{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:19:00Z","timestamp":1762251540242,"version":"build-2065373602"},"reference-count":43,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.tox.2009.10.002","type":"journal-article","created":{"date-parts":[[2009,10,10]],"date-time":"2009-10-10T04:58:27Z","timestamp":1255150707000},"page":"1-5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Adverse effect of fenofibrate on branched-chain \u03b1-ketoacid dehydrogenase complex in rat's liver"],"prefix":"10.1016","volume":"266","author":[{"given":"Malgorzata","family":"Knapik-Czajka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Gozdzialska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Jaskiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2009.10.002_bib1","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1093\/jn\/131.3.856S","article-title":"Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine","volume":"131","author":"Anthony","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.tox.2009.10.002_bib2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2165\/00003495-199040020-00007","article-title":"Fenofibrate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in dyslipidaemia","volume":"40","author":"Balfour","year":"1990","journal-title":"Drugs"},{"key":"10.1016\/j.tox.2009.10.002_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9150(03)00156-4","article-title":"Fibrates in 2003: therapeutic action in atherogenic dyslipidaemia and future perspectives","volume":"171","author":"Chapman","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.tox.2009.10.002_bib4","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1006\/bbrc.2000.2647","article-title":"Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight","volume":"271","author":"Chaput","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2009.10.002_bib5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/jn\/135.3.376","article-title":"Oral leucine administration stimulates protein synthesis in rat skeletal muscle","volume":"135","author":"Crozier","year":"2005","journal-title":"J. Nutr."},{"key":"10.1016\/j.tox.2009.10.002_bib6","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1073\/pnas.81.14.4335","article-title":"Purification and properties of branched-chain ( ketoacid dehydrogenase phosphatase from bovine kidney","volume":"81","author":"Damuni","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.tox.2009.10.002_bib7","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1152\/ajpcell.2000.279.5.C1587","article-title":"Amino acid deprivation induces translation of branched-chain (-keto acid dehydrogenase kinase","volume":"279","author":"Doering","year":"2000","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.tox.2009.10.002_bib8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1042\/bj2370285","article-title":"Effects of low-protein diet and starvation on the activity of branched-chain 2-oxo acid dehydrogenase kinase in rat liver and heart","volume":"237","author":"Espinal","year":"1986","journal-title":"Biochem. J."},{"key":"10.1016\/j.tox.2009.10.002_bib9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0076-6879(88)66025-3","article-title":"Determination of activity and activity state of branched-chain (-ketoacid dehydrogenase in rat tissues","volume":"166","author":"Goodwin","year":"1988","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.tox.2009.10.002_bib10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0003-9861(87)90325-0","article-title":"Activation of branched chain (-ketoacid dehydrogenase in isolated hepatocytes by branched chain (-ketoacids","volume":"258","author":"Han","year":"1987","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tox.2009.10.002_bib11","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/S0006-291X(82)80168-X","article-title":"Activation of the branched-chain \u03b1-ketoacid dehydrogenase complex by a broad specificity protein phosphatase","volume":"107","author":"Harris","year":"1982","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2009.10.002_bib12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0065-2571(86)90016-6","article-title":"Regulation of branched-chain \u03b1-ketoacid dehydrogenase complex by covalent modification","volume":"250","author":"Harris","year":"1986","journal-title":"Adv. Enzyme Regul."},{"key":"10.1016\/j.tox.2009.10.002_bib13","first-page":"307","article-title":"Nutritional and hormonal regulation of the activity state of hepatic branched-chain \u03b1-ketoacid dehydrogenase complex","volume":"804","author":"Harris","year":"1996","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.tox.2009.10.002_bib14","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0065-2571(96)00009-X","article-title":"Studies on the regulation of the mitochondrial \u03b1-ketoacid dehydrogenase complexes and their kinases","volume":"37","author":"Harris","year":"1997","journal-title":"Adv. Enzyme Rev."},{"key":"10.1016\/j.tox.2009.10.002_bib15","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.bbrc.2003.11.007","article-title":"Mechanism responsible for regulation of branched-chain amino acid catabolism","volume":"313","author":"Harris","year":"2004","journal-title":"Biochem. Bipohys. Res. Commun."},{"key":"10.1016\/j.tox.2009.10.002_bib16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0378-4274(02)00010-3","article-title":"Myopathy and rhabdomyolysis with lipid-lowering drugs","volume":"128","author":"Hodel","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2009.10.002_bib17","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1093\/oxfordjournals.jbchem.a123465","article-title":"Both induction and activation of the branched-chain 2-oxo acid dehydrogenase complex in primary-cultured rat hepatocytes by clofibrate","volume":"109","author":"Honda","year":"1991","journal-title":"J. Biochem."},{"key":"10.1016\/j.tox.2009.10.002_bib18","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1093\/jn\/131.3.846S","article-title":"Function of leucine in excitatory neurotransmitter metabolism in the central nervous system","volume":"131","author":"Hutson","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.tox.2009.10.002_bib19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0006-291X(03)00295-X","article-title":"Branched-chain amino acids promote albumin synthesis in rat primary hepatocytes through the mTOR signal transduction system","volume":"303","author":"Ijichi","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.tox.2009.10.002_bib20","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.lfs.2006.02.037","article-title":"Clofibrate treatment promotes branched-chain amino acid catabolism and decreases the phosphorylation state of mTOR, eIF4E-BP1, and S6K1 in rat liver","volume":"79","author":"Ishiguro","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.tox.2009.10.002_bib21","first-page":"191","article-title":"Effect of fibrates on the branched-chain \u03b1-ketoacid dehydrogenase complex in rat liver","volume":"10","author":"Knapik-Czajka","year":"2002","journal-title":"Acta Pol. Toxicol."},{"key":"10.1016\/j.tox.2009.10.002_bib22","first-page":"59","article-title":"Effect of fibrates on the branched chain \u03b1-ketoacid dehydroganase complex activity","volume":"11","author":"Knapik-Czajka","year":"2003","journal-title":"Acta Toxicol."},{"key":"10.1016\/j.tox.2009.10.002_bib23","first-page":"67","article-title":"The influence of fibrates on the branched-chain \u03b1-ketoacid dehydrogenase complex expression in rat's liver","volume":"11","author":"Knapik-Czajka","year":"2003","journal-title":"Acta Toxicol."},{"key":"10.1016\/j.tox.2009.10.002_bib24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0003-9861(02)00472-1","article-title":"Clofibric acid stimulates branched-chain amino acid catabolism by three mechanisms","volume":"407","author":"Kobayashi","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tox.2009.10.002_bib25","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.2337\/diabetes.52.9.2249","article-title":"Differential influences of peroxisome proliferator-activated receptors \u03b3 and \u03b1 on food intake and energy homeostasis","volume":"52","author":"Larsen","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.tox.2009.10.002_bib26","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1074\/jbc.M210577200","article-title":"Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets","volume":"278","author":"Li","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2009.10.002_bib27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1042\/cs0790457","article-title":"Effect of infused branched-chain amino acids on muscle and whole-body amino acid metabolism in man","volume":"79","author":"Louard","year":"1990","journal-title":"Clin. Sci."},{"key":"10.1016\/j.tox.2009.10.002_bib28","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1172\/JCI38151","article-title":"Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells","volume":"119","author":"Lu","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.tox.2009.10.002_bib29","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0014-5793(01)02146-9","article-title":"Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats","volume":"491","author":"Mancini","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.tox.2009.10.002_bib30","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/dmr.5610050303","article-title":"Effects of branched-chain amino acids on protein turnover","volume":"5","author":"May","year":"1989","journal-title":"Diabetes Metab. Rev."},{"key":"10.1016\/j.tox.2009.10.002_bib31","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1093\/jn\/135.6.1565S","article-title":"Markers associated with inborn errors of metabolism of branched-chain amino acids and their relevance to upper levels of intake in healthy people: an implication from clinical and molecular investigations on maple syrup urine disease","volume":"135","author":"Mitsubuchi","year":"2005","journal-title":"J. Nutr."},{"key":"10.1016\/j.tox.2009.10.002_bib32","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1152\/ajpendo.1992.263.5.E928","article-title":"Leucine as a regulator of whole body and skeletal muscle protein metabolism in humans","volume":"263","author":"Nair","year":"1992","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.tox.2009.10.002_bib33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3346\/jkms.2007.22.2.235","article-title":"The increase in hepatic uncoupling by fenofibrate contributes to a decrease in adipose tissue in obese rats","volume":"22","author":"Park","year":"2007","journal-title":"J. Kor. Med. Sci."},{"key":"10.1016\/j.tox.2009.10.002_bib34","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1042\/bj3170411","article-title":"Alternation in gene expression of branched-chain ketoacid dehydrogenase kinase but not in gene expression of its substrate in the liver of clofibrated rat","volume":"317","author":"Paul","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.tox.2009.10.002_bib35","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0003-9861(84)90362-X","article-title":"Clofibric acid, phenylpyruvate, and dichloroacetate inhibition of branched-chain \u03b1-ketoacid dehydrogenase kinase in vitro and in perfused rat heart","volume":"231","author":"Paxton","year":"1984","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tox.2009.10.002_bib36","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1006\/abbi.1995.1022","article-title":"Dietary control and tissue expression of branched-chain \u03b1-ketoacid dehydrogenase complex kinase","volume":"316","author":"Popov","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tox.2009.10.002_bib37","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1749-6632.1996.tb18616.x","article-title":"Peroxisome proliferator-induced pleiotropic responses: pursuit of phenomenon","volume":"804","author":"Reddy","year":"1996","journal-title":"Ann N. Y. Acad. Sci."},{"key":"10.1016\/j.tox.2009.10.002_bib38","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0022-2275(20)42003-6","article-title":"Role of peroxisome proliferator-activated receptor [PPAR] in mediating the effects of fibrates and fatty acid on gene expression","volume":"37","author":"Schoonjans","year":"1996","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.tox.2009.10.002_bib39","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0003-9861(90)90645-F","article-title":"Purification and partial characterization of branched-chain \u03b1-ketoacid dehydrogenase kinase from rat liver and rat heart","volume":"283","author":"Shimomura","year":"1990","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.tox.2009.10.002_bib40","first-page":"419","article-title":"Regulation of branched-chain amino acid catabolism: nutritional and hormonal regulation of activity and expression of the branched-chain \u03b1-keto acid dehydrogenase kinase","volume":"4","author":"Shimomura","year":"2001","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.tox.2009.10.002_bib41","series-title":"Alpha-keto Acid Dehydrogenase Complexes","first-page":"101","article-title":"Structure, function and assembly of mammalian branched-chain \u03b1-keto acid dehydrogenase complex","author":"Wynn","year":"1996"},{"key":"10.1016\/j.tox.2009.10.002_bib42","doi-asserted-by":"crossref","first-page":"18583","DOI":"10.1016\/S0021-9258(17)32349-9","article-title":"Site directed-mutagenesis of phosphorylation sites of the branched-chain \u03b1-ketoacid dehydrogenase complex","volume":"269","author":"Zhao","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.tox.2009.10.002_bib43","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1006\/abbi.1994.1063","article-title":"Effect of dietary protein on the liver content and subunit composition of the branched-chain \u03b1-ketoacid dehydrogenase complex","volume":"308","author":"Zhao","year":"1994","journal-title":"Arch. Biochem. Biophys."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X09004958?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X09004958?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:07:46Z","timestamp":1759532866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X09004958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":43,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0300483X09004958"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2009.10.002","relation":{},"ISSN":["0300-483X"],"issn-type":[{"type":"print","value":"0300-483X"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adverse effect of fenofibrate on branched-chain \u03b1-ketoacid dehydrogenase complex in rat's liver","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2009.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}