{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:04:05Z","timestamp":1767373445843,"version":"build-2065373602"},"reference-count":53,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.tox.2007.01.004","type":"journal-article","created":{"date-parts":[[2007,1,15]],"date-time":"2007-01-15T07:03:32Z","timestamp":1168844612000},"page":"200-215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mechanisms of inhibited liver tissue repair in toxicant challenged type 2 diabetic rats"],"prefix":"10.1016","volume":"232","author":[{"given":"Sharmilee P.","family":"Sawant","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankur V.","family":"Dnyanmote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harihara M.","family":"Mehendale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2007.01.004_bib1","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1101\/gad.7.5.812","article-title":"Cyclin D1 is a nuclear protein required for cell cycle progression in G1","volume":"7","author":"Baldin","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/j.tox.2007.01.004_bib2","first-page":"1895","article-title":"Constitutive MAP kinase phosphatase (MKP-1) expression blocks G1 specific gene transcription and S-phase entry in fibroblasts","volume":"10","author":"Brondello","year":"1995","journal-title":"Oncogene"},{"key":"10.1016\/j.tox.2007.01.004_bib3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.med.46.1.223","article-title":"Advanced protein glycosylation in diabetes and aging","volume":"46","author":"Brownlee","year":"1995","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.tox.2007.01.004_bib4","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0278-6915(95)00101-8","article-title":"A review of the role of tissue repair as an adaptive strategy: why low doses are often non-toxic and why high doses can be fatal","volume":"34","author":"Calabrese","year":"1996","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2007.01.004_bib5","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1006\/bbrc.1994.2097","article-title":"Elevated glucose concentrations inhibit DNA synthesis and expression of c-myc in cultured hepatocytes","volume":"202","author":"Dajani","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2007.01.004_bib6","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1289\/ehp.98106597","article-title":"Colchicine antimitosis abolishes resiliency of postnatally developing rats to chlordecone-amplified carbon tetrachloride hepatotoxicity and lethality","volume":"106","author":"Dalu","year":"1998","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2007.01.004_bib7","first-page":"5389","article-title":"Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice","volume":"61","author":"Deane","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.tox.2007.01.004_bib8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.taap.2005.02.007","article-title":"Disrupted G1 to S phase clearance via cyclin signaling impairs liver tissue repair in thioacetamide-treated type 1 diabetic rats","volume":"207","author":"Devi","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2007.01.004_bib9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejphar.2005.06.054","article-title":"NF-kB signaling in impaired liver tissue repair in thioacetamide-treated type 1 diabetic rats.","volume":"523","author":"Devi","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.tox.2007.01.004_bib10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.tox.2006.06.007","article-title":"Prior administration of a low dose of thioacetamide protects type 1 diabetic rats from subsequent administration of lethal dose of thioacetamide","volume":"226","author":"Devi","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2007.01.004_bib11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/hep.21530","article-title":"Nonalcoholic fatty liver sensitizes rats to carbon tetrachloride hepatotoxicity","volume":"45","author":"Donthamsetty","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2007.01.004_bib12","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/(SICI)1097-4644(20000315)76:4<567::AID-JCB5>3.0.CO;2-W","article-title":"Mitogen-activated protein phosphorylation in endothelial cells exposed to hyperosmolar conditions","volume":"76","author":"Duzgun","year":"2000","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.tox.2007.01.004_bib13","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1053\/gast.2002.33650","article-title":"Diabetes increases the risk of acute hepatic failure","volume":"122","author":"El-Serag","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tox.2007.01.004_bib14","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1053\/j.gastro.2003.10.065","article-title":"Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma","volume":"126","author":"El-Serag","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tox.2007.01.004_bib15","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1210\/er.2001-0039","article-title":"Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes","volume":"23","author":"Evans","year":"2002","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tox.2007.01.004_bib16","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0022-3565(25)30101-1","article-title":"Potentiation of carbon tetrachloride-induced hepatotoxicity in alloxan- or strepto-zotocin-diabetic rats","volume":"192","author":"Hanasono","year":"1975","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2007.01.004_bib17","doi-asserted-by":"crossref","first-page":"903","DOI":"10.3181\/00379727-149-38924","article-title":"Potentiation of the hepatotoxic responses to chemicals in alloxan-diabetic rats","volume":"149","author":"Hanasono","year":"1975","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.tox.2007.01.004_bib18","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.bbrc.2003.08.085","article-title":"Interleukin 6 and hepatocyte regeneration in acetaminophen toxicity in the mouse","volume":"309","author":"James","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2007.01.004_bib19","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/0006-2952(90)90327-H","article-title":"Altered hepatic energy status in chlordecone (Kepone)-potentiated CCl4 hepatotoxicity","volume":"40","author":"Kodavanti","year":"1990","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2007.01.004_bib20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/hep.510310123","article-title":"Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice","volume":"31","author":"Kovalovich","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2007.01.004_bib21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0300-483X(97)03627-5","article-title":"Antimitotic intervention with colchicine alters the outcome of o-DCB-induced hepatotoxicity in Fischer 344 rats","volume":"120","author":"Kulkarni","year":"1997","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2007.01.004_bib22","doi-asserted-by":"crossref","first-page":"20608","DOI":"10.1074\/jbc.271.34.20608","article-title":"Cyclin D1 expression is regulated positively by the p42\/p44MAPK and negatively by the p38\/HOGMAPK pathway","volume":"271","author":"Lavoie","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2007.01.004_bib23","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S0016-5085(03)00270-1","article-title":"Leptin-specific mechanisms for impaired liver regeneration in ob\/ob mice after toxic injury","volume":"124","author":"Leclercq","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tox.2007.01.004_bib24","first-page":"1099","article-title":"Induction of two different modes of cell death, apoptosis and necrosis, in rat liver after a single dose of thioacetamide","volume":"139","author":"Ledda-Columbano","year":"1991","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tox.2007.01.004_bib25","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2337\/diab.34.7.621","article-title":"Glucose toxicity for human endothelial cells in culture. Delayed replication, disturbed cell cycle, and accelerated death","volume":"34","author":"Lorenzi","year":"1985","journal-title":"Diabetes"},{"key":"10.1016\/j.tox.2007.01.004_bib26","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1023\/A:1006883919687","article-title":"Alterations in susceptibility to carbon tetrachloride toxicity and hepatic antioxidant\/detoxification system in streptozotocin-induced short-term diabetic rats: effects of insulin and Schisandrin B treatment","volume":"175","author":"Mak","year":"1997","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.tox.2007.01.004_bib27","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1600-0773.1995.tb01010.x","article-title":"Hepatocellular regeneration: key to thioacetamide autoprotection","volume":"77","author":"Mangipudy","year":"1995","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2007.01.004_bib28","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1289\/ehp.95103260","article-title":"Tissue repair response as a function of dose in thioacetamide hepatotoxicity","volume":"103","author":"Mangipudy","year":"1995","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2007.01.004_bib29","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1289\/ehp.96104744","article-title":"Effect of an antimitotic agent colchicine on thioacetamide hepatotoxicity","volume":"104","author":"Mangipudy","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2007.01.004_bib30","doi-asserted-by":"crossref","first-page":"E708","DOI":"10.1152\/ajpendo.00572.2002","article-title":"High glucose-mediated effects on endothelial cell proliferation occur via p38 MAP kinase","volume":"285","author":"McGinn","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tox.2007.01.004_bib31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/01926230590881808","article-title":"Tissue repair: an important determinant of final outcome of toxicant-induced injury","volume":"33","author":"Mehendale","year":"2005","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.tox.2007.01.004_bib32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/jbt.2570090304","article-title":"Autoprotection: stimulated tissue repair permits recovery from injury","volume":"9","author":"Mehendale","year":"1994","journal-title":"J. Biochem. Toxicol."},{"key":"10.1016\/j.tox.2007.01.004_bib33","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1076\/ceyr.19.2.162.5332","article-title":"Glucose-mediated regulation of transforming growth factor-beta (TGF-beta) and TGF-beta receptors in human retinal endothelial cells","volume":"19","author":"Pascal","year":"1999","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.tox.2007.01.004_bib34","first-page":"501","article-title":"The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation","volume":"20","author":"Pestell","year":"1999","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tox.2007.01.004_bib35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/109158199225215","article-title":"High glucose alters cell proliferation dynamics in human hepatoma cells","volume":"18","author":"Rao","year":"1999","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.tox.2007.01.004_bib36","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1113\/eph8802515","article-title":"Hyperglycaemia inhibits thymidine incorporation and cell growth via protein kinase C, mitogen-activated protein kinases and nitric oxide in human umbilical vein endothelium","volume":"88","author":"Rojas","year":"2003","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.tox.2007.01.004_bib37","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1124\/jpet.103.058834","article-title":"Potentiation of carbon tetrachloride hepatotoxicity and lethality in type 2 diabetic rats","volume":"308","author":"Sawant","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2007.01.004_bib38","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.taap.2005.07.019","article-title":"Type 2 diabetic rats are sensitive to thioacetamide hepatotoxicity","volume":"211","author":"Sawant","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2007.01.004_bib39","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1096\/fj.02-1186fje","article-title":"Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity","volume":"17","author":"Shankar","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.tox.2007.01.004_bib40","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1126\/science.274.5293.1672","article-title":"Cancer cell cycles","volume":"274","author":"Sherr","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.tox.2007.01.004_bib41","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0168-8278(05)80068-6","article-title":"Adenosine triphosphate protection of chlordecone-amplified CCl4 hepatotoxicity and lethality","volume":"20","author":"Soni","year":"1994","journal-title":"J. Hepatol."},{"issue":"Suppl. 6","key":"10.1016\/j.tox.2007.01.004_bib42","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1289\/ehp.98106s61307","article-title":"Role of tissue repair in toxicologic interactions among hepatotoxic organics","volume":"106","author":"Soni","year":"1998","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2007.01.004_bib43","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1076\/ceyr.18.6.423.5271","article-title":"Evidence of a glycemic threshold for the development of cataracts in diabetic rats","volume":"18","author":"Swamy-Mruthinti","year":"1999","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.tox.2007.01.004_bib44","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1172\/JCI19974","article-title":"Hepatoprotection via the IL-6\/Stat3 pathway","volume":"112","author":"Taub","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tox.2007.01.004_bib45","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1046\/j.1523-1755.1999.00665.x","article-title":"TGF-beta-activating kinase-1 inhibits cell cycle and expression of cyclin D1 and A in LLC-PK1 cells","volume":"56","author":"Terada","year":"1999","journal-title":"Kidney Int."},{"key":"10.1016\/j.tox.2007.01.004_bib46","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0002-9440(10)64167-3","article-title":"STAT-3 overexpression and p21 up-regulation accompany impaired regeneration of fatty livers","volume":"161","author":"Torbenson","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.tox.2007.01.004_bib47","doi-asserted-by":"crossref","first-page":"E161","DOI":"10.1152\/ajpendo.2002.282.1.E161","article-title":"High glucose-enhanced activation of mesangial cell p38 MAPK by ET-1, ANG II, and platelet-derived growth factor","volume":"282","author":"Tsiani","year":"2002","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tox.2007.01.004_bib48","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1006\/taap.2000.8952","article-title":"Enhanced hepatotoxicity and toxic outcome of thioacetamide in streptozotocin-induced diabetic rats","volume":"166","author":"Wang","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2007.01.004_bib49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1006\/taap.2001.9165","article-title":"Diallyl sulfide inhibition of CYP2E1 does not rescue diabetic rats from thioacetamide-induced mortality","volume":"173","author":"Wang","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2007.01.004_bib50","doi-asserted-by":"crossref","unstructured":"Wang, T., Shankar, K., Ronis, M.J., Mehendale, H.M., 2007. Mechanisms and outcomes of drug- and toxicant-induced liver toxicity in diabetes. Crit. Rev. Toxicol., 37, in press.","DOI":"10.1080\/10408440701215100"},{"key":"10.1016\/j.tox.2007.01.004_bib51","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0022-3565(24)39095-0","article-title":"Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1","volume":"294","author":"Wang","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2007.01.004_bib52","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0041-008X(88)90133-0","article-title":"The effect of long-term streptozotocin-induced diabetes on the hepatotoxicity of bromobenzene and carbon tetrachloride and hepatic biotransformation in rats","volume":"93","author":"Watkins","year":"1988","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2007.01.004_bib53","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/jcp.10243","article-title":"Biphasic role of TGF-beta1 in signal transduction and crosstalk","volume":"196","author":"Wenner","year":"2003","journal-title":"J. Cell Physiol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X07000182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X07000182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:57:19Z","timestamp":1759532239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X07000182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0300483X07000182"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2007.01.004","relation":{},"ISSN":["0300-483X"],"issn-type":[{"type":"print","value":"0300-483X"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of inhibited liver tissue repair in toxicant challenged type 2 diabetic rats","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2007.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}