{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:06:55Z","timestamp":1790838415359,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.tox.2006.04.043","type":"journal-article","created":{"date-parts":[[2006,5,9]],"date-time":"2006-05-09T14:07:11Z","timestamp":1147183631000},"page":"25-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Protection against soman-induced neuropathology and respiratory failure: A comparison of the efficacy of diazepam and avizafone in guinea pig"],"prefix":"10.1016","volume":"225","author":[{"given":"L.","family":"Taysse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Daulon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Delamanche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Bellier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Breton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2006.04.043_bib1","first-page":"485","article-title":"Efficacy of diazepam and avizafone against soman-induced neuropathology in brain of rats","volume":"14","author":"Clement","year":"1993","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2006.04.043_bib2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/jat.2550140502","article-title":"Review of oximes available for treatment of nerve agent poisoning","volume":"14","author":"Dawson","year":"1994","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tox.2006.04.043_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.2042-7158.1990.tb05401.x","article-title":"On the use of diazepam and pro-diazepam (2-benzol-4-chloro-N-methyl-N-lysylglycin anilide), as adjunct antidotes in the treatment of organophosphorus intoxication in the guinea-pig","volume":"42","author":"Karlsson","year":"1990","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.tox.2006.04.043_bib4","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1177\/096032719701601003","article-title":"Effect of Panpal pre-treatment and antidotal treatment (HI6 plus benactyzine) on respiratory and circulatory function in soman-poisoned rats","volume":"16","author":"Kassa","year":"1997","journal-title":"Human Exp. Toxicol."},{"key":"10.1016\/j.tox.2006.04.043_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0300-483X(97)00186-8","article-title":"The positive influence of a cholinergic-anticholinergic pre-treatment and antidotal treatment on rats poisoned with supralethal doses of soman","volume":"128","author":"Kassa","year":"1998","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2006.04.043_bib6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0300-483X(00)00322-X","article-title":"The influence of anticholinergic drug selection on the efficacy of antidotal treatment of soman-poisoned rats","volume":"154","author":"Kassa","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2006.04.043_bib7","first-page":"101","article-title":"A comparison of the neuroprotective efficacy of pharmacological pre-treatment and antidotal treatment in soman-poisoned rats","volume":"46","author":"Kassa","year":"2003","journal-title":"Acta Med."},{"key":"10.1016\/j.tox.2006.04.043_bib8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0378-4274(94)90121-X","article-title":"A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit","volume":"70","author":"Koplovitz","year":"1994","journal-title":"Tox. Lett."},{"key":"10.1016\/j.tox.2006.04.043_bib9","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/0006-8993(91)91539-D","article-title":"Effects of soman-induced seizures on different extracellular amino acid levels and glutamate uptake in rat hippocampus.","volume":"563","author":"Lallement","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.tox.2006.04.043_bib10","first-page":"557","article-title":"Extracellular acetylcholine changes in rat limbic structures during soman-induced seizures","volume":"13","author":"Lallement","year":"1992","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2006.04.043_bib11","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/0304-3940(92)90868-8","article-title":"Changes in hippocampal acetylcholine and glutamate extracellular levels during soman-induced seizures: influence of septal cholinoceptive cells","volume":"139","author":"Lallement","year":"1992","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.tox.2006.04.043_bib12","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s002040000146","article-title":"Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics","volume":"74","author":"Lallement","year":"2000","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2006.04.043_bib13","first-page":"1","article-title":"Protection against soman-induced lethality of the antidote combination atropine-pralidoxime-pro-diazepam packaged as a freeze-dried form","volume":"2","author":"Lallement","year":"2004","journal-title":"J. Med. Chem. Def."},{"key":"10.1016\/j.tox.2006.04.043_bib14","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.1016\/0272-0590(85)90132-0","article-title":"Treatment of poisoning by soman","volume":"5","author":"Leadbeater","year":"1985","journal-title":"Fund. Appl. Toxicol."},{"key":"10.1016\/j.tox.2006.04.043_bib15","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/0024-3205(85)90513-2","article-title":"Relationship between reversible acetylcholinesterase inhibition and efficacy against soman lethality","volume":"37","author":"Lennox","year":"1985","journal-title":"Life Sci."},{"key":"10.1016\/j.tox.2006.04.043_bib16","first-page":"64","article-title":"Gamma aminobutyric acid metabolism in different areas of rat brain at the onset of soman induced convulsions","volume":"234","author":"Lundy","year":"1978","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.tox.2006.04.043_bib17","first-page":"19","article-title":"Pharmacokinetics of the conversion of a peptide-aminobenzophenone pro-drug of diazepam in guinea pig and rhesus monkeys","volume":"1","author":"Maidment","year":"1990","journal-title":"J. Biopharm. Sci."},{"key":"10.1016\/j.tox.2006.04.043_bib18","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0149-7634(96)00050-4","article-title":"Neuropharmacological mechanisms of nerve agent-induced seizures and neuropathology","volume":"21","author":"McDonough","year":"1997","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.tox.2006.04.043_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0920-1211(99)00060-1","article-title":"Anticonvulsant treatment of nerve agent seizures: anticholinergics versus diazepam in soman-intoxicated guinea pigs","volume":"38","author":"McDonough","year":"2000","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.tox.2006.04.043_bib20","first-page":"53","article-title":"Acute neuropathology in soman poisoned rats","volume":"5","author":"McLeod","year":"1984","journal-title":"Neurotoxology"},{"key":"10.1016\/j.tox.2006.04.043_bib21","first-page":"176A","article-title":"Effet de l\u2019injection intraseptale de drogues pro et anticholinergiques sur le rythme theta hippocampique","volume":"98","author":"Monmaur","year":"1990","journal-title":"Arch. Int. Physiol. Bioch."},{"key":"10.1016\/j.tox.2006.04.043_bib22","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0006-8993(93)91551-3","article-title":"Hippocampal EEG responses induced by carbachol and atropine infusions into the septum and the hippocampus in the urethane-anaesthetized rat","volume":"631","author":"Monmaur","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.tox.2006.04.043_bib23","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.taap.2004.01.007","article-title":"Protection against soman-induced seizures in rats: relationship among doses of prophylactics, soman, and adjuncts","volume":"196","author":"Myhrer","year":"2004","journal-title":"Tox. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2006.04.043_bib24","first-page":"73","article-title":"Soman neurotoxicity","volume":"1","author":"Petras","year":"1983","journal-title":"Fund. Appl. Toxicol."},{"key":"10.1016\/j.tox.2006.04.043_bib25","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0091-3057(92)90019-C","article-title":"Behavioral performance, brain histology, and EEG sequela after immediate combined atropine\/diazepam treatment of soman-intoxicated rats","volume":"42","author":"Philippens","year":"1992","journal-title":"Pharm. Biochem. Behav."},{"key":"10.1016\/j.tox.2006.04.043_bib26","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/toxsci\/kfg166","article-title":"Anticholinergic and antiglutamatergic agents protect against soman-induced brain damage and cognitive dysfunction","volume":"75","author":"Raveh","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2006.04.043_bib27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/01480549109017867","article-title":"Protection from lethality and behavioural incapacitation resulting from intoxication by soman and treatment with atropine sulphate and 2-PAM chloride in the guinea pig, cavia porcellus","volume":"14","author":"Romano","year":"1991","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.tox.2006.04.043_bib28","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0091-3057(99)00114-8","article-title":"Organophosphorus nerve agents-induced seizures and efficacy of atropine sulphate as anticonvulsant treatment","volume":"64","author":"Shih","year":"1999","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.tox.2006.04.043_bib29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s002040050670","article-title":"Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication","volume":"74","author":"Shih","year":"2000","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2006.04.043_bib30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0300-483X(03)00086-6","article-title":"Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose","volume":"188","author":"Taysse","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2006.04.043_bib31","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.tox.2003.10.013","article-title":"Organophosphate-induced convulsions and prevention of neuropathological damages","volume":"196","author":"Tuovinen","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2006.04.043_bib32","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.lfs.2005.04.071","article-title":"Anticonvulsant effects of phencynonate hydrochloride and other anticholinergic drugs in soman poisoning: neurochemical mechanisms","volume":"78","author":"Wang","year":"2005","journal-title":"Life Sci."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X06002514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X06002514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:54:58Z","timestamp":1759532098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X06002514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0300483X06002514"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2006.04.043","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protection against soman-induced neuropathology and respiratory failure: A comparison of the efficacy of diazepam and avizafone in guinea pig","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2006.04.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}