{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T18:29:23Z","timestamp":1769020163276,"version":"3.49.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.tox.2008.03.013","type":"journal-article","created":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T09:44:44Z","timestamp":1206524684000},"page":"151-157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["An unexpected plasma cholinesterase activity rebound after challenge with a high dose of the nerve agent VX"],"prefix":"10.1016","volume":"248","author":[{"given":"F.","family":"Dorandeu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Foquin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Briot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Delacour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Denis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.T.","family":"Froment","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Renault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Lallement","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Masson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2008.03.013_bib1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tox.2006.04.030","article-title":"Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase","volume":"224","author":"Aurbek","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2008.03.013_bib2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/jat.1226","article-title":"Inhibition of blood cholinesterases following intoxication with VX and its derivatives","volume":"27","author":"Bajgar","year":"2007","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tox.2008.03.013_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2423(08)60046-3","article-title":"The plasma cholinesterases: a new perspective","volume":"22","author":"Brown","year":"1981","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.tox.2008.03.013_bib4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1191\/0960327103ht359oa","article-title":"Clinical manifestations of VX poisoning following percutaneous exposure in the domestic white pig","volume":"22","author":"Chilcott","year":"2003","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.tox.2008.03.013_bib5","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1191\/0960327105ht537oa","article-title":"In vivo skin absorption and distribution of the nerve agent VX (O-ethyl-S-[2(diisopropylamino)ethyl] methylphosphonothioate) in the domestic white pig","volume":"24","author":"Chilcott","year":"2005","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.tox.2008.03.013_bib6","unstructured":"Conn, L.W., Wiles, J.S., Horton, R.G. (1957). Preliminary toxicological studies of EA 1701 (Report CWLR 2134)."},{"key":"10.1016\/j.tox.2008.03.013_bib7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1677\/joe.0.1750241","article-title":"Effect of alloxan-induced diabetes on serum and cardiac butyrylcholinesterases in the rat","volume":"175","author":"Dave","year":"2002","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.tox.2008.03.013_bib8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0041-008X(92)90295-4","article-title":"Altered capillary filtration coefficient in parathion- and paraoxon-induced edema in isolated and perfused rabbit lungs","volume":"116","author":"Delaunois","year":"1992","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2008.03.013_bib9","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.tox.2006.09.013","article-title":"Swine models in the design of more effective medical countermeasures against organophosphorus poisoning","volume":"233","author":"Dorandeu","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2008.03.013_bib10","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2008.03.013_bib11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1191\/0960327105ht532oa","article-title":"Extremely sensitive biomarker of acute organophosphorus insecticide exposure","volume":"24","author":"Fujikawa","year":"2005","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.tox.2008.03.013_bib12","doi-asserted-by":"crossref","first-page":"10133","DOI":"10.1021\/bi00106a009","article-title":"Purification of rabbit and human serum paraoxonase","volume":"30","author":"Furlong","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/j.tox.2008.03.013_bib13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.tox.2006.12.015","article-title":"Behavioral and biochemical evaluation of sub-lethal inhalation exposure to VX in rats","volume":"232","author":"Genovese","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2008.03.013_bib14","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s002040050529","article-title":"Toxicokinetics of soman in cerebrospinal fluid and blood of anaesthetized pigs","volume":"72","author":"G\u00f6ransson-Nyberg","year":"1998","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2008.03.013_bib15","unstructured":"Hulet, S.W., Sommerville, D.R., Matson, K.L., Crouse, C.L., Scotto, J.A., Benton, B.J., Mioduszewski, R.J., Thomson, S.A., 2007. Estimating miotic, severe and lethal toxic effects in Gottingen minipigs following inhalation, intravenous and subcutaneous exposures to VX. HFM-149 RTO SYMPOSIUM Defense against the effects of chemical hazards: toxicology, diagnosis, and medical countermeasures."},{"key":"10.1016\/j.tox.2008.03.013_bib16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1432-1033.1994.00115.x","article-title":"Acetylcholinesterase and butyrylcholinesterase expression in adult rabbit tissues and during development","volume":"225","author":"Jbilo","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.tox.2008.03.013_bib17","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.atherosclerosis.2003.12.002","article-title":"Serum butyrylcholinesterase activity in hyperlipidaemia","volume":"173","author":"Kalman","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.tox.2008.03.013_bib18","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.lfs.2004.02.019","article-title":"Increased serum butyrylcholinesterase activity in type IIb hyperlipidaemic patients","volume":"75","author":"Kalman","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.tox.2008.03.013_bib19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/12.3.219","article-title":"A \u201cDirect-Coloring\u201d thiocholine method for cholinesterases","volume":"12","author":"Karnovsky","year":"1964","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.tox.2008.03.013_bib20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00000542-198708000-00025","article-title":"Atypical serum cholinesterase eliminated by orthotopic liver transplantation","volume":"67","author":"Khoury","year":"1987","journal-title":"Anesthesiology"},{"key":"10.1016\/j.tox.2008.03.013_bib21","unstructured":"Kimura, K.K., McNamara, B.P., Sim, V.M. (1960). Intravenous administration of VX in man. U.S. Army Chemical Corps Research and Development Command. Report CRDLR 3017."},{"key":"10.1016\/j.tox.2008.03.013_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0272-0590(91)90249-4","article-title":"Mechanisms of pulmonary edema induced by an organophosphorus compound in anesthetized dogs","volume":"17","author":"Lainee","year":"1991","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.tox.2008.03.013_bib23","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/j.bcp.2005.09.002","article-title":"Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma","volume":"70","author":"Li","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2008.03.013_bib24","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1213\/00000539-199912000-00052","article-title":"Increased plasma cholinesterase activity and mivacurium resistance: report of a family","volume":"89","author":"Naguib","year":"1999","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.tox.2008.03.013_bib25","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.taap.2006.11.002","article-title":"Medical countermeasure against respiratory toxicity and acute lung injury following inhalation exposure to chemical warfare nerve agent VX","volume":"219","author":"Nambiar","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2008.03.013_bib26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1078-5337(03)00049-2","article-title":"Inhalational exposure to nerve agents","volume":"10","author":"Niven","year":"2004","journal-title":"Respir. Care Clin. N. Am."},{"key":"10.1016\/j.tox.2008.03.013_bib27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0041-008X(74)90195-1","article-title":"The reactivatibility of cholinesterase inhibited by VX and sarin in man","volume":"27","author":"Sidell","year":"1974","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2008.03.013_bib28","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0041-008X(03)00216-3","article-title":"Toxicokinetics of the nerve agent (+\/\u2212)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration","volume":"191","author":"van der Schans","year":"2003","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2008.03.013_bib29","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jns.2006.06.007","article-title":"Sarin experiences in Japan: acute toxicity and long-term effects","volume":"249","author":"Yanagisawa","year":"2006","journal-title":"J. Neurol. Sci."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X08001340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X08001340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:00:28Z","timestamp":1759532428000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X08001340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":29,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0300483X08001340"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2008.03.013","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An unexpected plasma cholinesterase activity rebound after challenge with a high dose of the nerve agent VX","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2008.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}