{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:29:03Z","timestamp":1790857743762,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.tox.2006.03.021","type":"journal-article","created":{"date-parts":[[2006,4,19]],"date-time":"2006-04-19T13:42:46Z","timestamp":1145454166000},"page":"191-201","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Amelioration of fumonisin B1 hepatotoxicity in mice by depletion of T cells with anti-Thy-1.2"],"prefix":"10.1016","volume":"223","author":[{"given":"Neelesh","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanren","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghubir P.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2006.03.021_bib1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/383787a0","article-title":"Functional diversity of helper T lymphocytes","volume":"383","author":"Abbas","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.tox.2006.03.021_bib2","doi-asserted-by":"crossref","first-page":"d1662","DOI":"10.2741\/batey","article-title":"Molecular pathogenesis of T lymphocyte-induced liver injury in alcoholic hepatitis","volume":"7","author":"Batey","year":"2002","journal-title":"Front. Biosci."},{"key":"10.1016\/j.tox.2006.03.021_bib3","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/S0278-6915(02)00075-3","article-title":"Fumonisin B1-induced localized activation of cytokine network in mouse liver","volume":"40","author":"Bhandari","year":"2002","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2006.03.021_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1006\/taap.1995.1125","article-title":"Role of proinflammatory cytokines in acetaminophen hepatotoxicity","volume":"133","author":"Blazka","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2006.03.021_bib5","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0278-6915(97)87267-5","article-title":"Toxicity of fumonisin B1 to B6C3F1 mice: a 14-day gavage study","volume":"35","author":"Bondy","year":"1997","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2006.03.021_bib6","first-page":"548","article-title":"Fumonisin toxicosis in domestic animals: a review","volume":"36","author":"Diaz","year":"1994","journal-title":"Vet. Hum. Toxicol."},{"key":"10.1016\/j.tox.2006.03.021_bib7","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.4049\/jimmunol.163.4.2314","article-title":"The human liver contains multiple populations of NK cells, T cells, and CD3+CD56+ natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns","volume":"163","author":"Doherty","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2006.03.021_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0163-7258(96)00006-X","article-title":"Fumonisins, mycotoxins of increasing importance, their nature and their effects","volume":"70","author":"Dutton","year":"1996","journal-title":"Pharmacol. Therap."},{"key":"10.1016\/j.tox.2006.03.021_bib9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/toxsci\/67.2.173","article-title":"Persistence and reversibility of the elevation in free sphingoid bases induced by fumonisin inhibition of ceramide synthase","volume":"67","author":"Enongene","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2006.03.021_bib10","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1084\/jem.182.5.1223","article-title":"Involvement of the CD95(APO-1\/Fas) receptor and ligand in liver damage","volume":"182","author":"Galle","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tox.2006.03.021_bib11","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1096\/fj.02-0548com","article-title":"Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells","volume":"16","author":"Graeler","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.tox.2006.03.021_bib12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.tox.2004.09.013","article-title":"Fumonisin B1 hepatotoxicity in mice is attenuated by depletion of Kupffer cells by gadolinium chloride","volume":"207","author":"He","year":"2005","journal-title":"Toxicology"},{"issue":"Suppl 2","key":"10.1016\/j.tox.2006.03.021_bib13","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1289\/ehp.01109s2277","article-title":"Fumonisin B1 carcinogenicity in a two-year feeding study using F344 rats and B6C3F1 mice","volume":"109","author":"Howard","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2006.03.021_bib14","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1073\/pnas.81.3.886","article-title":"Functional T cells in athymic nude mice","volume":"81","author":"Ikehara","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tox.2006.03.021_bib15","first-page":"301","article-title":"Fumonicin B1. IARC Monograph on the Evaluation of carcinogenic Risks to Humans","volume":"822","author":"International Agency for research on Cancer","year":"1992","journal-title":"IARC"},{"issue":"Suppl 2","key":"10.1016\/j.tox.2006.03.021_bib16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1289\/ehp.01109s2315","article-title":"Analysis of fumonisin B1-induced apoptosis","volume":"109","author":"Jones","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2006.03.021_bib17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nm0497-409","article-title":"Essential roles of the Fas ligand in the development of hepatitis","volume":"3","author":"Kondo","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.tox.2006.03.021_bib18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF01103100","article-title":"Fumonisin B1 alters sphingolipid metabolism and immune function in BALB\/c mice: immunological responses to fumonisin B1","volume":"130","author":"Martinova","year":"1995","journal-title":"Mycopathologia"},{"issue":"Suppl 2","key":"10.1016\/j.tox.2006.03.021_bib19","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1289\/ehp.01109s2283","article-title":"Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins","volume":"109","author":"Merrill","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2006.03.021_bib20","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0171-2985(82)80007-7","article-title":"A new model for investigations of T-cell functions in mice: differential immunosuppressive effects of two monoclonal anti-Thy-1, 2 antibodies","volume":"160","author":"Opitz","year":"1982","journal-title":"Immunobiology"},{"key":"10.1016\/j.tox.2006.03.021_bib21","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.semcdb.2004.05.008","article-title":"Modulation of adaptive immune responses by sphingosine-1-phosphate","volume":"15","author":"Payne","year":"2004","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.tox.2006.03.021_bib22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/19960401NT2","article-title":"Evidence for disruption of sphingolipid metabolism as a contributing factor in the toxicity and carcinogenicity of fumonisins","volume":"4","author":"Riley","year":"1996","journal-title":"Nat. Toxins"},{"key":"10.1016\/j.tox.2006.03.021_bib23","doi-asserted-by":"crossref","first-page":"5745","DOI":"10.4049\/jimmunol.161.10.5745","article-title":"Acute hepatotoxicity of Pseudomonas aeruginosa exotoxin A in mice depends on T cells and TNF","volume":"161","author":"Schumann","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2006.03.021_bib24","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.tox.2004.06.017","article-title":"Augmented fumonisin B1 toxicity in co-cultures: evidence for crosstalk between macrophages and non-parenchymatous liver epithelial cells involving proinflammatory cytokines","volume":"203","author":"Sharma","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2006.03.021_bib25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0300-483X(00)00405-4","article-title":"Decreased fumonisin hepatotoxicity in mice with a targeted deletion of tumor necrosis factor receptor 1","volume":"159","author":"Sharma","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2006.03.021_bib26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0021-9975(97)80084-9","article-title":"Demonstration of in situ apoptosis in mouse liver and kidney after short-term repeated exposure to fumonisin B1","volume":"117","author":"Sharma","year":"1997","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/j.tox.2006.03.021_bib27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1089\/10799900360520414","article-title":"Deletion of IFN-\u03b3 reduces fumonisin-induced hepatotoxicity in mice via alterations in inflammatory cytokines and apoptotic factors","volume":"23","author":"Sharma","year":"2003","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.tox.2006.03.021_bib28","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.tox.2005.07.024","article-title":"Lupus-prone NZBWF1\/J mice, defective in cytokine signaling, are resistant to fumonisin hepatotoxicity despite accumulation of liver sphinganine","volume":"216","author":"Sharma","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2006.03.021_bib29","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.4049\/jimmunol.158.8.3682","article-title":"Thymus-independent generation of NK1+ T cells in vitro from fetal liver precursors","volume":"158","author":"Shimamura","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2006.03.021_bib30","doi-asserted-by":"crossref","first-page":"18749","DOI":"10.1074\/jbc.270.32.18749","article-title":"Differential roles of de novo sphingolipid biosynthesis and turnover in the \u201cburst\u201d of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in culture","volume":"270","author":"Smith","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2006.03.021_bib31","doi-asserted-by":"crossref","first-page":"514","DOI":"10.4049\/jimmunol.167.1.514","article-title":"Dissection of the intracellular pathways in hepatocytes suggests a role for Jun kinase and IFN regulatory factor-1 in con A-induced liver failure","volume":"167","author":"Streetz","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2006.03.021_bib32","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1021\/jf00100a004","article-title":"Natural occurrence of some Fusarium mycotoxins in corn from low and high esophageal cancer prevalence areas of the Transkei, Southern Africa","volume":"38","author":"Sydenham","year":"1990","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.tox.2006.03.021_bib33","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/toxsci\/kfi086","article-title":"Mycotoxin fumonisin B1 alters the cytokine profile and decreases the vaccinal antibody titer in pigs","volume":"84","author":"Taranu","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2006.03.021_bib34","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1172\/JCI115836","article-title":"A T cell-dependent experimental liver injury in mice inducible by concanavalin A","volume":"90","author":"Tiegs","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tox.2006.03.021_bib35","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/(SICI)1099-0461(1998)12:5<281::AID-JBT4>3.0.CO;2-H","article-title":"Early fumonisin B1 toxicity in relation to disrupted sphingolipid metabolism in male BALB\/c mice","volume":"12","author":"Tsunoda","year":"1998","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.tox.2006.03.021_bib36","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1006\/faat.1995.1012","article-title":"Subchronic feeding study of the mycotoxin fumonisin B1 in B6CF1 mice and Fischer 344 rats","volume":"24","author":"Voss","year":"1995","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.tox.2006.03.021_bib37","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1096\/fj.04-1555fje","article-title":"Physiological sphingosine 1-phosphate requirement for optimal activity of mouse CD4+ regulatory T Cells","volume":"18","author":"Wang","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.tox.2006.03.021_bib38","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.4049\/jimmunol.166.2.1300","article-title":"TNF-\u03b1-induced expression of adhesion molecules in the liver is under the control of TNFR1\u2014 relevance for concanavalin A-induced hepatitis","volume":"166","author":"Wolf","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.tox.2006.03.021_bib39","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2199-6-4","article-title":"Selection of reference genes for gene expression studies in human neutrophils by real-time PCR","volume":"6","author":"Zhang","year":"2005","journal-title":"BMC Mol. Biol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X06001831?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X06001831?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:54:09Z","timestamp":1759532049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X06001831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0300483X06001831"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2006.03.021","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amelioration of fumonisin B1 hepatotoxicity in mice by depletion of T cells with anti-Thy-1.2","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2006.03.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}