{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:52:53Z","timestamp":1785711173884,"version":"3.56.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.tox.2006.10.002","type":"journal-article","created":{"date-parts":[[2006,11,28]],"date-time":"2006-11-28T10:30:53Z","timestamp":1164709853000},"page":"73-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Activation of soluble guanylate cyclase by nitric oxide is increased in lymphocytes from both rats chronically exposed to 2,5-hexanedione and workers chronically exposed to n-hexane"],"prefix":"10.1016","volume":"229","author":[{"given":"M.J.","family":"Prieto-Castell\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.L.","family":"Hern\u00e1ndez-Viadel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cardona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Marhuenda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Felipo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2006.10.002_bib1","first-page":"133","article-title":"2,5-Hexanedione excretion after occupational exposure to n-hexane","volume":"45","author":"Ahonen","year":"1988","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.tox.2006.10.002_bib2","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0306-4522(95)00349-N","article-title":"Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase","volume":"69","author":"Boulton","year":"1995","journal-title":"Neuroscience"},{"key":"10.1016\/j.tox.2006.10.002_bib3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00586062","article-title":"Biological monitoring of occupational exposure to n-hexane by measurement of urinary 2,5-hexanedione","volume":"65","author":"Cardona","year":"1993","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.tox.2006.10.002_bib4","first-page":"88","article-title":"Behaviour of urinary 2,5-hexanedione in occupational co-exposure to n-hexane and acetone","volume":"68","author":"Cardona","year":"1996","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.tox.2006.10.002_bib5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1080\/15287398709530976","article-title":"Urinary excretion of 2,5-hexanedione and peripheral polyneuropathies in workers exposed to n-hexane","volume":"20","author":"Governa","year":"1987","journal-title":"J. Toxicol. Environ. Health"},{"issue":"6","key":"10.1016\/j.tox.2006.10.002_bib6","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1097\/00019052-199912000-00013","article-title":"Neurotoxicants and the cytoskeleton","volume":"12","author":"Graham","year":"1999","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.tox.2006.10.002_bib7","first-page":"465","article-title":"NO honey, I don\u2019t remember","volume":"16","author":"Hawkins","year":"1996","journal-title":"Neuro"},{"key":"10.1016\/j.tox.2006.10.002_bib8","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0197-0186(02)00190-0","article-title":"Chronic exposure to 2,5-hexanedione impairs the glutamate\u2013nitric oxide\u2013cyclic GMP pathway in cerebellar neurons in culture and in rat brain in vivo","volume":"42","author":"Hern\u00e1ndez-Viadel","year":"2003","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.tox.2006.10.002_bib9","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1056\/NEJM197107082850204","article-title":"n-Hexane neuropathy: a syndrome occurring as a result of industrial exposure","volume":"285","author":"Herskowitz","year":"1971","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tox.2006.10.002_bib10","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0076-6879(91)95184-L","article-title":"Preparation of soluble guanylyl cyclase from bovine lung by immunoaffinity chromatography","volume":"195","author":"Humbet","year":"1991","journal-title":"Meth. Enzymol."},{"key":"10.1016\/j.tox.2006.10.002_bib11","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF00377756","article-title":"A study on biological monitoring of n-hexane exposure","volume":"51","author":"Iwata","year":"1983","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.tox.2006.10.002_bib12","first-page":"533","article-title":"n-Hexane metabolism in occupationally exposed workers","volume":"41","author":"Mutti","year":"1984","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.tox.2006.10.002_bib13","series-title":"Manual of Analytical Methods","author":"NIOSH","year":"1978"},{"key":"10.1016\/j.tox.2006.10.002_bib14","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/mus.880170904","article-title":"Early diagnosis of n-hexane-caused neuropathy","volume":"17","author":"Pastore","year":"1994","journal-title":"Muscle & Nerve"},{"key":"10.1016\/j.tox.2006.10.002_bib15","first-page":"20","article-title":"Urinary excretion of the metabolites of n-hexane and its isomers during occupational exposure","volume":"38","author":"Perbellini","year":"1981","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.tox.2006.10.002_bib16","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0041-008X(80)90422-6","article-title":"Identification of the metabolites of n-hexane, cyclohexane, and their isomers in men's urine","volume":"53","author":"Perbellini","year":"1980","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2006.10.002_bib17","first-page":"421","article-title":"An improved method of analysing 2,5-hexanedione in urine","volume":"47","author":"Perbellini","year":"1990","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.tox.2006.10.002_bib18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0378-4274(03)00302-3","article-title":"Free and total 2,5-hexanedione in biological monitoring of workers exposed to n-hexane in the shoe industry","volume":"145","author":"Prieto","year":"2003","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2006.10.002_bib19","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1136\/jnnp.38.8.771","article-title":"Experimental neuropathy produced by 2,5-hexanedione a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone","volume":"8","author":"Spencer","year":"1975","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.tox.2006.10.002_bib20","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1021\/bi9519718","article-title":"Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxide","volume":"35","author":"Stone","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.tox.2006.10.002_bib21","first-page":"192","article-title":"An occurrence of polyneuritis by n-hexane in the polyethylene laminating plants","volume":"6","author":"Yamada","year":"1964","journal-title":"Jpn. J. Ind. Health"}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X0600607X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X0600607X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:57:23Z","timestamp":1759532243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X0600607X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":21,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0300483X0600607X"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2006.10.002","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of soluble guanylate cyclase by nitric oxide is increased in lymphocytes from both rats chronically exposed to 2,5-hexanedione and workers chronically exposed to n-hexane","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2006.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}