a mixture of di(2-ethylhexyl) phthalate and di(2-ethylhexyl) adipate","volume":"19","author":"Jarfelt","year":"2005","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2006.03.015_bib16","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1080\/15287390490514859","article-title":"Neonatal exposure to di(n-butyl) phthalate (DBP) alters male reproductive-tract development","volume":"67","author":"Kim","year":"2004","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.tox.2006.03.015_bib17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0378-4274(02)00414-9","article-title":"Changes in peroxisome proliferator-activated receptor gamma-regulated gene expression and inhibin\/activin-follistatin system gene expression in rat testis after an administration of di-n-butyl phthalate","volume":"138","author":"Kobayashi","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2006.03.015_bib18","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1210\/endo.143.3.8683","article-title":"Murine relaxin-like factor promoter: functional characterization and regulation by transcription factors steroidogenic factor 1 and DAX-1","volume":"143","author":"Koskimies","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2006.03.015_bib19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/toxsci\/kfh169","article-title":"Dose-dependent alterations in gene expression and testosterone synthesis in the fetal testes of male rats exposed to di(n-butyl) phthalate","volume":"81","author":"Lehmann","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2006.03.015_bib20","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1095\/biolreprod.104.039404","article-title":"Gene expression profiling following in utero exposure to phthalate esters reveals new gene targets in the etiology of testicular dysgenesis","volume":"73","author":"Liu","year":"2005","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2006.03.015_bib21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1006\/faat.1996.0047","article-title":"The direct effect of hepatic peroxisome proliferators on rat Leydig cell function in vitro","volume":"30","author":"Liu","year":"1996","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.tox.2006.03.015_bib22","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0006-291X(03)00819-2","article-title":"Hepatic scavenger receptor class B, type I is stimulated by peroxisome proliferator-activated receptor gamma and hepatocyte nuclear factor 4alpha","volume":"305","author":"Malerod","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2006.03.015_bib23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/toxsci\/58.2.339","article-title":"The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat","volume":"58","author":"Parks","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2006.03.015_bib24","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/humrep\/16.5.972","article-title":"Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects","volume":"16","author":"Skakkebaek","year":"2001","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.tox.2006.03.015_bib25","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1289\/ehp.8100","article-title":"Decrease in anogenital distance among male infants with prenatal phthalate exposure","volume":"113","author":"Swan","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2006.03.015_bib26","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1210\/en.2003-1475","article-title":"Di(n-butyl) phthalate impairs cholesterol transport and steroidogenesis in the fetal rat testis through a rapid and reversible mechanism","volume":"145","author":"Thompson","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2006.03.015_bib27","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1095\/biolreprod.105.042382","article-title":"Differential steroidogenic gene expression in the fetal adrenal gland versus the testis and rapid and dynamic response of the fetal testis to di(n-butyl) phthalate","volume":"73","author":"Thompson","year":"2005","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2006.03.015_bib28","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1478-1336-1-8","article-title":"SF-1 a key player in the development and differentiation of steroidogenic tissues","volume":"1","author":"Val","year":"2003","journal-title":"Nucl. Recept."},{"key":"10.1016\/j.tox.2006.03.015_bib29","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1053\/meta.2003.50028","article-title":"Reduced production rates of testosterone and dihydrotestosterone in healthy men treated with rosiglitazone","volume":"52","author":"Vierhapper","year":"2003","journal-title":"Metabolism"},{"key":"10.1016\/j.tox.2006.03.015_bib30","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1177\/019262339802600208","article-title":"Receptor and nonreceptor-mediated organ-specific toxicity of di(2-ethylhexyl)phthalate (DEHP) in peroxisome proliferator-activated receptor alpha-null mice","volume":"26","author":"Ward","year":"1998","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.tox.2006.03.015_bib31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.toxlet.2003.09.012","article-title":"Phthalate ester-induced gubernacular lesions are associated with reduced insl3 gene expression in the fetal rat testis","volume":"146","author":"Wilson","year":"2004","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2006.03.015_bib32","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1749-6632.2002.tb04600.x","article-title":"The effects of peroxisome proliferators on global lipid homeostasis and the possible significance of these effects to other responses to these xenobiotics: an hypothesis","volume":"973","author":"Xie","year":"2002","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.tox.2006.03.015_bib33","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1006\/dbio.2002.0663","article-title":"Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis","volume":"246","author":"Yao","year":"2002","journal-title":"Dev. Biol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X0600165X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X0600165X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:54:32Z","timestamp":1759532072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X0600165X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":33,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0300483X0600165X"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2006.03.015","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms underlying the anti-androgenic effects of diethylhexyl phthalate in fetal rat testis","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2006.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}