{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:07:05Z","timestamp":1785892025068,"version":"3.56.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.tox.2007.07.013","type":"journal-article","created":{"date-parts":[[2007,7,21]],"date-time":"2007-07-21T07:23:52Z","timestamp":1185002632000},"page":"38-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nephrotoxicity induced by the R- and S-enantiomers of N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and their sulfate conjugates in male Fischer 344 rats"],"prefix":"10.1016","volume":"240","author":[{"given":"Gary O.","family":"Rankin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne K.","family":"Anestis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica A.","family":"Valentovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Triest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2007.07.013_bib1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0009-2797(91)90107-I","article-title":"Toxicity of N-(3,5-dichlorophenyl)succinimide and metabolites to rat renal proximal tubules and mitochondria","volume":"78","author":"Aleo","year":"1991","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tox.2007.07.013_bib2","first-page":"1304","article-title":"Studies on the interactions of chiral secondary alcohols with rat hydroxysteroid sulfotransferase Sta","volume":"25","author":"Banoglu","year":"1997","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2007.07.013_bib3","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1021\/tx980219f","article-title":"Importance of peri-interactions on the stereospecificity of rat hydroxysteroid sulfotransferase Sta with 1-arylethanols","volume":"12","author":"Banoglu","year":"1999","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2007.07.013_bib4","first-page":"425","article-title":"Experimental interstitial renal fibrosis in rats: nephritis induced by N-(3,5-dichlorophenyl)succinimide","volume":"64","author":"Barrett","year":"1983","journal-title":"Br. J. Exp. Pathol."},{"key":"10.1016\/j.tox.2007.07.013_bib5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.tox.2007.07.013_bib6","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0006-2952(98)00342-6","article-title":"Stereoselective and substrate-dependent inhibition of hepatic mitochondria beta-oxidation and oxidative phosphorylation by the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen, and ketorolac","volume":"57","author":"Browne","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2007.07.013_bib7","first-page":"658","article-title":"d-Serine nephrotoxicity. The nature of proteinuria, glucosuria, and aminoaciduria in acute tubular necrosis","volume":"99","author":"Carone","year":"1975","journal-title":"Arch. Pathol."},{"key":"10.1016\/j.tox.2007.07.013_bib8","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1021\/tx0496587","article-title":"Metabolism of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide in rats: evidence for bioactivation through alcohol-O-glucuronidation and O-sulfation","volume":"18","author":"Cui","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2007.07.013_bib9","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s000110050640","article-title":"Intestinal toxicity of ketoprofen-trometamol versus its enantiomers in rat. Role of oxidative stress","volume":"49","author":"de la Lastra","year":"2000","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.tox.2007.07.013_bib10","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1271\/bbb1961.35.1707","article-title":"Studies on biological activity of cyclic imide compounds. Part I. Antimicrobial activity of 3-phenyloxazolidine-2,4-diones and related compounds","volume":"35","author":"Fujinami","year":"1971","journal-title":"Agric. Biol. Chem."},{"key":"10.1016\/j.tox.2007.07.013_bib11","first-page":"318","article-title":"Studies on biological activity of cyclic imide compounds. Part II. Antimicrobial activity of 1-phenylpyrrolidine-2,5-diones and related compounds","volume":"36","author":"Fujinami","year":"1972","journal-title":"Agric. Biol. Chem."},{"key":"10.1016\/j.tox.2007.07.013_bib12","first-page":"907","article-title":"In vivo metabolism and disposition of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide in Fischer 344 rats","volume":"26","author":"Griffin","year":"1998","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2007.07.013_bib13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0378-4274(92)90277-Q","article-title":"Nephrotoxic potential of N-(3,5-dichloro-4-hydroxyphenyl)succinimide and N-(3,5-dichloro-4-hydroxyphenyl)succinamic acid in Fischer 344 rats","volume":"60","author":"Harvison","year":"1992","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2007.07.013_bib14","first-page":"155","article-title":"Control of brown rot and transit rot of peaches with post-harvest fungicidal dips","volume":"37","author":"Heaton","year":"1980","journal-title":"Queensland J. Agric. Anim. Sci."},{"key":"10.1016\/j.tox.2007.07.013_bib15","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0022-3565(25)22366-7","article-title":"Stereoselective renal tubular secretion of an organic anion in isolated perfused rat kidney","volume":"270","author":"Higaki","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2007.07.013_bib16","first-page":"138","article-title":"Stereoselective uptake of an organic anion across the renal basolateral membrane in isolated perfused rat kidney","volume":"26","author":"Higaki","year":"1998","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2007.07.013_bib17","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1080\/009841098158647","article-title":"Gender differences in acute N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity in Fischer 344 rats","volume":"54","author":"Hong","year":"1998","journal-title":"J. Toxicol. Env. Health Part A"},{"key":"10.1016\/j.tox.2007.07.013_bib18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0300-483X(99)00102-X","article-title":"Sodium sulfate potentiates N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity in the Fischer 344 rat","volume":"138","author":"Hong","year":"1999","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2007.07.013_bib19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0300-483X(98)00140-1","article-title":"Effect of glucuronidation substrates\/inhibitors on N-(3,5-dichlorophenyl)succinimide nephrotoxicity in Fischer 344 rats","volume":"132","author":"Hong","year":"1999","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2007.07.013_bib20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/009841099157854","article-title":"Effect of sulfation substrates\/inhibitors on N-(3,5-dichlorophenyl)succinimide (NDPS) nephrotoxicity in Fischer 344 rats","volume":"57","author":"Hong","year":"1999","journal-title":"J. Toxicol. Env. Health Part A"},{"key":"10.1016\/j.tox.2007.07.013_bib21","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1006\/taap.1998.8554","article-title":"The role of glucuronidation in N-(3,5-dichlorophenyl)succinimide (NDPS) nephrotoxicity: nephrotoxic potential of NDPS and NDPS metabolites in Gunn, Wistar, and Fischer 344 rats","volume":"154","author":"Hong","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2007.07.013_bib22","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1021\/tx050072+","article-title":"Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases","volume":"18","author":"Huang","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2007.07.013_bib23","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/0006-2952(79)90378-2","article-title":"Use of isolated kidney cells for study of drug metabolism","volume":"28","author":"Jones","year":"1979","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2007.07.013_bib24","series-title":"Principles of Medicinal Chemistry","first-page":"25","article-title":"Structural features and pharmacological activity","author":"Mathison","year":"1995"},{"key":"10.1016\/j.tox.2007.07.013_bib25","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/toxsci\/56.1.124","article-title":"Characterization of the ototoxicity of difluoromethylornithine and its enantiomers","volume":"56","author":"McWilliams","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2007.07.013_bib26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0090-9556(25)06492-X","article-title":"Metabolism of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide (NDPS) by isolated rat hepatocytes","volume":"23","author":"Nyarko","year":"1995","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2007.07.013_bib27","first-page":"1359","article-title":"Metabolism of N-(3\u2032,5\u2032-dichlorophenyl)succinimide in rats and dogs","volume":"38","author":"Ohkawa","year":"1974","journal-title":"Agric. Biol. Chem."},{"key":"10.1016\/j.tox.2007.07.013_bib28","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/S0022-3565(25)38278-9","article-title":"Steroselectivity in glutathione conjugation and amidase-catalyzed hydrolysis of the 2-bromoisovalerylurea enantiomers in the single-pass perfused rat liver","volume":"265","author":"Polhuijs","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2007.07.013_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0300-483X(82)90038-5","article-title":"Nephrotoxicity following acute administration of N-(3,5-dichlorophenyl)succinimide in Sprague\u2013Dawley rats","volume":"23","author":"Rankin","year":"1982","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2007.07.013_bib30","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/10937400490486113","article-title":"Nephrotoxicity induced by C- and N-arylsuccinimides","volume":"7","author":"Rankin","year":"2004","journal-title":"J. Toxicol. Env. Health Part B"},{"key":"10.1016\/j.tox.2007.07.013_bib31","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0300-483X(84)90092-1","article-title":"Onset and recovery from acute N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity in Sprague\u2013Dawley rats","volume":"30","author":"Rankin","year":"1984","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2007.07.013_bib32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0378-4274(85)90146-8","article-title":"N-(3,5-Dichlorophenyl)succinimide nephrotoxicity in the Fischer 344 rat","volume":"24","author":"Rankin","year":"1985","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2007.07.013_bib33","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0041-008X(88)90001-4","article-title":"Nephrotoxicity of N-(3,5-dichlorophenyl)succinimide metabolites in vivo and in vitro","volume":"96","author":"Rankin","year":"1988","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2007.07.013_bib34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0378-4274(89)90047-7","article-title":"Acute nephrotoxicity induced by N-(3,5-dichlorophenyl)-3-hydroxysuccinamic acid in Fischer 344 rats","volume":"48","author":"Rankin","year":"1989","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2007.07.013_bib35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0378-4274(91)90204-J","article-title":"Effect of buthionine sulfoximine on N-(3,5-dichlorophenyl)-2-hydroxysuccinimide and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid nephrotoxicity","volume":"57","author":"Rankin","year":"1991","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2007.07.013_bib36","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0300-483X(91)90077-E","article-title":"N-(3,5-Dichlorophenyl)succinimide nephrotoxicity: evidence against the formation of nephrotoxic glutathione or cysteine conjugates","volume":"68","author":"Rankin","year":"1991","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2007.07.013_bib37","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0300-483X(94)90117-1","article-title":"Acute N-(3,5-dichlorophenyl)succinimide nephrotoxicity in female Fischer 344 rats","volume":"88","author":"Rankin","year":"1994","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2007.07.013_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0300-483X(97)00097-8","article-title":"Effects of sodium sulfate on acute N-(3,5-dichlorophenyl)succinimide (NDPS) nephrotoxicity in the Fischer 344 rat","volume":"123","author":"Rankin","year":"1997","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2007.07.013_bib39","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0300-483X(01)00376-6","article-title":"In vitro nephrotoxicity induced by N-(3,5-dichlorophenyl)succinimide (NDPS) metabolites in isolated renal cortical cells from male and female Fischer 344 rats: evidence for a nephrotoxic sulfate conjugate metabolite","volume":"163","author":"Rankin","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2007.07.013_bib40","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0300-483X(01)00476-0","article-title":"Role of stereochemistry in N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity","volume":"168","author":"Rankin","year":"2001","journal-title":"Toxicology"},{"issue":"15","key":"10.1016\/j.tox.2007.07.013_bib41","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1055\/s-2002-34858","article-title":"Synthesis of enantiopure N-(3,5-dichlorophenyl)-2-hydroxysuccinimides (NDHS) and N-(3,5-dichlorophenyl)-2-hydroxysuccinimide-O-sulfates (NSC)","volume":"2002","author":"Rankin","year":"2002","journal-title":"Synthesis"},{"key":"10.1016\/j.tox.2007.07.013_bib42","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1055\/s-1989-27415","article-title":"Convenient synthesis of N-aryl-2-hydroxysuccinimides and characterization of their hydrolyzed products","volume":"11","author":"Shih","year":"1989","journal-title":"Synthesis"},{"key":"10.1016\/j.tox.2007.07.013_bib43","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1128\/AAC.38.9.2165","article-title":"Nucleotide analogs related to acyclovir and gangciclovir are effective against murine cytomegalovirus infections in BALB\/c and severe combined immunodeficient mice","volume":"38","author":"Smee","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.tox.2007.07.013_bib44","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0022-3565(25)20104-5","article-title":"Stereospecificity in contraluminal and luminal transporters of organic cations in the rat renal proximal tubule","volume":"278","author":"Somogyi","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2007.07.013_bib45","first-page":"219","article-title":"Pathologic analysis of chemical nephritis in rats induced by N-(3,5-dichlorophenyl)succinimide","volume":"33","author":"Sugihara","year":"1975","journal-title":"Lab. Invest."},{"key":"10.1016\/j.tox.2007.07.013_bib46","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1021\/tx990069o","article-title":"Cytotoxicity and DNA interaction of the enantiomers of 6-amino-3-(chloromethyl)-1-[(5,6,7-trimethoxyindol-2-yl)carbonyl]indoline (amino-seco-CI-TMI)","volume":"12","author":"Tercel","year":"1999","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.tox.2007.07.013_bib47","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0022-3565(25)32762-X","article-title":"Structural specificity in the renal tubular transport of tyrosine","volume":"219","author":"Williams","year":"1981","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2007.07.013_bib48","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.tox.2004.08.008","article-title":"Sodium benzoate attenuates d-serine induced nephrotoxicity in the rat","volume":"207","author":"Williams","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2007.07.013_bib49","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0300-483X(85)90113-1","article-title":"Effect of succinimide ring modification on N-(3,5-dichlorophenyl)succinimide-induced nephrotoxicity in Sprague\u2013Dawley and Fischer 344 rats","volume":"37","author":"Yang","year":"1985","journal-title":"Toxicology"}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X07004660?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X07004660?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:59:03Z","timestamp":1759532343000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X07004660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":49,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0300483X07004660"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2007.07.013","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nephrotoxicity induced by the R- and S-enantiomers of N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and their sulfate conjugates in male Fischer 344 rats","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2007.07.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}