{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:22:27Z","timestamp":1791134547629,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1016\/j.tox.2008.12.018","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T04:40:27Z","timestamp":1230698427000},"page":"117-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["Hazard assessment of methylmercury toxicity to neuronal induction in embryogenesis using human embryonic stem cells"],"prefix":"10.1016","volume":"257","author":[{"given":"Tina C.","family":"Stummann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Hareng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Bremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2008.12.018_bib1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1476-069X-4-20","article-title":"Inter-individual variations of human mercury exposure biomarkers: a cross-sectional assessment","volume":"4","author":"Berglund","year":"2005","journal-title":"Environ. Health"},{"key":"10.1016\/j.tox.2008.12.018_bib2","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.2174\/138161207782110462","article-title":"The development of new concepts for assessing reproductive toxicity applicable to large scale toxicological programmes","volume":"13","author":"Bremer","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.tox.2008.12.018_bib3","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1523\/JNEUROSCI.07-11-03489.1987","article-title":"Two-stage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns","volume":"7","author":"Carden","year":"1987","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tox.2008.12.018_bib4","series-title":"Human Embryology and Developmental Biology","author":"Carlson","year":"2004"},{"key":"10.1016\/j.tox.2008.12.018_bib5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1016-8478(23)13113-X","article-title":"NeuroD: the predicted and the surprising","volume":"18","author":"Chae","year":"2004","journal-title":"Mol. Cell"},{"key":"10.1016\/j.tox.2008.12.018_bib6","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1523\/JNEUROSCI.04-08-02080.1984","article-title":"Initial expression of neurofilaments and vimentin in the central and peripheral nervous system of the mouse embryo in vivo","volume":"4","author":"Cochard","year":"1984","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tox.2008.12.018_bib7","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1542\/peds.113.S3.1023","article-title":"Mercury exposure and child development outcomes","volume":"113","author":"Davidson","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.tox.2008.12.018_bib8","unstructured":"EMEA, 1994. ICH Topic S5(R2) Diction of Toxicity to Reproduction for Medicinal Products & Toxicity to Male Fertility. EMEA, London http:\/\/www.emea.europa.eu\/pdfs\/human\/ich\/038695en.pdf (accessed 09.01.2008)."},{"key":"10.1016\/j.tox.2008.12.018_bib9","unstructured":"EMEA, 2001. ICH Topic S7A Safety Pharmacology Studies for Human Pharmaceuticals. EMEA, London http:\/\/www.emea.europa.eu\/pdfs\/human\/ich\/053900en.pdf (accessed 08.08.2007)."},{"key":"10.1016\/j.tox.2008.12.018_bib10","unstructured":"Eurocat, 2005. EUROCAT Annual Report to WHO 2004-5. EUROCAT Central Registry, Northern Ireland, United Kingdom www.eurocat.ulster.ac.uk\/pdf\/EUROCAT-Annual-Report-2005-for-WHO.pdf (accessed 30.06.2007)."},{"key":"10.1016\/j.tox.2008.12.018_bib11","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0272-0590(85)90185-X","article-title":"FDA perspectives on the use of teratology data for human risk assessment","volume":"5","author":"Frankos","year":"1985","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.tox.2008.12.018_bib12","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/nn828","article-title":"Glial cells generate neurons: the role of the transcription factor Pax6","volume":"5","author":"Heins","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.tox.2008.12.018_bib13","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00204-004-0577-9","article-title":"Animal testing and alternative approaches for the human health risk assessment under the proposed new European chemicals regulation","volume":"78","author":"Hofer","year":"2004","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2008.12.018_bib14","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0278-6915(02)00326-5","article-title":"Proposal for a tiered approach to developmental toxicity testing for veterinary pharmaceutical products for food-producing animals","volume":"41","author":"Hurtt","year":"2003","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2008.12.018_bib15","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1177\/088307380301801205","article-title":"Class III beta-tubulin isotype: a key cytoskeletal protein at the crossroads of developmental neurobiology and tumor neuropathology","volume":"18","author":"Katsetos","year":"2003","journal-title":"J. Child. Neurol."},{"key":"10.1016\/j.tox.2008.12.018_bib16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/neu.10270","article-title":"Functions of intermediate filaments in neuronal development and disease","volume":"58","author":"Lariviere","year":"2004","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.tox.2008.12.018_bib17","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-0177(200004)217:4<361::AID-DVDY3>3.0.CO;2-8","article-title":"Expression of neuroD\/BETA2 in mitotic and postmitotic neuronal cells during the development of nervous system","volume":"217","author":"Lee","year":"2000","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.tox.2008.12.018_bib18","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.tox.2008.12.018_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.ne.11.030188.000333","article-title":"Microtubule-associated proteins: their potential role in determining neuronal morphology","volume":"11","author":"Matus","year":"1988","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.tox.2008.12.018_bib20","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1523\/JNEUROSCI.1835-05.2006","article-title":"Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels","volume":"26","author":"Nakamura","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tox.2008.12.018_bib21","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.2174\/0929867033456774","article-title":"Untangling the functional potential of PSA-NCAM-expressing cells in CNS development and brain repair strategies","volume":"10","author":"Nguyen","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.tox.2008.12.018_bib22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1247\/csf.26.137","article-title":"Molecular mechanism to maintain stem cell renewal of ES cells","volume":"26","author":"Niwa","year":"2001","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/j.tox.2008.12.018_bib23","unstructured":"NRC, 2007. Toxicity Testing in the 21st Century: A Vision and A Strategy. National Research Council (NRC) Committee on Toxicity testing and assessment of Environmental agents. First edition, National Research Council, Washington, DC, US."},{"key":"10.1016\/j.tox.2008.12.018_bib24","unstructured":"OECD, 2001. Test No. 414: Prenatal Development Toxicity Study. Organisation for Economic Co-operation and Development, Paris, France http:\/\/213.253.134.43\/oecd\/pdfs\/browseit\/9741401E.PDF (accessed 09.01.2008)."},{"key":"10.1016\/j.tox.2008.12.018_bib25","unstructured":"OEHHA, 1999. Evaluation of Evidence Related to the Development of a Tolerable Daily Intake for Methylmercury. Office of Environmental Health Assessment Services, Washington, US http:\/\/www.doh.wa.gov\/ehp\/oehas\/publications_pdf\/hg99.pdf (accessed 11.04.2008)."},{"key":"10.1016\/j.tox.2008.12.018_bib26","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0012-1606(84)90021-6","article-title":"The differential appearance of neurofilament triplet polypeptides in the developing rat optic nerve","volume":"103","author":"Pachter","year":"1984","journal-title":"Dev. Biol."},{"key":"10.1016\/j.tox.2008.12.018_bib27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00404-001-0265-4","article-title":"Malformations in newborn: results based on 30,940 infants and fetuses from the Mainz congenital birth defect monitoring system (1990\u20131998)","volume":"266","author":"Queisser-Luft","year":"2002","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.tox.2008.12.018_bib28","unstructured":"Risher, J., DeWoskin, R., 2005. Toxicological Profile for Mercury. Agency for Toxic Substances and Disease Registry, Atlanta, Giorgia, http:\/\/www.atsdr.cdc.gov\/toxprofiles\/tp46.html (accessed 12.02.2007)."},{"key":"10.1016\/j.tox.2008.12.018_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-3806(84)90170-6","article-title":"Persistent, differential alterations in developing cerebellar cortex of male and female mice after methylmercury exposure","volume":"314","author":"Sager","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.tox.2008.12.018_bib30","series-title":"Chemically induced Birth Defects","author":"Schardein","year":"2000"},{"key":"10.1016\/j.tox.2008.12.018_bib31","first-page":"421","article-title":"Lithium influences differentiation and tissue-specific gene expression of mouse embryonic stem (ES) cells in vitro","volume":"45","author":"Schmidt","year":"2001","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.tox.2008.12.018_bib32","series-title":"Basic Neurochemistry: Molecular Cellular and Medical Aspects","author":"Siegel","year":"1998"},{"key":"10.1016\/j.tox.2008.12.018_bib33","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1523\/JNEUROSCI.14-03-01395.1994","article-title":"Roles of Pax-genes in developing and adult brain as suggested by expression patterns","volume":"14","author":"Stoykova","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.tox.2008.12.018_bib34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2174\/157488808784223104","article-title":"The possible impact of human embryonic stem cells on safety pharmacological and toxicological assessments in drug discovery and drug development","volume":"3","author":"Stummann","year":"2008","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.tox.2008.12.018_bib35","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.tox.2007.09.022","article-title":"Embryotoxicity hazard assessment of methylmercury and chromium using embryonic stem cells","volume":"242","author":"Stummann","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2008.12.018_bib36","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1126\/science.1078197","article-title":"Synthesis of serotonin by a second tryptophan hydroxylase isoform","volume":"299","author":"Walther","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.tox.2008.12.018_bib37","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1387\/ijdb.8735950","article-title":"Pax and vertebrate development","volume":"40","author":"Wehr","year":"1996","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.tox.2008.12.018_bib38","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1007\/s00018-004-4144-6","article-title":"Nestin expression\u2014a property of multi-lineage progenitor cells?","volume":"61","author":"Wiese","year":"2004","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.tox.2008.12.018_bib39","doi-asserted-by":"crossref","unstructured":"Zhang, S.C., Li, X.J., Johnson, M.A., Pankratz, M.T., 2008. Human embryonic stem cells for brain repair? Philos. Trans. R. Soc. Lond. B Biol. Sci. 363 (1489) 87-99 (Review).","DOI":"10.1098\/rstb.2006.2014"},{"key":"10.1016\/j.tox.2008.12.018_bib40","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/nbt1201-1129","article-title":"In vitro differentiation of transplantable neural precursors from human embryonic stem cells","volume":"19","author":"Zhang","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.tox.2008.12.018_bib41","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.taap.2003.09.019","article-title":"Molecular multiple endpoint embryonic stem cell test\u2014a possible approach to test for the teratogenic potential of compounds","volume":"194","author":"zur Nieden","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X08006082?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X08006082?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:03:52Z","timestamp":1759532632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X08006082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["S0300483X08006082"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2008.12.018","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hazard assessment of methylmercury toxicity to neuronal induction in embryogenesis using human embryonic stem cells","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2008.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}