{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:55:18Z","timestamp":1790362518661,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.tox.2007.10.015","type":"journal-article","created":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T17:23:59Z","timestamp":1195061039000},"page":"311-316","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice"],"prefix":"10.1016","volume":"243","author":[{"given":"Jiri","family":"Kassa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Karasova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Musilek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Kuca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2007.10.015_bib1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0065-2423(04)38006-6","article-title":"Organophosphate\/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis and treatment","volume":"38","author":"Bajgar","year":"2004","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.tox.2007.10.015_bib2","first-page":"27","article-title":"Tabun\u2014reappearance 50 years later (in Czech)","volume":"93","author":"Cabal","year":"1999","journal-title":"Chem. Listy"},{"key":"10.1016\/j.tox.2007.10.015_bib3","first-page":"81","article-title":"Specification of the structure of oximes able to reactivate tabun-inhibited acetylcholinesterase","volume":"95","author":"Cabal","year":"2004","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2007.10.015_bib4","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/BF01974018","article-title":"Efficacy of HL\u00f6-7 and pyrimidoxime as antidotes of nerve agent poisoning in mice","volume":"66","author":"Clement","year":"1992","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2007.10.015_bib5","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1021\/bi051286t","article-title":"Structural changes of phenylalanine 338 and histidine 447 revealed by the crystal structures of tabun-inhibited murine acetylcholinesterase","volume":"45","author":"Ekstr\u00f6m","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.tox.2007.10.015_bib6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2007.10.015_bib7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF02733672","article-title":"A comparison of trimedoxime, obidoxime, pralidoxime and HI-6 in the treatment of oral organophosphorus insecticide poisoning in the rat","volume":"70","author":"Jokanovic","year":"1995","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2007.10.015_bib8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0300-483X(95)03091-S","article-title":"Comparison of efficacy of two oximes (HI-6 and obidoxime) in soman poisoning in rats","volume":"101","author":"Kassa","year":"1995","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2007.10.015_bib9","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1081\/CLT-120015840","article-title":"Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents","volume":"40","author":"Kassa","year":"2002","journal-title":"J. Toxicol. Clin. Toxicol."},{"key":"10.1016\/j.tox.2007.10.015_bib10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF03033308","article-title":"The influence of oxime and anticholinergic drug selection on the potency of antidotal treatment to counteract acute toxic effects of tabun in mice","volume":"9","author":"Kassa","year":"2006","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.tox.2007.10.015_bib11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0300-483X(98)00146-2","article-title":"A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with currently available oximes and H oximes against soman by in vitro and in vivo methods","volume":"132","author":"Kassa","year":"1999","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2007.10.015_bib12","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1191\/096032799678845106","article-title":"A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with presently used oximes and H oximes against sarin by in vitro and in vivo methods","volume":"18","author":"Kassa","year":"1999","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.tox.2007.10.015_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-0773.1999.tb02109.x","article-title":"A comparison of the efficacy of acetylcholinesterase reactivators against cyclohexylmethylphosphonofluoridate (GF agent) by in vitro and in vivo methods","volume":"84","author":"Kassa","year":"1999","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2007.10.015_bib14","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2174\/138527207779940874","article-title":"The development of new structural analogues of oximes for the antidotal treatment of poisoning by nerve agents and the comparison of their reactivating and therapeutic efficacy with currently available oximes","volume":"11","author":"Kassa","year":"2007","journal-title":"Curr. Org. Chem."},{"key":"10.1016\/j.tox.2007.10.015_bib15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0378-4274(94)90121-X","article-title":"A comparison of the efficacy of HI-6 and 2-PAM against soman, tabun, sarin and VX in the rabbit","volume":"70","author":"Koplovitz","year":"1994","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2007.10.015_bib16","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2174\/138955706776073510","article-title":"Structural requirements of acetylcholinesterase reactivators","volume":"6","author":"Kuca","year":"2006","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.tox.2007.10.015_bib17","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.3390\/12081964","article-title":"Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide \u2013 a new nerve agent reactivator","volume":"12","author":"Kuca","year":"2007","journal-title":"Molecules"},{"key":"10.1016\/j.tox.2007.10.015_bib18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0163-7258(93)90066-M","article-title":"Organophosphate poisoning","volume":"58","author":"Marrs","year":"1993","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.tox.2007.10.015_bib19","doi-asserted-by":"crossref","DOI":"10.1080\/14756360601164960","article-title":"Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase","author":"Musilek","year":"2007","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.tox.2007.10.015_bib20","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.1016\/j.bmc.2007.08.002","article-title":"Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker\u2014preparation and reactivation of tabun and paraoxon-inhibited acetylcholinesterase","volume":"15","author":"Musilek","year":"2007","journal-title":"Bioorg. Med. Chem"},{"key":"10.1016\/j.tox.2007.10.015_bib21","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.1021\/jm070653r","article-title":"Design of a potent reactivator of tabun-inhibited acetylcholinesterase - synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203)","volume":"50","author":"Musilek","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.tox.2007.10.015_bib22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/jat.1224","article-title":"Five oximes (K-27, K-48, obidoxime, HI-6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl-paraoxon","volume":"27","author":"Petroianu","year":"2007","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tox.2007.10.015_bib23","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/0006-2952(86)90116-4","article-title":"Reactivation of nerve agent inhibited acetylcholinesterases by HI-6 and obidoxime","volume":"35","author":"Puu","year":"1986","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2007.10.015_bib24","series-title":"Manual of Pharmacological Calculation with Computer Programs","author":"Tallarida","year":"1987"},{"key":"10.1016\/j.tox.2007.10.015_bib25","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s002040050304","article-title":"Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds","volume":"70","author":"Worek","year":"1996","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2007.10.015_bib26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s002040050495","article-title":"Reactivating potency of obidoxime, pralidoxime, HI-6 and HL\u00f6-7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds","volume":"72","author":"Worek","year":"1998","journal-title":"Arch. Toxicol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X07007457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X07007457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:59:34Z","timestamp":1759532374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X07007457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0300483X07007457"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2007.10.015","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2007.10.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}