{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:20:42Z","timestamp":1792293642305,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.tox.2009.09.012","type":"journal-article","created":{"date-parts":[[2009,9,26]],"date-time":"2009-09-26T04:48:23Z","timestamp":1253940503000},"page":"56-67","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":231,"title":["Neonatal exposure of male rats to Bisphenol A impairs fertility and expression of sertoli cell junctional proteins in the testis"],"prefix":"10.1016","volume":"265","author":[{"given":"Smita","family":"Salian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanvi","family":"Doshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geeta","family":"Vanage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2009.09.012_bib1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00441-003-0806-1","article-title":"Relief effect of vitamin A on the decreased motility of sperm and the increased incidence of malformed sperm in mice exposed neonatally to Bisphenol A","volume":"315","author":"Aikawa","year":"2004","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.tox.2009.09.012_bib2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1034\/j.1600-0722.2002.11201.x","article-title":"Effects of Bisphenol A on adult male mouse fertility","volume":"110","author":"Al-Hiyasat","year":"2002","journal-title":"Eur. J. Oral Sci."},{"key":"10.1016\/j.tox.2009.09.012_bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1679\/aohc.69.101","article-title":"Estrogen agonists, 17 beta-estradiol, Bisphenol A, and diethylstilbestrol decrease cortactin expression in the mouse testis","volume":"69","author":"Anahara","year":"2006","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.tox.2009.09.012_bib4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s004419900076","article-title":"Modified expression of testicular gap-junction connexin 43 during normal spermatogenic cycle and in altered spermatogenesis","volume":"298","author":"Batias","year":"1999","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.tox.2009.09.012_bib5","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1177\/002215540004800608","article-title":"Connexin43 gene expression and regulation in the rodent seminiferous epithelium","volume":"48","author":"Batias","year":"2000","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.tox.2009.09.012_bib6","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1210\/endo.135.3.8070367","article-title":"Immunohistochemical localization of androgen receptors in the rat testes: evidence for stage-dependent expression and regulation by androgens","volume":"135","author":"Bremner","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2009.09.012_bib7","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1289\/ehp.95103608","article-title":"Xenoestrogens released from lacquer coatings in food cans","volume":"103","author":"Brotons","year":"1995","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2009.09.012_bib8","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1152\/physrev.00009.2002","article-title":"Cell junction dynamics in the testis: sertoli-germ cell interactions and male contraceptive development","volume":"82","author":"Cheng","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.tox.2009.09.012_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.mce.2005.04.011","article-title":"Effect of high intratesticular estrogen on the seminiferous epithelium in adult male rats","volume":"241","author":"D'Souza","year":"2005","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.tox.2009.09.012_bib10","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0890-6238(01)00160-5","article-title":"Rat two-generation reproductive toxicity study of Bisphenol A","volume":"15","author":"Ema","year":"2001","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2009.09.012_bib11","unstructured":"European food safety authority (EFSA), 2008. Scientific opinion of the panel on food additives, flavourings, processing aids and materials in contact with food (AFC). EFSA J. 759, 1\u201310."},{"key":"10.1016\/j.tox.2009.09.012_bib12","unstructured":"European union risk assessment report, 2003. 4,4\u2032-isopropylidenediphenol (Bisphenol A) risk assessment (EINECS no. 201-245-8)."},{"key":"10.1016\/j.tox.2009.09.012_bib13","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1593\/neo.06559","article-title":"Altered expression of ZO-1 and ZO-2 in Sertoli cells and loss of blood-testis barrier integrity in testicular carcinoma in situ","volume":"12","author":"Fink","year":"2006","journal-title":"Neoplasia"},{"key":"10.1016\/j.tox.2009.09.012_bib14","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.reprotox.2004.01.002","article-title":"Sertoli cell junctional proteins as early targets for different classes of reproductive toxicants","volume":"18","author":"Fiorini","year":"2004","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2009.09.012_bib15","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1095\/biolreprod.102.010637","article-title":"Neonatal estrogen exposure of male rats alters reproductive functions at adulthood","volume":"68","author":"Goyal","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2009.09.012_bib16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0278-6915(84)90092-9","article-title":"Effect of some phthalate esters and other testicular toxins on primary cultures of testicular cells","volume":"22","author":"Gray","year":"1984","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.tox.2009.09.012_bib17","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1095\/biolreprod43.3.525","article-title":"Quantitative and qualitative characteristics of the stages and transitions in the cycle of the rat seminiferous epithelium: light microscopic observations of perfusion-fixed and plastic embedded testes","volume":"43","author":"Hess","year":"1990","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2009.09.012_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3106\/mammalstudy.27.73","article-title":"Disturbed spermatogenesis in mice prenatally exposed to an endocrine disruptor Bisphenol A","volume":"27","author":"Iida","year":"2002","journal-title":"Mammal Study"},{"key":"10.1016\/j.tox.2009.09.012_bib19","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1210\/endo.141.2.7334","article-title":"Multiple cadherin superfamily members with unique expression profiles are produced in rat testis","volume":"141","author":"Johnson","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2009.09.012_bib20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.reprotox.2005.10.003","article-title":"Effects of Bisphenol A given neonatally on reproductive functions of male rats","volume":"22","author":"Kato","year":"2006","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2009.09.012_bib21","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1210\/endo.139.10.6216","article-title":"Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta","volume":"139","author":"Kuiper","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2009.09.012_bib22","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1080\/01926230290105695","article-title":"Recommended approaches for the evaluation of testicular and epididymal toxicity","volume":"30","author":"Lanning","year":"2002","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.tox.2009.09.012_bib23","unstructured":"NTP, 2001. National Toxicology Program's Report of the Endocrine Disruptors Low Dose Peer Review. National Toxicology Program, Research Triangle Park, NC."},{"key":"10.1016\/j.tox.2009.09.012_bib24","unstructured":"NTP, 2008. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A. NTP-08-5994. Research Triangle Park, NC."},{"key":"10.1016\/j.tox.2009.09.012_bib25","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1289\/ehp.96104298","article-title":"Estrogenicity of resin-based composites and sealants used in dentistry","volume":"104","author":"Olea","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2009.09.012_bib26","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0960-9822(00)00690-4","article-title":"Unique and shared functions of different connexins in mice","volume":"10","author":"Plum","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/j.tox.2009.09.012_bib27","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1210\/en.2002-0198","article-title":"Bisphenol A induces both transient and permanent histofunctional alterations of the hypothalamic\u2013pituitary\u2013gonadal axis in prenatally exposed male rats","volume":"144","author":"Ramos","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2009.09.012_bib28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/taap.1996.0055","article-title":"Mono-(2-ethylhexyl) phthalate rapidly alters both Sertoli cell vimentin filaments and germ cell apoptosis in young rat testes","volume":"137","author":"Richburg","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2009.09.012_bib29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.reprotox.2007.06.004","article-title":"In vivo effects of Bisphenol A in laboratory rodent studies","volume":"24","author":"Richter","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2009.09.012_bib30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1242\/jcs.103.1.81","article-title":"Cell-, age- and stage-dependent distribution of connexin43 gap junctions in testes","volume":"103","author":"Risley","year":"1992","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.tox.2009.09.012_bib31","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1539\/joh.43.185","article-title":"Bisphenol-A affects spermatogenesis in the adult rat even at a low dose","volume":"43","author":"Sakaue","year":"2001","journal-title":"J. Occup. Health"},{"key":"10.1016\/j.tox.2009.09.012_bib32","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1095\/biolreprod59.5.1084","article-title":"Abnormalities in functional development of the Sertoli cells in rats treated neonatally with diethylstilbestrol: a possible role for estrogens in Sertoli cell development","volume":"59","author":"Sharpe","year":"1998","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.tox.2009.09.012_bib33","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0890-6238(99)00020-9","article-title":"Cytotoxic effect of endosulfan on rat Sertoli-germ coculture","volume":"13","author":"Sinha","year":"1999","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2009.09.012_bib34","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.reprotox.2006.02.004","article-title":"Effect of di-(2-ethylhexyl) phthalate on N-cadherin and catenin protein expression in rat testis","volume":"22","author":"Sobarzo","year":"2006","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2009.09.012_bib35","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1196\/annals.1411.004","article-title":"Role of connexin 43 in Sertoli cells of testis","volume":"1120","author":"Sridharan","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.tox.2009.09.012_bib36","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s002040000204","article-title":"Testicular toxicity of dietary 2,2-Bis (4-hydroxyphenyl) propane (Bisphenol A) in F344 rats","volume":"75","author":"Takahashi","year":"2001","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.tox.2009.09.012_bib37","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1679\/aohc.67.373","article-title":"Adverse effect of Bisphenol A to spermiogenesis in mice and rats","volume":"67","author":"Toyama","year":"2004","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.tox.2009.09.012_bib38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.reprotox.2004.08.003","article-title":"Effects of neonatal administration of 17\u03b2-estradiol, \u03b2-estradiol 3-benzoate or Bisphenol A on mouse and rat spermatogenesis","volume":"19","author":"Toyama","year":"2004","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2009.09.012_bib39","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jsbmb.2004.12.008","article-title":"Assesment of human contamination of estrogenic endocrine disrupting chemicals and their risk for human reproduction","volume":"93","author":"Tsutsumi","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.tox.2009.09.012_bib40","first-page":"21","article-title":"Three-generation reproductive toxicity study of dietary Bisphenol A in CD Sprague-Dawley rats","volume":"681","author":"Tyl","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2009.09.012_bib41","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.reprotox.2007.07.010","article-title":"Human exposure to Bisphenol A (BPA)","volume":"24","author":"Vandenberg","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2009.09.012_bib42","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/074823379801400115","article-title":"A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior","volume":"14","author":"vom Saal","year":"1998","journal-title":"Toxicol. Ind. Health."},{"key":"10.1016\/j.tox.2009.09.012_bib43","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1289\/ehp.7713","article-title":"An extensive new literature concerning low-dose effects of Bisphenol A shows the need for a new risk assessment","volume":"113","author":"vom Saal","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2009.09.012_bib44","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.tox.2005.05.006","article-title":"Implications for human health of the extensive Bisphenol A literature showing adverse effects at low doses: a response to attempts to mislead the public","volume":"212","author":"vom Saal","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2009.09.012_bib45","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.reprotox.2007.07.005","article-title":"Chapel Hill Bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure","volume":"24","author":"vom Saal","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.tox.2009.09.012_bib46","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1242\/jcs.00900","article-title":"Regulation of blood-testis barrier dynamics: an in vivo study","volume":"117","author":"Wong","year":"2004","journal-title":"J. Cell Sci."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X09004855?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X09004855?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:08:11Z","timestamp":1759532891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X09004855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":46,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0300483X09004855"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2009.09.012","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neonatal exposure of male rats to Bisphenol A impairs fertility and expression of sertoli cell junctional proteins in the testis","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2009.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}