{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T21:45:57Z","timestamp":1759614357984,"version":"build-2065373602"},"reference-count":28,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.tox.2008.10.024","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T07:32:44Z","timestamp":1226475164000},"page":"25-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of immunotoxicity among tetrachloro-, pentachloro-, tetrabromo- and pentabromo-dibenzo-p-dioxins in mice"],"prefix":"10.1016","volume":"256","author":[{"given":"Kana","family":"Ao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikari","family":"Murai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiyo","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruko","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimi","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiharu","family":"Tohyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Nohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2008.10.024_bib1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0160-4120(03)00106-5","article-title":"Health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs)","volume":"29","author":"Birnbaum","year":"2003","journal-title":"Environ. Int."},{"key":"10.1016\/j.tox.2008.10.024_bib2","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1289\/ehp.8629","article-title":"Origin and health impacts of emissions of toxic by-products and fine particles from combustion and thermal treatment of hazardous wastes and materials","volume":"114","author":"Cormier","year":"2006","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2008.10.024_bib3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/taap.1994.1185","article-title":"Time course of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced thymic atrophy in the Wistar rat","volume":"128","author":"De Heer","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2008.10.024_bib4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1006\/taap.1997.8261","article-title":"Dose-response relationships for polyhalogenated dioxins and dibenzofurans following subchronic treatment in mice","volume":"147","author":"DeVito","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2008.10.024_bib5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/toxsci\/kfg132","article-title":"Suppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the high-affinity antibody response in C57BL\/6 mice","volume":"74","author":"Inouye","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2008.10.024_bib6","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.chemosphere.2005.01.014","article-title":"T cell-derived IL-5 production is a sensitive target of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)","volume":"60","author":"Inouye","year":"2005","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2008.10.024_bib7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/toxsci\/70.1.46","article-title":"Mechanism of TCDD-induced suppression of antibody production: effect on T cell-derived cytokine production in the primary immune reaction of mice","volume":"70","author":"Ito","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2008.10.024_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0300-483X(00)00330-9","article-title":"Sensitivity of the SRBC PFC assay versus ELISA for detection of immunosuppression by TCDD and TCDD-like congeners","volume":"156","author":"Johnson","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2008.10.024_bib9","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1126\/science.1089926","article-title":"Promotion of B cell immune responses via an alum-induced myeloid cell population","volume":"304","author":"Jordan","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.tox.2008.10.024_bib10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1289\/ehp.730549","article-title":"Synthesis of new steric and electronic analogs of 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"5","author":"Kende","year":"1973","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2008.10.024_bib11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1567-5769(01)00179-5","article-title":"Recent advances in understanding the mechanisms of TCDD immunotoxicity","volume":"2","author":"Kerkvliet","year":"2002","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.tox.2008.10.024_bib12","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1084\/jem.20071087","article-title":"Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells","volume":"205","author":"Kool","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.tox.2008.10.024_bib13","doi-asserted-by":"crossref","first-page":"5641","DOI":"10.1021\/es0702925","article-title":"Severe PCDD\/F and PBDD\/F pollution in air around an electronic waste dismantling area in China","volume":"41","author":"Li","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2008.10.024_bib14","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0272-0590(92)90047-L","article-title":"Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests","volume":"18","author":"Luster","year":"1992","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.tox.2008.10.024_bib15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0300-483X(87)90027-8","article-title":"Polybrominated dibenzo-p-dioxins and related compounds: quantitative in vivo and in vitro structure\u2013activity relationships","volume":"44","author":"Mason","year":"1987","journal-title":"Toxicology"},{"issue":"Suppl. 1","key":"10.1016\/j.tox.2008.10.024_bib16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1289\/ehp.94102s1265","article-title":"Polybrominated dibenzo-p-dioxins and dibenzofurans: literature review and health assessment","volume":"102","author":"Mennear","year":"1994","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2008.10.024_bib17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0300-483X(01)00582-0","article-title":"Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on T cell-derived cytokine production in ovalbumin (OVA)-immunized C57Bl\/6 mice","volume":"172","author":"Nohara","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2008.10.024_bib18","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.tox.2006.06.005","article-title":"Comparison of the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced CYP1A1 gene expression profile in lymphocytes from mice, rats, and humans: most potent induction in humans","volume":"225","author":"Nohara","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2008.10.024_bib19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/toxsci\/kfm096","article-title":"An aryl hydrocarbon receptor odyssey to the shores of toxicology: the Deichmann Lecture, International Congress of Toxicology-XI","volume":"98","author":"Okey","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2008.10.024_bib20","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1897\/07-004R.1","article-title":"Relative differences in aryl hydrocarbon receptor-mediated response for 18 polybrominated and mixed halogenated dibenzo-p-dioxins and -furans in cell lines from four different species","volume":"26","author":"Olsman","year":"2007","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.tox.2008.10.024_bib21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.tox.2004.06.024","article-title":"Evaluation of relative potencies of PCB126 and PCB169 for the immunotoxicities in ovalbumin (OVA)-immunized mice","volume":"204","author":"Pan","year":"2004","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2008.10.024_bib22","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0045-6535(00)00224-1","article-title":"Combustion of brominated flame retardants and behavior of its byproducts","volume":"42","author":"Sakai","year":"2001","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2008.10.024_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev.cellbio.12.1.55","article-title":"Ah receptor signaling pathways","volume":"12","author":"Schmidt","year":"1996","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.tox.2008.10.024_bib24","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.taap.2007.11.018","article-title":"Relative potency based on hepatic enzyme induction predicts immunosuppressive effects of a mixture of PCDDs\/PCDFs and PCBs","volume":"227","author":"Smialowicz","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2008.10.024_bib25","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1289\/ehp.98106775","article-title":"Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife","volume":"106","author":"Van den Berg","year":"1998","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2008.10.024_bib26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/toxsci\/kfl055","article-title":"The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds","volume":"93","author":"Van den Berg","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2008.10.024_bib27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/009841097160456","article-title":"The toxicity of brominated and mixed-halogenated dibenzo-p-dioxins and dibenzofurans: an overview","volume":"50","author":"Weber","year":"1997","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.tox.2008.10.024_bib28","article-title":"Polybrominated dibenzo-p-dioxins and dibenzofurans","volume":"205","author":"World Health Organization (WHO)","year":"1998","journal-title":"Environ. Health Criteria"}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X08005179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X08005179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:05:36Z","timestamp":1759532736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X08005179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":28,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0300483X08005179"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2008.10.024","relation":{},"ISSN":["0300-483X"],"issn-type":[{"type":"print","value":"0300-483X"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of immunotoxicity among tetrachloro-, pentachloro-, tetrabromo- and pentabromo-dibenzo-p-dioxins in mice","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2008.10.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}