{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:21:28Z","timestamp":1787235688763,"version":"build-2736575974"},"reference-count":48,"publisher":"Elsevier BV","issue":"1-3","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.tox.2010.04.006","type":"journal-article","created":{"date-parts":[[2010,4,19]],"date-time":"2010-04-19T04:49:08Z","timestamp":1271652548000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Quantitative characterization of changes in bone geometry, mineral density and biomechanical properties in two rat strains with different Ah-receptor structures after long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin"],"prefix":"10.1016","volume":"273","author":[{"given":"Maria","family":"Herlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Kalantari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salomon","family":"Sand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sune","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Viluksela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouni T.","family":"Tuomisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouko","family":"Tuomisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Tuukkanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"J\u00e4ms\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Monica","family":"Lind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"H\u00e5kansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.tox.2010.04.006_bib1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/aja.1002040205","article-title":"Developmental expression of two members of a new class of transcription factors: II. Expression of aryl hydrocarbon receptor nuclear translocator in the C57BL\/6N mouse embryo","volume":"204","author":"Abbott","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.tox.2010.04.006_bib2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.toxlet.2009.01.030","article-title":"Effects of 3,3\u2032,4,4\u2032,5-pentachlorobiphenyl (PCB126) on vertebral bone mineralization and on thyroxin and vitamin D levels in Sprague\u2013Dawley rats","volume":"187","author":"Alvarez-Lloret","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2010.04.006_bib3","doi-asserted-by":"crossref","first-page":"747","DOI":"10.2106\/00004623-199274050-00014","article-title":"Compressive mechanical properties of human cancellous bone after gamma irradiation","volume":"74","author":"Anderson","year":"1992","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.tox.2010.04.006_bib4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0300-483X(89)90036-X","article-title":"Polychlorinated biphenyl (Aroclor 1254) induced changes in femur morphometry calcium metabolism and nephrotoxicity","volume":"57","author":"Andrews","year":"1989","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2010.04.006_bib5","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.crvi.2007.09.002","article-title":"Effect of subchronic exposure to tetradifon on bone remodeling and metabolism in female rat","volume":"330","author":"Badraoui","year":"2007","journal-title":"C. R. Biol."},{"key":"10.1016\/j.tox.2010.04.006_bib6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/00039890009603403","article-title":"1,1,1-Trichloro-2,2-bis (p-chlorophenyl)-ethane (DDT) and reduced bone mineral density","volume":"55","author":"Beard","year":"2000","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.tox.2010.04.006_bib7","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1365-2133.1984.tb06603.x","article-title":"Porphyria turcica due to hexachlorobenzene: a 20 to 30 year follow-up study on 204 patients","volume":"111","author":"Cripps","year":"1984","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.tox.2010.04.006_bib8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev.pharmtox.43.100901.135828","article-title":"Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals","volume":"43","author":"Denison","year":"2003","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2010.04.006_bib9","first-page":"1","article-title":"Guidance of the Scientific Committee on a request from EFSA on the use of the benchmark dose approach in risk assessment","volume":"1150","author":"EFSA","year":"2009","journal-title":"EFSA J."},{"key":"10.1016\/j.tox.2010.04.006_bib10","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/0045-6535(89)90408-6","article-title":"Tumour promoting effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)\u2014effects of exposure duration, administration schedule and type of diet","volume":"19","author":"Flodstr\u00f6m","year":"1989","journal-title":"Chemosphere"},{"key":"10.1016\/j.tox.2010.04.006_bib11","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1080\/15287390802328788","article-title":"Health of herring gulls (Larus argentatus) in relation to breeding location in the early 1990s. III. Effects on the bone tissue","volume":"71","author":"Fox","year":"2008","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.tox.2010.04.006_bib12","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1007\/s001980070025","article-title":"Organochlorines and bone mineral density in Swedish men from the general population","volume":"11","author":"Glynn","year":"2000","journal-title":"Osteoporos Int."},{"key":"10.1016\/j.tox.2010.04.006_bib13","first-page":"36","article-title":"Hexachlorobenzene episode in Turkey","volume":"2","author":"Gocmen","year":"1989","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.tox.2010.04.006_bib14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.tox.2008.09.005","article-title":"In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affects bone tissue in rhesus monkeys","volume":"253","author":"Hermsen","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2010.04.006_bib15","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1289\/ehp.11107","article-title":"Bone mineral density changes in relation to environmental PCB exposure","volume":"116","author":"Hodgson","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2010.04.006_bib16","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.lfs.2005.01.027","article-title":"Bone resorption by aryl hydrocarbon receptor-expressing osteoclasts is not disturbed by TCDD in short-term cultures","volume":"77","author":"Ilvesaro","year":"2005","journal-title":"Life Sci."},{"issue":"Suppl. 1, Part 1","key":"10.1016\/j.tox.2010.04.006_bib17","first-page":"347","article-title":"Equipment for testing the biomechanical strength of bones","volume":"34","author":"J\u00e4ms\u00e4","year":"1996","journal-title":"Med. Biol. Eng. Comput."},{"key":"10.1016\/j.tox.2010.04.006_bib18","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1359\/jbmr.2001.16.10.1812","article-title":"Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on bone in two rat strains with different aryl hydrocarbon receptor structures","volume":"16","author":"J\u00e4ms\u00e4","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.tox.2010.04.006_bib19","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.bone.2009.02.019","article-title":"Dioxins interfere with differentiation of osteoblasts and osteoclasts","volume":"44","author":"Korkalainen","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.tox.2010.04.006_bib20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/8756-3282(95)00439-4","article-title":"Long-term effects of clodronate on growing rat bone","volume":"18","author":"Lepola","year":"1996","journal-title":"Bone"},{"key":"10.1016\/j.tox.2010.04.006_bib21","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1579\/0044-7447-32.6.385","article-title":"Bone mineral density in male Baltic grey seal (Halichoerus grypus)","volume":"32","author":"Lind","year":"2003","journal-title":"Ambio"},{"key":"10.1016\/j.tox.2010.04.006_bib22","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/taap.1998.8568","article-title":"Effects of the antiestrogenic environmental pollutant 3,3\u2032,4,4\u2032, 5-pentachlorobiphenyl (PCB #126) in rat bone and uterus: diverging effects in ovariectomized and intact animals","volume":"154","author":"Lind","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2010.04.006_bib23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0300-483X(00)00262-6","article-title":"Bone tissue composition, dimensions and strength in female rats given an increased dietary level of vitamin A or exposed to 3,3\u2032,4, 4\u2032,5-pentachlorobiphenyl (PCB126) alone or in combination with vitamin C","volume":"151","author":"Lind","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2010.04.006_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0300-483X(00)00245-6","article-title":"Change of bone tissue composition and impaired bone strength in rats exposed to 3,3\u2032,4,4\u2032,5-pentachlorobiphenyl (PCB126)","volume":"150","author":"Lind","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2010.04.006_bib25","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1289\/ehp.6524","article-title":"Abnormal bone composition in female juvenile American alligators from a pesticide-polluted lake (Lake Apopka, Florida)","volume":"112","author":"Lind","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2010.04.006_bib26","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/j.jbiomech.2008.03.017","article-title":"Biomechanical testing in experimental bone interventions\u2014may the power be with you","volume":"41","author":"Lepp\u00e4nen","year":"2008","journal-title":"J. Biomech."},{"key":"10.1016\/j.tox.2010.04.006_bib27","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1093\/toxsci\/kfi136","article-title":"Effects of in utero and lactational TCDD exposure on bone development in differentially sensitive rat lines","volume":"85","author":"Miettinen","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2010.04.006_bib28","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1289\/ehp.8560211","article-title":"Congenital PCB poisoning: a reevaluation","volume":"60","author":"Miller","year":"1985","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2010.04.006_bib29","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1210\/en.2002-220003","article-title":"3-Methylcholanthrene, which binds to the arylhydrocarbon receptor, inhibits proliferation and differentiation of osteoblasts in vitro and ossification in vivo","volume":"143","author":"Naruse","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.tox.2010.04.006_bib30","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/8756-3282(94)90276-3","article-title":"The mechanical strength of bone in different rat models of experimental osteoporosis","volume":"15","author":"Peng","year":"1994","journal-title":"Bone"},{"key":"10.1016\/j.tox.2010.04.006_bib31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1600-0773.1993.tb01958.x","article-title":"Comparative acute lethality of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 1,2,3,7,8-pentachlorodibenzo-p-dioxin and 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin in the most TCDD-susceptible and the most TCDD-resistant rat strain","volume":"73","author":"Pohjanvirta","year":"1993","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.tox.2010.04.006_bib32","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1124\/mol.54.1.86","article-title":"Point mutation in intron sequence causes altered C-terminal structure in the AH receptor of the most TCDD-resistant rat strain","volume":"54","author":"Pohjanvirta","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.tox.2010.04.006_bib33","doi-asserted-by":"crossref","first-page":"4936","DOI":"10.1021\/es060769x","article-title":"Effect of in ovo exposure to PCBs and Hg on Clapper Rail bone mineral chemistry from a contaminated salt marsh in coastal Georgia","volume":"40","author":"Rodriguez-Navarro","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.tox.2010.04.006_bib34","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1359\/jbmr.070615","article-title":"Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor","volume":"22","author":"Ryan","year":"2007","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.tox.2010.04.006_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2010.01.006","article-title":"Quantitative and statistical analysis of differences in sensitivity between Long\u2013Evans and Han\/Wistar rats following long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin","author":"Sand","year":"2010","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.tox.2010.04.006_bib36","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/jat.1298","article-title":"The current state of knowledge on the use of the benchmark dose concept in risk assessment","volume":"28","author":"Sand","year":"2008","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.tox.2010.04.006_bib37","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/taap.2002.9386","article-title":"Structure-activity relationships and dose responses of polychlorinated dibenzo-p-dioxins for short-term effects in 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant and -sensitive rat strains","volume":"181","author":"Simanainen","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2010.04.006_bib38","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1677\/joe.0.1670183","article-title":"Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon receptor antagonist, resveratrol","volume":"167","author":"Singh","year":"2000","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.tox.2010.04.006_bib39","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1289\/ehp.7293","article-title":"Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)?","volume":"112","author":"Sonne","year":"2004","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.tox.2010.04.006_bib40","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/taap.1998.8564","article-title":"The AH receptor and a novel gene determine acute toxic responses to TCDD: segregation of the resistant alleles to different rat lines","volume":"155","author":"Tuomisto","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2010.04.006_bib41","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1006\/taap.1994.1208","article-title":"Dose response and time course of alterations in tryptophan metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the most TCDD-susceptible and the most TCDD-resistant rat strain: relationship with TCDD lethality","volume":"128","author":"Unkila","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.tox.2010.04.006_bib42","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.toxlet.2008.03.003","article-title":"A 28-day oral dose toxicity study in Wistar rats enhanced to detect endocrine effects of decabromodiphenyl ether (decaBDE)","volume":"79","author":"van der Ven","year":"2008","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2010.04.006_bib43","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.toxlet.2008.12.003","article-title":"Endocrine effects of hexabromocyclododecane (HBCD) in a one-generation reproduction study in Wistar rats","volume":"185","author":"van der Ven","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.tox.2010.04.006_bib44","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.tox.2007.12.016","article-title":"A 28-day oral dose toxicity study enhanced to detect endocrine effects of a purified technical pentabromodiphenyl ether (pentaBDE) mixture in Wistar rats","volume":"245","author":"van der Ven","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2010.04.006_bib45","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tox.2007.12.009","article-title":"Endocrine effects of tetrabromobisphenol-A (TBBPA) in Wistar rats as tested in a one-generation reproduction study and a subacute toxicity study","volume":"245","author":"van der Ven","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.tox.2010.04.006_bib46","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1093\/toxsci\/kfl113","article-title":"A 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in Wistar rats","volume":"94","author":"van der Ven","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.tox.2010.04.006_bib47","first-page":"6911","article-title":"Liver tumor-promoting activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in TCDD-sensitive and TCDD-resistant rat strains","volume":"60","author":"Viluksela","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.tox.2010.04.006_bib48","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S1043-2760(02)00594-5","article-title":"Elucidation of estrogen receptor functions in bone with the use of mouse models","volume":"13","author":"Windahl","year":"2002","journal-title":"Trends Endocrinol. Metab."}],"container-title":["Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X10001794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300483X10001794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T23:11:37Z","timestamp":1759533097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300483X10001794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":48,"journal-issue":{"issue":"1-3","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0300483X10001794"],"URL":"https:\/\/doi.org\/10.1016\/j.tox.2010.04.006","relation":{},"ISSN":["0300-483X"],"issn-type":[{"value":"0300-483X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative characterization of changes in bone geometry, mineral density and biomechanical properties in two rat strains with different Ah-receptor structures after long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin","name":"articletitle","label":"Article Title"},{"value":"Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.tox.2010.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}