{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:38:39Z","timestamp":1760204319941,"version":"build-2065373602"},"reference-count":62,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.tox.2008.09.006","type":"journal-article","created":{"date-parts":[[2008,9,14]],"date-time":"2008-09-14T05:49:31Z","timestamp":1221371371000},"page":"117-124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Estrogen receptor subtypes selectively mediate female mouse reproductive abnormalities induced by neonatal exposure to estrogenic chemicals"],"prefix":"10.1016","volume":"253","author":[{"given":"Takeshi","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinao","family":"Katsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisen","family":"Iguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2008.09.006_bib1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1095\/biolreprod40.1.96","article-title":"Induction of persistent diestrus followed by persistent estrus is indicative of delayed maturation of tonic gonadotropin-releasing systems in the rat","volume":"40","author":"Aihara","year":"1989","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2008.09.006_bib2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1210\/endo-68-1-62","article-title":"Production of anovulatory, sterile rats by single injections of testosterone propionate","volume":"68","author":"Barraclough","year":"1961","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2008.09.006_bib3","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1210\/en.2005-0834","article-title":"Both estrogen receptor-\u03b1 and -\u03b2 are required for sexual differentiation of the anteroventral periventricular area in mice","volume":"147","author":"Bodo","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2008.09.006_bib4","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1210\/endo.139.10.6241","article-title":"Role of stromal and epithelial estrogen receptors in vaginal epithelial proliferation, stratification, and cornification","volume":"139","author":"Buchanan","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2008.09.006_bib5","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1210\/endo.140.1.6448","article-title":"Tissue compartment-specific estrogen receptor-\u03b1 participation in the mouse uterine epithelial secretory response","volume":"140","author":"Buchanan","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2008.09.006_bib6","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1210\/en.2007-0088","article-title":"Estradiol, progesterone, and genistein inhibit oocyte nest breakdown and primordial follicle assembly in the neonatal mouse ovary in vitro and in vivo","volume":"148","author":"Chen","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2008.09.006_bib7","doi-asserted-by":"crossref","first-page":"6535","DOI":"10.1073\/pnas.94.12.6535","article-title":"Stromal estrogen receptors mediate mitogenic effects of estradiol on uterine epithelium","volume":"94","author":"Cooke","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tox.2008.09.006_bib8","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0960-0760(00)00105-9","article-title":"Receptor null mice reveal contrasting roles for estrogen receptor \u03b1 and \u03b2 in reproductive tissues","volume":"74","author":"Couse","year":"2000","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.tox.2008.09.006_bib9","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1006\/dbio.2001.0413","article-title":"Estrogen receptor-\u03b1 knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract","volume":"238","author":"Couse","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.tox.2008.09.006_bib10","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1210\/edrv.20.3.0370","article-title":"Estrogen receptor null mice: what have we learned and where will they lead us?","volume":"20","author":"Couse","year":"1999","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.tox.2008.09.006_bib11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tox.2004.06.046","article-title":"Estrogen receptor-\u03b1 mediates the detrimental effects of neonatal diethylstilbestrol (DES) exposure in the murine reproductive tract","volume":"205","author":"Couse","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2008.09.006_bib12","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1210\/en.2005-0213","article-title":"Estrogen receptor-\u03b2 is critical to granulosa cell differentiation and the ovulatory response to gonadotropins","volume":"146","author":"Couse","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2008.09.006_bib13","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1210\/me.2002-0398","article-title":"Characterization of the hypothalamic\u2013pituitary\u2013gonadal axis in estrogen receptor (ER) null mice reveals hypergonadism and endocrine sex reversal in females lacking ER\u03b1 but not ER\u03b2","volume":"17","author":"Couse","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.tox.2008.09.006_bib14","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1124\/pr.58.4.8","article-title":"International union of pharmacology, LXIV. Estrogen receptors","volume":"58","author":"Dahlman-Wright","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.tox.2008.09.006_bib15","unstructured":"Damstra, T., Barlow, S., Bergman, A., Kavlock, R., Van der Kraak, G. (eds.), 2002. Global Assessment of the State-of-the-Science of Endocrine Disruptors. WHO\/IPCS."},{"key":"10.1016\/j.tox.2008.09.006_bib16","first-page":"41","article-title":"Developmental mechanism of estrogen-induced irreversible changes in the mouse cervicovaginal epithelium","volume":"51","author":"Forsberg","year":"1979","journal-title":"Natl. Cancer Inst. Monogr."},{"key":"10.1016\/j.tox.2008.09.006_bib17","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1210\/en.2002-0143","article-title":"Response-specific and ligand dose-dependent modulation of estrogen receptor (ER) \u03b1 activity by ER\u03b2 in the uterus","volume":"144","author":"Frasor","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2008.09.006_bib18","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1152\/ajplegacy.1963.205.5.842","article-title":"Modification of ovulatory mechanism by postnatal administration of estrogen to the rat","volume":"205","author":"Gorski","year":"1963","journal-title":"Am. J. Physiol."},{"year":"1980","series-title":"Sexual Differentiation of the Brain","author":"Goy","key":"10.1016\/j.tox.2008.09.006_bib19"},{"key":"10.1016\/j.tox.2008.09.006_bib20","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1210\/en.2002-220403","article-title":"Characterization of the biological roles of the estrogen receptors, ER\u03b1 and ER\u03b2, in estrogen target tissues in vivo through the use of an ER\u03b1-selective ligand","volume":"143","author":"Harris","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2008.09.006_bib21","first-page":"837","article-title":"Incidence of squamous neoplasia of the cervix and vagina in women exposed prenatally to diethylstilbestrol (United States)","volume":"12","author":"Hatch","year":"2001","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.tox.2008.09.006_bib22","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1006\/gyno.1999.5471","article-title":"Behavior of estrogen-associated female genital tract cancer and its relation to neoplasia following intrauterine exposure to diethylstilbestrol (DES)","volume":"76","author":"Herbst","year":"2000","journal-title":"Gynecol. Oncol."},{"year":"1981","series-title":"Developmental Effects of Diethylstilbestrol (DES) in Pregnancy","key":"10.1016\/j.tox.2008.09.006_bib23"},{"key":"10.1016\/j.tox.2008.09.006_bib24","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1056\/NEJM197104222841604","article-title":"Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women","volume":"284","author":"Herbst","year":"1971","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.tox.2008.09.006_bib25","doi-asserted-by":"crossref","first-page":"288","DOI":"10.2183\/pjab.61.288","article-title":"Occurrence of polyovular follicles in ovaries of mice treated neonatally with diethylstilbestrol","volume":"61B","author":"Iguchi","year":"1985","journal-title":"Proc. Japan Acad."},{"key":"10.1016\/j.tox.2008.09.006_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7696(08)61409-6","article-title":"Cellular effects of early exposure to sex hormones and antihormones","volume":"139","author":"Iguchi","year":"1992","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.tox.2008.09.006_bib27","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1095\/biolreprod43.3.478","article-title":"Polyovular follicles in mouse ovary exposed neonatally to diethylstilbestrol in vivo and in vitro","volume":"43","author":"Iguchi","year":"1990","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2008.09.006_bib28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF00315455","article-title":"Polyovular follicles in the ovary of prepubertal mice exposed prenatally to diethylstilbestrol","volume":"175","author":"Iguchi","year":"1986","journal-title":"Anat. Embryol."},{"key":"10.1016\/j.tox.2008.09.006_bib29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/tera.1420340105","article-title":"Frequent occurrence of polyovular follicles in ovaries of mice exposed neonatally to diethylstilbestrol","volume":"34","author":"Iguchi","year":"1986","journal-title":"Teratology"},{"key":"10.1016\/j.tox.2008.09.006_bib30","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1095\/biolreprod39.3.689","article-title":"The effect of an aromatase- and a 5\u03b1-reductase-inhibitor upon the occurrence of polyovular follicles, persistent anovulation, and permanent vaginal stratification in mice treated neonatally with testosterone","volume":"39","author":"Iguchi","year":"1988","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2008.09.006_bib31","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1073\/pnas.80.12.3743","article-title":"Growth of normal mouse vaginal epithelial cells in and on collagen gels","volume":"80","author":"Iguchi","year":"1983","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tox.2008.09.006_bib32","doi-asserted-by":"crossref","first-page":"292","DOI":"10.2183\/pjab.61.292","article-title":"Proliferation of normal mouse uterine luminal epithelial cells in serum-free collagen gel culture","volume":"61B","author":"Iguchi","year":"1985","journal-title":"Proc. Japan Acad."},{"key":"10.1016\/j.tox.2008.09.006_bib33","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1741-4520.2002.tb00858.x","article-title":"Developmental toxicity of estrogenic chemicals on rodents and other species","volume":"42","author":"Iguchi","year":"2002","journal-title":"Congenit. Anom."},{"key":"10.1016\/j.tox.2008.09.006_bib34","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1177\/153537020623100310","article-title":"Establishment of a primary culture model of mouse uterine and vaginal stroma for studying in vitro estrogen effects","volume":"231","author":"Inada","year":"2006","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.tox.2008.09.006_bib35","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1095\/biolreprod62.2.310","article-title":"Expression of estrogen receptor \u03b2 is developmentally regulated in reproductive tissues of male and female mice","volume":"62","author":"Jefferson","year":"2000","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2008.09.006_bib36","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1095\/biolreprod67.4.1285","article-title":"Neonatal exposure to genistein induces estrogen receptor (ER) \u03b1 expression and multioocyte follicles in the maturing mouse ovary: evidence for ER\u03b2-mediated and nonestrogenic actions","volume":"67","author":"Jefferson","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2008.09.006_bib37","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0890-6238(03)00002-9","article-title":"Changes in reproductive organs of female rats treated with bisphenol A during the neonatal period","volume":"17","author":"Kato","year":"2003","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2008.09.006_bib38","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mce.2006.07.001","article-title":"Molecular cloning of estrogen receptor alpha (ER\u03b1; ESR1) of the Japanese giant salamander, Andrias japonicus","volume":"257\u2013258","author":"Katsu","year":"2006","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.tox.2008.09.006_bib39","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1351\/pac200375112397","article-title":"Nature of the ligand-binding pocket of estrogen receptor \u03b1 and \u03b2: the search for subtype-selective ligands and implications for the prediction of estrogen activity","volume":"75","author":"Katzenellenbogen","year":"2003","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.tox.2008.09.006_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-83794-4_1","article-title":"Hormone toxicity in the newborn","volume":"31","author":"Kincl","year":"1990","journal-title":"Monogr. Endocrinol."},{"key":"10.1016\/j.tox.2008.09.006_bib41","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1210\/en.2006-1083","article-title":"Neonatal exposure to estrogens suppresses activin expression and signaling in the mouse ovary","volume":"148","author":"Kipp","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2008.09.006_bib42","first-page":"867","article-title":"Developmental effects of ethinylestradiol on reproductive organs of female mice","volume":"20","author":"Kirigaya","year":"2006","journal-title":"In Vivo"},{"key":"10.1016\/j.tox.2008.09.006_bib43","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/1521-1878(200010)22:10<902::AID-BIES5>3.0.CO;2-#","article-title":"The emergence of molecular gynecology: homeobox and Wnt genes in the female reproductive tract","volume":"22","author":"Kitajewski","year":"2000","journal-title":"Bioessays"},{"key":"10.1016\/j.tox.2008.09.006_bib44","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0960-0760(03)00348-0","article-title":"Update on animal models developed for analyses of estrogen receptor biological activity","volume":"86","author":"Korach","year":"2003","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.tox.2008.09.006_bib45","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1210\/endo.138.3.4979","article-title":"Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors \u03b1 and \u03b2","volume":"138","author":"Kuiper","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2008.09.006_bib46","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/dbio.1998.8907","article-title":"Abdominal B (AbdB) hoxa genes: regulation in adult uterus by estrogen and progesterone and repression in M\u00fcllerian duct by the synthetic estrogen diethylstilbestrol (DES)","volume":"197","author":"Ma","year":"1998","journal-title":"Dev. Biol."},{"key":"10.1016\/j.tox.2008.09.006_bib47","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/0959-8049(92)90482-H","article-title":"Diethylstilboestrol: I, pharmacology, toxicology and carcinogenicity in humans","volume":"28A","author":"Marselos","year":"1992","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.tox.2008.09.006_bib48","first-page":"149","article-title":"Diethylstilboestrol: II, pharmacology, toxicology and carcinogenicity in experimental animals","volume":"29A","author":"Marselos","year":"1992","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.tox.2008.09.006_bib49","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0018-506X(77)90060-5","article-title":"Aromatization: important for sexual differentiation of the neonatal rat brain","volume":"9","author":"McEwen","year":"1977","journal-title":"Horm. Behav."},{"key":"10.1016\/j.tox.2008.09.006_bib50","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1210\/en.2002-221069","article-title":"Immunolocalization of estrogen receptor \u03b2 in the mouse brain: comparison with estrogen receptor \u03b1","volume":"144","author":"Mitra","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2008.09.006_bib51","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/sj.onc.1207207","article-title":"Estrogen-independent activation of erbBs signaling and estrogen receptor \u03b1 in the mouse vagina exposed neonatally to diethylstilbestrol","volume":"23","author":"Miyagawa","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.tox.2008.09.006_bib52","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1677\/jme.0.0320663","article-title":"Persisitent gene expression in mouse vagina exposed neonatally to diethylstilbestrol","volume":"32","author":"Miyagawa","year":"2004","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.tox.2008.09.006_bib53","first-page":"753","article-title":"Risk of breast cancer in women exposed to diethylstilbestrol in utero: preliminary results (United States)","volume":"13","author":"Palmer","year":"2002","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.tox.2008.09.006_bib54","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ntt.2005.11.004","article-title":"Neonatal genistein or bisphenol-A exposure alters sexual differentiation of the AVPV","volume":"28","author":"Patisaul","year":"2006","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.tox.2008.09.006_bib55","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1095\/biolreprod64.3.831","article-title":"Stromal\u2013epithelial interactions modulate estrogen responsiveness in normal human endometrium","volume":"64","author":"Pierro","year":"2001","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2008.09.006_bib56","first-page":"151","article-title":"Estrogen receptor expression in the genital tract of female mice treated neonatally with diethylstilbestrol","volume":"6","author":"Sato","year":"1992","journal-title":"In Vivo"},{"key":"10.1016\/j.tox.2008.09.006_bib57","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0890-6238(02)00005-9","article-title":"Developmental effects of perinatal exposure to bisphenol-A and diethylstilbestrol on reproductive organs in female mice","volume":"16","author":"Suzuki","year":"2002","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2008.09.006_bib58","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0074-7696(08)61650-2","article-title":"Cytological basis for permanent vaginal changes in mice treated neonatally with steroid hormones","volume":"44","author":"Takasugi","year":"1976","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.tox.2008.09.006_bib59","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1126\/science.138.3538.438","article-title":"Persistent vaginal cornification in mice","volume":"138","author":"Takasugi","year":"1962","journal-title":"Science"},{"key":"10.1016\/j.tox.2008.09.006_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02136625","article-title":"Some aspects of hormonal mechanism involved in persistent estrus in the rat","volume":"18","author":"Takewaki","year":"1962","journal-title":"Experientia"},{"key":"10.1016\/j.tox.2008.09.006_bib61","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1046\/j.1365-2443.2002.00535.x","article-title":"Genome-wide analysis of changes in early gene expression induced by estrogen","volume":"7","author":"Watanabe","year":"2002","journal-title":"Genes Cells"},{"key":"10.1016\/j.tox.2008.09.006_bib62","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0014-5793(03)00436-8","article-title":"Update on estrogen signaling","volume":"546","author":"Weihua","year":"2003","journal-title":"FEBS Lett."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X08004253?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X08004253?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:02:10Z","timestamp":1759532530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X08004253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":62,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0300483X08004253"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2008.09.006","relation":{},"ISSN":["0300-483X"],"issn-type":[{"type":"print","value":"0300-483X"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Estrogen receptor subtypes selectively mediate female mouse reproductive abnormalities induced by neonatal exposure to estrogenic chemicals","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2008.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}