{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T23:58:58Z","timestamp":1778284738695,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.tox.2006.11.005","type":"journal-article","created":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T10:46:46Z","timestamp":1163501206000},"page":"21-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells"],"prefix":"10.1016","volume":"231","author":[{"given":"Shu-Shong","family":"Hsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Jen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He-Hsiung","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiang-Ting","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao-Ying","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jue-Long","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I-Shu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiuh-Inn","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yih-Chau","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Tai","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Khing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Shyr","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Ren","family":"Jan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2006.11.005_bib1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nri1865","article-title":"The many paths to p38 mitogen-activated protein kinase activation in the immune system","volume":"6","author":"Ashwell","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.tox.2006.11.005_bib2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1079\/BJN2001489","article-title":"Pancreatic islet insulin secretion and metabolism in adult rats malnourished during neonatal life","volume":"87","author":"Barbosa","year":"2002","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.tox.2006.11.005_bib3","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1053\/jhep.2003.50459","article-title":"Membrane cholesterol but not putative receptors mediates anandamide-induced hepatocyte apoptosis","volume":"38","author":"Biswas","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2006.11.005_bib4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0070-2153(05)73003-9","article-title":"Calcium sensing receptors and calcium oscillations: calcium as a first messenger","volume":"73","author":"Breitwieser","year":"2006","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.tox.2006.11.005_bib5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1023\/A:1006935114624","article-title":"TNF-alpha induced altered signaling mechanism in human neutrophil","volume":"197","author":"Das","year":"1999","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.tox.2006.11.005_bib6","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1046\/j.1471-4159.2001.00333.x","article-title":"Cannabinoids activate p38 mitogen-activated protein kinases through CB1 receptors in hippocampus","volume":"77","author":"Derkinderen","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tox.2006.11.005_bib7","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1523\/JNEUROSCI.23-06-02371.2003","article-title":"Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus","volume":"23","author":"Derkinderen","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tox.2006.11.005_bib8","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.4049\/jimmunol.173.4.2373","article-title":"Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation","volume":"173","author":"Do","year":"2004","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.tox.2006.11.005_bib9","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1089\/scd.2004.13.473","article-title":"Apoptosis: the sculptor of development","volume":"13","author":"Doseff","year":"2004","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.tox.2006.11.005_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neuron.2005.11.027","article-title":"The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells","volume":"49","author":"Eljaschewitsch","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.tox.2006.11.005_bib11","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1152\/jn.01227.2005","article-title":"Cannabinoids modulate the P-type high voltage-activated calcium currents in Purkinje neurons","volume":"96","author":"Fisyunov","year":"2006","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.tox.2006.11.005_bib12","first-page":"811","article-title":"Anandamide-induced apoptosis in Chang liver cells involves ceramide and JNK\/AP-1 pathway","volume":"17","author":"Giuliano","year":"2006","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.tox.2006.11.005_bib13","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.tox.2006.11.005_bib14","doi-asserted-by":"crossref","first-page":"7044","DOI":"10.1074\/jbc.M109808200","article-title":"Estradiol-induced non-genomic calcium signaling regulates genotropic signaling in macrophages","volume":"277","author":"Guo","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2006.11.005_bib15","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1042\/BST0340232","article-title":"Calcium, mitochondria and reperfusion injury: a pore way to die","volume":"34","author":"Halestrap","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.tox.2006.11.005_bib16","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1158\/0008-5472.CAN-03-3720","article-title":"Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE\/ADAM17)-mediated transactivation of the epidermal growth factor receptor","volume":"64","author":"Hart","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.tox.2006.11.005_bib17","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1742-7843.2004.950304.x","article-title":"Effect of nortriptyline on intracellular Ca2+ handling and proliferation in human osteosarcoma cells","volume":"95","author":"Hsu","year":"2004","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2006.11.005_bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.brainres.2005.09.004","article-title":"Anandamide suppression of Na+ currents in rat dorsal root ganglion neurons.","volume":"1062","author":"Kim","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.tox.2006.11.005_bib19","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nm1263","article-title":"Caspase-independent cell death","volume":"11","author":"Kroemer","year":"2005","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.tox.2006.11.005_bib20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ymeth.2005.11.007","article-title":"Western blotting","volume":"38","author":"Kurien","year":"2006","journal-title":"Methods"},{"issue":"6","key":"10.1016\/j.tox.2006.11.005_bib21","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/00001813-200507000-00001","article-title":"Screening for apoptosis\u2014classical and emerging techniques","volume":"16","author":"Lovborg","year":"2005","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.tox.2006.11.005_bib22","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/bbrc.1998.9131","article-title":"Thymic lymphomas are resistant to Nur77-mediated apoptosis","volume":"249","author":"Matuszyk","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.tox.2006.11.005_bib23","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1189\/jlb.71.3.487","article-title":"Beryllium fluoride-induced cell proliferation: a process requiring P21(ras)-dependent activated signal transduction and NF-kappaB-dependent gene regulation","volume":"71","author":"Misra","year":"2002","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.tox.2006.11.005_bib24","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/sj.cdd.4401442","article-title":"Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways","volume":"11","author":"Movsesyan","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.tox.2006.11.005_bib25","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.tibs.2006.03.009","article-title":"MAPK signal specificity: the right place at the right time","volume":"31","author":"Murphy","year":"2006","journal-title":"Trends. Biochem. Sci."},{"issue":"2","key":"10.1016\/j.tox.2006.11.005_bib26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ymeth.2006.05.006","article-title":"Determining selectivity of phosphoinositide-binding domains","volume":"39","author":"Narayan","year":"2006","journal-title":"Methods"},{"key":"10.1016\/j.tox.2006.11.005_bib27","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1124\/jpet.104.067751","article-title":"Differential effects of endogenous and synthetic cannabinoids on alpha7-nicotinic acetylcholine receptor-mediated responses in Xenopus oocytes","volume":"310","author":"Oz","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2006.11.005_bib28","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1158\/1078-0432.CCR-05-2539","article-title":"Targeting the mitogen-activated protein kinase pathway in the treatment of malignant melanoma","volume":"12","author":"Panka","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.tox.2006.11.005_bib29","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1136\/gut.2005.073403","article-title":"The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2","volume":"54","author":"Patsos","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.tox.2006.11.005_bib30","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jneumeth.2006.01.024","article-title":"Rapid assay for quantitative measurement of apoptosis in cultured cells and brain tissue","volume":"155","author":"Portier","year":"2006","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.tox.2006.11.005_bib31","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1124\/jpet.105.092858","article-title":"R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human non-pigmented ciliary epithelial cells","volume":"316","author":"Rosch","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2006.11.005_bib32","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1007\/s00018-003-3055-2","article-title":"Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: possible involvement of lipid rafts","volume":"60","author":"Sarker","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.tox.2006.11.005_bib33","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1046\/j.1471-4159.2003.01663.x","article-title":"ASK1-p38 MAPK\/JNK signaling cascade mediates anandamide-induced PC12 cell death","volume":"85","author":"Sarker","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.tox.2006.11.005_bib34","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2174\/156800705774933005","article-title":"Cannabinoids: between neuroprotection and neurotoxicity","volume":"4","author":"Sarne","year":"2005","journal-title":"Curr. Drug Targets CNS Neurol. Disord."},{"issue":"1","key":"10.1016\/j.tox.2006.11.005_bib35","doi-asserted-by":"crossref","first-page":"C34","DOI":"10.1152\/ajpcell.00441.2005","article-title":"CXCR3 chemokine receptor-induced chemotaxis in human airway epithelial cells: role of p38 MAPK and PI3K signaling pathways","volume":"291","author":"Shahabuddin","year":"2006","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.tox.2006.11.005_bib36","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/hep.20667","article-title":"Anandamide induces necrosis in primary hepatic stellate cells","volume":"41","author":"Siegmund","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2006.11.005_bib37","doi-asserted-by":"crossref","first-page":"10431","DOI":"10.1074\/jbc.M509706200","article-title":"Fatty acid amide hydrolase determines anandamide-induced cell death in the liver","volume":"281","author":"Siegmund","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2006.11.005_bib38","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1089\/ten.2006.12.927","article-title":"Bone-like tissue formation by three-dimensional culture of MG63 osteosarcoma cells in gelatin hydrogels using calcium-enriched medium","volume":"12","author":"Takagishi","year":"2006","journal-title":"Tissue Eng."},{"key":"10.1016\/j.tox.2006.11.005_bib39","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/sj.thj.6200036","article-title":"Enhancement of erythropoietin-stimulated cell proliferation by anandamide correlates with increased activation of the mitogen-activated protein kinases ERK1 and ERK2","volume":"1","author":"Valk","year":"2000","journal-title":"Hematol. J."},{"key":"10.1016\/j.tox.2006.11.005_bib40","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.prostaglandins.2004.09.007","article-title":"Anandamide as an intracellular messenger regulating ion channel activity","volume":"77","author":"van der Stelt","year":"2005","journal-title":"Prostag. Other Lipid Mediat."},{"key":"10.1016\/j.tox.2006.11.005_bib41","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1038\/sj.emboj.7600784","article-title":"Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels","volume":"24","author":"van der Stelt","year":"2005","journal-title":"EMBO J."},{"issue":"6","key":"10.1016\/j.tox.2006.11.005_bib42","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s00210-004-0997-3","article-title":"Stimulation of cellular free Ca2+ elevation and inhibition of store-operated Ca2+ entry by kazinol B in neutrophils","volume":"370","author":"Wang","year":"2004","journal-title":"Naunyn. Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.tox.2006.11.005_bib43","doi-asserted-by":"crossref","first-page":"R437","DOI":"10.1152\/ajpregu.00040.2006","article-title":"Expression and function of potassium channels in the human placental vasculature","volume":"291","author":"Wareing","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.tox.2006.11.005_bib44","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1055\/s-0037-1613475","article-title":"Anandamide induces apoptosis in human endothelial cells: its regulation system and clinical implications","volume":"89","author":"Yamaji","year":"2003","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.tox.2006.11.005_bib45","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1742-7843.2006.pto_350.x","article-title":"Effect of anandamide on cytosolic Ca2+ levels and proliferation in canine renal tubular cells","volume":"98","author":"Yeh","year":"2006","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2006.11.005_bib46","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/sj.bjp.0705529","article-title":"Anandamide initiates Ca2+ signaling via CB2 receptor linked to phospholipase C in calf pulmonary endothelial cells","volume":"140","author":"Zoratti","year":"2003","journal-title":"Br. J. Pharmacol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X06006500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X06006500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:56:24Z","timestamp":1759532184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X06006500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0300483X06006500"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2006.11.005","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2006.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}