{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T01:00:32Z","timestamp":1776128432787,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.tox.2007.05.033","type":"journal-article","created":{"date-parts":[[2007,6,17]],"date-time":"2007-06-17T23:32:29Z","timestamp":1182123149000},"page":"177-185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Effects of in utero and lactational exposure to triphenyltin chloride on pregnancy outcome and postnatal development in rat offspring"],"prefix":"10.1016","volume":"238","author":[{"given":"Konstanze","family":"Grote","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolin","family":"Hobler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson J.M.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Wichert","family":"Grande","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Gericke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris E.","family":"Talsness","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus E.","family":"Appel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Chahoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2007.05.033_bib1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/toxsci\/kfg131","article-title":"Effects of in utero tributyltin chloride exposure in the rat on pregnancy outcome","volume":"74","author":"Adeeko","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2007.05.033_bib2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1081\/DMR-200033490","article-title":"Organotin compounds: toxicokinetic aspects","volume":"36","author":"Appel","year":"2004","journal-title":"Drug Metab. Rev."},{"issue":"3","key":"10.1016\/j.tox.2007.05.033_bib3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1080\/15287399509532041","article-title":"Oral bis(tri-n-butyltin)oxide in pregnant mice. I. Potential influence of maternal behavior on postnatal mortality","volume":"46","author":"Baroncelli","year":"1995","journal-title":"J. Toxicol. Environ. Health"},{"issue":"6","key":"10.1016\/j.tox.2007.05.033_bib4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/jat.2550110604","article-title":"Immunotoxicity of tri-n-butyltin oxide (TBTO) and tri-n-butyltin chloride (TBTC) in the rat","volume":"11","author":"Bressa","year":"1991","journal-title":"J. Appl. Toxicol."},{"issue":"6","key":"10.1016\/j.tox.2007.05.033_bib5","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/tera.1420420610","article-title":"Effects of chemically induced maternal toxicity on prenatal development in the rat","volume":"42","author":"Chernoff","year":"1990","journal-title":"Teratology"},{"key":"10.1016\/j.tox.2007.05.033_bib6","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0378-4274(01)00451-9","article-title":"Effects of organotins on human aromatase activity in vitro","volume":"126","author":"Cooke","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2007.05.033_bib7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.fct.2003.09.003","article-title":"Oral (gavage), in utero and postnatal exposure of Sprague\u2013Dawley rats to low doses of tributyltin chloride. Part I. Toxicology, histopathology and clinical chemistry","volume":"42","author":"Cooke","year":"2004","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2007.05.033_bib8","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0039-128X(02)00051-X","article-title":"Effects of butyltins on human 5\u03b1-reductase type 1 and type 2 activity","volume":"67","author":"Doering","year":"2002","journal-title":"Steroids"},{"key":"10.1016\/j.tox.2007.05.033_bib9","first-page":"1","article-title":"Opinion of the scientific panel on contaminants in the food chain on a request from the commission to assess the health risks to consumers associated with exposure to organotins in foodstuffs","volume":"102","author":"EFSA","year":"2004","journal-title":"EFSA J."},{"key":"10.1016\/j.tox.2007.05.033_bib10","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s001289900883","article-title":"Developmental toxicity of triphenyltin chloride after administration on three consecutive days during organogenesis in rats","volume":"62","author":"Ema","year":"1999","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.tox.2007.05.033_bib11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0890-6238(02)00018-7","article-title":"Suppression of uterine decidualization correlated with reduction in serum progesterone levels as a cause of preimplantation embryonic loss induced by diphenyltin in rats","volume":"16","author":"Ema","year":"2002","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2007.05.033_bib12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.reprotox.2006.09.003","article-title":"Developmental toxicity of dibutyltin dichloride in cynomolgus monkeys","volume":"23","author":"Ema","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2007.05.033_bib13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0300-483X(94)90244-5","article-title":"Organotin compounds","volume":"91","author":"Fait","year":"1994","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2007.05.033_bib14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1741-4520.1997.tb00550.x","article-title":"Determination of the no-effect dose of bis(tri-n-butyltin)oxide (TBTO) for maternal toxicity and teratogenicity in mice","volume":"37","author":"Faqi","year":"1997","journal-title":"Cong. Anom."},{"key":"10.1016\/j.tox.2007.05.033_bib15","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1191\/074823399678846646","article-title":"Environmental antiandrogens: low doses of the fungicide vinclozolin alter sexual differentiation of the male rat","volume":"15","author":"Gray","year":"1999","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.tox.2007.05.033_bib16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.tox.2004.05.003","article-title":"Effects of organotin compounds on pubertal male rats","volume":"202","author":"Grote","year":"2004","journal-title":"Toxicology"},{"issue":"1\u20132","key":"10.1016\/j.tox.2007.05.033_bib17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tox.2006.01.008","article-title":"Effects of peripubertal exposure to triphenyltin on female sexual development of the rat","volume":"22","author":"Grote","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2007.05.033_bib18","first-page":"217","article-title":"Time course of the effects of trimethyltin on limbic evoked potentials and distribution of tin in blood and brain in the rat","volume":"5","author":"Hasan","year":"1984","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.tox.2007.05.033_bib19","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0039-128X(01)00108-8","article-title":"Inhibition of human cytochrome P450 aromatase activity by butyltins","volume":"66","author":"Heidrich","year":"2001","journal-title":"Steroids"},{"key":"10.1016\/j.tox.2007.05.033_bib20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0025-326X(96)00146-4","article-title":"Butyltin residues in sediment, fish, fish-eating birds, harbour porpoise and human tissues from the Polish coast of the Baltic Sea","volume":"34","author":"Kannan","year":"1997","journal-title":"Mar. Poll. Bull."},{"key":"10.1016\/j.tox.2007.05.033_bib21","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1021\/es990011w","article-title":"Occurence of butyltin compounds in human blood","volume":"33","author":"Kannan","year":"1999","journal-title":"Environ. Sci. Technol."},{"issue":"6","key":"10.1016\/j.tox.2007.05.033_bib22","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1271\/bbb.69.1104","article-title":"Effect of lactational exposure to tributyltin chloride on innate immunodefenses in the F1 generation in mice","volume":"69","author":"Kimura","year":"2005","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"5","key":"10.1016\/j.tox.2007.05.033_bib23","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1271\/bbb.70.1242","article-title":"Down-regulation of mdr1b mRNA expression in the kidneys of mice following maternal exposure to tributyltin chloride","volume":"70","author":"Kobayashi-Hattori","year":"2006","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"10.1016\/j.tox.2007.05.033_bib24","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0960-0760(03)00074-8","article-title":"Dithioerythritol (DTE) prevents inhibitory effects of triphenyltin (TPT) on the key enzymes of the human sex steroid hormone metabolism","volume":"84","author":"Lo","year":"2003","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.tox.2007.05.033_bib25","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.bcp.2006.01.014","article-title":"Organotin compounds enhance 17\u03b2-hydroxysteroid dehydrogenase type I activity in human choriocarcinoma jar cells: potential promotion of 17\u03b2-estradiol biosynthesis in human placenta","volume":"71","author":"Nakanishi","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2007.05.033_bib26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0378-4274(91)90108-I","article-title":"Effects of triphenyltin acetate on pregnancy in rats by oral administration","volume":"56","author":"Noda","year":"1991","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2007.05.033_bib27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/15287398309530409","article-title":"Dimethyltin chloride: investigations into its gastrointestinal absorption and transplacental transfer","volume":"12","author":"Noland","year":"1983","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.tox.2007.05.033_bib28","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0048-9697(96)05173-X","article-title":"Tributyltin (TBT) effects on Ocinebrina aciculata (Gastropoda: Muricida): imposex development, sterilization, sex change and population decline","volume":"188","author":"Oehlmann","year":"1996","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.tox.2007.05.033_bib29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1080\/15287390151126469","article-title":"Two-generation reproductive toxicity study of tributyltin chloride in female rats","volume":"63","author":"Ogata","year":"2001","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.tox.2007.05.033_bib30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0378-4274(95)03630-X","article-title":"Comparative study of the metabolism of triphenyltin in hamsters and rats after a single oral treatment with triphenyltin chloride","volume":"85","author":"Ohhira","year":"1996","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2007.05.033_bib31","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.steroids.2005.03.005","article-title":"Triphenyltin and tributyltin inhibit pig testicular 17\u03b2-hydroxysteroid dehydrogenase activity and suppress testicular testosterone biosynthesis","volume":"70","author":"Ohno","year":"2005","journal-title":"Steroids"},{"key":"10.1016\/j.tox.2007.05.033_bib32","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/toxsci\/64.2.224","article-title":"Two-generation reproductive toxicity study of tributyltin chloride in male rats","volume":"64","author":"Omura","year":"2001","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2007.05.033_bib33","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/0041-008X(85)90164-4","article-title":"Toxicity of triorganotin compounds: comparative in vivo studies with a series of trialkyltin compounds and triphenyltin chloride in male trats","volume":"81","author":"Snoeij","year":"1985","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2007.05.033_bib34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0300-483X(86)90160-5","article-title":"Triorganotin-induced cytotoxicity to rat thymus, bone marrow and red blood cells as determined by several in vitro assays","volume":"39","author":"Snoeij","year":"1986","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2007.05.033_bib35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0269-7491(99)00068-8","article-title":"Butyltin residues in livers of humans and wild terrestrial mammals and in plastic products","volume":"106","author":"Takahashi","year":"1999","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.tox.2007.05.033_bib36","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.fct.2003.08.019","article-title":"Oral (gavage), in utero and post-natal exposure of Sprague\u2013Dawey rats to low doses of tributyltin chloride. Part II. Effects on the immune system","volume":"42","author":"Tryphonas","year":"2004","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2007.05.033_bib37","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/toxsci\/kfg153","article-title":"Effects of butyltin compounds on mitochondrial respiration and its relation to hepatotoxicity in mice and guinea pigs","volume":"75","author":"Ueno","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2007.05.033_bib38","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00204-002-0429-4","article-title":"Comparison of hepatotoxicity and metabolism of butyltin compounds in the liver of mice, rats and guinea pigs","volume":"77","author":"Ueno","year":"2003","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2007.05.033_bib39","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/0041-008X(90)90366-3","article-title":"Immunotoxicity of bis(tributyltin) oxide in the rat: effect on the thymus-dependent immunity and on nonspecific resistance following long-term exposure in young versus aged rats","volume":"105","author":"Vos","year":"1990","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"3","key":"10.1016\/j.tox.2007.05.033_bib40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0278-6915(90)90006-9","article-title":"Chronic toxicity and carcinogenicity of bis(tri-n-butyltin) oxide (TBTO) in the rat","volume":"28","author":"Wester","year":"1990","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2007.05.033_bib41","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/BF01974012","article-title":"Studies on the hepatotoxicity induced by bis(tributyltin)oxide","volume":"66","author":"Yoshizuka","year":"1992","journal-title":"Arch. Toxicol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X07003228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X07003228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:57:55Z","timestamp":1759532275000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X07003228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":41,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S0300483X07003228"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2007.05.033","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of in utero and lactational exposure to triphenyltin chloride on pregnancy outcome and postnatal development in rat offspring","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2007.05.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}