{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T01:11:45Z","timestamp":1785028305801,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.tox.2009.07.017","type":"journal-article","created":{"date-parts":[[2009,7,31]],"date-time":"2009-07-31T12:48:41Z","timestamp":1249044521000},"page":"89-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Knockdown of superoxide dismutase 2 enhances acetaminophen-induced hepatotoxicity in rat"],"prefix":"10.1016","volume":"264","author":[{"given":"Yukitaka","family":"Yoshikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayu","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Hosomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Tsuneyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuki","family":"Fukami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Yokoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2009.07.017_bib1","doi-asserted-by":"crossref","first-page":"23996","DOI":"10.1074\/jbc.M702819200","article-title":"Knock down of \u03b3-glutamylcysteine synthetase in rat causes acetaminophen-induced hepatotoxicity","volume":"282","author":"Akai","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2009.07.017_bib2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.taap.2006.12.013","article-title":"Mitochondrial abnormalities\u2014a link to idiosyncratic drug hepatotoxicity?","volume":"220","author":"Boelsterli","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2009.07.017_bib3","doi-asserted-by":"crossref","first-page":"34639","DOI":"10.1074\/jbc.273.51.34639","article-title":"Protein kinase C delta-dependent induction of manganese superoxide dismutase gene expression by microtubule-active anticancer drugs","volume":"273","author":"Das","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2009.07.017_bib4","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/hep.21779","article-title":"Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice","volume":"46","author":"Ganey","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.tox.2009.07.017_bib5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/j.gastro.2006.03.045","article-title":"c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity","volume":"131","author":"Gunawan","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.tox.2009.07.017_bib6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0006-2952(95)00128-M","article-title":"Induction mechanisms of cytochrome P450 2E1 in liver: interplay between ethanol treatment and starvation","volume":"50","author":"Hu","year":"1995","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2009.07.017_bib7","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/0006-2952(85)90606-9","article-title":"Diurnal fluctuation and pharmacological alteration of mouse organ glutathione content","volume":"34","author":"Jaeschke","year":"1985","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2009.07.017_bib8","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nrd1750","article-title":"Idiosyncratic drug hepatotoxicity","volume":"4","author":"Kaplowitz","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.tox.2009.07.017_bib9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2131\/jts.31.23","article-title":"In vivo hepatotoxicity study of rats in comparison with in vitro hepatotoxicity screening system","volume":"31","author":"Kikkawa","year":"2006","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tox.2009.07.017_bib10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cbi.2006.03.008","article-title":"Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine","volume":"161","author":"Kim","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.tox.2009.07.017_bib11","doi-asserted-by":"crossref","first-page":"9782","DOI":"10.1073\/pnas.93.18.9782","article-title":"Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice","volume":"93","author":"Lebovitz","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tox.2009.07.017_bib12","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1042\/BJ20060784","article-title":"Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity","volume":"399","author":"Lei","year":"2006","journal-title":"Biochem. J."},{"key":"10.1016\/j.tox.2009.07.017_bib13","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/toxsci\/kfm165","article-title":"Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice","volume":"99","author":"McConnachie","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2009.07.017_bib14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nature02873","article-title":"Mechanisms of gene silencing by double-stranded RNA","volume":"431","author":"Meister","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.tox.2009.07.017_bib15","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1124\/jpet.106.102681","article-title":"Alterations in the rat serum proteome during liver injury from acetaminophen exposure","volume":"318","author":"Merrick","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.tox.2009.07.017_bib16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2131\/jts.31.491","article-title":"Gene expression profile in liver of differing ages of rats after single oral administration of acetaminophen","volume":"31","author":"Morishita","year":"2006","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.tox.2009.07.017_bib17","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1016\/0006-2952(80)90201-4","article-title":"Additive effects of inducers and fasting on acetaminophen hepatotoxicity","volume":"29","author":"Pessayre","year":"1980","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.tox.2009.07.017_bib18","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1124\/dmd.32.7.762","article-title":"Bioactivation of capecitabine in human liver: involvement of the cytosolic enzyme on 5\u2032-deoxy-5-fluorocytidine formation","volume":"32","author":"Tabata","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.tox.2009.07.017_bib19","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/0003-2697(69)90064-5","article-title":"Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues","volume":"27","author":"Tietze","year":"1969","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.tox.2009.07.017_bib20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1006\/abbi.1998.1060","article-title":"Characterization of the antioxidant status of the heterozygous manganese superoxide dismutase knockout mouse","volume":"363","author":"Van Remmen","year":"1999","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tox.2009.07.017_bib21","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1016\/S0021-9258(19)39880-1","article-title":"Regulation of manganese superoxide dismutase by lipopolysaccharide, interleukin-1, and tumor necrosis factor. Role in the acute inflammatory response","volume":"265","author":"Visner","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2009.07.017_bib22","doi-asserted-by":"crossref","unstructured":"Yoshikawa, Y., Hosomi, H., Fukami, T., Nakajima, M., Yokoi, T., 2009. Establishment of knockdown of superoxide dismutase 2 and expression of CYP3A4 cell system to evaluate drug-induced cytotoxicity. Toxicol. In Vitro, 1179\u20131187.","DOI":"10.1016\/j.tiv.2009.05.024"},{"key":"10.1016\/j.tox.2009.07.017_bib23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0891-5849(02)00905-X","article-title":"Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression","volume":"33","author":"Zelko","year":"2002","journal-title":"Free Radic. Biol. Med."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X09004090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X09004090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:08:25Z","timestamp":1759532905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X09004090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":23,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0300483X09004090"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2009.07.017","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Knockdown of superoxide dismutase 2 enhances acetaminophen-induced hepatotoxicity in rat","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2009.07.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}